Nomenclature for Factors of the HLA System
October 2015
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- HLA (2016) 87:117-21
- Human Immunology (2016) 77:440-4
- International Journal of Immunogenetics (2016) 43:111-5
The following sequences have been submitted to the Nomenclature Committee since the September 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:197 | HG00010818 | KT710866 | Histogenetics, Ossining, USA |
| A*01:198 | HG00010821 | KT600076 | Histogenetics, Ossining, USA |
| A*02:01:121 | NT01279 | KT819313 | Carolyn K Hurley, Washington DC, USA |
| A*02:599 | HG00010827 | KT600073 | Histogenetics, Ossining, USA |
| A*02:600 | HG00010828 | KT600078 | Histogenetics, Ossining, USA |
| A*02:601 | HG00010829 | KT710868 | Histogenetics, Ossining, USA |
| A*03:01:01:06 | NT01275 | KT819308 | Carolyn K Hurley, Washington DC, USA |
| A*03:154:02 | 15207482 | KT803854 | Daniel Fuerst, Ulm, Germany |
| A*03:235 | HG00010822 | KT760491 | Histogenetics, Ossining, USA |
| A*03:236 | HG00010823 | KT600070 | Histogenetics, Ossining, USA |
| A*24:324 | HG00010816 | KT600071 | Histogenetics, Ossining, USA |
| A*24:325 | SZGSQ24 | KT826594 | Su-Qing Gao, Shenzhen, China |
| A*24:326 | 275881 | KT878496 | Elena Longhi, Milano, Italy |
| A*30:01:11 | NT01272 | KT819305 | Carolyn K Hurley, Washington DC, USA |
| A*31:104 | HG00010808 | KT760485 | Histogenetics, Ossining, USA |
| A*32:80 | HG00010824 | KT760482 | Histogenetics, Ossining, USA |
| A*33:105 | HG00010809 | KT760493 | Histogenetics, Ossining, USA |
| A*68:138 | HG00010812 | KT710867 | Histogenetics, Ossining, USA |
| A*68:139 | NT01278 | KT819312 | Carolyn K Hurley, Washington DC, USA |
| A*74:27 | HG00010825 | KT760483 | Histogenetics, Ossining, USA |
| B*07:257 | HG00010700 | KT438907 | Histogenetics, Ossining, USA |
| B*07:258 | HG00010702 | KT438910 | Histogenetics, Ossining, USA |
| B*07:259 | HG00010857 | KT760505 | Histogenetics, Ossining, USA |
| B*07:260 | HG00010858 | KT760506 | Histogenetics, Ossining, USA |
| B*08:157 | HG00010836 | KT600096 | Histogenetics, Ossining, USA |
| B*08:158 | HG00010838 | KT710870 | Histogenetics, Ossining, USA |
| B*13:86 | HG00010840 | KT600089 | Histogenetics, Ossining, USA |
| B*13:87 | BY01270 | KT764976 | Carolyn K Hurley, Washington DC, USA |
| B*14:51 | HG00010856 | KT600097 | Histogenetics, Ossining, USA |
| B*15:04:03 | HG00010849 | KT600091 | Histogenetics, Ossining, USA |
| B*15:375N | 60750978 | KT768091 | Antonio Balas, Madrid, Spain |
| B*15:376 | HG00010852 | KT600094 | Histogenetics, Ossining, USA |
| B*15:377Q | NT01277 | KT819311 | Carolyn K Hurley, Washington DC, USA |
| B*18:01:24 | TMO27647 | KT807796 | Antonio Balas, Madrid, Spain |
| B*27:146 | HG00010830 | KT600085 | Histogenetics, Ossining, USA |
| B*35:301 | HG00010839 | KT600081 | Histogenetics, Ossining, USA |
