Nomenclature for Factors of the HLA System

March 2016

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the February 2016 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The allele B*07:44 has been shown to contain an alternative splice site that produces an abnormal, truncated protein, as such an N suffix has been added to the name making it now B*07:44N. A*23:69 has been shown to contain errors and be identical to A*23:01:01. DRB1*08:01:01 has been corrected at position 97C>A. Additionally DRB1*08:01:03 has been shown to be identical to the corrected DRB1*08:01:01 and has therefore been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell identification Accession number Submitting author
A*01:01:01:03M-155-12-1039-AKU528597Valia Bravo-Egana, Philadelphia, USA
A*03:01:01:07NT01337NT01338KU851937Carolyn K Hurley, Washington DC, USA
A*11:01:72BY009971KC172392Carolyn K Hurley, Washington DC, USA
A*23:72ID#297275KU871395Elena Longhi, Milano, Italy
A*24:02:01:06M-155-09-4890-AKU639955Valia Bravo-Egana, Philadelphia, USA
A*24:02:01:07M-155-12-0424-AKU528596Valia Bravo-Egana, Philadelphia, USA
A*24:02:01:08M-86-12-1068-AKU528599Valia Bravo-Egana, Philadelphia, USA
A*24:03:01:02M-82-11-7973-AKU528600Valia Bravo-Egana, Philadelphia, USA
A*24:03:01:02NT01333KU851939Carolyn K Hurley, Washington DC, USA
A*24:3375321500018KU563153Xiaoyun Chi, Qingdao, China
A*26:01:01:03NYUHS_UDKU721104Borae G Park, Seoul, South Korea
A*74:01:04BY00853JN383957Carolyn K Hurley, Washington DC, USA
B*07:06:02BY01225KJ623743Carolyn K Hurley, Washington DC, USA
B*13:916331500177KU517817Xiaoyun Chi, Qingdao, China
B*14:02:01:03NT01321NT01322KU743305Carolyn K Hurley, Washington DC, USA
B*15:02:115321500214KU517816Xiaoyun Chi, Qingdao, China
B*15:16:01:02M-164-09-2874-BM-155-11-8865-BKU528604Valia Bravo-Egana, Philadelphia, USA
B*15:383NT01325KU743302Carolyn K Hurley, Washington DC, USA
B*18:01:01:03NT01331NT01332KU851940Carolyn K Hurley, Washington DC, USA
B*18:72:02CTM-6037494KU754498Antonio Balas, Madrid, Spain
B*27:07:0515236LT160736Maria Loginova, Kirov, Russia
B*35:02:08BY01221KJ623747Carolyn K Hurley, Washington DC, USA
B*35:3145655LT160733Maria Loginova, Kirov, Russia
B*40:330UD19803KC218816Eun-Jeong Choi, Seoul, Korea
B*44:03:01:03M-82-08-2477-BKU639956Valia Bravo-Egana, Philadelphia, USA
B*44:2406187LT160735Maria Loginova, Kirov, Russia
B*51:2022403LT160734Maria Loginova, Kirov, Russia
B*57:03:01:02M-164-09-2874-BKU528603Valia Bravo-Egana, Philadelphia, USA
B*67:07Xian66113KT285900Jun Qi, Xian, China
C*02:10:01:03M-82-11-7973-CKU528609Valia Bravo-Egana, Philadelphia, USA
C*04:233N6698LT160738Maria Loginova, Kirov, Russia
C*07:01:01:05M-155-12-1067-CKU528607Valia Bravo-Egana, Philadelphia, USA
C*07:49923193LT160737Maria Loginova, Kirov, Russia
C*12:1744898LT160739Maria Loginova, Kirov, Russia
C*14:02:01:02M-155-11-8865-CKU528606Valia Bravo-Egana, Philadelphia, USA
C*14:02:20297042KU716000Elena Longhi, Milano, Italy
DRB1*04:01:175321500988KU517815Xiaoyun Chi, Qingdao, China
DRB1*07:01:01:03MANIKALT220254Steven GE Marsh, London, United Kingdom
DRB1*07:01:19151023KU207429Mingrui Huo, Beijing, China
DRB1*10:01:01:02RENLT220234Steven GE Marsh, London, United Kingdom
DRB1*11:01:01:02BRIPLT220247Steven GE Marsh, London, United Kingdom
DRB1*11:01:01:03DHFLT220250Steven GE Marsh, London, United Kingdom
DRB1*12:01:01:02HERLUFLT220232Steven GE Marsh, London, United Kingdom
DRB1*12:01:01:03AlMcLT220245Steven GE Marsh, London, United Kingdom
DRB1*13:01:01:02APDLT220242Steven GE Marsh, London, United Kingdom
DRB1*14:174JMDP01K0172LC126304Masahiro Satake, Tokyo, Japan
DRB1*15:02:01:02AKIBALT220229Steven GE Marsh, London, United Kingdom
DRB1*16:02:01:02RMLLT220235Steven GE Marsh, London, United Kingdom
DQA1*01:01:01:02VENKU319339Konstantinos Barsakis, Palo Alto, USA
DQA1*01:01:01:03MYE 2006KU319340Konstantinos Barsakis, Palo Alto, USA
DQA1*01:03:01:03IHL, AD036KU319345Konstantinos Barsakis, Palo Alto, USA
DQA1*01:03:01:04HS67KU319346Konstantinos Barsakis, Palo Alto, USA
DQA1*01:03:01:05FH44KU319347Konstantinos Barsakis, Palo Alto, USA
DQA1*01:03:01:06MYE 2003KU319348Konstantinos Barsakis, Palo Alto, USA
DQA1*01:04:01:03THAKU319349Konstantinos Barsakis, Palo Alto, USA
DQA1*01:04:01:04HAY,BDKU319350Konstantinos Barsakis, Palo Alto, USA
DQA1*02:01:01:02BEL5GBKU319351Konstantinos Barsakis, Palo Alto, USA
DQA1*03:03:01:02BUR,EKU319353Konstantinos Barsakis, Palo Alto, USA
DQA1*03:03:01:03FH44KU319354Konstantinos Barsakis, Palo Alto, USA
DQA1*05:01:01:03CHA, AJKU319357Konstantinos Barsakis, Palo Alto, USA
DQA1*05:05:01:04MYE 2003KU319358Konstantinos Barsakis, Palo Alto, USA
DQA1*05:05:01:05BUR,EKU319361Konstantinos Barsakis, Palo Alto, USA
DQB1*03:01:33M-156756LN997811Kristin Kipper, Martinsried, Germany
DPB1*02:01:19TW61343KU745858Susana G Marino, Chicago, USA
DPB2*01:01:01PRIESSAH002898Jack L Strominger, Boston,, USA
DPB2*01:01:01COXAL662824Stephan Beck, London, United Kingdom
DPB2*01:01:02QBLAL845446Stephan Beck, London, United Kingdom
DPB2*01:01:02MANNCR847849Stephan Beck, London, United Kingdom
DPB2*02:01KG1987AH002895Lars Rask, Uppsala, Sweden
Stephan Beck, London, United Kingdom
DPB2*03:01:01:02APDCT009497Stephan Beck, London, United Kingdom
DPB2*03:01:01:03SSTOBX120009Stephan Beck, London, United Kingdom

