Nomenclature for Factors of the HLA System
April 2017
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2017): 90:188-192
- Human Immunology (2017): 78:582-585
- International Journal of Immunogenetics (2017): 44:234-238
The following sequences have been submitted to the Nomenclature Committee since the March 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:01:131 | SEV170210_8373982 | KY658455, | Oh-Joong Kwon, Seoul, South Korea |
| A*02:07:09 | 17011 | KY927933, | Bo Jing Wang, Beijing, China |
| A*02:684 | D012006 | LT715984, | Edward KL Yang, Hualien, Taiwan |
| A*02:685 | 016208927 | LT838206, | Sarah Colom, La Tronche, France |
| A*02:686 | 016191323 | LT838209, | Sarah Colom, La Tronche, France |
| A*02:687 | CHA16-650 | KY929521, | Ji Young Huh, Sungnam-si, South Korea |
| A*11:263 | D353776 | LT838274, | Edward KL Yang, Hualien, Taiwan |
| A*24:20:01:02 | T324 | LC257695, | Takashi Shiina, Isehara, Japan |
| A*29:100 | 016249291 | LT838205, | Sarah Colom, La Tronche, France |
| A*30:118 | 9000615169747 | KY745906, | Faming Zhu, Hangzhou, China |
| A*32:102 | 015938972 | LT838195, | Sarah Colom, La Tronche, France |
| B*08:181 | UA2016TP2977 | LT707070, | Mats Bengtsson, Uppsala, Sweden |
| B*15:428 | T137 | LC257712, | Takashi Shiina, Isehara, Japan |
| B*18:137 | 015940578 | LT838211, | Sarah Colom, La Tronche, France |
| B*27:02:04 | CN_36515,CN_39545 | KY594041, | Lucia Assunta Longa, Cuneo, Italy |
| B*27:05:02:05 | JM44 | LC257714, | Takashi Shiina, Isehara, Japan |
| B*35:344 | 016229754 | LT838212, | Sarah Colom, La Tronche, France |
| B*39:01:03:02 | T106 | LC257720, | Takashi Shiina, Isehara, Japan |
| B*40:03:01:02 | T420 | LC257727, | Takashi Shiina, Isehara, Japan |
| B*40:356 | CXD0097 | KY774655, | Jian Tang, Jinan, China |
| B*40:357 | 5791600402 | KY865355, | Faming Zhu, Hangzhou, China |
| B*44:02:47 | 016214757 | LT838210, | Sarah Colom, La Tronche, France |
| B*44:03:01:10 | JM06 | LC257731, | Takashi Shiina, Isehara, Japan |
| B*46:72 | 9000615170050 | KY696709, | Faming Zhu, Hangzhou, China |
| B*48:01:01:02 | T138 | LC257734, | Takashi Shiina, Isehara, Japan |
| B*49:01:09 | 016198646 | LT838215, | Sarah Colom, La Tronche, France |
| B*51:224 | 015956440 | LT838213, | Sarah Colom, La Tronche, France |
| B*53:01:12 | 016207751 | LT838214, | Sarah Colom, La Tronche, France |
| B*57:01:24 | 016227123 | LT838216, | Sarah Colom, La Tronche, France |
| C*02:02:02:13 | BY01459 | KY626048, | Carolyn K Hurley, Washington DC, USA |
| C*03:99:02 | DKMS-LSL-C-949 | LN999637, | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:591 | 015849899 | LT838225, | Sarah Colom, La Tronche, France |
| C*08:01:20 | afn548 | KY938880, | Mingrui Huo, Beijing, China |
| C*12:02:02:03 | BY01445 | KY622046, | Carolyn K Hurley, Washington DC, USA |
| C*12:214 | UC5681 | KY906102, | Xiaodong Mo, Shenzhen, China |
| C*14:87 | R44801 | LT715985, | Edward KL Yang, Hualien, Taiwan |
| C*17:37 | H4E3 | KY859857, | Yvonne Thorstenson, Mountain View, USA |
| F*01:01:01:13 | KT17 | KY704496, | Mehdi Alizadeh, Rennes, Frances |
| G*01:01:01:08 | DUCAF | KY704495, | Mehdi Alizadeh, Rennes, Frances |
| DRB1*04:05:01:02 | JM15 | LC257779, | Takashi Shiina, Isehara, Japan |
| DRB1*04:05:01:03 | T300 | LC257780, | Takashi Shiina, Isehara, Japan |
| DRB1*04:07:06 | 078259 | LT555516, | Ute Geigenmuller, Westborough, USA |
| DRB1*08:02:01:02 | JM38 | LC257786, | Takashi Shiina, Isehara, Japan |
