Nomenclature for Factors of the HLA System
March 2016
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2016) 88:70-3
- Human Immunology (2016) 77:706-9
- International Journal of Immunogenetics (2016) 43:258-61
The following sequences have been submitted to the Nomenclature Committee since the February 2016 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The allele B*07:44 has been shown to contain an alternative splice site that produces an abnormal, truncated protein, as such an N suffix has been added to the name making it now B*07:44N. A*23:69 has been shown to contain errors and be identical to A*23:01:01. DRB1*08:01:01 has been corrected at position 97C>A. Additionally DRB1*08:01:03 has been shown to be identical to the corrected DRB1*08:01:01 and has therefore been abandoned.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/ipd/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:01:03 | M-155-12-1039-A | KU528597 | Valia Bravo-Egana, Philadelphia, USA |
| A*03:01:01:07 | NT01337NT01338 | KU851937 | Carolyn K Hurley, Washington DC, USA |
| A*11:01:72 | BY009971 | KC172392 | Carolyn K Hurley, Washington DC, USA |
| A*23:72 | ID#297275 | KU871395 | Elena Longhi, Milano, Italy |
| A*24:02:01:06 | M-155-09-4890-A | KU639955 | Valia Bravo-Egana, Philadelphia, USA |
| A*24:02:01:07 | M-155-12-0424-A | KU528596 | Valia Bravo-Egana, Philadelphia, USA |
| A*24:02:01:08 | M-86-12-1068-A | KU528599 | Valia Bravo-Egana, Philadelphia, USA |
| A*24:03:01:02 | M-82-11-7973-A | KU528600 | Valia Bravo-Egana, Philadelphia, USA |
| A*24:03:01:02 | NT01333 | KU851939 | Carolyn K Hurley, Washington DC, USA |
| A*24:337 | 5321500018 | KU563153 | Xiaoyun Chi, Qingdao, China |
| A*26:01:01:03N | YUHS_UD | KU721104 | Borae G Park, Seoul, South Korea |
| A*74:01:04 | BY00853 | JN383957 | Carolyn K Hurley, Washington DC, USA |
| B*07:06:02 | BY01225 | KJ623743 | Carolyn K Hurley, Washington DC, USA |
| B*13:91 | 6331500177 | KU517817 | Xiaoyun Chi, Qingdao, China |
| B*14:02:01:03 | NT01321NT01322 | KU743305 | Carolyn K Hurley, Washington DC, USA |
| B*15:02:11 | 5321500214 | KU517816 | Xiaoyun Chi, Qingdao, China |
| B*15:16:01:02 | M-164-09-2874-BM-155-11-8865-B | KU528604 | Valia Bravo-Egana, Philadelphia, USA |
| B*15:383 | NT01325 | KU743302 | Carolyn K Hurley, Washington DC, USA |
| B*18:01:01:03 | NT01331NT01332 | KU851940 | Carolyn K Hurley, Washington DC, USA |
| B*18:72:02 | CTM-6037494 | KU754498 | Antonio Balas, Madrid, Spain |
| B*27:07:05 | 15236 | LT160736 | Maria Loginova, Kirov, Russia |
| B*35:02:08 | BY01221 | KJ623747 | Carolyn K Hurley, Washington DC, USA |
| B*35:314 | 5655 | LT160733 | Maria Loginova, Kirov, Russia |
| B*40:330 | UD19803 | KC218816 | Eun-Jeong Choi, Seoul, Korea |
| B*44:03:01:03 | M-82-08-2477-B | KU639956 | Valia Bravo-Egana, Philadelphia, USA |
| B*44:240 | 6187 | LT160735 | Maria Loginova, Kirov, Russia |
| B*51:202 | 2403 | LT160734 | Maria Loginova, Kirov, Russia |
| B*57:03:01:02 | M-164-09-2874-B | KU528603 | Valia Bravo-Egana, Philadelphia, USA |
| B*67:07 | Xian66113 | KT285900 | Jun Qi, Xian, China |
| C*02:10:01:03 | M-82-11-7973-C | KU528609 | Valia Bravo-Egana, Philadelphia, USA |
| C*04:233N | 6698 | LT160738 | Maria Loginova, Kirov, Russia |
| C*07:01:01:05 | M-155-12-1067-C | KU528607 | Valia Bravo-Egana, Philadelphia, USA |
| C*07:499 | 23193 | LT160737 | Maria Loginova, Kirov, Russia |
| C*12:174 | 4898 | LT160739 | Maria Loginova, Kirov, Russia |
