Nomenclature for Factors of the HLA System

January 2016

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/ipd/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:74HG00010136KP872780Histogenetics, Ossining, USA
A*01:01:75HG00010224KR047745Histogenetics, Ossining, USA
A*02:01:122HG00010233KR047746Histogenetics, Ossining, USA
A*03:01:57H2846KP234088Xiaojing Wang, Tianjin, China
A*11:01:70HG00010218KR153541Histogenetics, Ossining, USA
A*23:7028414LN998640Maria Loginova, Kirov, Russia
A*29:84NT01305KU324528Carolyn K Hurley, Washington DC, USA
A*29:85M-568345LN997806Kristin Kipper, Martinsried, Germany
A*33:03:31386806LN995839Edward KL Yang, Hualien, Taiwan
B*07:02:49HG00010346KR677049Histogenetics, Ossining, USA
B*07:2662019LN998641Maria Loginova, Kirov, Russia
B*07:26720819LN998649Maria Loginova, Kirov, Russia
B*08:01:33HG00010248KR153542Histogenetics, Ossining, USA
B*08:01:34HG00010336KR677050Histogenetics, Ossining, USA
B*08:15927756LN998646Maria Loginova, Kirov, Russia
B*13:8881140928KU499989Daniel Fuerst, Ulm, Germany
B*15:02:10HG00010340KR270569Histogenetics, Ossining, USA
B*15:03:06HG00010344KR818715Histogenetics, Ossining, USA
B*15:380N FALA799527,
HAYO799382,
MOLA799284,
MOLA799613,
MALA800359
LN999845Steven GE Marsh, London, United Kingdom
B*27:147P10037KU350631Faming Zhu, Hangzhou, China
B*38:60NT01297KU324520Carolyn K Hurley, Washington DC, USA
B*39:11523855LN998645Maria Loginova, Kirov, Russia
B*40:01:45SZGSQ 26KU575251Su-Qing Gao, Shenzhen, China
B*40:02:2519224LN998642Maria Loginova, Kirov, Russia
B*44:02:40 BY01107,
BY01205
KF482396,
KJ418363
Carolyn K Hurley, Washington DC, USA
B*46:66BY01301KU516828Carolyn K Hurley, Washington DC, USA
B*50:44NT01299KU324518Carolyn K Hurley, Washington DC, USA
B*51:20117800LN998643Maria Loginova, Kirov, Russia
C*01:02:37BY01061KF266817Carolyn K Hurley, Washington DC, USA
C*01:02:38HG00010255KR105364Histogenetics, Ossining, USA
C*03:03:30NT01301KU324533Carolyn K Hurley, Washington DC, USA
C*04:01:7120018LN998648Maria Loginova, Kirov, Russia
C*04:01:7225966LN998647Maria Loginova, Kirov, Russia
C*05:128NNT01302KU324531Carolyn K Hurley, Washington DC, USA
C*06:02:45NT01320KU324536Carolyn K Hurley, Washington DC, USA
C*07:01:53HG00010261KR082295Histogenetics, Ossining, USA
C*07:02:72HG00010053KP792206Histogenetics, Ossining, USA
C*07:02:73HG00010060KP325457Histogenetics, Ossining, USA
C*07:488NT01298KU324519Carolyn K Hurley, Washington DC, USA
C*07:48981137868KU499987Daniel Fuerst, Ulm, Germany
C*08:129NBY01300KU324517Carolyn K Hurley, Washington DC, USA
C*15:02:25BY01067KF266811Carolyn K Hurley, Washington DC, USA
C*15:02:26BY01173KF946535Carolyn K Hurley, Washington DC, USA
C*15:122NNT01317KU324539Carolyn K Hurley, Washington DC, USA
C*16:01:20NT01304KU324529Carolyn K Hurley, Washington DC, USA
C*16:93NT01315KU324541Carolyn K Hurley, Washington DC, USA
DRB1*07:69M-565572LN997809Kristin Kipper, Martinsried, Germany