| DRB1*09:01:02:02 | T106 | LC257790, | Takashi Shiina, Isehara, Japan |
| DRB1*09:31 | DML-05 | KX810863, | Edward KL Yang, Hualien, Taiwan |
| DRB1*10:01:01:03 | T138 | LC257791, | Takashi Shiina, Isehara, Japan |
| DRB1*11:01:01:03 | T119 | LC257792, | Takashi Shiina, Isehara, Japan |
| DRB1*11:01:01:04 | JM15 | LC257793, | Takashi Shiina, Isehara, Japan |
| DRB1*12:01:01:04 | JM21 | LC257794, | Takashi Shiina, Isehara, Japan |
| DRB1*12:01:01:05 | T119 | LC257795, | Takashi Shiina, Isehara, Japan |
| DRB1*12:02:01:02 | KB74UK | LC218002, | Uma Kanga, New Delhi, India |
| DRB1*12:02:01:03 | T067 | LC257797, | Takashi Shiina, Isehara, Japan |
| DRB1*12:02:01:04 | T021 | LC257798, | Takashi Shiina, Isehara, Japan |
| DRB1*12:67 | 408443 | LT715986, | Edward KL Yang, Hualien, Taiwan |
| DRB1*13:237 | BY01467 | KY653747, | Carolyn K Hurley, Washington DC, USA |
| DRB3*01:01:07 | 063298 | LT555525, | Ute Geigenmuller, Westborough, USA |
| DRB3*01:01:08 | 097357 | LT555526, | Ute Geigenmuller, Westborough, USA |
| DRB3*02:02:07 | 094654 | LT555527, | Ute Geigenmuller, Westborough, USA |
| DRB3*02:02:08 | 060363 | LT555529, | Ute Geigenmuller, Westborough, USA |
| DRB3*02:02:09 | TAJA829106AN | LT837967, | Steven GE Marsh, London, United Kingdom |
| DQB1*02:95 | BY01465 | KY653745, | Carolyn K Hurley, Washington DC, USA |
| DQB1*02:96N | 276887 | KY856762, | Vera Balz, D,sseldorf, Germany |
| DQB1*03:01:01:06 | RML | KY704494, | Mehdi Alizadeh, Rennes, Frances |
| DQB1*03:01:01:07 | KB62UK | LC217997, | Uma Kanga, New Delhi, India |
| DQB1*03:01:01:08 | 100379,226489,276077,291441,293045 | KY856763, | Vera Balz, D,sseldorf, Germany |
| DQB1*03:01:38 | 080887 | LT555510, | Ute Geigenmuller, Westborough, USA |
| DQB1*03:02:01:03 | 295230 | KY856764, | Vera Balz, D,sseldorf, Germany |
| DQB1*03:264 | 83952_SFC | KY800897, | Maria Elisa Moraes, Rio de Janeiro, Brazil |
| DQB1*03:265 | UA2017tp819 | LT838343, | Mats Bengtsson, Uppsala, Sweden |
| DQB1*04:01:05 | ASAN170112_52201936 | KY658454, | Oh-Joong Kwon, Seoul, South Korea |
| DQB1*04:02:13 | BY01461 | KY653742, | Carolyn K Hurley, Washington DC, USA |
| DQB1*05:01:01:04 | MZ070782 | 1995398, | Mehdi Alizadeh, Rennes, Frances |
| DQB1*05:01:24 | HGL00600 | KY563265, | Rasmi Thomas, Silver Spring, USA |
| DQB1*05:03:01:03 | 83327,241799 | KY856766, | Vera Balz, D,sseldorf, Germany |
| DQB1*05:148 | 8986 | KY856765, | Vera Balz, D,sseldorf, Germany |
| DQB1*06:02:27 | 281518 | KY856767, | Vera Balz, D,sseldorf, Germany |
| DQB1*06:02:28 | 121240,280664 | KY856768, | Vera Balz, D,sseldorf, Germany |
| DQB1*06:09:07 | BY01468 | KY653748, | Carolyn K Hurley, Washington DC, USA |
| DRB5*02:02:02 | 087818 | LT555549, | Ute Geigenmuller, Westborough, USA |
| DPB1*02:01:02:23 | 293657 ,102477,126687,126337,276728,282407,283547 | KY801329, | Vera Balz, D,sseldorf, Germany |
| DPB1*02:01:02:24 | 68292,74676,292357 | KY801330, | Vera Balz, D,sseldorf, Germany |
| DPB1*02:01:02:25 | 283955,6074 | KY801332, | Vera Balz, D,sseldorf, Germany |
