Nomenclature for Factors of the HLA System
April 2016
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2016) 88:131-5
- Human Immunology (2016) 77:1300-3
- International Journal of Immunogenetics (2016) 43:310-13
The following sequences have been submitted to the Nomenclature Committee since the March 2016 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/ipd/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:202 | HG00011391 | KU668715 | Histogenetics, Ossining, USA |
| A*02:615 | HG00011396 | KU668720 | Histogenetics, Ossining, USA |
| A*02:616 | HG00011398 | KU668723 | Histogenetics, Ossining, USA |
| A*02:617 | HG00011399 | KU725853 | Histogenetics, Ossining, USA |
| A*02:618Q | 86020690 | KU744409 | Daniel Fuerst, Ulm, Germany |
| A*02:619 | 81143114 | KU904242 | Daniel Fuerst, Ulm, Germany |
| A*02:620 | 60761665 | KU934206 | Antonio Balas, Madrid, Spain |
| A*02:621 | 405272 | LT223710 | Edward KL Yang, Hualien, Taiwan |
| A*02:622N | 16030213 | KX024699 | Mingrui Huo, Beijing, China |
| A*02:623 | 15825213 | LT548090 | Dominique Masson, La Tronche, France |
| A*02:624 | 62539 | LT555471 | Ute Geigenmuller, Westborough, USA |
| A*02:625 | 5771500173 | KX058350 | Faming Zhu, Hangzhou, China |
| A*02:626 | AR-02134-044817 | LT555473 | Ute Geigenmuller, Westborough, USA |
| A*03:01:58 | 1432-3 | LT546644 | Viktoria Zakharova, Moscow, Russia |
| A*03:247 | HG00011390 | KU668718 | Histogenetics, Ossining, USA |
| A*03:248 | HG00011393 | KU725852 | Histogenetics, Ossining, USA |
| A*11:239 | HG00011378 | KU668716 | Histogenetics, Ossining, USA |
| A*11:240 | HG00011394 | KU668719 | Histogenetics, Ossining, USA |
| A*23:01:19 | BF | KT818786 | Abubaker ME Sidahmed, Calgary, Canada |
| A*23:73 | HG00011386 | KU668724 | Histogenetics, Ossining, USA |
| A*24:142:02 | HG00011383 | KU668714 | Histogenetics, Ossining, USA |
| A*24:14:01:02 | LC43 | KU319387 | Konstantinos Barsakis, Palo Alto, USA |
| A*24:338 | HG00011387 | KU668717 | Histogenetics, Ossining, USA |
| A*24:339 | HG00011388, HG00011389 | KU668710, KU668711 | Histogenetics, Ossining, USA |
| A*24:340 | HG00011397 | KU668729 | Histogenetics, Ossining, USA |
| A*24:341 | 16204931 | KU904241 | Daniel Fuerst, Ulm, Germany |
| A*25:34 | HG00011371 | KU668730 | Histogenetics, Ossining, USA |
| A*26:121 | HG00011375 | KU668725 | Histogenetics, Ossining, USA |
| A*26:122 | HG00011376 | KU748650 | Histogenetics, Ossining, USA |
| A*29:10:02 | 81142717 | KU904243 | Daniel Fuerst, Ulm, Germany |
| A*29:86 | HG00011372 | KU668708 | Histogenetics, Ossining, USA |
| A*30:100 | 15844200 | LT548089 | Dominique Masson, La Tronche, France |
| A*30:98 | HG00011381 | KU668731 | Histogenetics, Ossining, USA |
| A*30:99 | 34690 | KX024715 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| A*31:108 | B16375101 | KU981026 | Xin Ye, Guangzhou, China |
| A*33:109 | HG00011370 | KU748646 | Histogenetics, Ossining, USA |
| A*33:110 | UD27796 | JX984631 | Eun-Jeong Choi, Seoul, Korea |
| A*34:15 | HG00011377 | KU748649 | Histogenetics, Ossining, USA |
| A*68:145 | HG00011379 | KU668726 | Histogenetics, Ossining, USA |
| A*68:146 | HG00011380 | KU668709 | Histogenetics, Ossining, USA |
| B*07:05:01:02 | 60758910 | KU862684 | Antonio Balas, Madrid, Spain |
| B*07:269 | 398158 | LT223706 | Edward KL Yang, Hualien, Taiwan |
| B*08:01:01:02 | A4_136815 | KU319233 | Konstantinos Barsakis, Palo Alto, USA |
| B*08:162 | HG00011408 | KU668746 | Histogenetics, Ossining, USA |
| B*13:92 | 7761101630 | KU950381 | Pei Yongfeng, Nanning, China |
| B*15:01:01:05 | MYE 2001 | KU319237 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:04:01:02 | A2_117114 | KU319241 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:04:04 | CQABH88 | KU883264 | Gisele Rampim, Sao Paulo, Brazil |