| B*35:302 | HG00010843 | KT760498 | Histogenetics, Ossining, USA |
| B*35:303 | HG00010845 | KT760503 | Histogenetics, Ossining, USA |
| B*35:304 | HG00010846 | KT760495 | Histogenetics, Ossining, USA |
| B*35:305 | 96083726 | KT803855 | Daniel Fuerst, Ulm, Germany |
| B*35:306 | 93103407 | KT803856 | Daniel Fuerst, Ulm, Germany |
| B*38:59 | HG00010706 | KT355342 | Histogenetics, Ossining, USA |
| B*39:108 | HG00010704 | KT438911 | Histogenetics, Ossining, USA |
| B*39:109 | HG00010705 | KT315593 | Histogenetics, Ossining, USA |
| B*39:110 | HG00010708 | KT315595 | Histogenetics, Ossining, USA |
| B*40:318 | HG00010709 | KT438909 | Histogenetics, Ossining, USA |
| B*40:319 | HG00010831 | KT600082 | Histogenetics, Ossining, USA |
| B*40:320 | HG00010834 | KT600092 | Histogenetics, Ossining, USA |
| B*40:321 | BY01275 | KT819316 | Carolyn K Hurley, Washington DC, USA |
| B*41:42 | HG00010833 | KT760494 | Histogenetics, Ossining, USA |
| B*41:43 | 15700134 | KT852371 | Antonio Balas, Madrid, Spain |
| B*41:44 | NT01281 | KT819315 | Carolyn K Hurley, Washington DC, USA |
| B*42:22 | HG00010701 | KT282157 | Histogenetics, Ossining, USA |
| B*44:03:31 | HG00010861 | KT600093 | Histogenetics, Ossining, USA |
| B*44:03:32 | NT01280 | KT819314 | Carolyn K Hurley, Washington DC, USA |
| B*44:128:02 | LUMC-B-126 | LN887899 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*44:235 | HG00010841 | KT760501 | Histogenetics, Ossining, USA |
| B*45:18 | HG00010832 | KT760496 | Histogenetics, Ossining, USA |
| B*48:38 | HG00010860 | KT600090 | Histogenetics, Ossining, USA |
| B*51:196 | HG00010853 | KT760507 | Histogenetics, Ossining, USA |
| B*51:197 | HG00010854 | KT710873 | Histogenetics, Ossining, USA |
| B*51:198 | HG00010855 | KT600084 | Histogenetics, Ossining, USA |
| B*56:50 | 282336 | KT821556 | Elena Longhi, Milano, Italy |
| B*57:81 | HG00010850 | KT600083 | Histogenetics, Ossining, USA |
| B*57:82 | BY01274 | KT764975 | Carolyn K Hurley, Washington DC, USA |
| B*58:59:02 | HG00010848 | KT760500 | Histogenetics, Ossining, USA |
| B*58:74 | HG00010699 | KT315597 | Histogenetics, Ossining, USA |
| B*58:75 | HG00010847 | KT710871 | Histogenetics, Ossining, USA |
| B*58:76 | NT01271 | KT764974 | Carolyn K Hurley, Washington DC, USA |
| C*01:115 | HG00010862 | KT760521 | Histogenetics, Ossining, USA |
| C*01:116 | 81136719 | KT803858 | Daniel Fuerst, Ulm, Germany |
| C*01:117N | NT01273 | KT819306 | Carolyn K Hurley, Washington DC, USA |
| C*02:06:02 | BY01271 | KT764979 | Carolyn K Hurley, Washington DC, USA |
| C*02:10:01:02 | NT01276 | KT819309 | Carolyn K Hurley, Washington DC, USA |
| C*02:109 | HG00010889 | KT600113 | Histogenetics, Ossining, USA |
| C*03:04:49 | LUMC-C-117 | LN887896 | Jacqy DH Anholts, Leiden, The Netherlands |
| C*03:57:02 | HG00010737 | KT282169 | Histogenetics, Ossining, USA |
