Nomenclature for Factors of the HLA System

February 2018

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2018 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


SequenceCell identificationAccession numberSubmitting author
A*01:01:01:13BY01513MG779945,Carolyn K Hurley, Washington DC, USA
A*01:245NT02029MG882345,Carolyn K Hurley, Washington DC, USA
A*01:246HG00013605MG583996,Histogenetics, Ossining, USA
A*01:247NHG00014392MG756759,Histogenetics, Ossining, USA
A*01:248QHG00014394MG756761,Histogenetics, Ossining, USA
A*02:01:01:29BY01514MG779946,Carolyn K Hurley, Washington DC, USA
A*02:01:01:30BY01515MG779947,Carolyn K Hurley, Washington DC, USA
A*02:01:133HG00013611,HG00014019MG584002,MG724775,Histogenetics, Ossining, USA
A*02:01:134HG00014404MG756771,Histogenetics, Ossining, USA
A*02:06:01:0545910LT898196,Marcel GJ Tilanus, Maastricht, The Netherlands
A*02:708HG00015347KP131480,Histogenetics, Ossining, USA
A*02:709HG00013608MG583999,Histogenetics, Ossining, USA
A*02:710NHG00014389MG756756,Histogenetics, Ossining, USA
A*03:290HG00015344JQ237614,Histogenetics, Ossining, USA
A*11:271TIL.001MG686548,Amanda Willis, Dallas, USA
A*11:272QHG00013205MF460471,Histogenetics, Ossining, USA
A*11:273HG00013613MG584004,Histogenetics, Ossining, USA
A*11:274HG00013617MG584008,Histogenetics, Ossining, USA
A*23:84NHG00013503MG450936,Histogenetics, Ossining, USA
A*23:85HG00014402MG756769,Histogenetics, Ossining, USA
A*23:86HG00014406MG756773,Histogenetics, Ossining, USA
A*24:02:104HG00014407MG756774,Histogenetics, Ossining, USA
A*24:396NHG00014726KX619607,Histogenetics, Ossining, USA
A*24:397HG00013619MG584010,Histogenetics, Ossining, USA
A*26:01:45HG00013609MG584000,Histogenetics, Ossining, USA
A*29:112NHG00015341KX694123,Histogenetics, Ossining, USA
A*30:02:01:04BY01531MG873450,Carolyn K Hurley, Washington DC, USA
A*30:12:02BST007MG800668,Francesc Rudilla, Barcelona, Spain
A*31:01:27HG00014410MG756778,Histogenetics, Ossining, USA
A*31:134HG00014411MG756779,Histogenetics, Ossining, USA
A*32:108HG00015345KY196354,Histogenetics, Ossining, USA
A*33:139HG00015340KM454987,Histogenetics, Ossining, USA
A*33:140NHG00014408MG756776,Histogenetics, Ossining, USA
A*33:141HG00014409MG756777,Histogenetics, Ossining, USA
A*34:01:01:0245910LT976489,Marcel GJ Tilanus, Maastricht, The Netherlands
A*74:01:07NT02027MG878882,Carolyn K Hurley, Washington DC, USA
B*08:01:3781171212MG835322,Daniel Fuerst, Ulm, Germany
B*14:60HG00015362FJ875556,Histogenetics, Ossining, USA
B*15:78:04HG00015359JN124358,Histogenetics, Ossining, USA
B*15:43816QB10011MG944250,Janette Kwok, Pokfulam Road, Hong Kong
B*15:439HG00015360KY296565,Histogenetics, Ossining, USA
B*18:03:02HG00015352KM282230,Histogenetics, Ossining, USA
