Nomenclature for Factors of the HLA System
June 2018
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2018): 92:129-134
- Human Immunology(2018): 79:757-760
- International Journal of Immunogenetics(2018): 45:297-302
The following sequences have been submitted to the Nomenclature Committee since the May 2018 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:01:16 | AN00768 | LT963235, | Prof Steven GE Marsh |
| A*01:01:01:17 | AN00909 | LT963296, | Prof Steven GE Marsh |
| A*01:01:01:18 | 301156 | MH269331, | Dr Vera Balz |
| A*02:01:01:35 | AN00771 | LT963238, | Prof Steven GE Marsh |
| A*02:01:01:36 | AN00782 | LT963251, | Prof Steven GE Marsh |
| A*02:01:01:37 | AN00786 | LT963254, | Prof Steven GE Marsh |
| A*02:01:01:38 | AN00817 | LT963274, | Prof Steven GE Marsh |
| A*02:01:01:39 | AN00818 | LT963275, | Prof Steven GE Marsh |
| A*02:01:01:40 | AN00820 | LT963276, | Prof Steven GE Marsh |
| A*02:01:01:41 | AN00823 | LT963279, | Prof Steven GE Marsh |
| A*02:01:143 | AN00910 | LT963297, | Prof Steven GE Marsh |
| A*02:01:144 | 96094370 | MH382832, | Dr Daniel Fuerst |
| A*11:01:01:09 | BY01580 | MH427369, | Prof Carolyn K Hurley |
| A*11:288 | 449256 | MH271165, | Dr Antonio Balas |
| A*24:02:01:15 | AN00776 | LT963243, | Prof Steven GE Marsh |
| A*24:02:01:16 | AN00821 | LT963277, | Prof Steven GE Marsh |
| A*30:131 | 2016-7723 | MH028638, | Dr Mauro Castagnetta |
| A*30:132N | 18204989 | MH356752, | Dr Daniel Fuerst |
| A*31:01:02:09 | AN00802 | LT963263, | Prof Steven GE Marsh |
| A*31:01:29 | NT02150 | MH279565, | Prof Carolyn K Hurley |
| A*32:01:01:07 | AN00772 | LT963239, | Prof Steven GE Marsh |
| A*32:01:01:08 | 011804504192A | MH136583, | Mr Faisal Aloufi |
| A*33:03:01:03 | AN00777 | LT963244, | Prof Steven GE Marsh |
| A*66:01:05 | NT02149 | MH279564, | Prof Carolyn K Hurley |
| B*07:02:01:08 | AN00779 | LT963247, | Prof Steven GE Marsh |
| B*07:02:01:09 | DKMS-LSL-B-2651 | LS423082, | Ms DKMS Life Sciences Lab |
| B*07:312 | AN00759 | LT963229, | Prof Steven GE Marsh |
| B*07:313 | DKMS-LSL-B-2611 | LS423042, | Ms DKMS Life Sciences Lab |
| B*07:314 | DKMS-LSL-B-2602 | LS423033, | Ms DKMS Life Sciences Lab |
| B*07:315N | DKMS-LSL-B-2661 | LS423092, | Ms DKMS Life Sciences Lab |
| B*07:316N | DKMS-LSL-B-2657 | LS423088, | Ms DKMS Life Sciences Lab |
| B*08:01:01:06 | AN00758 | LT963228, | Prof Steven GE Marsh |
| B*08:01:01:07 | AN00774 | LT963241, | Prof Steven GE Marsh |
| B*08:01:01:08 | AN00812 | LT963271, | Prof Steven GE Marsh |
| B*08:01:01:09 | AN00896 | LT963286, | Prof Steven GE Marsh |
| B*08:196 | DKMS-LSL-B-2605 | LS423036, | Ms DKMS Life Sciences Lab |
| B*08:20:02 | DKMS-LSL-B-2649 | LS423080, | Ms DKMS Life Sciences Lab |
| B*08:38:02 | DKMS-LSL-B-2599 | LS423030, | Ms DKMS Life Sciences Lab |
| B*13:01:14 | DKMS-LSL-B-2616 | LS423047, | Ms DKMS Life Sciences Lab |
| B*13:02:01:05 | AN00824 | LT963280, | Prof Steven GE Marsh |
