Nomenclature for Factors of the HLA System

December 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 549 alleles were recently published but have not been included in Table 3 due to space considerations (2). The alleles F*01:01:03:01, F*01:01:03:02, F*01:01:03:03 and F*01:01:03:04 have been renamed F*01:01:01:09, F*01:01:01:10, F*01:01:01:11 and F*01:01:01:12, respectively, and their orginal designations have been deleted.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (3). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:19981138557KU199768Daniel Fuerst, Ulm, Germany
A*01:2005082501LN997652Renata Zunec, Zagreb, Croatia
A*02:157:02HG00011047KT968838Histogenetics, Ossining, USA
A*02:604HG00011045KT895305Histogenetics, Ossining, USA
A*02:605QHG00011046KT803910Histogenetics, Ossining, USA
A*02:606HG00011048KT968839Histogenetics, Ossining, USA
A*02:60730364LN908989Maria Loginova, Kirov, Russia
A*02:608N28669LN908987Maria Loginova, Kirov, Russia
A*02:60996085146KU199769Daniel Fuerst, Ulm, Germany
A*02:610378063LN995838Edward KL Yang, Hualien, Taiwan
A*03:237HG00011033KT844477Histogenetics, Ossining, USA
A*03:238HG00011034KT968837Histogenetics, Ossining, USA
A*03:239HG00011036KT968840Histogenetics, Ossining, USA
A*03:240HG00011037KT968834Histogenetics, Ossining, USA
A*03:241HG00011038KT968836Histogenetics, Ossining, USA
A*03:24229257LN908988Maria Loginova, Kirov, Russia
A*11:235Q388595LN995840Edward KL Yang, Hualien, Taiwan
A*24:327Xian61860KR604698Jun Qi, Xian, China
A*24:328HG00011027KT803906Histogenetics, Ossining, USA
A*24:329HG00011028KT943423Histogenetics, Ossining, USA
A*24:330HG00011029KU095786Histogenetics, Ossining, USA
A*24:331HG00011030KT844476Histogenetics, Ossining, USA
A*24:332HG00011031KT984958Histogenetics, Ossining, USA
A*24:333D324276LN909515Edward KL Yang, Hualien, Taiwan
A*24:334395968LN909519Edward KL Yang, Hualien, Taiwan
A*32:81HG00011039KT895303Histogenetics, Ossining, USA
A*32:82HG00011040KT803904Histogenetics, Ossining, USA
A*32:83HG00011041KT895301Histogenetics, Ossining, USA
A*32:84HG00011042KT943424Histogenetics, Ossining, USA
A*68:142NM-494468LN912993Kristin Kipper, Martinsried, Germany
B*07:264NT01283KT893448Carolyn K Hurley, Washington DC, USA
B*07:265M-574144LN912995Kristin Kipper, Martinsried, Germany
B*14:5373297LN995841Jane Rowlands, Pontyclun, United Kingdom
B*18:120M-357208LN912994Kristin Kipper, Martinsried, Germany
B*39:11432810LN908990Maria Loginova, Kirov, Russia
B*40:326399502LN909516Edward KL Yang, Hualien, Taiwan
B*40:327356043LN995836Edward KL Yang, Hualien, Taiwan
B*44:237N0270904217KU057090Wen Qiang, Wuhan, China
B*44:23831214LN908991Maria Loginova, Kirov, Russia
B*46:01:210271508832KU243150Wangxia Li, Wuhan, China
B*46:65337638LN995835Edward KL Yang, Hualien, Taiwan
B*58:02:02NT01282KT893449Carolyn K Hurley, Washington DC, USA
C*01:118HG00011079KT984964Histogenetics, Ossining, USA
C*01:119HG00011080KT984968Histogenetics, Ossining, USA
C*02:110HG00011105KT895313Histogenetics, Ossining, USA
C*02:111HG00011106KT968855Histogenetics, Ossining, USA
C*02:112HG00011109KT984966Histogenetics, Ossining, USA
C*03:308HG00011108KT943440Histogenetics, Ossining, USA
C*03:309HG00011111KT895315Histogenetics, Ossining, USA
C*03:310HG00011112KT943435Histogenetics, Ossining, USA