B*27:170BST1326561MG820619,Francesc Rudilla, Barcelona, Spain
B*27:17181177888MG844167,Daniel Fuerst, Ulm, Germany
B*27:172HG00015351JX441345,Histogenetics, Ossining, USA
B*35:01:01:09BY01516MG779948,Carolyn K Hurley, Washington DC, USA
B*35:02:01:03BY01533MG873452,Carolyn K Hurley, Washington DC, USA
B*35:03:01:0716QB9087MG944251,Janette Kwok, Pokfulam Road, Hong Kong
B*35:337:02HG00015355JN124360,Histogenetics, Ossining, USA
B*35:361HG00015354JN124336,Histogenetics, Ossining, USA
B*35:362HG00015356KX711910,Histogenetics, Ossining, USA
B*35:363HG00015357KJ535566,Histogenetics, Ossining, USA
B*37:01:12NT02026MG878881,Carolyn K Hurley, Washington DC, USA
B*39:132BY01520MG779952,Carolyn K Hurley, Washington DC, USA
B*39:133NHG00012912KY551531,Histogenetics, Ossining, USA
B*40:01:02:0746204LT618831,Marcel GJ Tilanus, Maastricht, The Netherlands
B*40:36617ZZ0500LC371655,Li-Qun Zhang, Beijing, China
B*44:02:01:07BY01535MG873454,Carolyn K Hurley, Washington DC, USA
B*50:55HG00015348KY196359,Histogenetics, Ossining, USA
B*51:08:01:02BY01534MG873453,Carolyn K Hurley, Washington DC, USA
B*51:230B51newMG725683,Ali Hajeer, Riyadh, Saudi Arabia
B*51:231HG00015361KJ408847,Histogenetics, Ossining, USA
B*52:01:01:05BY01517MG779949,Carolyn K Hurley, Washington DC, USA
B*56:01:01:05SCTM-1009506KJ872497,Antonio Balas, Madrid, Spain
B*56:55:01:02BY01518MG779950,Carolyn K Hurley, Washington DC, USA
C*01:02:01:08NT01994BMG787287,Carolyn K Hurley, Washington DC, USA
C*02:02:02:14BY01521MG788775,Carolyn K Hurley, Washington DC, USA
C*02:10:032017-2929MG940893,Mauro Castagnetta, Genova, Italy
C*02:135N18-004-020436MG944240,Ahmed Mostafa, Calgary, Canada
C*03:03:01:10BY01522MG788776,Carolyn K Hurley, Washington DC, USA
C*03:3761001583LT963511,Florian Emmerich, Freiburg, Germany
C*03:377NHG00015376KX694124,Histogenetics, Ossining, USA
C*04:01:01:1947101LT972199,Marcel GJ Tilanus, Maastricht, The Netherlands
C*04:01:01:19BY01525MG839187,Carolyn K Hurley, Washington DC, USA
C*04:01:01:20BY01524MG839186,Carolyn K Hurley, Washington DC, USA
C*04:01:01:21BY01526MG839188,Carolyn K Hurley, Washington DC, USA
C*04:01:01:22BY01527MG839189,Carolyn K Hurley, Washington DC, USA
C*04:01:851001479LT962625,Florian Emmerich, Freiburg, Germany
C*04:287BST1017434MG820616,Francesc Rudilla, Barcelona, Spain
C*04:28817-4748MG941004,Michele Curcio, Pisa, Italy
C*07:02:01:18BY01528MG839190,Carolyn K Hurley, Washington DC, USA
C*07:02:01:19NT02025BMG911200,Carolyn K Hurley, Washington DC, USA
C*07:611HG00015372KM282249,Histogenetics, Ossining, USA
C*07:612NA17281MG845550,Dimitri Monos, Philadelphia, USA
C*07:61317ZZ0832LC371657,Li-Qun Zhang, Beijing, China
C*08:161NHG00015366KX694129,Histogenetics, Ossining, USA
C*12:03:01:10BY01536MG873455,Carolyn K Hurley, Washington DC, USA