Table 2: Confirmatory Sequences

Sequence Cell identification Accession number Submitting author
A*01:04NMYE 2001KU319381Konstantinos Barsakis, Palo Alto, USA
A*02:01:01:05M-155-10-5195-AKU639954Valia Bravo-Egana, Philadelphia, USA
A*02:04M-155-11-7605-AKU528611Valia Bravo-Egana, Philadelphia, USA
A*02:16TUBOKU233197Konstantinos Barsakis, Palo Alto, USA
A*03:01:01:05M-155-10-6515-AKU528595Valia Bravo-Egana, Philadelphia, USA
A*23:01:0131667LN624391Maria Peixoto, Porto, Portugal
A*23:17NT01332KU851942Carolyn K Hurley, Washington DC, USA
A*24:02:01:04MYE 2003KU319385Konstantinos Barsakis, Palo Alto, USA
A*24:02:97HG00011384KU668722Histogenetics, Ossining, USA
A*24:248HG00011385KU668732Histogenetics, Ossining, USA
A*24:280NT01323KU743304Carolyn K Hurley, Washington DC, USA
A*68:11NMYE 2003KU319383Konstantinos Barsakis, Palo Alto, USA
A*68:18NMYE 2004KU319384Konstantinos Barsakis, Palo Alto, USA
B*07:02:01HAY, BDKU319228Konstantinos Barsakis, Palo Alto, USA
B*07:44NCTM9748540KU204955Antonio Balas, Madrid, Spain
B*08:01:0125247229LT220237Steven GE Marsh, London, United Kingdom
B*14:03M-155-12-0161-BKU528618Valia Bravo-Egana, Philadelphia, USA
B*15:01:01:04NT01329NT01330KU851943Carolyn K Hurley, Washington DC, USA
B*15:03:01:02M-155-12-1067-BKU528602Valia Bravo-Egana, Philadelphia, USA
B*15:03:01:02NT01327NT01328KU851944Carolyn K Hurley, Washington DC, USA
B*15:08:01M-155-12-9724-BKU528620Valia Bravo-Egana, Philadelphia, USA
B*15:30M-164-05-0642-BKU528621Valia Bravo-Egana, Philadelphia, USA
B*35:04:01M-82-11-7973-BKU528622Valia Bravo-Egana, Philadelphia, USA
B*35:43:01M-155-12-1066-BKU528619Valia Bravo-Egana, Philadelphia, USA
B*39:09:01M-155-11-9419-BKU528617Valia Bravo-Egana, Philadelphia, USA
B*47:01:01:03M-86-12-0986-BKU528605Valia Bravo-Egana, Philadelphia, USA
B*51:08:01M-155-11-7855-BKU528615Valia Bravo-Egana, Philadelphia, USA
B*58:02:01M-145-12-0518-BKU528613Valia Bravo-Egana, Philadelphia, USA
C*03:272JMDP36K0197LC126303Masahiro Satake, Tokyo, Japan
C*03:272UD77341KC137375Eun-Jeong Choi, Seoul, Korea
C*04:01:01:06M-155-12-9725-CKU528608Valia Bravo-Egana, Philadelphia, USA
C*04:09NAN300123LN877342Steven GE Marsh, London, United Kingdom
C*04:209HG00011335KT968854Histogenetics, Ossining, USA
C*04:218HG00011334KT760531Histogenetics, Ossining, USA
C*05:3725288483LT220238Steven GE Marsh, London, United Kingdom
C*06:66UD208881JX996167Eun-Jeong Choi, Seoul, Korea
C*12:03:37HG00011450KU668778Histogenetics, Ossining, USA
C*12:1650042404LT220239Steven GE Marsh, London, United Kingdom
C*17:01:01:05M-86-12-0077-CKU528610Valia Bravo-Egana, Philadelphia, USA
DRB1*01:01:01WT100BISLT220257Steven GE Marsh, London, United Kingdom
DRB1*01:03AlMcLT220244Steven GE Marsh, London, United Kingdom
DRB1*03:01:01:01COXLT220231Steven GE Marsh, London, United Kingdom
DRB1*03:01:01:01VAVYLT220256Steven GE Marsh, London, United Kingdom
DRB1*04:04:0150043221LT220240Steven GE Marsh, London, United Kingdom
