Nomenclature for Factors of the HLA System
May 2017
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2017): 90:193-196
- Human Immunology (2017): 78:586-588
- International Journal of Immunogenetics (2017): 44:239-242
The following sequences have been submitted to the Nomenclature Committee since the April 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:688 | M-18997 | LT852427, | Kristin Kipper, Martinsried, Germany |
| A*03:280 | M-689870 | LT852428, | Kristin Kipper, Martinsried, Germany |
| A*11:01:01:06 | 104305,274166,275513 | KY419439, | Vera Balz, D,sseldorf, Germany |
| A*23:01:01:04 | 283561 | KY419442, | Vera Balz, D,sseldorf, Germany |
| A*24:02:102 | 1750-2111-2 | MF069242, | Yuxin Yin, Los Angeles, USA |
| A*32:103 | 1743-9101-1 | MF069204, | Yuxin Yin, Los Angeles, USA |
| A*68:01:02:04 | 6722,31757,50202,54984,55286,72873,94276,221980 | KY419457, | Vera Balz, D,sseldorf, Germany |
| A*68:167 | 46271 | LT827024, | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*35:345 | M-96200 | LT852429, | Kristin Kipper, Martinsried, Germany |
| B*39:02:03 | T149 | LC257721, | Takashi Shiina, Isehara, Japan |
| B*40:06:04:02 | 4161115110 | MF058639, | Talitha de Hoop, Utrecht, The Netherlands |
| B*40:358 | M-317019 | LT852430, | Kristin Kipper, Martinsried, Germany |
| B*52:70 | Peripheral_Blood_UC3988 | KY906101, | Xiaodong Mo, Shenzhen, China |
| B*55:02:01:03 | JM02 | LC257740, | Takashi Shiina, Isehara, Japan |
| C*01:02:01:05 | JM11 | LC257748, | Takashi Shiina, Isehara, Japan |
| C*01:15:02 | M-668764 | LT852431, | Kristin Kipper, Martinsried, Germany |
| C*03:03:01:08 | T135 | LC257752, | Takashi Shiina, Isehara, Japan |
| C*03:03:35 | AMC170323_33635552 | KY863416, | Oh-Joong Kwon, Seoul, South Korea |
| C*03:357 | 016250885 | LT838221, | Sarah Colom, La Tronche, France |
| C*03:358 | 015959759 | LT838219, | Sarah Colom, La Tronche, France |
| C*03:359 | 015736202 | LT838233, | Sarah Colom, La Tronche, France |
| C*03:360 | M-597260 | LT852432, | Kristin Kipper, Martinsried, Germany |
| C*03:361 | 46272 | LT827025, | Marcel GJ Tilanus, Maastricht, The Netherlands |
| C*04:01:83 | 016335040 | LT838220, | Sarah Colom, La Tronche, France |
| C*04:274 | 015937518 | LT838227, | Sarah Colom, La Tronche, France |
| C*04:275 | 015874788 | LT838223, | Sarah Colom, La Tronche, France |
| C*04:276 | M-666485 | LT852433, | Kristin Kipper, Martinsried, Germany |
| C*05:153N | 016229771 | LT838237, | Sarah Colom, La Tronche, France |
| C*06:02:49 | 016209001 | LT838228, | Sarah Colom, La Tronche, France |
| C*06:02:50 | 1140_2 | LT837520, | Viktoria Zakharova, Moscow, Russia |
| C*07:592 | 015935663 | LT838222, | Sarah Colom, La Tronche, France |
| C*07:593N | 1788_5 | LT838332, | Viktoria Zakharova, Moscow, Russia |
| C*07:594 | 016264924 | LT838218, | Sarah Colom, La Tronche, France |
| C*07:595 | 016235959 | LT838234, | Sarah Colom, La Tronche, France |
| C*08:01:01:02 | T106 | LC257765, | Takashi Shiina, Isehara, Japan |
| C*08:02:15 | 016334442 | LT838230, | Sarah Colom, La Tronche, France |
| C*15:02:30 | 015953556 | LT838229, | Sarah Colom, La Tronche, France |
| C*16:111 | 016250842 | LT838226, | Sarah Colom, La Tronche, France |
