Nomenclature for Factors of the HLA System
August 2017
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2017): 90:388-390
- Human Immunology (2017): 78:762-764
- International Journal of Immunogenetics (2017): 45:31-34
The following sequences have been submitted to the Nomenclature Committee since the July 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 400 alleles were recently published but have not been included in Table 3 due to space considerations (2).
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (3). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:241 | NT01520 | MF582484, | Carolyn K Hurley, Washington DC, USA |
| A*02:07:11 | NT01518 | MF582482, | Carolyn K Hurley, Washington DC, USA |
| A*24:387 | 171173 | KY419446, | Vera Balz, D,sseldorf, Germany |
| A*24:388N | D14044610 | MF582637, | Daoming Wang, Shenzhen, China |
| A*26:01:43 | 285565 | KY419452, | Vera Balz, D,sseldorf, Germany |
| A*74:01:06 | NT01517 | MF582481, | Carolyn K Hurley, Washington DC, USA |
| B*18:01:01:08 | 272456 | KY419469, | Vera Balz, D,sseldorf, Germany |
| B*18:140 | 86590 | KY419471, | Vera Balz, D,sseldorf, Germany |
| B*18:141 | NT01514 | MF582478, | Carolyn K Hurley, Washington DC, USA |
| B*18:142 | NT01521 | MF582485, | Carolyn K Hurley, Washington DC, USA |
| B*27:02:01:05 | 257388 | KY419473, | Vera Balz, D,sseldorf, Germany |
| B*27:12:01:02 | 88076 | KY613920, | Vera Balz, D,sseldorf, Germany |
| B*37:01:01:02 | 104112,104113 | KY419482, | Vera Balz, D,sseldorf, Germany |
| B*40:02:01:04 | 242774,289484 | KY419486, | Vera Balz, D,sseldorf, Germany |
| B*40:298:02 | TYNPC27 | MF578382, | Wei Tian, Changsha, China |
| B*40:361N | X69963 | KY131799, | Jun Qi, Xian, China |
| B*45:21 | 282512 | KY419493, | Vera Balz, D,sseldorf, Germany |
| B*48:42 | X72637 | MF523650, | Jun Qi, Xian, China |
| B*48:43 | 16ZZ1133 | LC314579, | Li-Qun Zhang, Beijing, China |
| B*57:01:01:02 | 295215 | KY419505, | Vera Balz, D,sseldorf, Germany |
| C*01:02:43 | NT01519 | MF582483, | Carolyn K Hurley, Washington DC, USA |
| C*03:03:37 | X71814 | MF523651, | Jun Qi, Xian, China |
| C*03:04:56 | NT01516 | MF582480, | Carolyn K Hurley, Washington DC, USA |
| C*03:366N | 268989 | KY499648, | Vera Balz, D,sseldorf, Germany |
| C*03:367 | NT01515 | MF582479, | Carolyn K Hurley, Washington DC, USA |
| C*05:01:01:09 | BY01454 | KY622036, | Carolyn K Hurley, Washington DC, USA |
| C*05:01:36 | KY620037 | KY620037, | Francisco Angelo Fernandez Moral, Aparecida de Goinia, Brazil |
| C*06:02:01:09 | 280622 | KY419397, | Vera Balz, D,sseldorf, Germany |
| C*06:205 | 4671500300 | MF680541, | Xin Li, Harbin, China |
| C*07:02:81 | 0107042 | 2026512, | Chun-Ying Lin, Taipei, Taiwan |
| C*07:600N | NT01522 | MF582486, | Carolyn K Hurley, Washington DC, USA |
| C*15:02:01:08N | 38149,66184,204794,234730,282784,287676 | KY419371, | Vera Balz, D,sseldorf, Germany |
| C*15:146 | 293542 | KY419421, | Vera Balz, D,sseldorf, Germany |
| C*16:114 | NT01523 | MF582487, | Carolyn K Hurley, Washington DC, USA |
| DRB1*01:84 | JMDP01K0204 | LC315682, | Masahiro Satake, Tokyo, Japan |
| DRB1*04:234 | JMDP36K0253 | LC315683, | Masahiro Satake, Tokyo, Japan |
| DRB1*04:235 | JMDP36K0266 | LC315797, | Masahiro Satake, Tokyo, Japan |
| DRB1*04:236 | JMDP36K0276 | LC315798, | Masahiro Satake, Tokyo, Japan |
| DRB1*07:01:22 | 3133 | LT896717, | Xiao Yang Zhou, Beijing, China |
| DRB1*12:68 | D192622 | LT903664, | Edward KL Yang, Hualien, Taiwan |
| DRB1*13:242 | JMDP36K0283 | LC315800, | Masahiro Satake, Tokyo, Japan |
| DRB1*14:187 | JMDP01K0181 | LC315679, | Masahiro Satake, Tokyo, Japan |
| DRB1*14:188N | JMDP36K0278 | LC315799, | Masahiro Satake, Tokyo, Japan |
| DRB1*15:01:34 | 4511102542 | MF403091, | Xin Li, Harbin, China |
| DQB1*04:42 | X72050 | MF523654, | Jun Qi, Xian, China |
| DQB1*06:242 | X72651 | MF523653, | Jun Qi, Xian, China |