DRB1*11:198M-554548LN997810Kristin Kipper, Martinsried, Germany
DRB1*14:172331239LN875779Valentina Cappuzzo, Palermo, Italy
DRB3*01:20HG00011269KU248917Histogenetics, Ossining, USA
DRB3*01:21HG00011270KU302289Histogenetics, Ossining, USA
DRB3*01:22HG00011271KU167589Histogenetics, Ossining, USA
DRB3*02:34HG00011273KU167590Histogenetics, Ossining, USA
DRB3*02:35HG00011274KU248918Histogenetics, Ossining, USA
DRB3*02:3681139579KU517233Daniel Fuerst, Ulm, Germany
DRB3*03:05 HG00011275,
HG00011276
KU214481,
KU187273
Histogenetics, Ossining, USA
DRB3*03:06HG00011277KU302290Histogenetics, Ossining, USA
DRB4*01:11HG00011278KU248924Histogenetics, Ossining, USA
DRB4*01:12HG00011280KU248925Histogenetics, Ossining, USA
DRB4*01:13HG00011282KU248926Histogenetics, Ossining, USA
DRB4*01:14 HG00011283,
HG00011284,
HG00011285
KU167591,
KU167592,
KU302292
Histogenetics, Ossining, USA
DRB4*01:1493053764KU517236Daniel Fuerst, Ulm, Germany
DRB4*01:15HG00011287KU214485Histogenetics, Ossining, USA
DRB4*01:16NHG00011288KU248919Histogenetics, Ossining, USA
DRB4*01:17 HG00011290,
HG00011291
KU302291,
KU302293
Histogenetics, Ossining, USA
DRB5*01:18HG00011292KU214487Histogenetics, Ossining, USA
DRB5*02:07HG00011294KU248922Histogenetics, Ossining, USA
DQB1*03:01:32HG00010084KP342361Histogenetics, Ossining, USA
DQB1*03:19:02HG00010487KT037060Histogenetics, Ossining, USA
DQB1*03:222SZGSQ 25KU575250Su-Qing Gao, Shenzhen, China
DPB1*04:01:32HG00010297KR047766Histogenetics, Ossining, USA
DPB1*423:01:02HG00011296KU248920Histogenetics, Ossining, USA
DPB1*537:01HG00011295KU167595Histogenetics, Ossining, USA
DPB1*538:01HG00011297KU167606Histogenetics, Ossining, USA
DPB1*539:01HG00011298KU302295Histogenetics, Ossining, USA
DPB1*540:01HG00011300KU302297Histogenetics, Ossining, USA
DPB1*541:01HG00011301KU167599Histogenetics, Ossining, USA
DPB1*542:01HG00011303KU302296Histogenetics, Ossining, USA
DPB1*543:01HG00011304KU167596Histogenetics, Ossining, USA
DPB1*544:01HG00011305KU187275Histogenetics, Ossining, USA
DPB1*545:01HG00011306KU214488Histogenetics, Ossining, USA
DPB1*546:01HG00011307KU167605Histogenetics, Ossining, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:03:01GEE018LN999851Steven GE Marsh, London, United Kingdom
A*02:046966_C01LN999848Steven GE Marsh, London, United Kingdom
A*02:564NT01311KU324523Carolyn K Hurley, Washington DC, USA
A*11:096966_B04LN999846Steven GE Marsh, London, United Kingdom
A*26:02:016966_B07LN999847Steven GE Marsh, London, United Kingdom
A*29:01:01:01GEE018LN999852Steven GE Marsh, London, United Kingdom
A*66:036966_F04LN999850Steven GE Marsh, London, United Kingdom
B*07:05:01GEE018LN999853Steven GE Marsh, London, United Kingdom
B*15:19GEE018LN999854Steven GE Marsh, London, United Kingdom
B*51:200M-569432LN997808Kristin Kipper, Martinsried, Germany
B*56:02:02NT01318KU324538Carolyn K Hurley, Washington DC, USA
C*01:93NT01308KU324526Carolyn K Hurley, Washington DC, USA