| C*17:38 | 1918_1 | LT838331, | Viktoria Zakharova, Moscow, Russia |
| F*01:01:01:14 | DEU | KY704497, | Mehdi Alizadeh, Rennes, Frances |
| DRB1*04:231 | M-76062 | LT852434, | Kristin Kipper, Martinsried, Germany |
| DRB1*13:01:17 | 1945_1 | LT838782, | Viktoria Zakharova, Moscow, Russia |
| DRB3*01:43 | NHSBT04517 | LT844633, | Francisco Boix, London, United Kingdom |
| DQA1*01:01:01:04 | JM02 | LC257814, | Takashi Shiina, Isehara, Japan |
| DQA1*01:01:01:05 | JM10 | LC257815, | Takashi Shiina, Isehara, Japan |
| DQA1*01:02:01:08 | T253 | LC257819, | Takashi Shiina, Isehara, Japan |
| DQA1*01:03:01:07 | T063 | LC257823, | Takashi Shiina, Isehara, Japan |
| DQA1*01:03:01:08 | JM35 | LC257824, | Takashi Shiina, Isehara, Japan |
| DQA1*01:16N | UA2017tp865 | LT838778, | Mats Bengtsson, Uppsala, Sweden |
| DQA1*03:02:01:02 | T097 | LC257831, | Takashi Shiina, Isehara, Japan |
| DQA1*03:02:01:03 | JM30 | LC257832, | Takashi Shiina, Isehara, Japan |
| DQA1*03:04 | 015940462 | LT838896, | Sarah Colom, La Tronche, France |
| DQA1*04:01:01:02 | T131 | LC257838, | Takashi Shiina, Isehara, Japan |
| DQA1*04:01:01:03 | T106 | LC257839, | Takashi Shiina, Isehara, Japan |
| DQB1*03:01:39 | 015901653 | LT838900, | Sarah Colom, La Tronche, France |
| DQB1*03:02:01:04 | BY01483 | MF033149, | Carolyn K Hurley, Washington DC, USA |
| DQB1*05:149 | 016211227 | LT838889, | Sarah Colom, La Tronche, France |
| DQB1*05:150 | 016265351 | LT840076, | Sarah Colom, La Tronche, France |
| DQB1*05:151 | M-423861 | LT852435, | Kristin Kipper, Martinsried, Germany |
| DQB1*06:03:27 | NHSBT210417 | LT837517, | Francisco Boix, London, United Kingdom |
| DQB1*06:04:11 | 016225015 | LT838901, | Sarah Colom, La Tronche, France |
| DQB1*06:237 | 016266064 | LT838899, | Sarah Colom, La Tronche, France |
| DQB1*06:238 | M-595286 | LT852436, | Kristin Kipper, Martinsried, Germany |
| DPA1*02:07:01:03 | DNA174 | KY807148, | Yvonne Thorstenson, Mountain View, USA |
| DPB1*02:01:21 | 81145175 | KU904251, | Daniel Fuerst, Ulm, Germany |
| DPB1*14:01:04 | 016185960 | LT838895, | Sarah Colom, La Tronche, France |
| DPB1*654:01 | H4G1 | KY859858, | Yvonne Thorstenson, Mountain View, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*03:01:14 | 46270, | LT827023, | Marcel GJ Tilanus, Maastricht, The Netherlands |
| A*24:02:79 | 4140319104, | KY964232, | Talitha de Hoop, Utrecht, The Netherlands |
| A*29:02:20 | 1940-5814-5, | MF069203, | Yuxin Yin, Los Angeles, USA |
| A*68:23 | BY01482, | KY906170, | Carolyn K Hurley, Washington DC, USA |
| B*07:75:01:01 | 4140313015, | KY964230, | Talitha de Hoop, Utrecht, The Netherlands |
| B*15:01:06 | 4150211022, | KY964231, | Talitha de Hoop, Utrecht, The Netherlands |
| B*40:01:02:01 | T119, | LC257725, | Takashi Shiina, Isehara, Japan |
| B*40:01:45 | R40519, | LN901490, | Edward KL Yang, Hualien, Taiwan |
| B*40:06:04:01 | 3161027257, | MF058631, | Talitha de Hoop, Utrecht, The Netherlands |
| B*40:42 | 4161018040, | MF058632, | Talitha de Hoop, Utrecht, The Netherlands |
| B*44:29 | 4161115048, | MF058633, | Talitha de Hoop, Utrecht, The Netherlands |
| B*44:29 | 4161005080, | MF058634, | Talitha de Hoop, Utrecht, The Netherlands |
