Nomenclature for Factors of the HLA System
February 2016
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2016) 88:66-9
- Human Immunology (2016) 77:702-5
- International Journal of Immunogenetics (2016) 43:254-7
The following sequences have been submitted to the Nomenclature Committee since the January 2016 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/ipd/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:201 | HG00011193 | KU248908 | Histogenetics, Ossining, USA |
| A*02:524:02 | HG00011200 | KR868778 | Histogenetics, Ossining, USA |
| A*02:611 | HG00011197 | KU167554 | Histogenetics, Ossining, USA |
| A*02:612 | HG00011198 | KU167556 | Histogenetics, Ossining, USA |
| A*02:613 | HG00011201 | KU302254 | Histogenetics, Ossining, USA |
| A*02:614 | R41246 | LT158301 | Edward KL Yang, Hualien, Taiwan |
| A*03:243 | HG00011181 | KT282149 | Histogenetics, Ossining, USA |
| A*03:244 | HG00011195 | KU167553 | Histogenetics, Ossining, USA |
| A*03:245 | HG00011196 | KU302261 | Histogenetics, Ossining, USA |
| A*03:246 | 17880 | LT160731 | Maria Loginova, Kirov, Russia |
| A*11:01:71 | 14977 | LT160730 | Maria Loginova, Kirov, Russia |
| A*11:236 | HG00011186 | KU302257 | Histogenetics, Ossining, USA |
| A*11:237 | HG00011187 | KU167555 | Histogenetics, Ossining, USA |
| A*11:238N | HG00011189 | KU248905 | Histogenetics, Ossining, USA |
| A*23:71 | HG00011192 | KU302255 | Histogenetics, Ossining, USA |
| A*24:02:97 | 20278 | LT160732 | Maria Loginova, Kirov, Russia |
| A*24:335 | HG00011190 | KU167558 | Histogenetics, Ossining, USA |
| A*24:336 | HG00011191 | KU214471 | Histogenetics, Ossining, USA |
| A*31:106 | HG00011182 | KU248906 | Histogenetics, Ossining, USA |
| A*31:107 | HG00011184 | KU167557 | Histogenetics, Ossining, USA |
| A*33:107 | HG00011183 | KU302256 | Histogenetics, Ossining, USA |
| A*33:108 | 0270907169 | KU641691 | Wen Qiang, Wuhan, China |
| A*68:143 | HG00011188 | KT282150 | Histogenetics, Ossining, USA |
| A*68:144 | 216199 | KU233192 | Konstantinos Barsakis, Palo Alto, USA |
| B*07:268 | HG00011218 | KU248909 | Histogenetics, Ossining, USA |
| B*08:160 | NT01316 | KU324540 | Carolyn K Hurley, Washington DC, USA |
| B*08:161 | HG00011207 | KU302266 | Histogenetics, Ossining, USA |
| B*13:01:12 | D315253 | LT158304 | Edward KL Yang, Hualien, Taiwan |
| B*13:89 | HG00011209 | KU214474 | Histogenetics, Ossining, USA |
| B*13:90 | 0270905529 | KU641690 | Wen Qiang, Wuhan, China |
| B*14:54 | HG00011217 | KU302268 | Histogenetics, Ossining, USA |
| B*15:381 | HG00011205 | KU302262 | Histogenetics, Ossining, USA |
| B*15:382 | HG00011220 | KU167563 | Histogenetics, Ossining, USA |
| B*35:312 | HG00011212 | KU302271 | Histogenetics, Ossining, USA |
| B*35:313 | NT01319 | KU324537 | Carolyn K Hurley, Washington DC, USA |
| B*38:61 | HG00011219 | KU302269 | Histogenetics, Ossining, USA |
| B*39:116N | 0270907525 | KU641692 | Wen Qiang, Wuhan, China |
| B*40:01:46 | 0271110296 | KU641693 | Wen Qiang, Wuhan, China |
| B*40:01:47 | 0271210542 | KU641694 | Wen Qiang, Wuhan, China |
| B*40:06:15 | HG00011202 | KU167560 | Histogenetics, Ossining, USA |
| B*40:186:02 | SYNPC211 | KU598668 | Wei Tian, Changsha, China |
| B*40:328 | HG00011206 | KU167561 | Histogenetics, Ossining, USA |