C*14:02:01:05BY01529MG839191,Carolyn K Hurley, Washington DC, USA
C*14:93NDE-FRB 62196LT963358,Florian Emmerich, Freiburg, Germany
C*15:02:02:02NT02074MG944957,Carolyn K Hurley, Washington DC, USA
C*15:02:31BST1315788MG820620,Francesc Rudilla, Barcelona, Spain
C*16:117HG00015375KM987207,Histogenetics, Ossining, USA
DPA1*02:10NA17020MG938526,Dimitri Monos, Philadelphia, USA
DPB1*04:02:1193019624KU517234,Daniel Fuerst, Ulm, Germany
DPB1*696:01NHG00015403KX694127,Histogenetics, Ossining, USA
DPB1*697:01QHG00015365KX694131,Histogenetics, Ossining, USA
DPB1*698:01HG00015404KF577636,Histogenetics, Ossining, USA
DQB1*03:03:1615219571KU199766,Daniel Fuerst, Ulm, Germany
DQB1*03:278HG00015379KP131501,Histogenetics, Ossining, USA
DQB1*03:27917ZZ1136LC371659,Li-Qun Zhang, Beijing, China
DQB1*05:15993101662MG844182,Daniel Fuerst, Ulm, Germany
DQB1*06:02:2917ZZ1000LC371658,Li-Qun Zhang, Beijing, China
DQB1*06:25081162457MG844183,Daniel Fuerst, Ulm, Germany
DQB1*06:251HG00012947KY416533,Histogenetics, Ossining, USA
DQB1*06:252NHG00015377KX694125,Histogenetics, Ossining, USA
DRB1*01:85HG00015400GU551922,Histogenetics, Ossining, USA
DRB1*01:86HG00015401KX426006,Histogenetics, Ossining, USA
DRB1*04:01:18HG00015387JN418860,Histogenetics, Ossining, USA
DRB1*04:04:13HG00015391JN561768,Histogenetics, Ossining, USA
DRB1*04:238HG00015383KY196384,Histogenetics, Ossining, USA
DRB1*04:239HG00015388JN418865,Histogenetics, Ossining, USA
DRB1*04:240HG00015389JN418857,Histogenetics, Ossining, USA
DRB1*04:241HG00015390JN418862,Histogenetics, Ossining, USA
DRB1*08:01:072017092901MG252376,Antonio Balas, Madrid, Spain
DRB1*12:01:01:06JM31LC257796,Takashi Shiina, Isehara, Japan
DRB1*12:69IKDRC01MF098755,Anila Sharma, Ahmedabad, India
DRB1*13:89:02HG00015397KC473890,Histogenetics, Ossining, USA
DRB1*13:248HG00015392KJ619565,Histogenetics, Ossining, USA
DRB1*13:249NHG00015394KX619610,Histogenetics, Ossining, USA
DRB1*13:250HG00015395KJ667138,Histogenetics, Ossining, USA
DRB1*15:01:3516QB8856MG944252,Janette Kwok, Pokfulam Road, Hong Kong
DRB1*15:149D352432LT978461,Edward KL Yang, Hualien, Taiwan
DRB1*15:150HG00015402GU228845,Histogenetics, Ossining, USA
DRB3*02:02:1081153041KY123262,Daniel Fuerst, Ulm, Germany
DRB3*02:02:11IME 2559-17MG934287,Mariarosa Battarra, Roma, Italy
DRB3*02:7086025074MG844166,Daniel Fuerst, Ulm, Germany
DRB3*02:71scu22597MG922498,Francisco de Paula Sanchez Gordo, Malaga, Spain
MICB*002:02WN29MG873180,Tian Wei, Urumqi, China
MICB*032WN39MG837221,Tian Wei, Urumqi, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:82HG00013620,MG584011,Histogenetics, Ossining, USA
A*02:01:01:06BY01541,MG905188,Carolyn K Hurley, Washington DC, USA
A*02:01:01:20BY01530,MG873449,Carolyn K Hurley, Washington DC, USA