C*02:02:27NT01300KU324532Carolyn K Hurley, Washington DC, USA
C*03:03:27NT01310KU324524Carolyn K Hurley, Washington DC, USA
C*03:87:02NT01303KU324530Carolyn K Hurley, Washington DC, USA
C*04:03:01GEE018LN999855Steven GE Marsh, London, United Kingdom
C*04:136966_D05LN999849Steven GE Marsh, London, United Kingdom
C*06:127:01NT01313KU324521Carolyn K Hurley, Washington DC, USA
C*06:138NT01314KU324542Carolyn K Hurley, Washington DC, USA
DRB1*04:20518517LN998644Maria Loginova, Kirov, Russia
DQB1*05:01:01:03DKMS-LSL-DQB1-491LN871066DKMS Life Sciences Lab, Dresden, Germany
DPB1*04:01:04BY00788HQ717411Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*02:07:08(3)
A*02:431(4)
A*24:309(5)
B*07:261(6)
B*15:259(7)
B*15:375N(8)
B*35:254(9)
B*35:269(10)
B*37:58(11)
B*40:324(12)
B*41:43(13)
DQB1*02:02:01:02(14)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
  3. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291-455.
  4. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015: 43: D423-31.
  5. Wang WY, Zhang W, Li LX, Zhu FM, Tian W. Characterization of a new HLA-A allele, HLA-A*02:07:08, by cloning and sequencing. Int J Immunogenet 2016: 43: 109-10.
  6. Zhen JX, Liang H. Characterization of the novel HLA-A*02:431 allele identified in a Chinese Han individual. HLA 2016: 87: 100-1.
  7. Sciarrino R, Putignano AL, Biagini C, Rombola G, Curcio M. Identification of a new HLA-A*24 allele, A*24:309, in an Italian bone marrow donor. HLA 2016: 87: 101-2.
  8. Brunet L, Mouron D, Villard J, Tiercy JM, Buhler S. Identification of the novel HLA-B*07:261 allele. HLA 2016: 87: 102-3.
  9. Chang CL, Lin CY. A novel allele, HLA-B*15:259, was identified in a Taiwanese individual by sequence-based typing. HLA 2016: 87: 103-4.
  10. Planelles D, Balas A, Munoz C, Puig N, Vicario JL. A novel null HLA-B allele, B*15:375N, due to a seven base pair deletion within exon 3. HLA 2016: 87: 104-6.
  11. Li WX, Xia JA, Yuan MX, Li G, Wang X. A novel HLA-B allele, HLA-B*35:254, identified by sequence-based typing from a HIV-associated tuberculosis sufferer. HLA 2016: 87: 106-7.
  12. Zhu X, Yang T, Tan R, Su P, Li Z. A novel HLA-B allele, HLA-B*35:269. HLA 2016: 87: 107-9.
  13. Ibanez C, Marie-Line M, Canivet S, Pellet P, Ba I. A novel HLA-B*37 allele, HLA-B*37:58, identified in a Turkish family. HLA 2016: 87: 109-10.
  14. Zou J, Qiang W, Shen G, Zhu YY, Li WX, Liu GJ. Identification of a novel HLA-B*40 allele, HLA-B*40:324, by sequence-based typing, in a Chinese individual. HLA 2016: 87: 110-1.
  15. Santos S, Azkarate M, Eguizabal C, Balas A, Vicario JL. Genomic sequence of HLA-B*41:43, a new HLA-B allele generated by an intralocus recombination mechanism. HLA 2016: 87: 111-3.
  16. Montero-Martin G, Cervera I, Teniente-Serra A, Fonolleda M, Martinez-Laso J. Description of the novel HLA-DQB1*02:02:01:02 allele in a Spanish individual. HLA 2016: 87: 113-4