| B*40:329 | AS3213 | LT158302 | Edward KL Yang, Hualien, Taiwan |
| B*41:46 | HG00011203 | KT282158 | Histogenetics, Ossining, USA |
| B*44:239 | HG00011210 | KU302265 | Histogenetics, Ossining, USA |
| B*49:42 | HG00011204 | KU167564 | Histogenetics, Ossining, USA |
| B*52:60 | HG00011208 | KU302264 | Histogenetics, Ossining, USA |
| B*52:61 | HG00011213 | KU302270 | Histogenetics, Ossining, USA |
| B*55:01:16 | HG00011216 | KU167562 | Histogenetics, Ossining, USA |
| B*57:83 | NT01312 | KU324522 | Carolyn K Hurley, Washington DC, USA |
| B*67:06 | JRC-D08-041 | LC121599 | Masahiro Satake, Tokyo, Japan |
| C*02:113 | HG00011239 | KU302276 | Histogenetics, Ossining, USA |
| C*02:114 | HG00011240 | KU167570 | Histogenetics, Ossining, USA |
| C*03:03:31 | NT01307 | KU324534 | Carolyn K Hurley, Washington DC, USA |
| C*03:314 | HG00011241 | KU302278 | Histogenetics, Ossining, USA |
| C*03:315 | HG00011242 | KU302280 | Histogenetics, Ossining, USA |
| C*03:316N | HG00011243 | KU302301 | Histogenetics, Ossining, USA |
| C*04:231 | HG00011244 | KU302272 | Histogenetics, Ossining, USA |
| C*04:232 | HG00011245 | KU302274 | Histogenetics, Ossining, USA |
| C*05:129 | HG00011234 | KU214475 | Histogenetics, Ossining, USA |
| C*06:174 | HG00011221 | KU167573 | Histogenetics, Ossining, USA |
| C*06:175N | HG00011222 | KU167568 | Histogenetics, Ossining, USA |
| C*07:341:02 | D228203 | LT158303 | Edward KL Yang, Hualien, Taiwan |
| C*07:490 | HG00011224 | KU248913 | Histogenetics, Ossining, USA |
| C*07:491N | HG00011225 | KU167569 | Histogenetics, Ossining, USA |
| C*07:492 | HG00011227 | KU302277 | Histogenetics, Ossining, USA |
| C*07:493 | HG00011228 | KR047761 | Histogenetics, Ossining, USA |
| C*07:494Q | HG00011229 | KU167574 | Histogenetics, Ossining, USA |
| C*07:495 | HG00011230 | KU187267 | Histogenetics, Ossining, USA |
| C*07:496 | HG00011231 | KU167571 | Histogenetics, Ossining, USA |
| C*07:497 | HG00011232 | KU248912 | Histogenetics, Ossining, USA |
| C*07:498 | HG00011233 | KU302273 | Histogenetics, Ossining, USA |
| C*08:130N | HG00011235 | KU167567 | Histogenetics, Ossining, USA |
| C*12:173 | HG00011238 | KU167577 | Histogenetics, Ossining, USA |
| DRB1*01:73 | HG00011267 | KU248916 | Histogenetics, Ossining, USA |
| DRB1*01:74 | 292118 | KU522303 | Elena Longhi, Milano, Italy |
| DRB1*03:128 | HG00011265 | KU302288 | Histogenetics, Ossining, USA |
| DRB1*03:129 | HG00011266 | KU302287 | Histogenetics, Ossining, USA |
| DRB1*04:03:12 | HG00011262 | KU167582 | Histogenetics, Ossining, USA |
| DRB1*08:80 | HG00011263 | KU167585 | Histogenetics, Ossining, USA |
| DRB1*13:214 | HG00011264 | KU187271 | Histogenetics, Ossining, USA |
| DRB1*14:173 | K140401 | LC109323 | Yuto Horie, Kyoto, Japan |
| DRB1*15:01:29 | HG00011259 | KU187272 | Histogenetics, Ossining, USA |
| DRB1*16:38 | HG00011258 | KU167580 | Histogenetics, Ossining, USA |
| DQB1*02:66 | HG00011247 | KU302284 | Histogenetics, Ossining, USA |
| DQB1*02:67N | HG00011253 | KU214477 | Histogenetics, Ossining, USA |
| DQB1*03:223 | HG00011251 | KU302286 | Histogenetics, Ossining, USA |
| DQB1*03:224 | HG00011252 | KU187270 | Histogenetics, Ossining, USA |
| DQB1*04:34 | HG00011255 | KU167579 | Histogenetics, Ossining, USA |