A*02:01:19BY01542,MG905189,Carolyn K Hurley, Washington DC, USA
A*11:01:01:07BY01545,MG905192,Carolyn K Hurley, Washington DC, USA
A*24:02:01:06BY01538,MG905184,Carolyn K Hurley, Washington DC, USA
A*30:04:01BY01540,MG905186,Carolyn K Hurley, Washington DC, USA
A*32:01:01:04BY01544,MG905191,Carolyn K Hurley, Washington DC, USA
A*33:136HG00013616,MG584007,Histogenetics, Ossining, USA
A*68:01:02:04BY01543,MG905190,Carolyn K Hurley, Washington DC, USA
A*68:05BY01539,MG905185,Carolyn K Hurley, Washington DC, USA
B*07:03BY01547,MG905194,Carolyn K Hurley, Washington DC, USA
B*08:25HG00015367,HM768852,Histogenetics, Ossining, USA
B*14:02:01:03BY01554,MG905204,Carolyn K Hurley, Washington DC, USA
B*15:01:01:03BY01549,MG905196,Carolyn K Hurley, Washington DC, USA
B*15:07:01:02BY01532,MG873451,Carolyn K Hurley, Washington DC, USA
B*15:13:01BY01550,MG905197,Carolyn K Hurley, Washington DC, USA
B*18:01:01:03BY01546,MG905193,Carolyn K Hurley, Washington DC, USA
B*18:01:01:09BY01519,MG779951,Carolyn K Hurley, Washington DC, USA
B*27:02:01:01BY01548 ,MG905198,Carolyn K Hurley, Washington DC, USA
B*35:03:01:04BY01556,MG905203,Carolyn K Hurley, Washington DC, USA
B*35:08:01:01BY01551,MG905199,Carolyn K Hurley, Washington DC, USA
B*38:12HG00015368,HM594792,Histogenetics, Ossining, USA
B*40:175HG00015349,JN124204,Histogenetics, Ossining, USA
B*40:223HG00015350,JX174603,Histogenetics, Ossining, USA
B*41:02:01BY01552,MG905200,Carolyn K Hurley, Washington DC, USA
B*44:03:01:09BY01555,MG905202,Carolyn K Hurley, Washington DC, USA
B*44:04BY01553,MG905201,Carolyn K Hurley, Washington DC, USA
B*51:20BY01519,MG905195,Carolyn K Hurley, Washington DC, USA
B*51:173QNT02028,MG878883,Carolyn K Hurley, Washington DC, USA
C*01:02:03NT02056,NT02057,MG944942,Carolyn K Hurley, Washington DC, USA
C*01:02:04NT02058,MG944943,Carolyn K Hurley, Washington DC, USA
C*01:02:16NT02019,MG911193,Carolyn K Hurley, Washington DC, USA
C*01:02:16NT02059,MG944944,Carolyn K Hurley, Washington DC, USA
C*01:02:18NT02060,MG944945,Carolyn K Hurley, Washington DC, USA
C*02:02:02:05BY01560,MG905209,Carolyn K Hurley, Washington DC, USA
C*02:02:07NT02061,MG944946,Carolyn K Hurley, Washington DC, USA
C*02:03NT02003,MG911177,Carolyn K Hurley, Washington DC, USA
C*02:07NT02078,MG952911,Carolyn K Hurley, Washington DC, USA
C*02:12NT02004 ,MG911178,Carolyn K Hurley, Washington DC, USA
C*02:27:01NT02063,MG952919,Carolyn K Hurley, Washington DC, USA
C*02:27:01NT02020,MG911194,Carolyn K Hurley, Washington DC, USA
C*02:46NT01939,MG779912,Carolyn K Hurley, Washington DC, USA
C*03:04:02BY01561,MG905210,Carolyn K Hurley, Washington DC, USA
C*03:04:18NT02021,MG911195,Carolyn K Hurley, Washington DC, USA
C*03:04:18NT02064,MG944947,Carolyn K Hurley, Washington DC, USA
C*03:05BY01562,MG905211,Carolyn K Hurley, Washington DC, USA