| B*13:111 | DKMS-LSL-B-2631 | LS423062, | Ms DKMS Life Sciences Lab |
| B*14:01:07 | DKMS-LSL-B-2612 | LS423043, | Ms DKMS Life Sciences Lab |
| B*14:02:01:05 | AN00769 | LT963236, | Prof Steven GE Marsh |
| B*14:02:01:06 | DKMS-LSL-B-2624 | LS423055, | Ms DKMS Life Sciences Lab |
| B*15:01:01:14 | DKMS-LSL-B-2610 | LS423041, | Ms DKMS Life Sciences Lab |
| B*15:01:01:15 | BY01581 | MH427370, | Prof Carolyn K Hurley |
| B*15:01:43 | DKMS-LSL-B-2632 | LS423063, | Ms DKMS Life Sciences Lab |
| B*15:251:02 | DKMS-LSL-B-2623 | LS423054, | Ms DKMS Life Sciences Lab |
| B*15:447 | DKMS-LSL-B-2618 | LS423049, | Ms DKMS Life Sciences Lab |
| B*15:448 | DKMS-LSL-B-2646 | LS423077, | Ms DKMS Life Sciences Lab |
| B*15:449 | DKMS-LSL-B-2663 | LS423094, | Ms DKMS Life Sciences Lab |
| B*15:450 | HGL04675 | MH423502, | Dr Rasmi Thomas |
| B*18:01:01:11 | AN00708 | LT963193, | Prof Steven GE Marsh |
| B*18:01:01:12 | AN00822 | LT963278, | Prof Steven GE Marsh |
| B*18:01:01:13 | DKMS-LSL-B-2614 | LS423045, | Ms DKMS Life Sciences Lab |
| B*18:01:28 | DKMS-LSL-B-2628 | LS423059, | Ms DKMS Life Sciences Lab |
| B*18:147 | DKMS-LSL-B-2622 | LS423053, | Ms DKMS Life Sciences Lab |
| B*18:148 | DKMS-LSL-B-2642 | LS423073, | Ms DKMS Life Sciences Lab |
| B*18:149 | DKMS-LSL-B-2660 | LS423091, | Ms DKMS Life Sciences Lab |
| B*35:01:01:10 | AN00760 | LT963230, | Prof Steven GE Marsh |
| B*35:01:01:11 | DKMS-LSL-B-2664 | LS423095, | Ms DKMS Life Sciences Lab |
| B*35:03:01:08 | AN00831 | LT906359, | Prof Steven GE Marsh |
| B*35:03:01:09 | AN00908 | LT963295, | Prof Steven GE Marsh |
| B*35:03:01:10 | DKMS-LSL-B-2659 | LS423090, | Ms DKMS Life Sciences Lab |
| B*35:14:03 | DKMS-LSL-B-2641 | LS423072, | Ms DKMS Life Sciences Lab |
| B*35:372 | DKMS-LSL-B-2655 | LS423086, | Ms DKMS Life Sciences Lab |
| B*38:71 | DKMS-LSL-B-2656 | LS423087, | Ms DKMS Life Sciences Lab |
| B*39:135 | DKMS-LSL-B-2625 | LS423056, | Ms DKMS Life Sciences Lab |
| B*39:136 | DKMS-LSL-B-2639 | LS423070, | Ms DKMS Life Sciences Lab |
| B*40:02:01:06 | AN00830 | LT963282, | Prof Steven GE Marsh |
| B*40:371 | DKMS-LSL-B-2615 | LS423046, | Ms DKMS Life Sciences Lab |
| B*41:01:01:02 | DKMS-LSL-B-2654 | LS423085, | Ms DKMS Life Sciences Lab |
| B*44:02:01:08 | AN00784 | LT963253, | Prof Steven GE Marsh |
| B*44:02:01:09 | AN00794 | LT963258, | Prof Steven GE Marsh |
| B*44:02:01:10 | AN00803 | LT963264, | Prof Steven GE Marsh |
| B*44:02:01:11 | AN00806 | LT963267, | Prof Steven GE Marsh |
| B*44:02:01:12 | AN00808 | LT963269, | Prof Steven GE Marsh |
| B*44:02:01:13 | 313170 | MH269350, | Dr Vera Balz |
| B*44:02:50 | DKMS-LSL-B-2613 | LS423044, | Ms DKMS Life Sciences Lab |
| B*44:03:01:12 | AN00809 | LT963270, | Prof Steven GE Marsh |
| B*44:03:01:13 | AN00826 | LT963281, | Prof Steven GE Marsh |
| B*44:03:42 | DKMS-LSL-B-2626 | LS423057, | Ms DKMS Life Sciences Lab |
| B*44:285 | 1704225 | LT962486, | Dr Florian Emmerich |