| DPB1*02:01:02:26 | DKMS-LSL-DPB1-1584 | LT718922, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:27 | DKMS-LSL-DPB1-1582 | LT718920, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:02:28 | DKMS-LSL-DPB1-1583 | LT718921, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*02:01:20 | 62090 | KY801333, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:12 | DKMS-LSL-DPB1-1605 | LT718943, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:01:13 | DKMS-LSL-DPB1-1607 | LT718945, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:01:14 | DKMS-LSL-DPB1-1606 | LT718944, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:01:15 | DKMS-LSL-DPB1-1601 | LT718939, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:01:16 | DKMS-LSL-DPB1-1600 | LT718938, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:01:17 | DKMS-LSL-DPB1-1602 | LT718940, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:01:18 | 286773,295516,299754,4431,8200,10621,10769,13117,30934,47491 | KY793541, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:19 | 286414 | KY793542, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:20 | 88081,282145 | KY793543, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:21 | 109154,289111 | KY793544, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:22 | 292380,281897 | KY793546, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:23 | 293029 | KY793547, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:24N | 76685 | KY793548, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:01:25 | 280475 | KY793545, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:01:04:02 | DKMS-LSL-DPB1-1608 | LT718946, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:33 | 286474 | KY793549, | Vera Balz, D,sseldorf, Germany |
| DPB1*04:02:01:09 | DKMS-LSL-DPB1-1609 | LT718947, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:02:10 | 24187 | KY793550, | Vera Balz, D,sseldorf, Germany |
| DPB1*06:01:01:03 | DKMS-LSL-DPB1-1619 | LT718957, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*06:01:04 | DKMS-LSL-DPB1-1618 | LT718956, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*39:01:02 | DKMS-LSL-DPB1-1668 | LT719001, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*49:01:01:03 | DKMS-LSL-DPB1-1573 | LT718911, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*105:01:01:04 | DKMS-LSL-DPB1-1630 | LT718968, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*124:01:01:02 | DKMS-LSL-DPB1-1632 | LT718970, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*162:01:02 | UA2015tp3400 | LT70773, | Mats Bengtsson, Uppsala, Sweden |
| DPB1*649:01 | DKMS-LSL-DPB1-1631 | LT718969, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*650:01 | DKMS-LSL-DPB1-1621 | LT718959, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*651:01 | 109297 | KY856757, | Vera Balz, D,sseldorf, Germany |
| DPB1*652:01 | 282474,282927 | KY856759, | Vera Balz, D,sseldorf, Germany |
| DPB1*653:01 | 289118 | KY856758, | Vera Balz, D,sseldorf, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:18 | JM35, | LC257688, | Takashi Shiina, Isehara, Japan |
| A*02:621 | 393489, | LT838275, | Edward KL Yang, Hualien, Taiwan |
| A*02:653 | IME 592-16, | KY703437, | Mariarosa Battarra, Roma, Italy |
| A*03:20 | 4160707058, | KY883673, | Talitha de Hoop, Utrecht, The Netherlands |
| A*11:256Q | 377092, | LN835249, | Edward KL Yang, Hualien, Taiwan |
| A*24:58 | 4160926035, | KY883674, | Talitha de Hoop, Utrecht, The Netherlands |
| A*29:02:20 | 016221117,015939065, | LT838207,LT838208, | Sarah Colom, La Tronche, France |
| A*29:10:01 | 4140312112, | KY883675, | Talitha de Hoop, Utrecht, The Netherlands |
| A*32:60 | NT01405, | KX453669, | Carolyn K Hurley, Washington DC, USA |
| B*13:01:01:01 | T061, | LC257697, | Takashi Shiina, Isehara, Japan |
| B*27:70 | 2009tp3623, | LT838194, | Mats Bengtsson, Uppsala, Sweden |
| B*27:112 | 406114, | LT623896, | Edward KL Yang, Hualien, Taiwan |