C*03:08NT02005,MG911179,Carolyn K Hurley, Washington DC, USA
C*03:16BY01557,MG905206,Carolyn K Hurley, Washington DC, USA
C*03:17:01NT02022,MG911196,Carolyn K Hurley, Washington DC, USA
C*03:18:01NT02023,MG911197,Carolyn K Hurley, Washington DC, USA
C*03:18:01NT02065,MG944948,Carolyn K Hurley, Washington DC, USA
C*03:37:01NT02083,MG952916,Carolyn K Hurley, Washington DC, USA
C*03:47NT02006,MG911180,Carolyn K Hurley, Washington DC, USA
C*03:58NT01940,MG779913,Carolyn K Hurley, Washington DC, USA
C*03:87:01NT02024,MG911198,Carolyn K Hurley, Washington DC, USA
C*03:113:01BY01558,MG905207,Carolyn K Hurley, Washington DC, USA
C*03:358BY01523,MG839185,Carolyn K Hurley, Washington DC, USA
C*04:01:03NT02066,MG944949,Carolyn K Hurley, Washington DC, USA
C*04:01:29NT02025A,MG911199,Carolyn K Hurley, Washington DC, USA
C*04:01:49NT02067,MG944950,Carolyn K Hurley, Washington DC, USA
C*04:14NT02079,MG952912,Carolyn K Hurley, Washington DC, USA
C*04:29NT02007,MG911181,Carolyn K Hurley, Washington DC, USA
C*04:153NT02054 ,MG944940,Carolyn K Hurley, Washington DC, USA
C*05:01:02NT02068,MG944951,Carolyn K Hurley, Washington DC, USA
C*05:10NT01944,NT02008,MG779918,MG911182,Carolyn K Hurley, Washington DC, USA
C*05:14NT01945,MG779919,Carolyn K Hurley, Washington DC, USA
C*05:29:01NT02069,MG944952,Carolyn K Hurley, Washington DC, USA
C*06:06NT02009,MG911183,Carolyn K Hurley, Washington DC, USA
C*06:09NT01930,MG715481,Carolyn K Hurley, Washington DC, USA
C*07:01:08NT02030,MG911201,Carolyn K Hurley, Washington DC, USA
C*07:01:08NT02070,MG944953,Carolyn K Hurley, Washington DC, USA
C*07:02:01:11BY01564,MG905212,Carolyn K Hurley, Washington DC, USA
C*07:02:11NT02031,MG911202,Carolyn K Hurley, Washington DC, USA
C*07:02:11NT02071,MG944954,Carolyn K Hurley, Washington DC, USA
C*07:07NT02080,NT02010,MG952913,MG911184,Carolyn K Hurley, Washington DC, USA
C*07:10NT02035,MG944921,Carolyn K Hurley, Washington DC, USA
C*07:16NT02011,MG911185,Carolyn K Hurley, Washington DC, USA
C*07:22NT02037,MG944923,Carolyn K Hurley, Washington DC, USA
C*07:24NT02012,MG911186,Carolyn K Hurley, Washington DC, USA
C*07:25NT02013,MG911187,Carolyn K Hurley, Washington DC, USA
C*07:28NT02038,MG944924,Carolyn K Hurley, Washington DC, USA
C*07:35NT02039,MG944925,Carolyn K Hurley, Washington DC, USA
C*07:40NT02040,MG944926,Carolyn K Hurley, Washington DC, USA
C*07:51NT02014,MG911188,Carolyn K Hurley, Washington DC, USA
C*07:51HG00015373,HG00015374,GQ180224,GQ240445,Histogenetics, Ossining, USA
C*07:72NT02041,MG944927,Carolyn K Hurley, Washington DC, USA
C*07:80NT02042,MG944928,Carolyn K Hurley, Washington DC, USA
C*07:100BY01559,MG905208,Carolyn K Hurley, Washington DC, USA
C*07:363NT02055,MG944941,Carolyn K Hurley, Washington DC, USA