| B*44:286 | DKMS-LSL-B-2645 | LS423076, | Ms DKMS Life Sciences Lab |
| B*44:287 | DKMS-LSL-B-2643 | LS423074, | Ms DKMS Life Sciences Lab |
| B*44:288 | DKMS-LSL-B-2662 | LS423093, | Ms DKMS Life Sciences Lab |
| B*45:22 | M04 | MH121147, | Mr Brian Dukek |
| B*45:23 | DKMS-LSL-B-2619 | LS423050, | Ms DKMS Life Sciences Lab |
| B*49:01:11 | DKMS-LSL-B-2620 | LS423051, | Ms DKMS Life Sciences Lab |
| B*49:01:12 | DKMS-LSL-B-2633 | LS423064, | Ms DKMS Life Sciences Lab |
| B*51:01:01:26 | AN00764 | LT963232, | Prof Steven GE Marsh |
| B*51:01:01:27 | AN00777 | LT963245, | Prof Steven GE Marsh |
| B*51:01:01:28 | 309377 | MH350868, | Dr Vera Balz |
| B*51:01:63 | DKMS-LSL-B-2604 | LS423035, | Ms DKMS Life Sciences Lab |
| B*51:04:02 | DKMS-LSL-B-2640 | LS423071, | Ms DKMS Life Sciences Lab |
| B*51:235N | DKMS-LSL-B-2634 | LS423065, | Ms DKMS Life Sciences Lab |
| B*51:236 | 350011 | MH362796, | Dr Elena Longhi |
| B*52:01:31 | DKMS-LSL-B-2601 | LS423032, | Ms DKMS Life Sciences Lab |
| B*52:76 | DKMS-LSL-B-2607 | LS423038, | Ms DKMS Life Sciences Lab |
| B*53:01:16 | DKMS-LSL-B-2647 | LS423078, | Ms DKMS Life Sciences Lab |
| B*55:88 | DKMS-LSL-B-2652 | LS423083, | Ms DKMS Life Sciences Lab |
| B*55:89N | DKMS-LSL-B-2653 | LS423084, | Ms DKMS Life Sciences Lab |
| B*56:57 | DKMS-LSL-B-2665 | LS423096, | Ms DKMS Life Sciences Lab |
| B*57:03:01:03 | DKMS-LSL-B-2603 | LS423034, | Ms DKMS Life Sciences Lab |
| B*57:100 | DKMS-LSL-B-2658 | LS423089, | Ms DKMS Life Sciences Lab |
| B*57:97 | DKMS-LSL-B-2617 | LS423048, | Ms DKMS Life Sciences Lab |
| B*57:98Q | DKMS-LSL-B-2637 | LS423068, | Ms DKMS Life Sciences Lab |
| B*57:99 | DKMS-LSL-B-2650 | LS423081, | Ms DKMS Life Sciences Lab |
| C*01:02:01:10 | AN00770 | LT963237, | Prof Steven GE Marsh |
| C*01:156 | DKMS-LSL-C-2742 | LS453274, | Ms DKMS Life Sciences Lab |
| C*02:02:41 | BST016 | MH362799, | Dr Francesc Rudilla |
| C*03:03:43 | DKMS-LSL-C-2741 | LS453273, | Ms DKMS Life Sciences Lab |
| C*03:390 | DKMS-LSL-C-2738 | LS453270, | Ms DKMS Life Sciences Lab |
| C*04:01:93 | BST013 | MH142314, | Dr Francesc Rudilla |
| C*04:01:94 | Lift06 | MH301278, | Dr Paul Norman |
| C*05:01:01:10 | AN00767 | LT963234, | Prof Steven GE Marsh |
| C*05:01:01:11 | AN00783 | LT963252, | Prof Steven GE Marsh |
| C*05:01:01:12 | BY01578 | MH179261, | Prof Carolyn K Hurley |
| C*06:02:01:13 | AN00791 | LT963257, | Prof Steven GE Marsh |
| C*06:02:01:14 | 321464 | MH269356, | Dr Vera Balz |
| C*07:01:01:24 | AN00795 | LT963259, | Prof Steven GE Marsh |
| C*07:02:01:21 | AN00762 | LT963231, | Prof Steven GE Marsh |
| C*07:02:01:22 | AN00801 | LT963262, | Prof Steven GE Marsh |
| C*07:02:01:23 | AN00804 | LT963265, | Prof Steven GE Marsh |
| C*07:02:01:24 | AN00894 | LT963284, | Prof Steven GE Marsh |
| C*07:02:01:25 | AN00897 | LT963287, | Prof Steven GE Marsh |
| C*07:02:01:26 | AN00905 | LT963293, | Prof Steven GE Marsh |