C*03:31193013850KU199770Daniel Fuerst, Ulm, Germany
C*03:3121434-3PRJEB12062Viktoria Zakharova, Moscow, Russia
C*03:313TS1LC105699Takashi Shiina, Isehara, Japan
C*04:227HG00011113KU095792Histogenetics, Ossining, USA
C*04:228HG00011114KU095791Histogenetics, Ossining, USA
C*04:229HG00011115KT895318Histogenetics, Ossining, USA
C*04:230HG00011116KT803917Histogenetics, Ossining, USA
C*05:127HG00011103KT943436Histogenetics, Ossining, USA
C*06:171NHG00011083KT803914Histogenetics, Ossining, USA
C*06:172HG00011085KT943434Histogenetics, Ossining, USA
C*06:173HG00011093KT895314Histogenetics, Ossining, USA
C*06:42:02HG00011084KT895320Histogenetics, Ossining, USA
C*07:26:02HG00011104KT968853Histogenetics, Ossining, USA
C*07:479HG00011078KT968856Histogenetics, Ossining, USA
C*07:480HG00011082KT968851Histogenetics, Ossining, USA
C*07:481HG00011087KT984965Histogenetics, Ossining, USA
C*07:482HG00011088KT895319Histogenetics, Ossining, USA
C*07:483NHG00011089KU095790Histogenetics, Ossining, USA
C*07:484NHG00011090KT803915Histogenetics, Ossining, USA
C*07:485HG00011091KT968848Histogenetics, Ossining, USA
C*07:486D208295LN909517Edward KL Yang, Hualien, Taiwan
C*07:48715224828KU199764Daniel Fuerst, Ulm, Germany
C*12:17229759LN908992Maria Loginova, Kirov, Russia
C*15:121HG00011110KT803916Histogenetics, Ossining, USA
C*16:90OC0075SRR2182095Bowen Liu, Shandong, China
C*16:91HG00011094KU095795Histogenetics, Ossining, USA
C*16:92M-568097LN912996Kristin Kipper, Martinsried, Germany
C*17:31HG00011102KT943437Histogenetics, Ossining, USA
DRB1*04:203HG00011142KT895335Histogenetics, Ossining, USA
DRB1*04:204HG00011143KT895333Histogenetics, Ossining, USA
DRB1*04:205HG00011144KT895334Histogenetics, Ossining, USA
DRB1*04:206HG00011145KT803922Histogenetics, Ossining, USA
DRB1*04:207364139LN995837Edward KL Yang, Hualien, Taiwan
DRB1*08:03:06HG00011148KT984972Histogenetics, Ossining, USA
DRB1*08:79HG00011147KT943442Histogenetics, Ossining, USA
DRB1*10:01:09BY01283KU159285Carolyn K Hurley, Washington DC, USA
DRB1*11:101:02HG00011151KT844491Histogenetics, Ossining, USA
DRB1*11:197HG00011152KU095797Histogenetics, Ossining, USA
DRB1*12:59HG00011146KT943441Histogenetics, Ossining, USA
DRB1*13:213HG00011149KT968862Histogenetics, Ossining, USA
DRB1*15:130HG00011137KT895329Histogenetics, Ossining, USA
DRB1*15:131HG00011141KT895330Histogenetics, Ossining, USA
DRB1*15:15:02HG00011140KT844489Histogenetics, Ossining, USA
DRB1*16:01:11HG00011138KT844490Histogenetics, Ossining, USA
DRB1*16:02:06HG00011139KT895331Histogenetics, Ossining, USA
DRB3*01:01:06HG00011153KU095801Histogenetics, Ossining, USA
DRB3*02:33HG00011157KU095798Histogenetics, Ossining, USA
DRB3*03:04HG00011158KU095803Histogenetics, Ossining, USA
DRB5*01:01:03HG00011160KU095805Histogenetics, Ossining, USA
DRB5*01:17HG00011159KU095804Histogenetics, Ossining, USA
DQB1*03:219HG00011119KT844488Histogenetics, Ossining, USA
DQB1*03:220HG00011122KT984971Histogenetics, Ossining, USA
DQB1*03:221HG00011123KT968860Histogenetics, Ossining, USA
DQB1*05:112HG00011117KT803918Histogenetics, Ossining, USA
DQB1*05:113HG00011125KU095796Histogenetics, Ossining, USA
DQB1*05:114HG00011126KT895325Histogenetics, Ossining, USA
DQB1*05:115HG00011127KT803920Histogenetics, Ossining, USA
DQB1*05:116HG00011128KT968858Histogenetics, Ossining, USA