| C*03:304 | HG00010736 | KT282176 | Histogenetics, Ossining, USA |
| C*03:305 | HG00010738 | KT361896 | Histogenetics, Ossining, USA |
| C*03:306 | HG00010739 | KT282168 | Histogenetics, Ossining, USA |
| C*03:307 | HG00010894 | KT710876 | Histogenetics, Ossining, USA |
| C*04:218 | HG00010741, HG00010742 | KT282167, KT282174 | Histogenetics, Ossining, USA |
| C*04:219 | HG00010743 | KT235658 | Histogenetics, Ossining, USA |
| C*04:220 | HG00010865 | KT760516 | Histogenetics, Ossining, USA |
| C*04:221 | HG00010898 | KT760514 | Histogenetics, Ossining, USA |
| C*04:222 | HG00010899 | KT600112 | Histogenetics, Ossining, USA |
| C*04:223 | HG00010900 | KT600123 | Histogenetics, Ossining, USA |
| C*04:224 | HG00010901 | KT600106 | Histogenetics, Ossining, USA |
| C*04:225N | HG00010902 | KT760508 | Histogenetics, Ossining, USA |
| C*04:226 | LUMC-C-118 | LN887897 | Jacqy DH Anholts, Leiden, The Netherlands |
| C*05:125 | HG00010724 | KT361897 | Histogenetics, Ossining, USA |
| C*05:126 | HG00010886 | KT600122 | Histogenetics, Ossining, USA |
| C*06:167 | HG00010711 | KT315601 | Histogenetics, Ossining, USA |
| C*06:168 | HG00010712 | KT235659 | Histogenetics, Ossining, USA |
| C*06:169 | HG00010864 | KT600116 | Histogenetics, Ossining, USA |
| C*06:170 | HG00010866 | KT710874 | Histogenetics, Ossining, USA |
| C*07:257:04 | HG00010870 | KT600119 | Histogenetics, Ossining, USA |
| C*07:460 | HG00010716 | KT355373 | Histogenetics, Ossining, USA |
| C*07:461 | HG00010717 | KT355367 | Histogenetics, Ossining, USA |
| C*07:462 | HG00010718 | KT315604 | Histogenetics, Ossining, USA |
| C*07:463 | HG00010719 | KT282172 | Histogenetics, Ossining, USA |
| C*07:464 | HG00010721 | KT315606 | Histogenetics, Ossining, USA |
| C*07:465 | HG00010723 | KT282179 | Histogenetics, Ossining, USA |
| C*07:466 | HG00010868 | KT760522 | Histogenetics, Ossining, USA |
| C*07:467 | HG00010869 | KT760512 | Histogenetics, Ossining, USA |
| C*07:468 | HG00010871 | KT600103 | Histogenetics, Ossining, USA |
| C*07:469 | HG00010872 | KT760510 | Histogenetics, Ossining, USA |
| C*07:470 | HG00010875 | KT600111 | Histogenetics, Ossining, USA |
| C*07:471 | HG00010876 | KT760524 | Histogenetics, Ossining, USA |
| C*07:472 | HG00010878 | KT600120 | Histogenetics, Ossining, USA |
| C*07:473 | HG00010879 | KT760520 | Histogenetics, Ossining, USA |
| C*07:474 | HG00010880 | KT760532 | Histogenetics, Ossining, USA |
| C*07:475 | HG00010882 | KT760528 | Histogenetics, Ossining, USA |
| C*07:476N | HG00010722 | KT315600 | Histogenetics, Ossining, USA |
| C*08:126 | HG00010725 | KT361894 | Histogenetics, Ossining, USA |
| C*08:127N | 13QB5759 | KP760115 | Janette Kwok, Pokfulam Road, Hong Kong |
| C*12:168 | HG00010728 | KT282164 | Histogenetics, Ossining, USA |
| C*12:169 | HG00010729 | KT355374 | Histogenetics, Ossining, USA |
| C*12:170 | HG00010888 | KT600105 | Histogenetics, Ossining, USA |