| C*07:02:01:27 | AN00906 | LT963294, | Prof Steven GE Marsh |
| C*07:06:02 | DKMS-LSL-C-2744 | LS453276, | Ms DKMS Life Sciences Lab |
| C*07:632Q | 18204994 | MH294124, | Dr Daniel Fuerst |
| C*07:633N | DKMS-LSL-C-2736 | LS453268, | Ms DKMS Life Sciences Lab |
| C*07:634 | DKMS-LSL-C-2739 | LS453271, | Ms DKMS Life Sciences Lab |
| C*12:13:01:02 | AN00815 | LT963272, | Prof Steven GE Marsh |
| C*12:235 | DKMS-LSL-C-2740 | LS453272, | Ms DKMS Life Sciences Lab |
| C*14:02:01:07 | AN00904 | LT963292, | Prof Steven GE Marsh |
| C*15:157 | DKMS-LSL-C-2745 | LS453277, | Ms DKMS Life Sciences Lab |
| C*16:02:16 | DKMS-LSL-C-2747 | LS453279, | Ms DKMS Life Sciences Lab |
| C*16:123N | 005/01/25/2018 | MG869125, | Dr Zain Al Yafei |
| C*17:01:14 | DKMS-LSL-C-2748 | LS453280, | Ms DKMS Life Sciences Lab |
| F*01:06 | AMALA | MG701281, | Dr Mehdi Alizadeh |
| DRB1*13:01:22 | 81181131 | MH382831, | Dr Daniel Fuerst |
| DRB1*14:54:01:03 | ABUC | LT991997, | Prof Steven GE Marsh |
| DRB1*15:158 | 409750 | LS451022, | Prof Edward KL Yang |
| DRB3*02:78 | 81179196 | MH196404, | Dr Daniel Fuerst |
| DRB3*02:79 | 81181142 | MH382828, | Dr Daniel Fuerst |
| DQB1*06:275 | AN01069 | LT991999, | Prof Steven GE Marsh |
| DPA1*01:15 | HG00016514 | MH249152, | Dr Histogenetics |
| DPB1*02:01:02:39 | BM16 | LT992002, | Prof Steven GE Marsh |
| DPB1*02:01:02:40 | AN01070 | LT992000, | Prof Steven GE Marsh |
| DPB1*04:01:01:28 | ABUC,ARBO | LT991996,LT992001, | Prof Steven GE Marsh |
| DPB1*04:02:01:11 | OZB | LT992009, | Prof Steven GE Marsh |
| DPB1*105:01:01:09 | AMAI | LT991998, | Prof Steven GE Marsh |
| DPB1*11:01:01:02 | J0528239 | LT992004, | Prof Steven GE Marsh |
| DPB1*720:01 | 81183297 | MH382830, | Dr Daniel Fuerst |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:83 | G072415707667Q, | MH285865, | Dr Dimitra Niokou |
| A*02:01:01:16 | AN00796, | LT963260, | Prof Steven GE Marsh |
| B*08:183 | DKMS-LSL-B-2630, | LS423061, | Ms DKMS Life Sciences Lab |
| B*14:01:01:03 | AN00788, | LT963256, | Prof Steven GE Marsh |
| B*15:266 | NT02155, | MH443004, | Prof Carolyn K Hurley |
| B*15:432 | DKMS-LSL-B-2648, | LS423079, | Ms DKMS Life Sciences Lab |
| B*15:45 | NT02159, | MH445975, | Prof Carolyn K Hurley |
| B*15:65 | NT02157, | MH443006, | Prof Carolyn K Hurley |
| B*27:07:01 | DKMS-LSL-B-2638, | LS423069, | Ms DKMS Life Sciences Lab |
| B*35:01:01:04 | AN00780, | LT963248, | Prof Steven GE Marsh |
| B*35:03:01:03 | AN00895, | LT963285, | Prof Steven GE Marsh |
| B*35:49 | NT02156, | MH443005, | Prof Carolyn K Hurley |
| B*40:55 | AS3641, | LT978461, | Prof Edward KL Yang |
| B*44:265 | DKMS-LSL-B-2609, | LS423040, | Ms DKMS Life Sciences Lab |
| B*47:02 | DKMS-LSL-B-2635, | LS423066, | Ms DKMS Life Sciences Lab |
| B*51:01:01:19 | DKMS-LSL-B-2629, | LS423060, | Ms DKMS Life Sciences Lab |
| B*51:10 | NT02158, | MH445974, | Prof Carolyn K Hurley |