DQB1*05:117HG00011131KT803919Histogenetics, Ossining, USA
DQB1*05:118HG00011132KT895322Histogenetics, Ossining, USA
DQB1*05:119HG00011136KT895324Histogenetics, Ossining, USA
DQB1*06:03:22BY01294KU204384Carolyn K Hurley, Washington DC, USA
DQB1*06:199HG00011121KT984969Histogenetics, Ossining, USA
DQB1*06:200BY01297KU214213Carolyn K Hurley, Washington DC, USA
DPB1*02:01:18HG00011167KT895338Histogenetics, Ossining, USA
DPB1*20:01:03HG00011179KT803933Histogenetics, Ossining, USA
DPB1*520:01HG00011161KT803925Histogenetics, Ossining, USA
DPB1*521:01HG00011162KT844493Histogenetics, Ossining, USA
DPB1*522:01HG00011163KT895337Histogenetics, Ossining, USA
DPB1*523:01HG00011164KT968865Histogenetics, Ossining, USA
DPB1*524:01HG00011165KT803930Histogenetics, Ossining, USA
DPB1*525:01HG00011166KT984975Histogenetics, Ossining, USA
DPB1*526:01HG00011169,
HG00011170		KT803926,
 KT803928		Histogenetics, Ossining, USA
DPB1*527:01HG00011172KT844494Histogenetics, Ossining, USA
DPB1*528:01HG00011173KT984973Histogenetics, Ossining, USA
DPB1*529:01HG00011174KT803932Histogenetics, Ossining, USA
DPB1*530:01HG00011175,
HG00011176		KT844495,
 KT984974		Histogenetics, Ossining, USA
DPB1*531:01HG00011178KU095806Histogenetics, Ossining, USA
DPB1*532:01HG00011180KU095808Histogenetics, Ossining, USA
DPB1*533:01BY01292KU173870Carolyn K Hurley, Washington DC, USA
DPB1*534:01BY01291KU173871Carolyn K Hurley, Washington DC, USA
DPB1*534:01BY01291KU204381Carolyn K Hurley, Washington DC, USA
DPB1*535:01BY01289KU173873Carolyn K Hurley, Washington DC, USA
DPB1*536:01BY01293KU204383Carolyn K Hurley, Washington DC, USA
E*01:01:01:0430401LN846935Marcel GJ Tilanus, Maastricht, The Netherlands
E*01:01:01:0540423LN846936Marcel GJ Tilanus, Maastricht, The Netherlands
E*01:1013713LN846934Marcel GJ Tilanus, Maastricht, The Netherlands
F*01:01:01:09LKT3AB088082Hidetoshi Inoko, Isehara, Kanagawa, Japan
F*01:01:01:09LBF,
STEINLIN,
BM15		AF523285,
 AF523286,
 AF523289		Daniel E Geraghty, Seattle, USA
F*01:01:01:09COXAL669813Stephan Beck, London, United Kingdom
F*01:01:01:09RPCI5AB023058Hidetoshi Inoko, Isehara, Kanagawa, Japan
F*01:01:01:10IHW01143,
IHW01152		AY645752Daniel E Geraghty, Seattle, USA
F*01:01:01:11MT14BAF523290Daniel E Geraghty, Seattle, USA
F*01:01:01:12435,
1350,
1199		AF523293,
 AF523296,
 AF523297		Daniel E Geraghty, Seattle, USA
MICA*012:05SINC14,
SINC15		KU213643Wei Tian, Changsha, China
MICA*0875404SKU199765Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*26:04280599KU233191Konstantinos Barsakis, Palo Alto, USA
A*69:01IDFKU233190Konstantinos Barsakis, Palo Alto, USA
DRB3*02:02:06HG00011154KU095802Histogenetics, Ossining, USA
DQB1*06:77NBY01298KU201527Carolyn K Hurley, Washington DC, USA
DQB1*06:78BY01296KU204386Carolyn K Hurley, Washington DC, USA
DPB1*225:01BY01290KU173872Carolyn K Hurley, Washington DC, USA
DPB1*350:01BY01295KU204385Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*02:06:21(7)
A*02:432(8)
A*02:572(9)
A*02:586(10)
A*03:225(9)
A*11:152(11)
A*23:01:01(12)
A*23:68(13)
A*24:02:01:01(12)
A*24:03:01(14)
A*24:07:01(14)
A*24:321(15)
B*35:168(16)
B*40:306(17)
B*58:72N(18)
C*08:121N(19)
DRB1*03:112(20)
DRB1*14:166N(21)
DRB1*15:66:02(22)
DQB1*03:02:16(20)
DQB1*03:139(20)
DQB1*04:01:01(23)
DQB1*06:126(24)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010 75 291-455.
