Nomenclature for Factors of the HLA System
January 2016
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2016) 88:63-5
- Human Immunology (2016) 77:699-701
- International Journal of Immunogenetics (2016) 43:251-3
The following sequences have been submitted to the Nomenclature Committee since the December 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/ipd/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:74 | HG00010136 | KP872780 | Histogenetics, Ossining, USA |
| A*01:01:75 | HG00010224 | KR047745 | Histogenetics, Ossining, USA |
| A*02:01:122 | HG00010233 | KR047746 | Histogenetics, Ossining, USA |
| A*03:01:57 | H2846 | KP234088 | Xiaojing Wang, Tianjin, China |
| A*11:01:70 | HG00010218 | KR153541 | Histogenetics, Ossining, USA |
| A*23:70 | 28414 | LN998640 | Maria Loginova, Kirov, Russia |
| A*29:84 | NT01305 | KU324528 | Carolyn K Hurley, Washington DC, USA |
| A*29:85 | M-568345 | LN997806 | Kristin Kipper, Martinsried, Germany |
| A*33:03:31 | 386806 | LN995839 | Edward KL Yang, Hualien, Taiwan |
| B*07:02:49 | HG00010346 | KR677049 | Histogenetics, Ossining, USA |
| B*07:266 | 2019 | LN998641 | Maria Loginova, Kirov, Russia |
| B*07:267 | 20819 | LN998649 | Maria Loginova, Kirov, Russia |
| B*08:01:33 | HG00010248 | KR153542 | Histogenetics, Ossining, USA |
| B*08:01:34 | HG00010336 | KR677050 | Histogenetics, Ossining, USA |
| B*08:159 | 27756 | LN998646 | Maria Loginova, Kirov, Russia |
| B*13:88 | 81140928 | KU499989 | Daniel Fuerst, Ulm, Germany |
| B*15:02:10 | HG00010340 | KR270569 | Histogenetics, Ossining, USA |
| B*15:03:06 | HG00010344 | KR818715 | Histogenetics, Ossining, USA |
| B*15:380N | FALA799527, HAYO799382, MOLA799284, MOLA799613, MALA800359 |
LN999845 | Steven GE Marsh, London, United Kingdom |
| B*27:147 | P10037 | KU350631 | Faming Zhu, Hangzhou, China |
| B*38:60 | NT01297 | KU324520 | Carolyn K Hurley, Washington DC, USA |
| B*39:115 | 23855 | LN998645 | Maria Loginova, Kirov, Russia |
| B*40:01:45 | SZGSQ 26 | KU575251 | Su-Qing Gao, Shenzhen, China |
| B*40:02:25 | 19224 | LN998642 | Maria Loginova, Kirov, Russia |
| B*44:02:40 | BY01107, BY01205 |
KF482396, KJ418363 | Carolyn K Hurley, Washington DC, USA |
| B*46:66 | BY01301 | KU516828 | Carolyn K Hurley, Washington DC, USA |
| B*50:44 | NT01299 | KU324518 | Carolyn K Hurley, Washington DC, USA |
| B*51:201 | 17800 | LN998643 | Maria Loginova, Kirov, Russia |
| C*01:02:37 | BY01061 | KF266817 | Carolyn K Hurley, Washington DC, USA |
| C*01:02:38 | HG00010255 | KR105364 | Histogenetics, Ossining, USA |
| C*03:03:30 | NT01301 | KU324533 | Carolyn K Hurley, Washington DC, USA |
| C*04:01:71 | 20018 | LN998648 | Maria Loginova, Kirov, Russia |
| C*04:01:72 | 25966 | LN998647 | Maria Loginova, Kirov, Russia |
| C*05:128N | NT01302 | KU324531 | Carolyn K Hurley, Washington DC, USA |
| C*06:02:45 | NT01320 | KU324536 | Carolyn K Hurley, Washington DC, USA |
| C*07:01:53 | HG00010261 | KR082295 | Histogenetics, Ossining, USA |
| C*07:02:72 | HG00010053 | KP792206 | Histogenetics, Ossining, USA |
| C*07:02:73 | HG00010060 | KP325457 | Histogenetics, Ossining, USA |
| C*07:488 | NT01298 | KU324519 | Carolyn K Hurley, Washington DC, USA |
| C*07:489 | 81137868 | KU499987 | Daniel Fuerst, Ulm, Germany |
| C*08:129N | BY01300 | KU324517 | Carolyn K Hurley, Washington DC, USA |
| C*15:02:25 | BY01067 | KF266811 | Carolyn K Hurley, Washington DC, USA |
