Nomenclature for Factors of the HLA System
January 2017
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2017): 90:56-61
- Human Immunology (2017): 78:451-454
- International Journal of Immunogenetics (2017): 44:171-176
The following sequences have been submitted to the Nomenclature Committee since the December 2016 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:01:08 | 282004 | KY419425 | Vera Balz, Dsseldorf, Germany |
| A*01:01:01:09 | 281454 | KY419426 | Vera Balz, Dsseldorf, Germany |
| A*01:01:01:10 | 293849 | KY419427 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:19 | 130087 | KY419428 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:20 | 279696 | KY419429 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:21 | 295673 | KY419430 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:22 | 295044,120259,286954 | KY419431 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:23 | 95035 | KY419432 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:24 | 289180 | KY419433 | Vera Balz, Dsseldorf, Germany |
| A*02:01:01:25 | 281241 | KY419434 | Vera Balz, Dsseldorf, Germany |
| A*02:01:130 | 416121,301601 | KY391795 | Talitha de Hoop, Utrecht, The Netherlands |
| A*02:05:01:02 | 107110 | KY419435 | Vera Balz, Dsseldorf, Germany |
| A*02:670 | HG00012761 | KY345172 | Histogenetics, Ossining, USA |
| A*02:671 | HG00012762 | KY296551 | Histogenetics, Ossining, USA |
| A*03:01:01:11 | 286116,277074 | KY419437 | Vera Balz, Dsseldorf, Germany |
| A*03:01:01:12 | 284643 | KY419438 | Vera Balz, Dsseldorf, Germany |
| A*03:276 | HG00012758 | KY364235 | Histogenetics, Ossining, USA |
| A*11:01:01:05 | 295837 | KY419440 | Vera Balz, Dsseldorf, Germany |
| A*11:261 | 289263 | KY419441 | Vera Balz, Dsseldorf, Germany |
| A*24:02:01:11 | 125291,125292 | KY419444 | Vera Balz, Dsseldorf, Germany |
| A*24:02:101 | 274362 | KY419445 | Vera Balz, Dsseldorf, Germany |
| A*24:347:02 | HG00012757 | KY345171 | Histogenetics, Ossining, USA |
| A*25:01:01:02 | 100379 | KY419447 | Vera Balz, Dsseldorf, Germany |
| A*26:01:01:06 | 276835 | KY419448 | Vera Balz, Dsseldorf, Germany |
| A*26:01:01:07 | 286377 | KY419449 | Vera Balz, Dsseldorf, Germany |
| A*26:01:01:08 | 73345 | KY419450 | Vera Balz, Dsseldorf, Germany |
| A*26:01:01:09 | 256977 | KY419451 | Vera Balz, Dsseldorf, Germany |
| A*29:02:01:04 | 29556, 27958, 52583 | KY419453 | Vera Balz, Dsseldorf, Germany |
| A*30:114 | 75643 | KY419454 | Vera Balz, Dsseldorf, Germany |
| A*32:01:01:04 | 112111 | KY419455 | Vera Balz, Dsseldorf, Germany |
| A*32:100 | HG00012759, HG00012760 | KY263961KY296550 | Histogenetics, Ossining, USA |
| A*32:101Q | DKMS-LSL-A-845 | LN994746 | DKMS Life Sciences Lab, Dresden, Germany |
| A*68:164 | scu22150 | KY368174 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| B*07:02:52 | 253049 | KY419460 | Vera Balz, Dsseldorf, Germany |
| B*07:291 | 259017 | KY419461 | Vera Balz, Dsseldorf, Germany |
| B*08:01:01:04 | 266660 | KY419462 | Vera Balz, Dsseldorf, Germany |
| B*13:02:01:02 | 28209, 71441 | KY419463 | Vera Balz, Dsseldorf, Germany |
| B*13:100 | 277219 | KY419464 | Vera Balz, Dsseldorf, Germany |
| B*15:01:01:10 | 240389 | KY419465 | Vera Balz, Dsseldorf, Germany |
| B*15:01:01:11 | 295746 | KY419466 | Vera Balz, Dsseldorf, Germany |
