Nomenclature for Factors of the HLA System
September 2017
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2017): 90:391-395
- Human Immunology(2017): 78:765-767
- International Journal of Immunogenetics(2017): 45:35-39
The following sequences have been submitted to the Nomenclature Committee since the August 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequences A*03:200Q, A*03:260, DQA1*01:01:01:04, DQA1*03:02:01:03, DQB1*04:02:01:02, DQB1*04:02:01:03 have been shown to contain errors and are identical to A*03:266N, A*03:284N, DQA1*01:01:01:01, DQA1*03:02:01:02, DQB1*04:02:01:01, and DQB1*04:02:01:01 respectively. The names A*03:200Q, A*03:260, DQA1*01:01:01:04, DQA1*03:02:01:03, DQB1*04:02:01:02 and DQB1*04:02:01:03 have been abandoned.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*03:284N | DKMS-LSL-A-712 | LN994613, | DKMS Life Sciences Lab, Dresden, Germany |
| A*24:389N | DKMS-LSL-A-202 | LK022021, | DKMS Life Sciences Lab, Dresden, Germany |
| A*26:01:44 | 01-17-177-0005 | MF801621, | Ahmed Mostafa, Calgary, Canada |
| A*31:128 | 39138 | MF928088, | Maria Loginova, Kirov, Russia |
| A*68:168 | DKMS-LSL-A-1136_A*68new | LT882772, | DKMS Life Sciences Lab, Dresden, Germany |
| A*68:169 | 60788879 | MF797879, | Antonio Balas, Madrid, Spain |
| B*15:30:01:02 | M-164-05-0642-B | KU528621, | Valia Bravo-Egana, Philadelphia, USA |
| B*46:01:23 | 5741601306 | MF689004, | Faming Zhu, Hangzhou, China |
| C*04:01:01:13 | BeWo | AJ238694, | Paul Dunn, Leicester, United Kingdom |
| C*04:01:01:14 | BM9 | KX687303, | Konstantinos Barsakis, Palo Alto, USA |
| C*07:02:82 | 15-3261 | MF797880, | Antonio Balas, Madrid, Spain |
| C*07:04:02:02 | TER-223 | HG965156, | Steven GE Marsh, London, United Kingdom |
| C*17:03:01:03 | 55131 | KJ562278, | Talitha de Hoop, Utrecht, The Netherlands |
| C*17:03:01:03 | 1002009 | HG970095, | Steven GE Marsh, London, United Kingdom |
| DRB1*04:01:01:03 | T420 | LC257775, | Takashi Shiina, Isehara, Japan |
| DRB1*04:03:01:02 | T088 | LC257776, | Takashi Shiina, Isehara, Japan |
| DRB1*04:73:02 | JMDP36K0307 | LC315803, | Masahiro Satake, Tokyo, Japan |
| DRB1*09:32 | cl161111 | KJ920279, | Lina Chen, Xiamen, China |
| DRB1*13:243 | JMDP36K0306 | LC315802, | Masahiro Satake, Tokyo, Japan |
| DQB1*03:02:26 | 016596897 | MF795057, | Sarah Colom, La Tronche, France |
| DQB1*03:10:02:02 | DKMS-LSL-DQB1-1008 | LN999671, | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*06:243 | BST003 | MF924374, | Francesc Rudilla, Barcelona, Spain |
| DPB1*02:01:02:34 | DKMS-LSL-DPB1-1565,DKMS-LSL-DPB1-1566 | LT718903,LT718904, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:35 | DKMS-LSL-DPB1-1572 | LT718910, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:36 | DKMS-LSL-DPB1-1571 | LT718909, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:37 | DKMS-LSL-DPB1-1574,DKMS-LSL-DPB1-1586 | LT718912,LT718924, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:34 | DKMS-LSL-DPB1-1725,DKMS-LSL-DPB1-1724 | LT882750,LT882749, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:35 | DKMS-LSL-DPB1-1707 | LT882731, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:36 | DKMS-LSL-DPB1-1756,DKMS-LSL-DPB1-1755 | LT883482,LT883481, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*20:01:04 | DKMS-LSL-DPB1-1740,DKMS-LSL-DPB1-1739 | LT882765,LT882764, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*30:01:01:02 | DKMS-LSL-DPB1-1658 | LT718992, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*33:01:01:03 | DKMS-LSL-DPB1-1661 | LT718995, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*33:01:01:04 | DKMS-LSL-DPB1-1662 | LT718996, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*33:01:01:05 | DKMS-LSL-DPB1-1660 | LT718994, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*39:01:01:02 | DKMS-LSL-DPB1-1674 | LT719007, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*39:01:01:03 | DKMS-LSL-DPB1-1675 | LT719008, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*39:01:01:04 | DKMS-LSL-DPB1-1672 | LT719005, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*41:01:01:02 | DKMS-LSL-DPB1-1677 | LT719009, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*414:01:01:02 | DKMS-LSL-DPB1-1678 | LT719010, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*666:01 | DKMS-LSL-DPB1-1738 | LT882763, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*667:01 | DKMS-LSL-DPB1-1731 | LT882756, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*668:01:01:01 | DKMS-LSL-DPB1-1732,DKMS-LSL-DPB1-1733 | LT882757,LT882758, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*668:01:01:02 | DKMS-LSL-DPB1-1734 | LT882759, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*669:01 | DKMS-LSL-DPB1-1735 | LT882760, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*670:01 | DKMS-LSL-DPB1-1737 | LT882762, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*671:01 | DKMS-LSL-DPB1-1736 | LT882761, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*672:01 | DKMS-LSL-DPB1-1716,DKMS-LSL-DPB1-1717 | LT882740,LT882741, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*673:01 | DKMS-LSL-DPB1-1714 | LT882738, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*674:01 | DKMS-LSL-DPB1-1718,DKMS-LSL-DPB1-1719 | LT882742,LT882743, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*675:01 | DKMS-LSL-DPB1-1742 | LT882767, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*676:01 | DKMS-LSL-DPB1-1748,DKMS-LSL-DPB1-1747 | LT883474,LT883473, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*677:01 | DKMS-LSL-DPB1-1774,DKMS-LSL-DPB1-1773 | LT883500,LT883499, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*678:01 | DKMS-LSL-DPB1-1762,DKMS-LSL-DPB1-1761 | LT883488,LT883487, | DKMS Life Sciences Lab, Dresden, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*03:266N | DKMS-LSL-A-158, | LK021976, | DKMS Life Sciences Lab, Dresden, Germany |
| B*40:01:45 | SZ-GSQ26, | MF946654, | Su-Qing Gao, Shenzhen, China |
| B*40:50 | 0992117901793L, | ERZ477899, | Francisco Boix, London, United Kingdom |
| B*51:90 | JP-LE, | MF686924, | Robert Bradshaw, Leicester, United Kingdom |
| DRB1*15:140 | D333473, | LT904700, | Edward KL Yang, Hualien, Taiwan |
| DQB1*04:02:01:01 | DKMS-LSL-DQB1-985, | LN999688, | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*04:02:01:01 | DKMS-LSL-DQB1-1121, | LT578450, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:04 | DKMS-LSL-DPB1-1685, | LT719017, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:04 | DKMS-LSL-DPB1-1746, | LT882771, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:10 | DKMS-LSL-DPB1-1778, | LT883504, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:15 | DKMS-LSL-DPB1-1772,DKMS-LSL-DPB1-1771, | LT883498,LT883497, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:20 | DKMS-LSL-DPB1-1763,DKMS-LSL-DPB1-1764, | LT883489,LT883490, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:02:01:03 | DKMS-LSL-DPB1-1777,DKMS-LSL-DPB1-1776, | LT883503,LT883502, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:02:10 | DKMS-LSL-DPB1-1741, | LT882766, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*49:01:01:03 | DKMS-LSL-DPB1-1684, | LT719016, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*104:01:01:02 | DKMS-LSL-DPB1-1723_DPB1*104new, | LT882748, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*104:01:01:03 | DKMS-LSL-DPB1-1745, | LT882770, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*178:01 | DKMS-LSL-DPB1-1766,DKMS-LSL-DPB1-1765, | LT883492,LT883491, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*184:01 | DKMS-LSL-DPB1-1720, | LT882744, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*187:01 | DKMS-LSL-DPB1-1730, | LT882755, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*190:01 | DKMS-LSL-DPB1-1712,DKMS-LSL-DPB1-1713, | LT882736,LT882737, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*208:01 | DKMS-LSL-DPB1-1706,DKMS-LSL-DPB1-1705, | LT882730, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*236:01:01 | DKMS-LSL-DPB1-1729,DKMS-LSL-DPB1-1728, | LT882754,LT882753, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*244:01 | DKMS-LSL-DPB1-1721,DKMS-LSL-DPB1-1722, | LT882745,LT882746, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*260:01 | DKMS-LSL-DPB1-1768,DKMS-LSL-DPB1-1767, | LT883493,LT883494, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*328:01N | DKMS-LSL-DPB1-1744,DKMS-LSL-DPB1-1743, | LT882769,LT882768, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*415:01 | DKMS-LSL-DPB1-1727,DKMS-LSL-DPB1-1726, | LT882752,LT882751, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*498:01 | DKMS-LSL-DPB1-1754,DKMS-LSL-DPB1-1753, | LT883479,LT883480, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*535:01 | DKMS-LSL-DPB1-1758,DKMS-LSL-DPB1-1757, | LT883483,LT883484, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*572:01 | DKMS-LSL-DPB1-1750,DKMS-LSL-DPB1-1749, | LT883476,LT883475, | DKMS Life Sciences Lab, Dresden, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:07:09 | (3) |
| A*02:315 | (4) |
| A*02:653 | (5) |
| A*02:684 | (6) |
| A*02:687 | (7) |
| A*11:263 | (8) |
| A*24:02:01:09 | (9) |
| A*24:198 | (10) |
| A*26:82 | (11) |
| A*30:62 | (12) |
| B*07:294 | (13) |
| B*27:149 | (14) |
| B*40:01:45 | (15) |
| B*40:238 | (16) |
| B*40:356 | (17) |
| B*52:70 | (18) |
| B*59:01:01:01 | (19) |
| C*01:135 | (20) |
| C*02:02:33 | (21) |
| C*04:277 | (22) |
| C*14:02:01:03 | (23) |
| DRB1*09:31 | (24) |
| DRB1*11:143 | (25) |
| DRB1*12:67 | (26) |
| DRB1*14:32:03 | (27) |
| DQB1*03:73 | (28) |
| DQB1*05:01:24 | (29) |
| DQB1*06:123 | (30) |
| DPB1*518:01 | (31) |
| DPB1*519:01 | (32) |
| DPB1*665:01 | (29) |
| HFE*001:01:01 | (33) |
| HFE*002 | (33) |
| HFE*003 | (33) |
| HFE*004 | (33) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
- Wang BJ, Huo MR, Gao YH, et al.Identification of a new HLA-A allele, HLA-A*02:07:09, in a Chinese non-Hodgkin lymphoma patient HLA 2017 90: 243-244.
- Lin FQ, Li XF, Zhang X, et al.Identification of a novel HLA-A allele, HLA-A*02:315 HLA 2017 90: 244-246.
- Condello R, Picardi A, Battarra M, et al.Identification of the novel allele, HLA-A*02:653, in an Italian patient. HLA 2017 90: 300-301.
- Yang KL, Lin PY.Discovery of a novel HLA-A*02 variant, HLA-A*02:684, in a Taiwanese individual. HLA 2017 90: 301-302.
- Kim KM, Han OJ, Kang MS, et al.HLA-A*02:687, a novel allele identified by sequence-based typing in a cord blood from a Korean woman. HLA 2017 90: 246-247.
- Yang KL, Lin PY.Detection of a novel HLA-A*11 variant, A*11:263, in a Taiwanese individual HLA 2017 90: 303-304.
- Choi HJ, Lee JH, Kim SH, et al.HLA-A*24:02:01:09, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 90: 304-305.
- Wang K, Li XF, Zhang X, et al.Detection of a novel allele, HLA-A*24:198, by sequence-based typing in a Chinese individual. HLA 2017 90: 306-307.