| C*15:02:26 | BY01173 | KF946535 | Carolyn K Hurley, Washington DC, USA |
| C*15:122N | NT01317 | KU324539 | Carolyn K Hurley, Washington DC, USA |
| C*16:01:20 | NT01304 | KU324529 | Carolyn K Hurley, Washington DC, USA |
| C*16:93 | NT01315 | KU324541 | Carolyn K Hurley, Washington DC, USA |
| DRB1*07:69 | M-565572 | LN997809 | Kristin Kipper, Martinsried, Germany |
| DRB1*11:198 | M-554548 | LN997810 | Kristin Kipper, Martinsried, Germany |
| DRB1*14:172 | 331239 | LN875779 | Valentina Cappuzzo, Palermo, Italy |
| DRB3*01:20 | HG00011269 | KU248917 | Histogenetics, Ossining, USA |
| DRB3*01:21 | HG00011270 | KU302289 | Histogenetics, Ossining, USA |
| DRB3*01:22 | HG00011271 | KU167589 | Histogenetics, Ossining, USA |
| DRB3*02:34 | HG00011273 | KU167590 | Histogenetics, Ossining, USA |
| DRB3*02:35 | HG00011274 | KU248918 | Histogenetics, Ossining, USA |
| DRB3*02:36 | 81139579 | KU517233 | Daniel Fuerst, Ulm, Germany |
| DRB3*03:05 | HG00011275, HG00011276 |
KU214481, KU187273 | Histogenetics, Ossining, USA |
| DRB3*03:06 | HG00011277 | KU302290 | Histogenetics, Ossining, USA |
| DRB4*01:11 | HG00011278 | KU248924 | Histogenetics, Ossining, USA |
| DRB4*01:12 | HG00011280 | KU248925 | Histogenetics, Ossining, USA |
| DRB4*01:13 | HG00011282 | KU248926 | Histogenetics, Ossining, USA |
| DRB4*01:14 | HG00011283, HG00011284, HG00011285 |
KU167591, KU167592, KU302292 | Histogenetics, Ossining, USA |
| DRB4*01:14 | 93053764 | KU517236 | Daniel Fuerst, Ulm, Germany |
| DRB4*01:15 | HG00011287 | KU214485 | Histogenetics, Ossining, USA |
| DRB4*01:16N | HG00011288 | KU248919 | Histogenetics, Ossining, USA |
| DRB4*01:17 | HG00011290, HG00011291 |
KU302291, KU302293 | Histogenetics, Ossining, USA |
| DRB5*01:18 | HG00011292 | KU214487 | Histogenetics, Ossining, USA |
| DRB5*02:07 | HG00011294 | KU248922 | Histogenetics, Ossining, USA |
| DQB1*03:01:32 | HG00010084 | KP342361 | Histogenetics, Ossining, USA |
| DQB1*03:19:02 | HG00010487 | KT037060 | Histogenetics, Ossining, USA |
| DQB1*03:222 | SZGSQ 25 | KU575250 | Su-Qing Gao, Shenzhen, China |
| DPB1*04:01:32 | HG00010297 | KR047766 | Histogenetics, Ossining, USA |
| DPB1*423:01:02 | HG00011296 | KU248920 | Histogenetics, Ossining, USA |
| DPB1*537:01 | HG00011295 | KU167595 | Histogenetics, Ossining, USA |
| DPB1*538:01 | HG00011297 | KU167606 | Histogenetics, Ossining, USA |
| DPB1*539:01 | HG00011298 | KU302295 | Histogenetics, Ossining, USA |
| DPB1*540:01 | HG00011300 | KU302297 | Histogenetics, Ossining, USA |
| DPB1*541:01 | HG00011301 | KU167599 | Histogenetics, Ossining, USA |
| DPB1*542:01 | HG00011303 | KU302296 | Histogenetics, Ossining, USA |
| DPB1*543:01 | HG00011304 | KU167596 | Histogenetics, Ossining, USA |
| DPB1*544:01 | HG00011305 | KU187275 | Histogenetics, Ossining, USA |
| DPB1*545:01 | HG00011306 | KU214488 | Histogenetics, Ossining, USA |
| DPB1*546:01 | HG00011307 | KU167605 | Histogenetics, Ossining, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:03:01 | GEE018 | LN999851 | Steven GE Marsh, London, United Kingdom |
| A*02:04 | 6966_C01 | LN999848 | Steven GE Marsh, London, United Kingdom |
| A*02:564 | NT01311 | KU324523 | Carolyn K Hurley, Washington DC, USA |
| A*11:09 | 6966_B04 | LN999846 | Steven GE Marsh, London, United Kingdom |
| A*26:02:01 | 6966_B07 | LN999847 | Steven GE Marsh, London, United Kingdom |
| A*29:01:01:01 | GEE018 | LN999852 | Steven GE Marsh, London, United Kingdom |