| C*14:02:01:02 | M-155-11-8865-C | KU528606 | Valia Bravo-Egana, Philadelphia, USA |
| C*14:02:20 | 297042 | KU716000 | Elena Longhi, Milano, Italy |
| DRB1*04:01:17 | 5321500988 | KU517815 | Xiaoyun Chi, Qingdao, China |
| DRB1*07:01:01:03 | MANIKA | LT220254 | Steven GE Marsh, London, United Kingdom |
| DRB1*07:01:19 | 151023 | KU207429 | Mingrui Huo, Beijing, China |
| DRB1*10:01:01:02 | REN | LT220234 | Steven GE Marsh, London, United Kingdom |
| DRB1*11:01:01:02 | BRIP | LT220247 | Steven GE Marsh, London, United Kingdom |
| DRB1*11:01:01:03 | DHF | LT220250 | Steven GE Marsh, London, United Kingdom |
| DRB1*12:01:01:02 | HERLUF | LT220232 | Steven GE Marsh, London, United Kingdom |
| DRB1*12:01:01:03 | AlMc | LT220245 | Steven GE Marsh, London, United Kingdom |
| DRB1*13:01:01:02 | APD | LT220242 | Steven GE Marsh, London, United Kingdom |
| DRB1*14:174 | JMDP01K0172 | LC126304 | Masahiro Satake, Tokyo, Japan |
| DRB1*15:02:01:02 | AKIBA | LT220229 | Steven GE Marsh, London, United Kingdom |
| DRB1*16:02:01:02 | RML | LT220235 | Steven GE Marsh, London, United Kingdom |
| DQA1*01:01:01:02 | VEN | KU319339 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:01:01:03 | MYE 2006 | KU319340 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:03:01:03 | IHL, AD036 | KU319345 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:03:01:04 | HS67 | KU319346 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:03:01:05 | FH44 | KU319347 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:03:01:06 | MYE 2003 | KU319348 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:04:01:03 | THA | KU319349 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:04:01:04 | HAY,BD | KU319350 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*02:01:01:02 | BEL5GB | KU319351 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*03:03:01:02 | BUR,E | KU319353 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*03:03:01:03 | FH44 | KU319354 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*05:01:01:03 | CHA, AJ | KU319357 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*05:05:01:04 | MYE 2003 | KU319358 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*05:05:01:05 | BUR,E | KU319361 | Konstantinos Barsakis, Palo Alto, USA |
| DQB1*03:01:33 | M-156756 | LN997811 | Kristin Kipper, Martinsried, Germany |
| DPB1*02:01:19 | TW61343 | KU745858 | Susana G Marino, Chicago, USA |
| DPB2*01:01:01 | PRIESS | AH002898 | Jack L Strominger, Boston,, USA |
| DPB2*01:01:01 | COX | AL662824 | Stephan Beck, London, United Kingdom |
| DPB2*01:01:02 | QBL | AL845446 | Stephan Beck, London, United Kingdom |
| DPB2*01:01:02 | MANN | CR847849 | Stephan Beck, London, United Kingdom |
| DPB2*02:01 | KG1987 | AH002895 | Lars Rask, Uppsala, Sweden |
| DPB2*03:01:01:01 | PGF | AL645931, AL645940 | Stephan Beck, London, United Kingdom |
| DPB2*03:01:01:02 | APD | CT009497 | Stephan Beck, London, United Kingdom |
| DPB2*03:01:01:03 | SSTO | BX120009 | Stephan Beck, London, United Kingdom |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:04N | MYE 2001 | KU319381 | Konstantinos Barsakis, Palo Alto, USA |
| A*02:01:01:05 | M-155-10-5195-A | KU639954 | Valia Bravo-Egana, Philadelphia, USA |
| A*02:04 | M-155-11-7605-A | KU528611 | Valia Bravo-Egana, Philadelphia, USA |
| A*02:16 | TUBO | KU233197 | Konstantinos Barsakis, Palo Alto, USA |
| A*03:01:01:05 | M-155-10-6515-A | KU528595 | Valia Bravo-Egana, Philadelphia, USA |