| C*12:171 | 281512 | KT878495 | Elena Longhi, Milano, Italy |
| C*14:73 | HG00010897 | KT760529 | Histogenetics, Ossining, USA |
| C*15:118 | HG00010731, HG00010732 | KT282163, KT282166 | Histogenetics, Ossining, USA |
| C*15:119 | HG00010890 | KT760519 | Histogenetics, Ossining, USA |
| C*15:120 | HG00010892 | KT760530 | Histogenetics, Ossining, USA |
| C*16:88 | HG00010727 | KT282178 | Histogenetics, Ossining, USA |
| C*16:89N | HG00010730 | KT282159 | Histogenetics, Ossining, USA |
| C*18:10 | NT01274 | KT819307 | Carolyn K Hurley, Washington DC, USA |
| DRB1*01:65:02 | HG00010916 | KT600135 | Histogenetics, Ossining, USA |
| DRB1*03:126 | HG00010776 | KT282190 | Histogenetics, Ossining, USA |
| DRB1*03:127 | HG00010912 | KT760538 | Histogenetics, Ossining, USA |
| DRB1*07:67 | HG00010915 | KT600137 | Histogenetics, Ossining, USA |
| DRB1*08:78N | HG00010917 | KT600130 | Histogenetics, Ossining, USA |
| DRB1*11:02:05 | HG00010922 | KT760539 | Histogenetics, Ossining, USA |
| DRB1*13:211 | HG00010919 | KT760542 | Histogenetics, Ossining, USA |
| DRB1*13:212 | HG00010920 | KT760540 | Histogenetics, Ossining, USA |
| DRB1*14:169 | HG00010780 | KT438916 | Histogenetics, Ossining, USA |
| DRB1*14:170 | HG00010923 | KT760543 | Histogenetics, Ossining, USA |
| DRB1*15:01:28 | HG00010914 | KT760541 | Histogenetics, Ossining, USA |
| DRB1*15:128 | HG00010913 | KT600131 | Histogenetics, Ossining, USA |
| DRB1*15:129N | LUMC-DRB1-124 | LN887900 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB3*01:18 | HG00010937 | KT781582 | Histogenetics, Ossining, USA |
| DRB3*01:19 | HG00010938 | KT781581 | Histogenetics, Ossining, USA |
| DRB3*02:02:06 | LUMC-DRB3-122 | LN887898 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB3*02:30 | HG00010939 | KT781583 | Histogenetics, Ossining, USA |
| DRB3*02:31 | HG00010940 | KT781584 | Histogenetics, Ossining, USA |
| DRB3*02:32 | HG00010941 | KT781585 | Histogenetics, Ossining, USA |
| DQA1*01:13 | 60753693 | KT807797 | Antonio Balas, Madrid, Spain |
| DQB1*02:65 | SNUH150818_27385852 | KT878020 | Oh-Joong Kwon, Seoul, South Korea |
| DQB1*03:216 | HG00010903 | KT710877 | Histogenetics, Ossining, USA |
| DQB1*03:217 | HG00010905 | KT760536 | Histogenetics, Ossining, USA |
| DQB1*03:218 | 93023157 | KT803857 | Daniel Fuerst, Ulm, Germany |
| DQB1*04:33 | HG00010910 | KT600129 | Histogenetics, Ossining, USA |
| DQB1*05:66:02 | IU060320150001 | KT728007 | Jeremy Sherrill, Indianapolis, USA |
| DQB1*05:89:02 | HG00010906 | KT760533 | Histogenetics, Ossining, USA |
| DQB1*05:110N | HG00010908 | KT600125 | Histogenetics, Ossining, USA |
| DQB1*05:111 | HG00010909 | KT760534 | Histogenetics, Ossining, USA |
| DQB1*06:198 | HG00010911 | KT600126 | Histogenetics, Ossining, USA |
| DPA1*02:01:01:02 | BY01256 | KT716046 | Carolyn K Hurley, Washington DC, USA |