| B*51:50 | 4161102015, | MF058635, | Talitha de Hoop, Utrecht, The Netherlands |
| B*55:04 | JM30, | LC257741, | Takashi Shiina, Isehara, Japan |
| B*82:01 | 4160316008, | MF058636, | Talitha de Hoop, Utrecht, The Netherlands |
| C*02:06:01 | 4161011039, | MF058637, | Talitha de Hoop, Utrecht, The Netherlands |
| C*03:03:01:01 | T088, | LC257751, | Takashi Shiina, Isehara, Japan |
| C*07:02:01:01 | T106, | LC257759, | Takashi Shiina, Isehara, Japan |
| C*07:02:01:15 | JM31, | LC257762, | Takashi Shiina, Isehara, Japan |
| C*07:07 | 4140319028, | MF045355, | Talitha de Hoop, Utrecht, The Netherlands |
| C*07:22 | 4140319132, | MF045356, | Talitha de Hoop, Utrecht, The Netherlands |
| C*07:165 | 4140918100, | MF045357, | Talitha de Hoop, Utrecht, The Netherlands |
| C*07:533 | 015643310, | LT838217, | Sarah Colom, La Tronche, France |
| C*15:29 | 4160608069, | MF045358, | Talitha de Hoop, Utrecht, The Netherlands |
| DRB5*01:01:01 | HAY,BD, | KU593577, | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*01:01:01 | 171333, | KU593580, | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*01:01:01 | 280599, | KU593576, | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*01:02 | 164639, | KU593573, | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*02:02:01 | CHA,AJ, | KU593578, | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*03:02:01:01 | T106, | LC257830, | Takashi Shiina, Isehara, Japan |
| DQA1*03:03:01:03 | T331, | LC257835, | Takashi Shiina, Isehara, Japan |
| DQB1*03:03:02:04 | BY01486, | MF033146, | Carolyn K Hurley, Washington DC, USA |
| DQB1*03:37 | 1878_2, | LT838781, | Viktoria Zakharova, Moscow, Russia |
| DQB1*03:243 | BY01484, | MF033148, | Carolyn K Hurley, Washington DC, USA |
| DQB1*05:12 | 4140602043, | MF045360, | Talitha de Hoop, Utrecht, The Netherlands |
| DQB1*05:31 | BY01487, | MF033145, | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*30:109 | (3) |
| B*15:416 | (4) |
| B*27:04:01 | (5) |
| B*27:07:01 | (5) |
| B*27:25 | (5) |
| B*49:39 | (6) |
| B*55:02:01:01 | (5) |
| B*55:02:09 | (7) |
| B*55:80 | (7) |
| C*15:02:01:04 | (8) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
- Yang KL, Lin PY.Detection of a novel HLA-A*30 variant, A*30:109, in a Taiwanese individual. HLA 2017 90: 36-37.
- Proust B, Masson D, Proust BP, et al.Identification of a novel HLA allele, HLA-B*15:416, in a bone marrow hematopoietic stem cell donor. HLA 2017 90: 39-40.
- Li Z, Zou HY.Full-length sequence of three HLA-B alleles, HLA-B*27:04:01, B*27:07:01 and B*27:25, confirmed by cloning and sequencing. HLA 2017 90: 40-43.
- Becker PSA, Lindner S, Kim-Wanner SZ, et al.Characterization of the novel HLA-B*49:39 allele identified in a German leukaemia patient. HLA 2017 90: 43-45.
- Li Z, Zou HY.Full-length sequence of HLA-B*55:02:01:01 confirmed by cloning and sequencing. HLA 2017 90: 45-48.
- Tao SD, ~Domng LN, Han ZD, et al.Identification of two novel HLA-B alleles, HLA-B*55:02:09 and HLA-B*55:80 in Chinese individuals. HLA 2017 90: 48-50.
- Yang KL, Ng J, Lazaro A, et al.A novel HLA allele, HLA-C*15:02:01:04, identified in a Taiwanese individual. HLA 2017 90: 50-51.
