Nomenclature for Factors of the HLA System

April 2016

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the March 2016 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell identification Accession number Submitting author
A*01:202HG00011391KU668715Histogenetics, Ossining, USA
A*02:615HG00011396KU668720Histogenetics, Ossining, USA
A*02:616HG00011398KU668723Histogenetics, Ossining, USA
A*02:617HG00011399KU725853Histogenetics, Ossining, USA
A*02:618Q86020690KU744409Daniel Fuerst, Ulm, Germany
A*02:61981143114KU904242Daniel Fuerst, Ulm, Germany
A*02:62060761665KU934206Antonio Balas, Madrid, Spain
A*02:621405272LT223710Edward KL Yang, Hualien, Taiwan
A*02:622N16030213KX024699Mingrui Huo, Beijing, China
A*02:62315825213LT548090Dominique Masson, La Tronche, France
A*02:62462539LT555471Ute Geigenmuller, Westborough, USA
A*02:6255771500173KX058350Faming Zhu, Hangzhou, China
A*02:626AR-02134-044817LT555473Ute Geigenmuller, Westborough, USA
A*03:01:581432-3LT546644Viktoria Zakharova, Moscow, Russia
A*03:247HG00011390KU668718Histogenetics, Ossining, USA
A*03:248HG00011393KU725852Histogenetics, Ossining, USA
A*11:239HG00011378KU668716Histogenetics, Ossining, USA
A*11:240HG00011394KU668719Histogenetics, Ossining, USA
A*23:01:19BFKT818786Abubaker ME Sidahmed, Calgary, Canada
A*23:73HG00011386KU668724Histogenetics, Ossining, USA
A*24:142:02HG00011383KU668714Histogenetics, Ossining, USA
A*24:14:01:02LC43KU319387Konstantinos Barsakis, Palo Alto, USA
A*24:338HG00011387KU668717Histogenetics, Ossining, USA
A*24:339HG00011388, HG00011389KU668710, KU668711Histogenetics, Ossining, USA
A*24:340HG00011397KU668729Histogenetics, Ossining, USA
A*24:34116204931KU904241Daniel Fuerst, Ulm, Germany
A*25:34HG00011371KU668730Histogenetics, Ossining, USA
A*26:121HG00011375KU668725Histogenetics, Ossining, USA
A*26:122HG00011376KU748650Histogenetics, Ossining, USA
A*29:10:0281142717KU904243Daniel Fuerst, Ulm, Germany
A*29:86HG00011372KU668708Histogenetics, Ossining, USA
A*30:10015844200LT548089Dominique Masson, La Tronche, France
A*30:98HG00011381KU668731Histogenetics, Ossining, USA
A*30:9934690KX024715Francisco de Paula Sanchez Gordo, Malaga, Spain
A*31:108B16375101KU981026Xin Ye, Guangzhou, China
A*33:109HG00011370KU748646Histogenetics, Ossining, USA
A*33:110UD27796JX984631Eun-Jeong Choi, Seoul, Korea
A*34:15HG00011377KU748649Histogenetics, Ossining, USA
A*68:145HG00011379KU668726Histogenetics, Ossining, USA
A*68:146HG00011380KU668709Histogenetics, Ossining, USA
B*07:05:01:0260758910KU862684Antonio Balas, Madrid, Spain
B*07:269398158LT223706Edward KL Yang, Hualien, Taiwan
B*08:01:01:02A4_136815KU319233Konstantinos Barsakis, Palo Alto, USA
B*08:162HG00011408KU668746Histogenetics, Ossining, USA
B*13:927761101630KU950381Pei Yongfeng, Nanning, China
B*15:01:01:05MYE 2001KU319237Konstantinos Barsakis, Palo Alto, USA
B*15:04:01:02A2_117114KU319241Konstantinos Barsakis, Palo Alto, USA
B*15:04:04CQABH88KU883264Gisele Rampim, Sao Paulo, Brazil