- Zhu C, Nie X, Song Y, et al.Sequence identification, serological reactivity and family genetics of a novel HLA allele, HLA-A*26:82 HLA 2017 90: 308-309.
- Zhang X, Li XF, Lin FQ, et al.A new HLA-A allele, HLA-A*30:62, sequenced in a Chinese individual. HLA 2017 90: 249-251.
- Liu B, Lv J, Ma Z.Discovery of a novel HLA-B*07 variant, HLA-B*07:294, in a Chinese individual. HLA 2017 90: 251-252.
- Wang J, Zhang Y, Li Q, et al.A novel allele, HLA-B*27:149, identified by sequence-based typing in a Chinese individual. HLA 2017 90: 309-310.
- Yang LK, Lin PY.HLA-B*40:01:45, a novel variant of HLA-B*40:01, discovered in a Taiwanese hematopoitic stem cell donor HLA 2017 90: 311-312.
- Lee HL, Lai SK, Chen PL, et al.Identification of a novel HLA-B allele, HLA-B*40:238, in a Taiwanese individual. HLA 2017 90: 252-253.
- Tang J, Chen X, Liu S, et al.HLA-B*40:356, identified by next-generation sequence based typing in a Chinese tuberculosis patient HLA 2017 90: 312-313.
- Mo X, Zhang T.Full length sequencing of the HLA region identified a novel HLA allele, HLA-B*52:70 HLA 2017 90: 253-254.
- Li Z, Zou HY, Zhou D.The full-length sequence of HLA-B*59:01:01:01 confirmed by cloning and sequencing. HLA 2017 90: 255-258.
- Park Y, Im J, Yoon CE, et al.Identification of a novel allele, HLA-C*01:135, by full length-genomic sequencing. HLA 2017 90: 258-259.
- Park Y, Kim H, Im J, et al.Identification of the novel allele, HLA-C*02:02:33, by full-length genomic sequencing. HLA 2017 90: 313-314.
- Zhou XY, Zhang LQ, Yao X, et al.Characterization of a novel HLA-C*04 allele, HLA-C*04:277. HLA 2017 90: 315-316.
- Park Y, Park BG, Im J, et al.A novel allele, HLA-C*14:02:01:03, identified by full-length genomic sequencing. HLA 2017 90: 260-261.
- Yang KL, Lin PY.Detection of a novel HLA-DRB1*09 variant, HLA-DRB1*09:31, in a College of American Pathologists HLA survey samples. HLA 2017 90: 320-321.
- Li XF, Li GJ, Zhang X, et al.A variant of HLA-DRB1*11, HLA-DRB1*11:143, discovered in a Chinese hematopoietic stem cell donor. HLA 2017 90: 321-323.
- Yang KL, Lin PY.Detection of a novel HLA-DRB1*12 variant, HLA-DRB1*12:67, in a Taiwanese individual. HLA 2017 90: 323-324.
- Li JP, Zhang X, Lin FQ, et al.Sequence-based typing of a novel HLA-DRB1 allele, HLA-DRB1*14:32:03, in a Chinese individual. HLA 2017 90: 325-326.
- Zheng JW, Xie JH, Sun Y, et al.A novel HLA class II allele, HLA-DQB1*03:73. HLA 2017 90: 261-262.
- Ehrenberg PK, Geretz A, Sindhu RK, et al.High-throughput next-generation sequencing to genotype six classical HLA loci from 96 donors in a single MiSeq run. HLA 2017 90: 284-291.
- Fakhoury HA, Alzahrani M, Alaskar AS, et al.Identification of the HLA-DQB1*06:123 allele in an unrelated stem cell donor from the Saudi Registry HLA 2017 90: 262-263.
- Choi HJ, Im J, Lee JH, et al.HLA-DPB1*518:01, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 90: 316-318.
- Choi HJ, Im J, Lee JH, et al.HLA-DPB1*519:01, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 90: 318-319.
- Campos WN, Massaro JD, Martinelli ALC, et al.HFE gene polymorphism defined by sequence based typing of the Brazilian population and a standardized nomenclature for HFE allele sequences. HLA 2017 90: 238-242.