| B*15:07:01:02 | 98963,94204,76970,28453 | KY419467 | Vera Balz, Dsseldorf, Germany |
| B*15:09:02 | 278303 | KY419468 | Vera Balz, Dsseldorf, Germany |
| B*15:17:06 | HG00012796 | KY345181 | Histogenetics, Ossining, USA |
| B*15:18:01:03 | BY01431 | KY464940 | Carolyn K Hurley, Washington DC, USA |
| B*15:425 | HG00012804 | KY345183 | Histogenetics, Ossining, USA |
| B*18:01:01:07 | 273722 | KY419470 | Vera Balz, Dsseldorf, Germany |
| B*18:04:02 | HG00012795 | KY263979 | Histogenetics, Ossining, USA |
| B*27:02:01:03 | 260850, 219700 | KY419472 | Vera Balz, Dsseldorf, Germany |
| B*27:05:02:02 | 54200 | KY419474 | Vera Balz, Dsseldorf, Germany |
| B*27:05:02:03 | 121742,125278 | KY419475 | Vera Balz, Dsseldorf, Germany |
| B*27:05:02:04Q | 237050 | KY419367 | Vera Balz, Dsseldorf, Germany |
| B*35:03:01:04 | 281414,283710 | KY419479 | Vera Balz, Dsseldorf, Germany |
| B*35:03:01:05 | 125015,267108,289232 | KY419480 | Vera Balz, Dsseldorf, Germany |
| B*35:05:01:03 | 265817 | KY419478 | Vera Balz, Dsseldorf, Germany |
| B*35:08:01:02 | 284438 | KY419481 | Vera Balz, Dsseldorf, Germany |
| B*35:336 | 276623 | KY419476 | Vera Balz, Dsseldorf, Germany |
| B*39:06:02:04 | 268511 | KY419484 | Vera Balz, Dsseldorf, Germany |
| B*39:09:01:02 | BY01434 | KY464938 | Carolyn K Hurley, Washington DC, USA |
| B*39:127 | HG00012802 | KX711909 | Histogenetics, Ossining, USA |
| B*40:01:02:05 | 274658 | KY419485 | Vera Balz, Dsseldorf, Germany |
| B*44:02:01:06 | 287730 | KY419488 | Vera Balz, Dsseldorf, Germany |
| B*44:03:01:05 | 181561 | KY419489 | Vera Balz, Dsseldorf, Germany |
| B*44:03:01:06 | 92349 | KY419490 | Vera Balz, Dsseldorf, Germany |
| B*44:03:01:07 | 121747 | KY419491 | Vera Balz, Dsseldorf, Germany |
| B*44:03:01:08 | 297416 | KY419492 | Vera Balz, Dsseldorf, Germany |
| B*44:267N | 274382 | KY419368 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:14 | 27631, 27612, 6928, 28669, 44151 | KY419494 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:15 | 276952 | KY419495 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:16 | 76926 | KY419496 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:17 | 109994 | KY419497 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:18 | 290751 | KY419498 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:19 | 293176 | KY419499 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:20 | 268734 | KY419500 | Vera Balz, Dsseldorf, Germany |
| B*51:01:01:21 | 21329, 67685 | KY419501 | Vera Balz, Dsseldorf, Germany |
| B*51:01:56 | 285340, 281763, 115272, 101132 | KY419502 | Vera Balz, Dsseldorf, Germany |
| B*51:218 | HG00012801 | KY345179 | Histogenetics, Ossining, USA |
| B*51:219 | 284169 | KY419503 | Vera Balz, Dsseldorf, Germany |
| B*52:01:01:04 | 282115 | KY419504 | Vera Balz, Dsseldorf, Germany |
| B*55:85 | BY01428 | KY464944 | Carolyn K Hurley, Washington DC, USA |
| B*58:01:01:04 | BY01435,BY01433 | KY464937 | Carolyn K Hurley, Washington DC, USA |
| C*01:02:01:02 | 103629 | KY419372 | Vera Balz, Dsseldorf, Germany |
| C*01:137N | 280659 | KY419369 | Vera Balz, Dsseldorf, Germany |
| C*02:02:02:06 | 100506, 286375, 300230, 100366 | KY419373 | Vera Balz, Dsseldorf, Germany |
| C*02:02:02:07 | 217925 | KY419374 | Vera Balz, Dsseldorf, Germany |