B*15:18:01:02THAKU319245Konstantinos Barsakis, Palo Alto, USA
B*15:384HG00011416KU668742Histogenetics, Ossining, USA
B*15:385HG00011418KU668750Histogenetics, Ossining, USA
B*15:386HG00011419KU668744Histogenetics, Ossining, USA
B*15:387HG00011420KU668740Histogenetics, Ossining, USA
B*15:388AB3544LT223703Edward KL Yang, Hualien, Taiwan
B*15:38915825175LT548092Dominique Masson, La Tronche, France
B*15:40:02HG00011417KU668733Histogenetics, Ossining, USA
B*18:12184021821KU904244Daniel Fuerst, Ulm, Germany
B*18:12270758KU923578Michele Curcio, Pisa, Italy
B*27:148HG00011405KU668754Histogenetics, Ossining, USA
B*27:149H3055KP710197Xiaojing Wang, Tianjin, China
B*27:15060764375KU884471Antonio Balas, Madrid, Spain
B*35:315HG00011415KU725854Histogenetics, Ossining, USA
B*40:331HG00011403KU668752Histogenetics, Ossining, USA
B*40:332SCL151124_151111KU886072Oh-Joong Kwon, Seoul, South Korea
B*40:3335711501044KX058349Faming Zhu, Hangzhou, China
B*44:192:02HG00011412KU668738Histogenetics, Ossining, USA
B*44:241HG00011413KU668734Histogenetics, Ossining, USA
B*44:242HG00011414KU668749Histogenetics, Ossining, USA
B*44:24315825701LT548093Dominique Masson, La Tronche, France
B*50:45HG00011401, HG00011402KU709833, KU748653Histogenetics, Ossining, USA
B*56:5115844196LT548095Dominique Masson, La Tronche, France
B*58:79HG00011409KU668753Histogenetics, Ossining, USA
B*58:80398464LT223707Edward KL Yang, Hualien, Taiwan
C*01:12081142529KU904247Daniel Fuerst, Ulm, Germany
C*02:02:02:03BRUGLN877311Steven GE Marsh, London, United Kingdom
C*02:11581142970KU904246Daniel Fuerst, Ulm, Germany
C*03:31781141206KU904249Daniel Fuerst, Ulm, Germany
C*05:130143576712LT548084Dominique Masson, La Tronche, France
C*06:17615850218LT548086Dominique Masson, La Tronche, France
C*07:500151350205LT548085Dominique Masson, La Tronche, France
C*15:12381141714KU904245Daniel Fuerst, Ulm, Germany
C*17:3284013902KU904248Daniel Fuerst, Ulm, Germany
DRB1*03:130NT01342KU955855Carolyn K Hurley, Washington DC, USA
DRB1*09:28409933LT223705Edward KL Yang, Hualien, Taiwan
DRB1*13:21514-1392KU923577Michele Curcio, Pisa, Italy
DRB1*13:21660765049KX083401Antonio Balas, Madrid, Spain
DRB1*16:39400181LT223704Edward KL Yang, Hualien, Taiwan
DRB3*02:3784022362KU744410Daniel Fuerst, Ulm, Germany
DQA1*01:02:01:05PGFKU319341Konstantinos Barsakis, Palo Alto, USA
DQA1*01:02:01:06LEO23KU319342Konstantinos Barsakis, Palo Alto, USA
DQA1*01:02:01:07RD-DJKU319343Konstantinos Barsakis, Palo Alto, USA
DQA1*05:05:01:06GRC-138KU319362Konstantinos Barsakis, Palo Alto, USA
DPB1*06:01:02HG00011806KU963158Histogenetics, Ossining, USA
DPB1*548:0184022128KU904240Daniel Fuerst, Ulm, Germany
DPB1*549:0181142264KU904252Daniel Fuerst, Ulm, Germany
DPB1*550:01HG00011805KU992622Histogenetics, Ossining, USA

Table 2: Confirmatory Sequences

Sequence Cell identification Accession number Submitting author
A*66:02DL61_05C50983_B11KU233194Konstantinos Barsakis, Palo Alto, USA