| DPB1*14:01:03 | HG00010931 | KT760552 | Histogenetics, Ossining, USA |
| DPB1*498:01 | UNC11 | KT001470 | Eric Weimer, Chapel Hill, USA |
| DPB1*499:01 | HG00010789 | KT315617 | Histogenetics, Ossining, USA |
| DPB1*500:01 | HG00010791 | KT315616 | Histogenetics, Ossining, USA |
| DPB1*501:01 | HG00010793 | KT355357 | Histogenetics, Ossining, USA |
| DPB1*502:01 | HG00010794 | KT438920 | Histogenetics, Ossining, USA |
| DPB1*503:01 | HG00010796 | KT361915 | Histogenetics, Ossining, USA |
| DPB1*504:01 | HG00010797 | KT361912 | Histogenetics, Ossining, USA |
| DPB1*505:01 | HG00010798 | KT282196 | Histogenetics, Ossining, USA |
| DPB1*506:01 | HG00010800 | KT235669 | Histogenetics, Ossining, USA |
| DPB1*507:01N | HG00010802, HG00010803 | KT438918, KT361911 | Histogenetics, Ossining, USA |
| DPB1*508:01 | HG00010804 | KT235664 | Histogenetics, Ossining, USA |
| DPB1*509:01 | HG00010806 | KT315618 | Histogenetics, Ossining, USA |
| DPB1*510:01 | HG00010925 | KT600138 | Histogenetics, Ossining, USA |
| DPB1*511:01 | HG00010926 | KT600145 | Histogenetics, Ossining, USA |
| DPB1*512:01 | HG00010928 | KT760547 | Histogenetics, Ossining, USA |
| DPB1*513:01 | HG00010930 | KT600142 | Histogenetics, Ossining, USA |
| DPB1*514:01 | HG00010932, HG00010933 | KT760546, KT600143 | Histogenetics, Ossining, USA |
| DPB1*515:01 | HG00010934 | KT760544 | Histogenetics, Ossining, USA |
| DPB1*516:01 | HG00010935 | KT760553 | Histogenetics, Ossining, USA |
| DPB1*517:01 | HG00010936 | KT760549 | Histogenetics, Ossining, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:190 | 281368 | KT878494 | Elena Longhi, Milano, Italy |
| A*11:190 | BY01273 | KT764980 | Carolyn K Hurley, Washington DC, USA |
| B*07:02:48 | HG00010859 | KT600086 | Histogenetics, Ossining, USA |
| B*18:01:21 | BY01272 | KT764977 | Carolyn K Hurley, Washington DC, USA |
| B*38:01:08 | HG00010707 | KT315592 | Histogenetics, Ossining, USA |
| B*40:01:40 | BY01214 | KJ623754 | Carolyn K Hurley, Washington DC, USA |
| C*02:91 | HG00010733 | KT282165 | Histogenetics, Ossining, USA |
| C*04:01:01:06 | BY01272 | KT764978 | Carolyn K Hurley, Washington DC, USA |
| C*05:111 | HG00010884 | KT600102 | Histogenetics, Ossining, USA |
| C*07:02:49 | BY00761 | HQ700658 | Carolyn K Hurley, Washington DC, USA |
| C*14:70 | HG00010896 | KT760517 | Histogenetics, Ossining, USA |
| C*16:01:18 | NT01276 | KT819310 | Carolyn K Hurley, Washington DC, USA |
| DQB1*02:53Q | 81135639 | KT803859 | Daniel Fuerst, Ulm, Germany |
| DQB1*03:200 | HG00010904 | KT760535 | Histogenetics, Ossining, USA |
| DQB1*06:04:01 | NT01262, NT01263 | KT591471 | Carolyn K Hurley, Washington DC, USA |
| DPA1*02:02:02 | BY01262, BY01263 | KT716050 | Carolyn K Hurley, Washington DC, USA |
Table 3: Recently Published Sequences
References:
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