| C*02:02:02:08 | 126452 | KY419375 | Vera Balz, Dsseldorf, Germany |
| C*02:02:02:09 | 120258 | KY419376 | Vera Balz, Dsseldorf, Germany |
| C*02:02:02:10 | 245650 | KY419377 | Vera Balz, Dsseldorf, Germany |
| C*02:02:02:11 | 296224 | KY419378 | Vera Balz, Dsseldorf, Germany |
| C*02:02:33 | SEV161205_8349791 | KY399965 | Oh-Joong Kwon, Seoul, South Korea |
| C*03:03:01:03 | 282863 | KY419380 | Vera Balz, Dsseldorf, Germany |
| C*03:03:01:04 | 285186 | KY419381 | Vera Balz, Dsseldorf, Germany |
| C*03:03:01:05 | 28105 | KY419382 | Vera Balz, Dsseldorf, Germany |
| C*03:03:01:06 | 283896 | KY419383 | Vera Balz, Dsseldorf, Germany |
| C*03:04:01:05 | 137452 | KY419384 | Vera Balz, Dsseldorf, Germany |
| C*03:04:01:06 | 275957 | KY419385 | Vera Balz, Dsseldorf, Germany |
| C*03:04:01:07 | 281355 | KY419386 | Vera Balz, Dsseldorf, Germany |
| C*03:352 | HG00012818 | KY345185 | Histogenetics, Ossining, USA |
| C*03:353 | HG00012819 | KY263989 | Histogenetics, Ossining, USA |
| C*04:01:01:08 | 292102 | KY419389 | Vera Balz, Dsseldorf, Germany |
| C*04:01:01:09 | 223299 | KY419390 | Vera Balz, Dsseldorf, Germany |
| C*04:01:01:10 | 25410 | KY419391 | Vera Balz, Dsseldorf, Germany |
| C*04:01:82 | 211404 | KY419392 | Vera Balz, Dsseldorf, Germany |
| C*04:04:01:02 | BY01420 | KY379092 | Carolyn K Hurley, Washington DC, USA |
| C*04:264 | HG00012820 | KY263988 | Histogenetics, Ossining, USA |
| C*04:265 | HG00012821 | KY263981 | Histogenetics, Ossining, USA |
| C*04:266 | HG00012822 | KY263986 | Histogenetics, Ossining, USA |
| C*04:267 | 197270257294 | KY419393 | Vera Balz, Dsseldorf, Germany |
| C*04:268 | 295237 | KY419394 | Vera Balz, Dsseldorf, Germany |
| C*05:01:01:06 | 273536 | KY419395 | Vera Balz, Dsseldorf, Germany |
| C*05:01:01:07 | 281153 | KY419396 | Vera Balz, Dsseldorf, Germany |
| C*05:149 | HG00012811 | KY263990 | Histogenetics, Ossining, USA |
| C*06:02:01:04 | 296419 | KY419398 | Vera Balz, Dsseldorf, Germany |
| C*06:02:01:05 | 209008 | KY419399 | Vera Balz, Dsseldorf, Germany |
| C*06:02:01:06 | 281355 | KY419401 | Vera Balz, Dsseldorf, Germany |
| C*07:01:01:09 | MUMC1968 | LT618799 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| C*07:01:01:10 | 266453 | KY419402 | Vera Balz, Dsseldorf, Germany |
| C*07:01:01:11 | 298341 | KY419403 | Vera Balz, Dsseldorf, Germany |
| C*07:01:01:12 | 298270298310 | KY419404 | Vera Balz, Dsseldorf, Germany |
| C*07:01:01:13 | 258284 | KY419405 | Vera Balz, Dsseldorf, Germany |
| C*07:01:01:14Q | 241952 | KY419370 | Vera Balz, Dsseldorf, Germany |
| C*07:02:01:14 | 271147 | KY419406 | Vera Balz, Dsseldorf, Germany |
| C*07:02:79 | 256986 | KY419407 | Vera Balz, Dsseldorf, Germany |
| C*07:581 | HG00012807 | KY399929 | Histogenetics, Ossining, USA |
| C*07:582Q | HG00012808 | KX711933 | Histogenetics, Ossining, USA |
| C*07:583 | HG00012812 | KY263982 | Histogenetics, Ossining, USA |
| C*07:584 | 192768 | KY419409 | Vera Balz, Dsseldorf, Germany |
| C*07:585 | 109461 | KY419410 | Vera Balz, Dsseldorf, Germany |
| C*07:586 | 295502 | KY419411 | Vera Balz, Dsseldorf, Germany |
| C*08:147 | 187212 | KY419412 | Vera Balz, Dsseldorf, Germany |
| C*12:207 | HG00012813 | KY263983 | Histogenetics, Ossining, USA |
| C*12:208 | HG00012814 | KY263984 | Histogenetics, Ossining, USA |