B*07:02:01M4KU319229Konstantinos Barsakis, Palo Alto, USA
B*07:03BPOTKU319240Konstantinos Barsakis, Palo Alto, USA
B*07:05:01:01CHI007KU319230Konstantinos Barsakis, Palo Alto, USA
B*07:24615825183LT548091Dominique Masson, La Tronche, France
B*08:01:01:01KLOKU319232Konstantinos Barsakis, Palo Alto, USA
B*13:02:01M1_78084KU319234Konstantinos Barsakis, Palo Alto, USA
B*14:02:01:01MYE 2004KU319235Konstantinos Barsakis, Palo Alto, USA
B*15:01:01:01FOREKU319236Konstantinos Barsakis, Palo Alto, USA
B*15:01:01:04NT01334, NT01335, NT01336KU851938Carolyn K Hurley, Washington DC, USA
B*15:02:01FH44KU319238Konstantinos Barsakis, Palo Alto, USA
B*15:04:01:01GRC-138KU319239Konstantinos Barsakis, Palo Alto, USA
B*15:08:01LATIFKU319242Konstantinos Barsakis, Palo Alto, USA
B*15:10:01B5_156949KU319243Konstantinos Barsakis, Palo Alto, USA
B*15:15C2_163183KU319244Konstantinos Barsakis, Palo Alto, USA
B*15:26NISH3KU319247Konstantinos Barsakis, Palo Alto, USA
B*15:30B8_158666KU319248Konstantinos Barsakis, Palo Alto, USA
B*15:379948KU934215Mette Christiansen, Aarhus N, Denmark
B*15:71FH67KU319249Konstantinos Barsakis, Palo Alto, USA
B*18:01:01:01VENKU319251Konstantinos Barsakis, Palo Alto, USA
B*35:135NT01326KU743301Carolyn K Hurley, Washington DC, USA
B*44:0634379KX024714Francisco de Paula Sanchez Gordo, Malaga, Spain
C*02:10:01:02NT01331KU851941Carolyn K Hurley, Washington DC, USA
C*07:01:4215665054LT548083Dominique Masson, La Tronche, France
C*07:44515820441LT548087Dominique Masson, La Tronche, France
DRB1*03:23NT01352KX059427Carolyn K Hurley, Washington DC, USA
DRB1*04:40NT01344KU955853Carolyn K Hurley, Washington DC, USA
DRB1*09:04NT01346KX059433Carolyn K Hurley, Washington DC, USA
DRB1*09:25405061LT223708Edward KL Yang, Hualien, Taiwan
DRB1*11:01:07NT01340KU955857Carolyn K Hurley, Washington DC, USA
DRB1*11:07:01NT01345KU955851Carolyn K Hurley, Washington DC, USA
DRB1*11:07:01NT01350KX059429Carolyn K Hurley, Washington DC, USA
DRB1*11:24NT01339KU955858Carolyn K Hurley, Washington DC, USA
DRB1*11:47NT01351KX059428Carolyn K Hurley, Washington DC, USA
DRB1*14:02:01AZLLT220243Steven GE Marsh, London, United Kingdom
DRB1*14:02:01LZLLT220253Steven GE Marsh, London, United Kingdom
DRB1*14:42NT01348KX059430Carolyn K Hurley, Washington DC, USA
DRB1*14:53NT01349KX059431Carolyn K Hurley, Washington DC, USA
DRB1*15:01:03NT01345KU955852Carolyn K Hurley, Washington DC, USA
DRB1*15:123H3021KP710196Xiaojing Wang, Tianjin, China
DRB1*15:22NT01341KU955856Carolyn K Hurley, Washington DC, USA
DQA1*05:09FH67KU319363Konstantinos Barsakis, Palo Alto, USA
DQB1*04:02:03UD157552KC218815Eun-Jeong Choi, Seoul, Korea
DPB1*130:01NT01347KX059432Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences

Sequence References


  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015 43: D423-31.
  3. Maskalan M, Grubic Z, Jankovic KS, Cepulic BG, Zunec R. Identification of the novel HLA-A*01:200 allele by sequence-based typing in a Croatian individual. HLA 2016 87: 381-2.