| A*23:01:01 | 31667 | LN624391 | Maria Peixoto, Porto, Portugal |
| A*23:17 | NT01332 | KU851942 | Carolyn K Hurley, Washington DC, USA |
| A*24:02:01:04 | MYE 2003 | KU319385 | Konstantinos Barsakis, Palo Alto, USA |
| A*24:02:97 | HG00011384 | KU668722 | Histogenetics, Ossining, USA |
| A*24:248 | HG00011385 | KU668732 | Histogenetics, Ossining, USA |
| A*24:280 | NT01323 | KU743304 | Carolyn K Hurley, Washington DC, USA |
| A*68:11N | MYE 2003 | KU319383 | Konstantinos Barsakis, Palo Alto, USA |
| A*68:18N | MYE 2004 | KU319384 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:02:01 | HAY, BD | KU319228 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:44N | CTM9748540 | KU204955 | Antonio Balas, Madrid, Spain |
| B*08:01:01 | 25247229 | LT220237 | Steven GE Marsh, London, United Kingdom |
| B*14:03 | M-155-12-0161-B | KU528618 | Valia Bravo-Egana, Philadelphia, USA |
| B*15:01:01:04 | NT01329NT01330 | KU851943 | Carolyn K Hurley, Washington DC, USA |
| B*15:03:01:02 | M-155-12-1067-B | KU528602 | Valia Bravo-Egana, Philadelphia, USA |
| B*15:03:01:02 | NT01327NT01328 | KU851944 | Carolyn K Hurley, Washington DC, USA |
| B*15:08:01 | M-155-12-9724-B | KU528620 | Valia Bravo-Egana, Philadelphia, USA |
| B*15:30 | M-164-05-0642-B | KU528621 | Valia Bravo-Egana, Philadelphia, USA |
| B*35:04:01 | M-82-11-7973-B | KU528622 | Valia Bravo-Egana, Philadelphia, USA |
| B*35:43:01 | M-155-12-1066-B | KU528619 | Valia Bravo-Egana, Philadelphia, USA |
| B*39:09:01 | M-155-11-9419-B | KU528617 | Valia Bravo-Egana, Philadelphia, USA |
| B*47:01:01:03 | M-86-12-0986-B | KU528605 | Valia Bravo-Egana, Philadelphia, USA |
| B*51:08:01 | M-155-11-7855-B | KU528615 | Valia Bravo-Egana, Philadelphia, USA |
| B*58:02:01 | M-145-12-0518-B | KU528613 | Valia Bravo-Egana, Philadelphia, USA |
| C*03:272 | JMDP36K0197 | LC126303 | Masahiro Satake, Tokyo, Japan |
| C*03:272 | UD77341 | KC137375 | Eun-Jeong Choi, Seoul, Korea |
| C*04:01:01:06 | M-155-12-9725-C | KU528608 | Valia Bravo-Egana, Philadelphia, USA |
| C*04:09N | AN300123 | LN877342 | Steven GE Marsh, London, United Kingdom |
| C*04:209 | HG00011335 | KT968854 | Histogenetics, Ossining, USA |
| C*04:218 | HG00011334 | KT760531 | Histogenetics, Ossining, USA |
| C*05:37 | 25288483 | LT220238 | Steven GE Marsh, London, United Kingdom |
| C*06:66 | UD208881 | JX996167 | Eun-Jeong Choi, Seoul, Korea |
| C*12:03:37 | HG00011450 | KU668778 | Histogenetics, Ossining, USA |
| C*12:16 | 50042404 | LT220239 | Steven GE Marsh, London, United Kingdom |
| C*17:01:01:05 | M-86-12-0077-C | KU528610 | Valia Bravo-Egana, Philadelphia, USA |
| DRB1*01:01:01 | WT100BIS | LT220257 | Steven GE Marsh, London, United Kingdom |
| DRB1*01:03 | AlMc | LT220244 | Steven GE Marsh, London, United Kingdom |
| DRB1*03:01:01:01 | COX | LT220231 | Steven GE Marsh, London, United Kingdom |
| DRB1*03:01:01:01 | VAVY | LT220256 | Steven GE Marsh, London, United Kingdom |
| DRB1*04:04:01 | 50043221 | LT220240 | Steven GE Marsh, London, United Kingdom |
| DRB1*04:07:01 | JHF | LT220251 | Steven GE Marsh, London, United Kingdom |
| DRB1*07:61 | HG00011343, HG00011344, HG00011345 |
KT803923, KT844492, KU167584 | Histogenetics, Ossining, USA |
| DRB1*08:01:01 | MADURA | LT220233 | Steven GE Marsh, London, United Kingdom |
| DRB1*09:27 | HG00011346 | KT895336 | Histogenetics, Ossining, USA |
| DRB1*11:02:01 | JVM | LT220252 | Steven GE Marsh, London, United Kingdom |