C*07:607M1,MG948558,Brian Dukek, Rochester, USA
C*08:06NT02043,MG944929,Carolyn K Hurley, Washington DC, USA
C*08:10NT02044,MG944930,Carolyn K Hurley, Washington DC, USA
C*08:13NT02015,MG911189,Carolyn K Hurley, Washington DC, USA
C*08:30NT02045,MG944931,Carolyn K Hurley, Washington DC, USA
C*08:34NT02046,MG944932,Carolyn K Hurley, Washington DC, USA
C*12:03:08NT02072 ,MG944955,Carolyn K Hurley, Washington DC, USA
C*12:18:01NT02032,MG911203,Carolyn K Hurley, Washington DC, USA
C*12:20NT02047,MG944933,Carolyn K Hurley, Washington DC, USA
C*14:02:02NT02033,MG911204,Carolyn K Hurley, Washington DC, USA
C*14:02:03NT02073,MG944956,Carolyn K Hurley, Washington DC, USA
C*14:06NT02016,MG911190,Carolyn K Hurley, Washington DC, USA
C*14:11NT02048,MG944934,Carolyn K Hurley, Washington DC, USA
C*14:29NT02049,MG944935,Carolyn K Hurley, Washington DC, USA
C*15:02:02:01NT02034 ,MG911205,Carolyn K Hurley, Washington DC, USA
C*15:15NT02050,MG944936,Carolyn K Hurley, Washington DC, USA
C*15:16NT02051,MG944937,Carolyn K Hurley, Washington DC, USA
C*15:22NT02081,MG952914,Carolyn K Hurley, Washington DC, USA
C*15:29D353252,LT978513,Edward KL Yang, Hualien, Taiwan
C*16:01:04NT02075,MG944958,Carolyn K Hurley, Washington DC, USA
C*16:01:09NT02076 ,MG944959,Carolyn K Hurley, Washington DC, USA
C*16:07:01NT02077,MG944960,Carolyn K Hurley, Washington DC, USA
C*16:08NT02082,MG952915,Carolyn K Hurley, Washington DC, USA
C*16:42NT02018,MG911192,Carolyn K Hurley, Washington DC, USA
C*17:03:01:03BY01537,BY01566,MG873456,Carolyn K Hurley, Washington DC, USA
C*17:04NT02052,MG944938,Carolyn K Hurley, Washington DC, USA
C*17:21NT02053 ,MG944939,Carolyn K Hurley, Washington DC, USA
DQB1*03:01:40D319272,LT978525,Edward KL Yang, Hualien, Taiwan
DQB1*03:13SZGSQ-36,MG969503,Suqing Gao, Shenzhen, China
DQB1*03:27717228611,MG872326,Daniel Fuerst, Ulm, Germany
DQB1*05:02:1496089495,MG912100,Daniel Fuerst, Ulm, Germany
DQB1*06:37HG00015380,KC136259,Histogenetics, Ossining, USA
DQB1*06:41SZGSQ-38,MG969502,Suqing Gao, Shenzhen, China
DRB1*04:04:02HG00015386,JN418859,Histogenetics, Ossining, USA
DRB1*04:79HG00015384,JN418856,Histogenetics, Ossining, USA
DRB1*04:103HG00015385,JN418863,Histogenetics, Ossining, USA
DRB1*13:194HG00015398,KF577635,Histogenetics, Ossining, USA
DRB1*14:171HG00015396,KC748265,Histogenetics, Ossining, USA
DRB4*02:01NGN016,MG949118,Carolyn K Hurley, Washington DC, USA
DRB4*03:01NGN076,GN017,GN020,GN092,MG721436,Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*02:01:01:28(4)
A*03:289(5)
B*14:56(6)
B*40:01:31(7)
B*51:220(8)
C*03:02:01(9)
C*03:40:01(10)
C*05:156(11)
C*07:530(12)
C*12:221(13)
C*15:13:01:01(14)
DQB1*03:01:01:12(15)
DQB1*03:01:01:20(16)

References:

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