| C*12:209 | 218857 | KY419414 | Vera Balz, Dsseldorf, Germany |
| C*12:210 | 289263 | KY419415 | Vera Balz, Dsseldorf, Germany |
| C*12:211 | 282557 | KY419416 | Vera Balz, Dsseldorf, Germany |
| C*15:02:01:05 | 279650, 278877, 278607, 277867 | KY419417 | Vera Balz, Dsseldorf, Germany |
| C*15:02:01:06 | 289528, 287457, 286577, 282160, 204757, 202483 | KY419418 | Vera Balz, Dsseldorf, Germany |
| C*15:02:01:07 | 63374 | KY419419 | Vera Balz, Dsseldorf, Germany |
| C*15:138 | HG00012805 | KY399925 | Histogenetics, Ossining, USA |
| C*16:01:01:03 | 257545 | KY419422 | Vera Balz, Dsseldorf, Germany |
| C*16:106 | 275320 | KY419424 | Vera Balz, Dsseldorf, Germany |
| DPA1*01:14 | 94-16 | KY244023 | Reem Ameen, Jabriya, Kuwait |
| DPB1*637:01 | HG00012864 | KY345204 | Histogenetics, Ossining, USA |
| DPB1*638:01 | HG00012865 | KY345201 | Histogenetics, Ossining, USA |
| DPB1*639:01 | HG00012867 | KY399944 | Histogenetics, Ossining, USA |
| DQB1*02:89 | 88-15 | KY230421 | Reem Ameen, Jabriya, Kuwait |
| DQB1*02:90 | HG00012828 | KY263998 | Histogenetics, Ossining, USA |
| DQB1*03:257 | HG00012825 | KY263996 | Histogenetics, Ossining, USA |
| DQB1*03:258 | HG00012833 | KY296577 | Histogenetics, Ossining, USA |
| DQB1*03:259 | HG00012832 | KY345188 | Histogenetics, Ossining, USA |
| DQB1*05:144 | 01-16-278-0007X | KY379031 | Ahmed Mostafa, Calgary, Canada |
| DQB1*05:145 | HG00012835 | KY263992 | Histogenetics, Ossining, USA |
| DQB1*05:146 | HG00012836 | KY263994 | Histogenetics, Ossining, USA |
| DQB1*06:231 | HG00012831 | KY345186 | Histogenetics, Ossining, USA |
| DQB1*06:232 | HG00012838 | KY399933 | Histogenetics, Ossining, USA |
| DRB1*01:03:02 | HG00012854 | KY399937 | Histogenetics, Ossining, USA |
| DRB1*03:138 | HG00012851 | KY296582 | Histogenetics, Ossining, USA |
| DRB1*04:222 | HG00012846 | KY264004 | Histogenetics, Ossining, USA |
| DRB1*04:223 | HG00012847 | KY264005 | Histogenetics, Ossining, USA |
| DRB1*07:77 | HG00012845 | KY345191 | Histogenetics, Ossining, USA |
| DRB1*11:209 | HG00012850 | KY264003 | Histogenetics, Ossining, USA |
| DRB1*11:210 | HG00012855 | KY296580 | Histogenetics, Ossining, USA |
| DRB1*11:42:02 | HG00012853 | KY296583 | Histogenetics, Ossining, USA |
| DRB1*12:65 | HG00012849 | KY364243 | Histogenetics, Ossining, USA |
| DRB1*13:232 | P489 | EF541487 | Yan Li, Guangzhou, China |
| DRB1*13:233 | 296123EPL | KY171939 | Maria Elisa Moraes, Rio de Janeiro, Brazil |
| DRB1*15:143 | HG00012842 | KY345189 | Histogenetics, Ossining, USA |
| DRB1*15:144 | HG00012844 | KY264006 | Histogenetics, Ossining, USA |
| DRB1*15:145 | UA2016tp2754 | LT707066 | Mats Bengtsson, Uppsala, Sweden |
| DRB1*15:15:03 | HG00012840, HG00012841 | KY345192KY296585 | Histogenetics, Ossining, USA |
| DRB1*16:02:07 | HG00012843 | KY296584 | Histogenetics, Ossining, USA |
| DRB3*02:62 | HG00012857 | KY345197 | Histogenetics, Ossining, USA |
| DRB3*02:63 | HG00012858 | KY345193 | Histogenetics, Ossining, USA |
| DRB3*02:64 | HG00012859 | KY296588 | Histogenetics, Ossining, USA |
| DRB3*02:65 | HG00012860 | KY345196 | Histogenetics, Ossining, USA |
| DRB3*03:12 | HG00012861 | KY345195 | Histogenetics, Ossining, USA |
| DRB3*03:13 | UA2016TP2987 | LT707072 | Mats Bengtsson, Uppsala, Sweden |