| DRB1*11:03:01 | TISI | LT220255 | Steven GE Marsh, London, United Kingdom |
| DRB1*11:189 | HG00011348 | KU167583 | Histogenetics, Ossining, USA |
| DRB1*13:183 | HG00011349 | KP057136 | Histogenetics, Ossining, USA |
| DRB1*13:213 | HG00011347 | KU167581 | Histogenetics, Ossining, USA |
| DRB1*15:03:01:02 | AMAI | LT220241 | Steven GE Marsh, London, United Kingdom |
| DRB1*15:123 | HG00011476 | KU668800 | Histogenetics, Ossining, USA |
| DRB1*16:01:01 | CALOGERO | LT220249 | Steven GE Marsh, London, United Kingdom |
| DRB1*16:01:10 | HG00011341 | KT968863 | Histogenetics, Ossining, USA |
| DRB1*16:37 | HG00011342 | KU360762 | Histogenetics, Ossining, USA |
| DQA1*01:01:01:01 | #15310-LN | KU319338 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*01:02:02 | HS67 | KU319344 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*04:01:01 | BM9 | KU319355 | Konstantinos Barsakis, Palo Alto, USA |
| DQA1*05:01:01:01 | QBL | KU319356 | Konstantinos Barsakis, Palo Alto, USA |
| DQB1*03:05:03 | 266080 | LT158300 | Robert Bradshaw, Leicester, United Kingdom |
| DQB1*03:205 | HG00011339 | KT895326 | Histogenetics, Ossining, USA |
| DQB1*03:207 | HG00011336 | KT895327 | Histogenetics, Ossining, USA |
| DQB1*03:221 | HG00011338 | KU350650 | Histogenetics, Ossining, USA |
| DQB1*05:111 | HG00011340 | KU302282 | Histogenetics, Ossining, USA |
| DQB1*06:184 | HG00011337 | KU167578 | Histogenetics, Ossining, USA |
| DPB1*09:01:04 | HG00011363 | KT943443 | Histogenetics, Ossining, USA |
| DPB1*144:01 | HG00011350 | KF263521 | Histogenetics, Ossining, USA |
| DPB1*155:01:02 | HG00011356, HG00011357, HG00011358 |
KU167603, KT984976, KT943444 | Histogenetics, Ossining, USA |
| DPB1*312:01 | HG00011364 | KM216209 | Histogenetics, Ossining, USA |
| DPB1*413:01 | HG00011366 | KM405425 | Histogenetics, Ossining, USA |
| DPB1*445:01 | HG00011360, HG00011361, HG00011362 |
KU167597, KU167600, KU167602 | Histogenetics, Ossining, USA |
| DPB1*448:01 | HG00011368, HG00011369 |
KU214489, KU167601 | Histogenetics, Ossining, USA |
| DPB1*454:01 | HG00011352 | KU095807 | Histogenetics, Ossining, USA |
| DPB1*485:01 | HG00011351 | KT803931 | Histogenetics, Ossining, USA |
| DPB1*493:01 | HG00011365 | KU248921 | Histogenetics, Ossining, USA |
| DPB1*501:01 | HG00011354, HG00011355 |
KU167604, KU302298 | Histogenetics, Ossining, USA |
| DPB1*503:01 | HG00011359 | KT984977 | Histogenetics, Ossining, USA |
| DPB1*507:01N | HG00011367 | KU187274 | Histogenetics, Ossining, USA |
| DPB1*512:01 | HG00011353 | KU167598 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| DPB2*01:01 | (3) |
| DPB2*03:01 | (4) |
| DPB2*04:01:01:01 | (5) |
| DPB2*04:01:01:02 | (6) |
| DPB2*03:01 | (6) |
| DPB2*05:01 | (6) |
| DPB2*02:01 | (7) |
| DPB2*01:01 | (5) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
- Kappes DJ, Strominger JL. Structure and evolution of the HLA class II SX beta gene. Immunogenetics 1986: 24: 1-7.
- Traherne JA, Horton R, Roberts AN, et al. Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet 2006: 2: e9.
- Stewart CA, Horton R, Allcock RJ, et al. Complete MHC haplotype sequencing for common disease gene mapping. Genome Res 2004: 14: 1176-87.
- Horton R, Gibson R, Coggill P, et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics 2008: 60: 1-18.
- Gustafsson K, Widmark E, Jonsson AK, et al. Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes. J Biol Chem 1987: 262: 8778-86.