| DPB1*03:01:01:10 | DKMS-LSL-DPB1-1625 | LT718963, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*13:01:01:02 | DKMS-LSL-DPB1-1638 | LT719040, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*13:01:01:03 | DKMS-LSL-DPB1-1636 | LT719042, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*13:01:01:04 | DKMS-LSL-DPB1-1637 | LT719041, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*14:01:01:03 | DKMS-LSL-DPB1-1644 | LT718978, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*19:01:01:02 | DKMS-LSL-DPB1-1652 | LT718986, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*34:01:01:02 | DKMS-LSL-DPB1-1663 | LT718997, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*40:01:01:02 | ASHI_HT_201 | KX121039, | Amanda Willis, Dallas, USA |
| DPB1*69:01:01:02 | DKMS-LSL-DPB1-1694 | LT719036, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*104:01:01:04 | DKMS-LSL-DPB1-1624 | LT718962, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*104:01:01:05 | DKMS-LSL-DPB1-1623 | LT718961, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*105:01:01:06 | DKMS-LSL-DPB1-1628 | LT718966, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*105:01:01:07 | DKMS-LSL-DPB1-1627 | LT718965, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*105:01:01:08 | DKMS-LSL-DPB1-1626 | LT718964, | DKMS Life Sciences Lab, Dresden, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*24:02:103 | 016322363, | LT883521, | Sarah Colom, La Tronche, France |
| A*26:140 | X70281, | KY020415, | Jun Qi, Xian, China |
| C*01:55 | JRC-D03326, | LC314768, | Masahiro Satake, Tokyo, Japan |
| C*03:99:01 | JRC-D03395, | LC314767, | Masahiro Satake, Tokyo, Japan |
| C*04:30 | 4161117022, | MF045353, | Talitha de Hoop, Utrecht, The Netherlands |
| C*04:180:01 | NT01513, | MF619962, | Carolyn K Hurley, Washington DC, USA |
| C*15:10:02 | JRC-D03403, | LC314769, | Masahiro Satake, Tokyo, Japan |
| DQB1*03:12 | BY01503, | MF619961, | Carolyn K Hurley, Washington DC, USA |
| DPB1*138:01 | DKMS-LSL-DPB1-1643, | LT718977, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*141:01 | DKMS-LSL-DPB1-1646, | LT718980, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*191:01 | DKMS-LSL-DPB1-1653, | LT718987, | DKMS Life Sciences Lab, Dresden, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:681 | (4) |
| A*30:111 | (4) |
| A*68:164 | (4) |
| B*27:112 | (5) |
| B*35:01:46 | (4) |
| B*50:51 | (6) |
| C*05:142 | (7) |
| C*08:01:20 | (8) |
| C*12:214 | (9) |
| DRB1*14:186 | (10) |
| DRB1*15:11 | (11) |
| DRB3*02:61Q | (12) |
| DQB1*03:82 | (13) |
| DQB1*05:144 | (14) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Chai X, Zhang H, Yang X, Yang Fm Liu N. Identification of 400 novel alleles at the HLA-A, -B, -C, -DRB1, -DQB1 loci from the China Marrow Donor Program. HLA 2017 90 171-173
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
- Sanchez-Gordo F, Balas A, Gomez-Zumaquero JM, et al.Four new HLA class I alleles, HLA-A*02:681, HLA-A*30:111, HLA-A*68:164 and HLA-B*35:01:46. HLA 2017 90: 174-174.
- Yang KL, Lin PY.Identification of a novel HLA-B*27 variant, B*27:112, by sequence-based typing in a Taiwanese donor. HLA 2017 90: 175-176.
- Sanchez-Gordo F, , Gomez-Zumaquero JM, et al.The new HLA-B*50:51 allele was generated by intralocus recombination between B*50:01:01:02 and B*14:02:01. HLA 2017 90: 176-178.
- Rowlands J, Climer T, Harvey C, et al.The HLA-C*05 family allele - C*05:142 Int. J. Immunogenetics 2017 44: 169-170.
- Huo MR, Xi B, Yu Y, et al.Identification of a novel HLA-C*08 allele, HLA-C*08:01:20. HLA 2017 90: 178-179.
- Yang H, Mo X, Fang J, et al.Sequence-based typing identification of a novel HLA-C allele, C*12:214, in a Han-Chinese individual. HLA 2017 90: 179-180.
- Zanchi F, Castellani L, Gualandris F, et al.Identification of the new HLA-DRB1*14:186 allele in an Italian bone marrow donor. HLA 2017 90: 183-184.
- Yang KL, Lin PY.The DRB1*15:11 allele discovered in a Taiwanese unrelated hematopoietic stem cell donor. HLA 2017 90: 184-185.
- Ulrich S, Matzhold E, Posch U, et al.HLA-DRB3*02:61Q, a novel HLA-DRB3 allele identified in a volunteer bone marrow donor. HLA 2017 90: 186-187.
- Burkitbayev ZhK, Abdrakhmanova SA, Turganbekova AA, et al.Detection of the HLA-DQB1 allele, DQB1*03:82, in a Kazakh patient with acute myeloid leukaemia HLA 2017 90: 181-182.
- Mostafa AA, Faisal K, Stamm L, et al.HLA-DQB1*05:144, a novel allele, discovered in a Southeast Asian donor for stem cell transplantation HLA 2017 90: 182-183.