| DQB1*06:201 | HG00011257 | KU248914 | Histogenetics, Ossining, USA |
| DQB1*06:202 | M-570130 | LN997812 | Kristin Kipper, Martinsried, Germany |
| DPB1*547:01 | BWU053_AD11859 | KU055451 | Oh-Joong Kwon, Seoul, South Korea |
| G*01:08:02 | EKU1 | KP739973 | Antonio Arnaiz-Villena, Madrid, Spain |
| G*01:20 | Dom1 | KP739974 | Antonio Arnaiz-Villena, Madrid, Spain |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:71 | HG00011311 | KU350642 | Histogenetics, Ossining, USA |
| A*01:169 | HG00011313 | KT803907 | Histogenetics, Ossining, USA |
| A*01:198 | HG00011312 | KU167559 | Histogenetics, Ossining, USA |
| A*02:08 | KLO | KU233198 | Konstantinos Barsakis, Palo Alto, USA |
| A*02:11:01 | GRC-138 | KU233200 | Konstantinos Barsakis, Palo Alto, USA |
| A*02:11:09 | HG00011315 | KU302259 | Histogenetics, Ossining, USA |
| A*02:30 | FH21 | KU233199 | Konstantinos Barsakis, Palo Alto, USA |
| A*24:14 | LC101 | KU319386 | Konstantinos Barsakis, Palo Alto, USA |
| A*24:322 | HG00011309 | KT895306 | Histogenetics, Ossining, USA |
| A*24:324 | HG00011310 | KT803908 | Histogenetics, Ossining, USA |
| A*26:03:01 | SM | KU233195 | Konstantinos Barsakis, Palo Alto, USA |
| A*29:40 | 139370 | KU319388 | Konstantinos Barsakis, Palo Alto, USA |
| A*29:81 | HG00011308 | KU302260 | Histogenetics, Ossining, USA |
| A*30:03 | JS | KU319389 | Konstantinos Barsakis, Palo Alto, USA |
| A*30:78N | DL61_05C49901_A04 | KU319382 | Konstantinos Barsakis, Palo Alto, USA |
| A*68:05 | LC83 | KU233196 | Konstantinos Barsakis, Palo Alto, USA |
| A*74:27 | HG00011314 | KU350638 | Steven GE Marsh, London, United Kingdom |
| B*08:135 | HG00011319 | KC424466 | Histogenetics, Ossining, USA |
| B*08:137 | HG00011318 | JX089367 | Histogenetics, Ossining, USA |
| B*15:369 | HG00011320 | KU248911 | Histogenetics, Ossining, USA |
| B*27:141 | HG00011317 | KU360743 | Histogenetics, Ossining, USA |
| B*39:108 | HG00011321 | KT600087 | Histogenetics, Ossining, USA |
| B*40:318 | HG00011322 | KT600088 | Histogenetics, Ossining, USA |
| B*44:03:32 | HG00011211 | KU248910 | Histogenetics, Ossining, USA |
| B*49:41 | HG00011316 | KU302267 | Histogenetics, Ossining, USA |
| C*02:55:02 | HG00011333 | KT844485 | Histogenetics, Ossining, USA |
| C*06:158 | HG00011324 | KT895317 | Histogenetics, Ossining, USA |
| C*07:01:51 | HG00011226 | KU302279 | Histogenetics, Ossining, USA |
| C*07:310 | HG00011325 | KC875921 | Histogenetics, Ossining, USA |
| C*07:429 | HG00011326 | KU095794 | Histogenetics, Ossining, USA |
| C*07:450 | HG00011327 | KU167572 | Histogenetics, Ossining, USA |
| C*08:02:10 | HG00011329 | KC441498 | Histogenetics, Ossining, USA |
| C*08:103 | NT01306 | KU324527 | Carolyn K Hurley, Washington DC, USA |
| C*12:153 | HG00011236, HG00011237 |
KU167576, KU214476 | Histogenetics, Ossining, USA |
| C*12:162 | HG00011331 | KT895311 | Histogenetics, Ossining, USA |
| C*12:163 | HG00011328 | KT968849 | Histogenetics, Ossining, USA |
| C*12:164 | HG00011330 | KU187266 | Histogenetics, Ossining, USA |
| C*15:118 | HG00011332 | KT600100 | Histogenetics, Ossining, USA |
| C*18:06 | HG00011323 | JX970481 | Histogenetics, Ossining, USA |