| B*15:18:01:02 | THA | KU319245 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:384 | HG00011416 | KU668742 | Histogenetics, Ossining, USA |
| B*15:385 | HG00011418 | KU668750 | Histogenetics, Ossining, USA |
| B*15:386 | HG00011419 | KU668744 | Histogenetics, Ossining, USA |
| B*15:387 | HG00011420 | KU668740 | Histogenetics, Ossining, USA |
| B*15:388 | AB3544 | LT223703 | Edward KL Yang, Hualien, Taiwan |
| B*15:389 | 15825175 | LT548092 | Dominique Masson, La Tronche, France |
| B*15:40:02 | HG00011417 | KU668733 | Histogenetics, Ossining, USA |
| B*18:121 | 84021821 | KU904244 | Daniel Fuerst, Ulm, Germany |
| B*18:122 | 70758 | KU923578 | Michele Curcio, Pisa, Italy |
| B*27:148 | HG00011405 | KU668754 | Histogenetics, Ossining, USA |
| B*27:149 | H3055 | KP710197 | Xiaojing Wang, Tianjin, China |
| B*27:150 | 60764375 | KU884471 | Antonio Balas, Madrid, Spain |
| B*35:315 | HG00011415 | KU725854 | Histogenetics, Ossining, USA |
| B*40:331 | HG00011403 | KU668752 | Histogenetics, Ossining, USA |
| B*40:332 | SCL151124_151111 | KU886072 | Oh-Joong Kwon, Seoul, South Korea |
| B*40:333 | 5711501044 | KX058349 | Faming Zhu, Hangzhou, China |
| B*44:192:02 | HG00011412 | KU668738 | Histogenetics, Ossining, USA |
| B*44:241 | HG00011413 | KU668734 | Histogenetics, Ossining, USA |
| B*44:242 | HG00011414 | KU668749 | Histogenetics, Ossining, USA |
| B*44:243 | 15825701 | LT548093 | Dominique Masson, La Tronche, France |
| B*50:45 | HG00011401, HG00011402 | KU709833, KU748653 | Histogenetics, Ossining, USA |
| B*56:51 | 15844196 | LT548095 | Dominique Masson, La Tronche, France |
| B*58:79 | HG00011409 | KU668753 | Histogenetics, Ossining, USA |
| B*58:80 | 398464 | LT223707 | Edward KL Yang, Hualien, Taiwan |
| C*01:120 | 81142529 | KU904247 | Daniel Fuerst, Ulm, Germany |
| C*02:02:02:03 | BRUG | LN877311 | Steven GE Marsh, London, United Kingdom |
| C*02:115 | 81142970 | KU904246 | Daniel Fuerst, Ulm, Germany |
| C*03:317 | 81141206 | KU904249 | Daniel Fuerst, Ulm, Germany |
| C*05:130 | 143576712 | LT548084 | Dominique Masson, La Tronche, France |
| C*06:176 | 15850218 | LT548086 | Dominique Masson, La Tronche, France |
| C*07:500 | 151350205 | LT548085 | Dominique Masson, La Tronche, France |
| C*15:123 | 81141714 | KU904245 | Daniel Fuerst, Ulm, Germany |
| C*17:32 | 84013902 | KU904248 | Daniel Fuerst, Ulm, Germany |
| DRB1*03:130 | NT01342 | KU955855 | Carolyn K Hurley, Washington DC, USA |
| DRB1*09:28 | 409933 | LT223705 | Edward KL Yang, Hualien, Taiwan |
| DRB1*13:215 | 14-1392 | KU923577 | Michele Curcio, Pisa, Italy |
| DRB1*13:216 | 60765049 | KX083401 | Antonio Balas, Madrid, Spain |
| DRB1*16:39 | 400181 | LT223704 | Edward KL Yang, Hualien, Taiwan |
| DRB3*02:37 | 84022362 | KU744410 | Daniel Fuerst, Ulm, Germany |
| DQA1*01:02:01:05 | PGF | KU319341 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:02:01:06 | LEO23 | KU319342 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:02:01:07 | RD-DJ | KU319343 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*05:05:01:06 | GRC-138 | KU319362 | Konstantinos Barsakis, Palo Alto, USA |
| DPB1*06:01:02 | HG00011806 | KU963158 | Histogenetics, Ossining, USA |
| DPB1*548:01 | 84022128 | KU904240 | Daniel Fuerst, Ulm, Germany |
| DPB1*549:01 | 81142264 | KU904252 | Daniel Fuerst, Ulm, Germany |
| DPB1*550:01 | HG00011805 | KU992622 | Histogenetics, Ossining, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*66:02 | DL61_05C50983_B11 | KU233194 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:02:01 | M4 | KU319229 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:03 | BPOT | KU319240 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:05:01:01 | CHI007 | KU319230 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:246 | 15825183 | LT548091 | Dominique Masson, La Tronche, France |