  4. Pei YF, Huang HN, Li HC, Shen WD. HLA-A*02:513, a novel HLA-A*02 allele. HLA 2016 87: 382-3.
  5. Dong LN, Chen NY, Zhang W, He J, Zhu FM. A novel HLA-A*02 allele, A*02:543 was identified by polymerase chain reaction sequence-based typing in a Chinese cord blood donor. HLA 2016 87: 384-5.
  6. Yang KL, Hung JH, Lin PY. Identification of a novel HLA-A*02 variant, HLA-A*02:610, in a Taiwanese individual. HLA 2016 87: 385-6.
  7. Ou G, Wang J, Ji X, Chen Q, Liu Z. Identification of a novel HLA-A allele, A*11:209 by sequence-based high-resolution typing in an HIV-infected individual. HLA 2016 87: 387-8.
  8. Li JP, Li XF, Zhang X, Lin FQ, Zhang KL. Identification of a novel allele, HLA-A*24:02:50, by sequence-based typing. HLA 2016 87: 388-90.
  9. Yang KL, Hung JH, Lin PY. HLA-A*24:334, a novel variant of HLA-A*24, discovered in a Taiwanese individual. HLA 2016 87: 390-1.
  10. Kim KM, Han OJ, Kang MS, Huh JY. HLA-A*33:102, a novel allele identified by sequence-based typing in cord blood from a Korean woman. HLA 2016 87: 391-2.
  11. Brown NK, Kheradmand T, Wang J, Marino SR. Identification and characterization of novel HLA alleles: Utility of next-generation sequencing methods. Hum Immunol 2016 77: 313-6.
  12. Li XF, Zhang X, Lin FQ, Zhang KL, Li JP. HLA-B*40:167, a novel allele, identified in a Chinese individual. HLA 2016 87: 392-4.
  13. Yang KL, Hung JH, Lin PY. HLA-B*40:326, a novel variant of HLA-B*40, discovered in a Taiwanese blood donor. HLA 2016 87: 394-5.
  14. Yang KL, Hung JH, Lin PY. HLA-B*40:327, a novel HLA-B*40 variant, discovered in a Taiwanese blood donor. HLA 2016 87: 395-7.
  15. Yang KL, Hung JH, Lin PY. HLA-B*46:65, a novel HLA-B*46 variant, detected in a Taiwanese unrelated bone marrow stem cell donor. HLA 2016 87: 397-8.
  16. Chen NY, Dong LN, Zhang W, He J, Zhu FM. Identification of the novel HLA-B*52:42 allele by polymerase chain reaction sequence-based typing in a Chinese bone marrow donor. HLA 2016 87: 400-2.
  17. Yang KL, Hung JH, Lin PY. Discovery of HLA-B*58:77, a novel HLA-B*58 variant, in a Taiwanese blood donor. HLA 2016 87: 398-9.
  18. Shepherd BL, Ferrand R, Rowland-Jones S, Yindom LM. HLA-C*06:04:02 a novel HLA-C allele isolated from donors of Southern African descent. HLA 2016 87: 402-3.
  19. Delbos F, Poulet E, Guillot M, Pare B, Ansart-Pirenne H. A novel allele HLA-C*07:445 identified in a French hematopoietic stem cell donor. HLA 2016 87: 403-4.
  20. Yang KL, Hung JH, Lin PY. HLA-C*07:486, a novel HLA-C*07 variant, detected in a Taiwanese individual. HLA 2016 87: 404-5.
  21. Yang KL, Hung JH, Chen CP, Lin PY. Detection of HLA-DRB1*04:207, a novel HLA-DRB1*04 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016 87: 406-7.
  22. Balas A, Planelles D, Garcia-Sanchez F, Prior C, Vicario JL. Three new HLA class II alleles: DRB1*08:70, DQA1*01:13 and DQA1*03:01:03. Int J Immunogenet 2016 43: 107-8.
  23. Wang WY, Tian W, Zhu FM, Liu XX, Li LX, Wang F. MICA, MICB Polymorphisms and Linkage Disequilibrium with HLA-B in a Chinese Mongolian Population. Scand J Immunol 2016 83: 456-62.