| DRB4*01:49 | HG00012862 | KY399939 | Histogenetics, Ossining, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:01:120 | AL00000007 | KY129729 | Histogenetics, Ossining, USA |
| A*02:528:02 | 12455 | KY419436 | Vera Balz, Dsseldorf, Germany |
| B*07:252 | AL00000025 | KY129739 | Histogenetics, Ossining, USA |
| B*07:287 | HG00012800 | KY263976 | Histogenetics, Ossining, USA |
| B*35:04:01 | BY01429 | KY464943 | Carolyn K Hurley, Washington DC, USA |
| B*35:19 | BY01430 | KY464942 | Carolyn K Hurley, Washington DC, USA |
| B*35:279 | 121300834 | LT627192 | Frank Gruenebach, Tbingen, Germany |
| B*37:58 | AL00000012 | KY078224 | Histogenetics, Ossining, USA |
| B*39:06:02:03 | 9694, 6359, 5667, 5980 | KY419483 | Vera Balz, Dsseldorf, Germany |
| B*41:49 | AL00000009 | KY129734 | Histogenetics, Ossining, USA |
| B*44:250 | AL00000013 | KY129744 | Histogenetics, Ossining, USA |
| B*49:38 | AL00000024 | KY129738 | Histogenetics, Ossining, USA |
| B*55:74 | AL00000016 | KY078226 | Histogenetics, Ossining, USA |
| C*01:02:30 | BY01413 | KY379096 | Carolyn K Hurley, Washington DC, USA |
| C*02:02:02:02 | BY01410, BY01411 | KY379095 | Carolyn K Hurley, Washington DC, USA |
| C*02:08 | BY01415 | KY379097 | Carolyn K Hurley, Washington DC, USA |
| C*02:128 | 52244 | KY419379 | Vera Balz, Dsseldorf, Germany |
| C*03:38:01 | BY01412 | KY379093 | Carolyn K Hurley, Washington DC, USA |
| C*04:04:01:01 | BY01416 | KY379089 | Carolyn K Hurley, Washington DC, USA |
| C*04:184 | AL00000031 | KY129748 | Histogenetics, Ossining, USA |
| C*04:65 | BY01418 | KY379091 | Carolyn K Hurley, Washington DC, USA |
| C*07:441:02 | 253585 | KY419408 | Vera Balz, Dsseldorf, Germany |
| C*08:08:01 | BY01408 | KY379088 | Carolyn K Hurley, Washington DC, USA |
| C*15:10:02 | BY01417 | KY379090 | Carolyn K Hurley, Washington DC, USA |
| C*15:88 | BY01409 | KY379094 | Carolyn K Hurley, Washington DC, USA |
| C*16:01:04 | BY01414 | KY379098 | Carolyn K Hurley, Washington DC, USA |
| DPA1*02:07:01:01 | UA2016tp2805 | LT707074 | Mats Bengtsson, Uppsala, Sweden |
| DQB1*03:255 | HG00012826 | KY264001 | Histogenetics, Ossining, USA |
| DQB1*05:66:02 | AL00000035, AL00000036, AL00000037, HG00012834 | KY129757KY129756KY129755KY263993. | Histogenetics, Ossining, USA |
| DRB1*03:132 | UA16tp850 | LT707071 | Mats Bengtsson, Uppsala, Sweden |
| DRB1*11:147:02 | AL00000045 | KY078229 | Histogenetics, Ossining, USA |
| DRB1*13:230 | HG00012852 | KY296581 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| B*52:01:01:01 | (3) |
| B*52:01:02:01 | (3) |
| C*16:97 | (4) |
| E*01:01:01:06 | (5) |
| G*01:08:02 | (6) |
| G*01:20 | (6) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: 423-31.
- Li Z, Zou HY.Full-length sequence of 2 HLA-B alleles, B*52:01:01:01 and B*52:01:02:01, identified by cloning and sequencing. HLA 2016 89: 163-165.
- Vecchiato C, Lochmann E, Gentilini I.Confirmation of the HLA-C*16:97 allele in multiple individuals, a new common and well defined allele? HLA 2016 89: 170-171.
- Xu YP, Wang SX, Hing WZ.A novel HLA-E allele, HLA-E*01:01:01:06, identified in a Chinese Leukemia patient. HLA 2016 89: 260-262.
- Arnaiz-Villena A, Enriquez-de-Salamanca M, Palaco-Grber, et al.Characterisation and functional implications of the two new HLA-G alleles found in Amerindian and Caribbean populations. Human Immunology 2016 77: 812-816.