| A*66:03 | 6966_F04 | LN999850 | Steven GE Marsh, London, United Kingdom |
| B*07:05:01 | GEE018 | LN999853 | Steven GE Marsh, London, United Kingdom |
| B*15:19 | GEE018 | LN999854 | Steven GE Marsh, London, United Kingdom |
| B*51:200 | M-569432 | LN997808 | Kristin Kipper, Martinsried, Germany |
| B*56:02:02 | NT01318 | KU324538 | Carolyn K Hurley, Washington DC, USA |
| C*01:93 | NT01308 | KU324526 | Carolyn K Hurley, Washington DC, USA |
| C*02:02:27 | NT01300 | KU324532 | Carolyn K Hurley, Washington DC, USA |
| C*03:03:27 | NT01310 | KU324524 | Carolyn K Hurley, Washington DC, USA |
| C*03:87:02 | NT01303 | KU324530 | Carolyn K Hurley, Washington DC, USA |
| C*04:03:01 | GEE018 | LN999855 | Steven GE Marsh, London, United Kingdom |
| C*04:13 | 6966_D05 | LN999849 | Steven GE Marsh, London, United Kingdom |
| C*06:127:01 | NT01313 | KU324521 | Carolyn K Hurley, Washington DC, USA |
| C*06:138 | NT01314 | KU324542 | Carolyn K Hurley, Washington DC, USA |
| DRB1*04:205 | 18517 | LN998644 | Maria Loginova, Kirov, Russia |
| DQB1*05:01:01:03 | DKMS-LSL-DQB1-491 | LN871066 | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*04:01:04 | BY00788 | HQ717411 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:07:08 | (3) |
| A*02:431 | (4) |
| A*24:309 | (5) |
| B*07:261 | (6) |
| B*15:259 | (7) |
| B*15:375N | (8) |
| B*35:254 | (9) |
| B*35:269 | (10) |
| B*37:58 | (11) |
| B*40:324 | (12) |
| B*41:43 | (13) |
| DQB1*02:02:01:02 | (14) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291-455.
- Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
- Wang WY, Zhang W, Li LX, Zhu FM, Tian W. Characterization of a new HLA-A allele, HLA-A*02:07:08, by cloning and sequencing. Int J Immunogenet 2016: 43: 109-10.
- Zhen JX, Liang H. Characterization of the novel HLA-A*02:431 allele identified in a Chinese Han individual. HLA 2016: 87: 100-1.
- Sciarrino R, Putignano AL, Biagini C, Rombola G, Curcio M. Identification of a new HLA-A*24 allele, A*24:309, in an Italian bone marrow donor. HLA 2016: 87: 101-2.
- Brunet L, Mouron D, Villard J, Tiercy JM, Buhler S. Identification of the novel HLA-B*07:261 allele. HLA 2016: 87: 102-3.
- Chang CL, Lin CY. A novel allele, HLA-B*15:259, was identified in a Taiwanese individual by sequence-based typing. HLA 2016: 87: 103-4.
- Planelles D, Balas A, Munoz C, Puig N, Vicario JL. A novel null HLA-B allele, B*15:375N, due to a seven base pair deletion within exon 3. HLA 2016: 87: 104-6.
- Li WX, Xia JA, Yuan MX, Li G, Wang X. A novel HLA-B allele, HLA-B*35:254, identified by sequence-based typing from a HIV-associated tuberculosis sufferer. HLA 2016: 87: 106-7.
- Zhu X, Yang T, Tan R, Su P, Li Z. A novel HLA-B allele, HLA-B*35:269. HLA 2016: 87: 107-9.
- Ibanez C, Marie-Line M, Canivet S, Pellet P, Ba I. A novel HLA-B*37 allele, HLA-B*37:58, identified in a Turkish family. HLA 2016: 87: 109-10.
- Zou J, Qiang W, Shen G, Zhu YY, Li WX, Liu GJ. Identification of a novel HLA-B*40 allele, HLA-B*40:324, by sequence-based typing, in a Chinese individual. HLA 2016: 87: 110-1.
- Santos S, Azkarate M, Eguizabal C, Balas A, Vicario JL. Genomic sequence of HLA-B*41:43, a new HLA-B allele generated by an intralocus recombination mechanism. HLA 2016: 87: 111-3.
- Montero-Martin G, Cervera I, Teniente-Serra A, Fonolleda M, Martinez-Laso J. Description of the novel HLA-DQB1*02:02:01:02 allele in a Spanish individual. HLA 2016: 87: 113-4