  2. Hern�ndez-Frederick CJ, Cereb N, Giani AS, et al. Detection of 549 new HLA alleles in potential stem cell donors from the United States, Poland and Germany. HLA. 2016 87 31-5.
  3. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res. 2015 43 D423-31.
  4. Shiina T, Tamiya G, Oka A, et al. Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc Natl Acad Sci USA. 1999 96 13282-7.
  5. Pyo CW, Williams LM, Moore Y, et al. HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes. Immunogenetics. 2006 58 241-51.
  6. Stewart CA, Horton R, Allcock RJ, et al. Complete MHC haplotype sequencing for common disease gene mapping. Genome Res. 2004 14 1176-87.
  7. Yang KL, Ng J, Lazaro A, Hung JH, Lin PY. HLA-A*02:06:21, a novel variant of HLA-A*02:06, discovered in a Taiwanese bone marrow hematopoietic stem cell donor. HLA. 2016 87 36-7.
  8. Jin SZ, Li Z, Zou HY. Identification of a novel HLA-A*02 allele, HLA-A*02:432, in a Chinese individual. HLA. 2016 87 37-8.
  9. Balas A, Garcia-Sanchez F, Vicario JL. Description of two new HLA-A alleles, HLA-A*02:572 and HLA-A*03:225. HLA. 2016 87 39-40.
  10. Yang KL, Ng J, Lazaro A, Hung JH, Lin PY. Identification of a novel HLA-A*02 variant, HLA-A*02:586, in a Taiwanese bone marrow hematopoietic stem cell donor. HLA. 2016 87 40-1.
  11. Shen G, Qiang W, Zhu YY, et al. A novel allele HLA-A*11:152 was identified by sequence-based typing in a Chinese individual. HLA. 2016 87 41-2.
  12. Wang SX, Xu YP, Zhang H. Genomic full-length sequence of two HLA-A alleles, A*23:01:01 and A*24:02:01:01, identified by cloning and sequencing. HLA. 2016 87 43-5.
  13. Street J, Lemin AJ, Darke C. A further HLA-A*23 family allele - HLA-A*23:68. HLA. 2016 87 49-50.
  14. Xu YP, Wang SX. Genomic full-length sequence of two HLA-A alleles, A*24:03:01 and A*24:07:01, identified by cloning and sequencing. HLA. 2016 87 46-8.
  15. Azkarate M, Santos S, Eguizabal C, Balas A, Vicario JL. The new HLA-A*24:321 shows one conservative amino acid replacement compared with HLA-A*24:02:01. HLA. 2016 87 50-1.
  16. Li XF, Li GJ, Zhang X, Li JP. HLA-B*35:168, a novel HLA allele identified in a Chinese platelet donor. HLA. 2016 87 51-2.
  17. Yang KL, Hung JH, Lin PY. HLA-B*40:306, a novel variant of HLA-B*40, discovered in a Taiwanese bone marrow hematopoietic stem cell donor. HLA. 2016 87 53-4.
  18. Yang KL, Hung JH, Lin PY. A single nucleotide insertion in Exon 3 produces a novel HLA-B*58 null allele, HLA-B*58:72N. HLA. 2016 87 54-5.
  19. Zhang X, Reed EF. A novel HLA-C null allele, HLA-C*08:121N. HLA 2016 87 55-6.
  20. Street J, Johnson J, Lemin AJ, Harvey C, Darke C. Immunogenetics of three novel HLA-Class II alleles: DRB1*03:112, DQB1*03:02:16 and DQB1*03:139. Int J Immunogenet 2015.
  21. Testi M, Troiano M, Paladini E, Di Luzio A, Andreani M. A nucleotide insertion in Exon 2 is responsible for a new HLA-DRB1 null allele, HLA-DRB1*14:166N. HLA. 2016 87 60.
  22. Nie XM, Zhang Y, Qiao WB, Zhu CF, Zhao YR. A novel HLA-DRB1 allele, DRB1*15:66:02 was identified in a Chinese potential donor by sequence-based typing. HLA 2016 87 61-3.
  23. Okudaira Y, Hosomichi K, Ozaki Y, Shiina T, Mitsunaga S. Correction of the HLA-DQB1*04:01:01 sequence at position 79 in exon 1. HLA. 2016 87 57-8.
  24. Fakhoury HA, Alzahrani M, Alaskar AS, Hajeer AH. Description of a novel HLA-DQB1 allele, HLA-DQB1*06:126, in the Saudi stem cell donor registry. HLA. 2016 87 58-9.