| B*51:158:02 | DKMS-LSL-B-2627, | LS423058, | Ms DKMS Life Sciences Lab |
| B*57:84 | DKMS-LSL-B-2608, | LS423039, | Ms DKMS Life Sciences Lab |
| C*02:02:33 | BY01577, | MH179260, | Prof Carolyn K Hurley |
| C*02:26:02 | NT02147 , | MH187566, | Prof Carolyn K Hurley |
| C*03:04:06 | NT02142, | MH108956, | Prof Carolyn K Hurley |
| C*03:187 | D333128, | LS481151, | Prof Edward KL Yang |
| C*03:23 | JM236, | LC385607, | Prof Takashi Shiina |
| C*04:27 | NT01976, | MH187567, | Prof Carolyn K Hurley |
| C*05:22:01 | NT02148, | MH191368, | Prof Carolyn K Hurley |
| C*06:08 | NT02161, | MH454601, | Prof Carolyn K Hurley |
| C*07:01:01:19 | AN00892, | LT906361, | Prof Steven GE Marsh |
| C*07:18 | AB4745, | LS453312, | Prof Edward KL Yang |
| C*12:217 | DKMS-LSL-C-2751, | LS453283, | Ms DKMS Life Sciences Lab |
| C*15:11 | NT02160, | MH454600, | Prof Carolyn K Hurley |
| C*15:139 | DKMS-LSL-C-2746, | LS453278, | Ms DKMS Life Sciences Lab |
| C*15:25 | DKMS-LSL-C-2743, | LS453275, | Ms DKMS Life Sciences Lab |
| DRB1*07:01:01:01 | MOU,PITOUT, | LT963692,LT963701, | Prof Steven GE Marsh |
| DRB1*08:02:01:01 | SPL, | LT963707, | Prof Steven GE Marsh |
| DRB1*13:03:01 | CB, | LT963649, | Prof Steven GE Marsh |
| DRB1*16:01:01 | CALOGERO, | LT963645, | Prof Steven GE Marsh |
| DQB1*03:01:01:02 | OZB, | LT963698, | Prof Steven GE Marsh |
| DQB1*03:01:01:03 | OZB,CB,JBUSH,ZM-FC, | LT963699,LT963717,LT963672,LT963646, | Prof Steven GE Marsh |
| DQB1*03:02:01:01 | EC, | LT963665,LT963686, | Prof Steven GE Marsh |
| DQB1*03:03:02:01 | MANIKA, | LT963686, | Prof Steven GE Marsh |
| DQB1*03:04:01 | ZM-FC, | LT963718, | Prof Steven GE Marsh |
| DQB1*04:02:01:04 | SPL,MADURA,OLL, | LT963706,LT963694,LT963684, | Prof Steven GE Marsh |
| DQB1*05:01:01:01 | LWAGS, | LT963683, | Prof Steven GE Marsh |
| DQB1*05:01:01:03 | DOP-ND,MARMarg, | LT963661,LT963689, | Prof Steven GE Marsh |
| DQB1*05:01:01:04 | MZ070782, | LT963693, | Prof Steven GE Marsh |
| DQB1*05:02:01:01 | WJR076, | LT963713, | Prof Steven GE Marsh |
| DQB1*05:03:01:01 | KOSE,MARMarg, | LT963674,LT963690, | Prof Steven GE Marsh |
| DQB1*06:02:01:01 | DOP-ND,DO208915, | LT963662,LT963658, | Prof Steven GE Marsh |
| DQB1*06:04:01 | KOSE,HOR,WT47, | LT963675,LT963714,LT963668, | Prof Steven GE Marsh |
| DPB1*01:01:01:01 | CTM1953541, | LT963654, | Prof Steven GE Marsh |
| DPB1*02:01:02:01 | ZM-FC, | LT963715, | Prof Steven GE Marsh |
| DPB1*02:01:02:10 | BEL5GB, | LT963644, | Prof Steven GE Marsh |
| DPB1*03:01:01:01 | COX,MARMarg, | LT963653,LT963687, | Prof Steven GE Marsh |
| DPB1*04:01:01:02 | DBB, | LT963655, | Prof Steven GE Marsh |
| DPB1*04:01:01:26 | HOR, | LT963667, | Prof Steven GE Marsh |
| DPB1*04:02:01:02 | MCF,SPL, | LT963691,LT963705, | Prof Steven GE Marsh |
| DPB1*04:02:01:03 | ZM-FC, | LT963716, | Prof Steven GE Marsh |
| DPB1*05:01:01:08 | PAR, | LT963700, | Prof Steven GE Marsh |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