| B*08:01:01:01 | KLO | KU319232 | Konstantinos Barsakis, Palo Alto, USA |
| B*13:02:01 | M1_78084 | KU319234 | Konstantinos Barsakis, Palo Alto, USA |
| B*14:02:01:01 | MYE 2004 | KU319235 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:01:01:01 | FORE | KU319236 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:01:01:04 | NT01334, NT01335, NT01336 | KU851938 | Carolyn K Hurley, Washington DC, USA |
| B*15:02:01 | FH44 | KU319238 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:04:01:01 | GRC-138 | KU319239 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:08:01 | LATIF | KU319242 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:10:01 | B5_156949 | KU319243 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:15 | C2_163183 | KU319244 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:26N | ISH3 | KU319247 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:30 | B8_158666 | KU319248 | Konstantinos Barsakis, Palo Alto, USA |
| B*15:379 | 948 | KU934215 | Mette Christiansen, Aarhus N, Denmark |
| B*15:71 | FH67 | KU319249 | Konstantinos Barsakis, Palo Alto, USA |
| B*18:01:01:01 | VEN | KU319251 | Konstantinos Barsakis, Palo Alto, USA |
| B*35:135 | NT01326 | KU743301 | Carolyn K Hurley, Washington DC, USA |
| B*44:06 | 34379 | KX024714 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| C*02:10:01:02 | NT01331 | KU851941 | Carolyn K Hurley, Washington DC, USA |
| C*07:01:42 | 15665054 | LT548083 | Dominique Masson, La Tronche, France |
| C*07:445 | 15820441 | LT548087 | Dominique Masson, La Tronche, France |
| DRB1*03:23 | NT01352 | KX059427 | Carolyn K Hurley, Washington DC, USA |
| DRB1*04:40 | NT01344 | KU955853 | Carolyn K Hurley, Washington DC, USA |
| DRB1*09:04 | NT01346 | KX059433 | Carolyn K Hurley, Washington DC, USA |
| DRB1*09:25 | 405061 | LT223708 | Edward KL Yang, Hualien, Taiwan |
| DRB1*11:01:07 | NT01340 | KU955857 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:07:01 | NT01345 | KU955851 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:07:01 | NT01350 | KX059429 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:24 | NT01339 | KU955858 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:47 | NT01351 | KX059428 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:02:01 | AZL | LT220243 | Steven GE Marsh, London, United Kingdom |
| DRB1*14:02:01 | LZL | LT220253 | Steven GE Marsh, London, United Kingdom |
| DRB1*14:42 | NT01348 | KX059430 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:53 | NT01349 | KX059431 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:01:03 | NT01345 | KU955852 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:123 | H3021 | KP710196 | Xiaojing Wang, Tianjin, China |
| DRB1*15:22 | NT01341 | KU955856 | Carolyn K Hurley, Washington DC, USA |
| DQA1*05:09 | FH67 | KU319363 | Konstantinos Barsakis, Palo Alto, USA |
| DQB1*04:02:03 | UD157552 | KC218815 | Eun-Jeong Choi, Seoul, Korea |
| DPB1*130:01 | NT01347 | KX059432 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*01:200 | (3) |
| A*02:513 | (4) |
| A*02:543 | (5) |
| A*02:610 | (6) |
| A*11:209 | (7) |
| A*24:02:50 | (8) |
| A*24:334 | (9) |
| A*33:102 | (10) |
| A*66:22 | (11) |
| B*07:238 | (11) |
| B*40:167 | (12) |
| B*40:326 | (13) |
| B*40:327 | (14) |
| B*46:65 | (15) |
| B*52:42 | (16) |
| B*58:77 | (17) |
| C*06:04:02 | (18) |
| C*07:445 | (19) |
| C*07:486 | (20) |
| DRB1*04:207 | (21) |
| DRB1*08:70 | (22) |
| DQA1*01:13 | (22) |
| DQA1*03:01:03 | (22) |
| DQB1*03:180 | (11) |
| MICB*031 | (23) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015 43: D423-31.