| DRB5*01:02 | THA | KU593571 | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*01:03 | 119990 | KU593574 | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*01:08N | 164787 | KU593575 | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*02:02 | DAN723 | KU593572 | Konstantinos Barsakis, Palo Alto, USA |
| DRB5*02:03 | 156478 | KU593579 | Konstantinos Barsakis, Palo Alto, USA |
| DQB1*02:62 | HG00011248 | KU214479 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*03:181 | (3) |
| A*03:229 | (3) |
| A*11:01:69 | (4) |
| A*11:120 | (5) |
| A*11:231 | (6) |
| A*24:02:96 | (7) |
| A*24:258 | (8) |
| A*24:305 | (8) |
| B*15:300 | (9) |
| B*35:307 | (10) |
| B*40:01:44 | (11) |
| B*54:34 | (12) |
| B*55:02:10 | (13) |
| B*55:70 | (14) |
| B*55:77 | (15) |
| C*03:313 | (16) |
| C*04:212 | (17) |
| C*16:90 | (18) |
| DRB1*12:48 | (19) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
- Tao SD, Chen NY, Dong LN, He J, Zhu FM. Identification of two novel HLA-A alleles, HLA-A*03:181 and HLA-A*03:229 in Chinese individuals. HLA 2016: 87: 165-6.
- Yang EK, Hung JH, Lin PY. Discovery of HLA-A*11:01:69, a novel HLA-A*11:01 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 166-7.
- Zhang X, Li GJ, Li XF, Fan H, Li JP. A new HLA-A allele, HLA-A*11:120, sequenced in a Chinese hematopoietic stem cell donor. HLA 2016: 87: 168-70.
- Yang KL, Hung JH, Lin PY. HLA-A*11:231, a novel variant of HLA-A*11, found in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 170-1.
- Zhu YY, Qiang W, Shen G, Zou J, Liu GJ. HLA-A*24:02:96, a novel variant of HLA-A*24:02:01:01, identified in a Chinese individual by sequence-based typing. HLA 2016: 87: 171-2.
- He JJ, Chen NY, Dong LN, He J, Zhu FM. Two novel HLA-A alleles: A*24:258 and A*24:305 were identified in Chinese individuals. HLA 2016: 87: 173-4.
- Li WX, Xia JA, Mao Y, Li G, Shen G. Identification of a new HLA-B allele, HLA-B*15:300, in a Chinese individual. HLA 2016: 87: 175-6.
- Yang KL, Hung JH, Lin PY. Discovery of HLA-B*35:307, a novel HLA-B*35 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 178-9.
- Yang KL, Hung JH, Lin PY. HLA-B*40:01:44, a novel variant of HLA-B*40:01, discovered in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 179-80.
- Han ZD, Dong LN, Wang W, He J, Zhu FM. Identification of a novel HLA-B*54:34 allele by polymerase chain reaction sequence-based typing in a Chinese leukemia patient. HLA 2016: 87: 180-2.
- Yang KL, Hung JH, Lin PY. Discovery of HLA-B*55:02:10, a novel HLA-B*55:02 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 182-3.
- Wang W, Chen NY, Dong LN, He J, Zhu FM. A novel allele, HLA-B*55:70 was identified in a Chinese cord blood donor. HLA 2016: 87: 183-5.
- Qiang W, Shen G, Zhu YY, Zou J. A novel allele, HLA-B*55:77, identified by sequence-based typing in a Chinese individual. HLA 2016: 87: 185-6.
- Suzuki S, Sato T, Akatsuka H, Kimura M, Shiina T. Identification of a novel HLA-C allele, HLA-C*03:313, in a Japanese individual. HLA 2016: 87: 186-7.
- Yang EK, Ng J, Lazaro A, Hung JH, Lin PY. Detection of HLA-C*04:212, a novel HLA-C*04 variant, in a Taiwanese hematopoietic stem cell donor. HLA 2016: 87: 187-9.
- Liu B, Yang P, Ma Z, Ma Y, Sheng X. Identification of a novel HLA-C*16 variant, HLA-C*16:90, in a Chinese individual. HLA 2016: 87: 189-90.
- Zhu X, Yang T, Tan R, Su P, Gao H. A novel HLA-DRB1 allele, HLA-DRB1*12:48. HLA 2016: 87: 190-1.