DRB1*04:07:01JHFLT220251Steven GE Marsh, London, United Kingdom
DRB1*07:61 HG00011343,
Histogenetics, Ossining, USA
DRB1*08:01:01MADURALT220233Steven GE Marsh, London, United Kingdom
DRB1*09:27HG00011346KT895336Histogenetics, Ossining, USA
DRB1*11:02:01JVMLT220252Steven GE Marsh, London, United Kingdom
DRB1*11:03:01TISILT220255Steven GE Marsh, London, United Kingdom
DRB1*11:189HG00011348KU167583Histogenetics, Ossining, USA
DRB1*13:183HG00011349KP057136Histogenetics, Ossining, USA
DRB1*13:213HG00011347KU167581Histogenetics, Ossining, USA
DRB1*15:03:01:02AMAILT220241Steven GE Marsh, London, United Kingdom
DRB1*15:123HG00011476KU668800Histogenetics, Ossining, USA
DRB1*16:01:01CALOGEROLT220249Steven GE Marsh, London, United Kingdom
DRB1*16:01:10HG00011341KT968863Histogenetics, Ossining, USA
DRB1*16:37HG00011342KU360762Histogenetics, Ossining, USA
DQA1*01:01:01:01#15310-LNKU319338Konstantinos Barsakis, Palo Alto, USA
DQA1*01:02:02HS67KU319344Konstantinos Barsakis, Palo Alto, USA
DQA1*04:01:01BM9KU319355Konstantinos Barsakis, Palo Alto, USA
DQA1*05:01:01:01QBLKU319356Konstantinos Barsakis, Palo Alto, USA
DQB1*03:05:03266080LT158300Robert Bradshaw, Leicester, United Kingdom
DQB1*03:205HG00011339KT895326Histogenetics, Ossining, USA
DQB1*03:207HG00011336KT895327Histogenetics, Ossining, USA
DQB1*03:221HG00011338KU350650Histogenetics, Ossining, USA
DQB1*05:111HG00011340KU302282Histogenetics, Ossining, USA
DQB1*06:184HG00011337KU167578Histogenetics, Ossining, USA
DPB1*09:01:04HG00011363KT943443Histogenetics, Ossining, USA
DPB1*144:01HG00011350KF263521Histogenetics, Ossining, USA
DPB1*155:01:02 HG00011356,
Histogenetics, Ossining, USA
DPB1*312:01HG00011364KM216209Histogenetics, Ossining, USA
DPB1*413:01HG00011366KM405425Histogenetics, Ossining, USA
DPB1*445:01 HG00011360,
Histogenetics, Ossining, USA
DPB1*448:01 HG00011368,
Histogenetics, Ossining, USA
DPB1*454:01HG00011352KU095807Histogenetics, Ossining, USA
DPB1*485:01HG00011351KT803931Histogenetics, Ossining, USA
DPB1*493:01HG00011365KU248921Histogenetics, Ossining, USA
DPB1*501:01 HG00011354,
Histogenetics, Ossining, USA
DPB1*503:01HG00011359KT984977Histogenetics, Ossining, USA
DPB1*507:01NHG00011367KU187274Histogenetics, Ossining, USA
DPB1*512:01HG00011353KU167598Histogenetics, Ossining, USA

Table 3: Recently Published Sequences

Sequence References


  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
  3. Kappes DJ, Strominger JL. Structure and evolution of the HLA class II SX beta gene. Immunogenetics 1986: 24: 1-7.
  4. Traherne JA, Horton R, Roberts AN, et al. Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet 2006: 2: e9.
  5. Stewart CA, Horton R, Allcock RJ, et al. Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004: 14: 1176-87.
  6. Horton R, Gibson R, Coggill P, et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics 2008: 60: 1-18.
  7. Gustafsson K, Widmark E, Jonsson AK, et al. Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes. J Biol Chem 1987: 262: 8778-86.