- Maskalan M, Grubic Z, Jankovic KS, Cepulic BG, Zunec R. Identification of the novel HLA-A*01:200 allele by sequence-based typing in a Croatian individual. HLA 2016 87: 381-2.
- Pei YF, Huang HN, Li HC, Shen WD. HLA-A*02:513, a novel HLA-A*02 allele. HLA 2016 87: 382-3.
- Dong LN, Chen NY, Zhang W, He J, Zhu FM. A novel HLA-A*02 allele, A*02:543 was identified by polymerase chain reaction sequence-based typing in a Chinese cord blood donor. HLA 2016 87: 384-5.
- Yang KL, Hung JH, Lin PY. Identification of a novel HLA-A*02 variant, HLA-A*02:610, in a Taiwanese individual. HLA 2016 87: 385-6.
- Ou G, Wang J, Ji X, Chen Q, Liu Z. Identification of a novel HLA-A allele, A*11:209 by sequence-based high-resolution typing in an HIV-infected individual. HLA 2016 87: 387-8.
- Li JP, Li XF, Zhang X, Lin FQ, Zhang KL. Identification of a novel allele, HLA-A*24:02:50, by sequence-based typing. HLA 2016 87: 388-90.
- Yang KL, Hung JH, Lin PY. HLA-A*24:334, a novel variant of HLA-A*24, discovered in a Taiwanese individual. HLA 2016 87: 390-1.
- Kim KM, Han OJ, Kang MS, Huh JY. HLA-A*33:102, a novel allele identified by sequence-based typing in cord blood from a Korean woman. HLA 2016 87: 391-2.
- Brown NK, Kheradmand T, Wang J, Marino SR. Identification and characterization of novel HLA alleles: Utility of next-generation sequencing methods. Hum Immunol 2016 77: 313-6.
- Li XF, Zhang X, Lin FQ, Zhang KL, Li JP. HLA-B*40:167, a novel allele, identified in a Chinese individual. HLA 2016 87: 392-4.
- Yang KL, Hung JH, Lin PY. HLA-B*40:326, a novel variant of HLA-B*40, discovered in a Taiwanese blood donor. HLA 2016 87: 394-5.
- Yang KL, Hung JH, Lin PY. HLA-B*40:327, a novel HLA-B*40 variant, discovered in a Taiwanese blood donor. HLA 2016 87: 395-7.
- Yang KL, Hung JH, Lin PY. HLA-B*46:65, a novel HLA-B*46 variant, detected in a Taiwanese unrelated bone marrow stem cell donor. HLA 2016 87: 397-8.
- Chen NY, Dong LN, Zhang W, He J, Zhu FM. Identification of the novel HLA-B*52:42 allele by polymerase chain reaction sequence-based typing in a Chinese bone marrow donor. HLA 2016 87: 400-2.
- Yang KL, Hung JH, Lin PY. Discovery of HLA-B*58:77, a novel HLA-B*58 variant, in a Taiwanese blood donor. HLA 2016 87: 398-9.
- Shepherd BL, Ferrand R, Rowland-Jones S, Yindom LM. HLA-C*06:04:02 a novel HLA-C allele isolated from donors of Southern African descent. HLA 2016 87: 402-3.
- Delbos F, Poulet E, Guillot M, Pare B, Ansart-Pirenne H. A novel allele HLA-C*07:445 identified in a French hematopoietic stem cell donor. HLA 2016 87: 403-4.
- Yang KL, Hung JH, Lin PY. HLA-C*07:486, a novel HLA-C*07 variant, detected in a Taiwanese individual. HLA 2016 87: 404-5.
- Yang KL, Hung JH, Chen CP, Lin PY. Detection of HLA-DRB1*04:207, a novel HLA-DRB1*04 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016 87: 406-7.
- Balas A, Planelles D, Garcia-Sanchez F, Prior C, Vicario JL. Three new HLA class II alleles: DRB1*08:70, DQA1*01:13 and DQA1*03:01:03. Int J Immunogenet 2016 43: 107-8.
- Wang WY, Tian W, Zhu FM, Liu XX, Li LX, Wang F. MICA, MICB Polymorphisms and Linkage Disequilibrium with HLA-B in a Chinese Mongolian Population. Scand J Immunol 2016 83: 456-62.