| B*35:28 | 5160706186, | KY883676, | Talitha de Hoop, Utrecht, The Netherlands |
| B*39:04 | T253, | LC257722, | Takashi Shiina, Isehara, Japan |
| B*39:23 | JM39, | LC257723, | Takashi Shiina, Isehara, Japan |
| B*40:50 | JM34, | LC257729, | Takashi Shiina, Isehara, Japan |
| B*40:353 | 23470, | KY419487, | Vera Balz, D,sseldorf, Germany |
| C*01:127 | 016215486, | LT838224, | Sarah Colom, La Tronche, France |
| DRB1*04:05:01:01 | JM06, | LC257778, | Takashi Shiina, Isehara, Japan |
| DRB1*04:06:01 | JM43, | LC257781, | Takashi Shiina, Isehara, Japan |
| DRB1*04:10:03 | T253, | LC257783, | Takashi Shiina, Isehara, Japan |
| DRB1*08:02:01:01 | JM18, | LC257785, | Takashi Shiina, Isehara, Japan |
| DRB1*08:09 | JM27, | LC257788, | Takashi Shiina, Isehara, Japan |
| DRB1*09:01:02:01 | JM30, | LC257789, | Takashi Shiina, Isehara, Japan |
| DRB1*12:02:01:01 | KB62UK, | LC218001, | Uma Kanga, New Delhi, India |
| DRB1*14:04:01 | KB100UK, | LC217998, | Uma Kanga, New Delhi, India |
| DRB1*15:11 | D156038, | LT837799, | Edward KL Yang, Hualien, Taiwan |
| DPB1*02:01:02:12 | 287826, | KY801331, | Vera Balz, D,sseldorf, Germany |
| DPB1*131:01 | DKMS-LSL-DPB1-1639, | LT718974, | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*519:01 | Peripheral Blood, | KY697988, | Xiaodong Mo, Shenzhen, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:01:01:09 | (3) |
| A*11:256Q | (4) |
| A*24:353 | (5) |
| B*07:05:01:01 | (6) |
| B*14:01:01:01 | (6) |
| B*15:03:01:01 | (6) |
| B*15:07:01:01 | (6) |
| B*15:13:01 | (6) |
| B*15:18:01:01 | (6) |
| B*15:25:01 | (6) |
| B*15:27:01 | (6) |
| B*15:32:01 | (6) |
| B*15:58 | (6) |
| B*18:02 | (6) |
| B*35:02:01:01 | (6) |
| B*35:03:01:01 | (6) |
| B*35:05:01:01 | (6) |
| B*35:08:01:01 | (6) |
| B*40:01:01 | (6) |
| B*40:03:01:01 | (6) |
| B*40:40 | (6) |
| B*67:01:01 | (6) |
| B*67:01:02 | (6) |
| E*01:01:01:07 | (7) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
- Yang KL, Lin PY.Identification of a novel HLA-A*02:01:01 variant, HLA-A*02:01:01:09, in a Taiwanese bone marrow. HLA 2017 89: 301-302.
- Yang KL, Ng J, Lazaro A, et al.HLA-A*11:256Q, a novel HLA-A*11 variant, detected in a Taiwanese individual. HLA 2017 89: 302-304.
- Gao SQ, Xu YP, He LM, et al.The full length genomic sequence of a novel HLA-A*24 allele, HLA-A*24:353, identified in a patient with hepatitis B infection. HLA 2017 89: 304-305.
- Li Z, Zou HY.Full-length sequences of 3 HLA-B alleles, B*07:05:01:01, B*14:01:01 and B*18:02, confirmed by cloning and sequencing. HLA 2017 89: 305-308.
- Li Z, Zou HY.Full-length sequences of 4 HLA-B*15 alleles, B*15:03:01:01, B*15:13:01, B*15:18:01:01: and B*15:25:01, confirmed by cloning and sequencing. HLA 2017 89: 309-312.
- Li Z, Zou HY.Full-length sequences of 4 HLA-B*15 alleles, B*15:07:01:01, B*15:27:01, B*15:32:01 and B*15:58, confirmed by cloning and sequencing. HLA 2017 89: 313-317.
- Li Z, Zou HY.Full-length sequences of four HLA-B*35 alleles, B*35:02:01:01, B*35:03:01:01, B*35:05:01:01 and B*35:08:01:01, confirmed by cloning and sequencing. HLA 2017 89: 317-321.
- Li Z, Zou HY.Full-length sequence of 3 HLA-B alleles, HLA-B*40:01:01, B*40:03 and B*40:40 confirmed by cloning and sequencing. HLA 2017 89: 321-324.
- Li Z, Zou HY.Full-length sequences of HLA-B*67:01:01 and B*67:01:02, confirmed by cloning and sequencing. HLA 2017 89: 324-327.
- Wang SX, Xu YP.A novel HLA-E allele, HLA-E*01:01:01:07, identified in a Chinese Leukemia patient. HLA 2017 89: 327-330.
