Nomenclature for Factors of the HLA System

August 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the July 2015 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:19510575KT220195Wael Abdrabou, Abu Dhabi, United Arab Emirates
A*02:01:01:06DKMS-LSL-A-244LN600104DKMS Life Sciences Lab, Dresden, Germany
A*02:02:01:02NT01256KT454933Carolyn K Hurley, Washington DC, USA
A*02:589HG00010230KR082286Histogenetics, Ossining, USA
A*02:590Hallym_B15-231KT372921Oh-Joong Kwon, Seoul, South Korea
A*03:01:56LUMC-A-110LN873254Jacqy DH Anholts, Leiden, The Netherlands
A*34:14NT01247KT387297Carolyn K Hurley, Washington DC, USA
A*68:01:02:03NT01248KT387296Carolyn K Hurley, Washington DC, USA
B*15:17:04HG00010456KT162066Histogenetics, Ossining, USA
B*15:17:05HG00010457KT037045Histogenetics, Ossining, USA
B*15:275:02HG00010459KR868783Histogenetics, Ossining, USA
B*15:368HG00010455KT037046Histogenetics, Ossining, USA
B*15:369HG00010460KT190998Histogenetics, Ossining, USA
B*15:37081135729KT305947Daniel Fuerst, Ulm, Germany
B*35:01:01:03NT01259KT454929Carolyn K Hurley, Washington DC, USA
B*35:59:02HG00010453KT190996Histogenetics, Ossining, USA
B*35:299HG00010452KT037036Histogenetics, Ossining, USA
B*38:58LUMC-B-106LN873252Jacqy DH Anholts, Leiden, The Netherlands
B*39:10781135131KT305949Daniel Fuerst, Ulm, Germany
B*40:31581136463KT305950Daniel Fuerst, Ulm, Germany
B*40:316NT01258KT454930Carolyn K Hurley, Washington DC, USA
B*41:40NT01246KT387298Carolyn K Hurley, Washington DC, USA
B*44:03:29HG00010449KT037039Histogenetics, Ossining, USA
B*44:226HG00010448KT037047Histogenetics, Ossining, USA
B*44:227HG00010450, HG00010451KT037040, KT190999Histogenetics, Ossining, USA
B*44:228HG00010463KT037044Histogenetics, Ossining, USA
B*51:09:03HG00010461KT162065Histogenetics, Ossining, USA
B*51:191HG00010462KR868781Histogenetics, Ossining, USA
B*51:192NT01244KT367883Carolyn K Hurley, Washington DC, USA
B*51:193LUMC-B-104LN873251Jacqy DH Anholts, Leiden, The Netherlands
B*52:52HG00010454KR868780Histogenetics, Ossining, USA
B*52:53LUMC-B-107LN873253Jacqy DH Anholts, Leiden, The Netherlands
B*53:4045613ALEM KT454780Maria Elisa Moraes, Rio de Janeiro, Brazil
B*55:76NT01255KT425099Carolyn K Hurley, Washington DC, USA
B*78:09NT01236KT321460Carolyn K Hurley, Washington DC, USA
C*01:114HG00010464KR868790Histogenetics, Ossining, USA
C*02:55:02HG00010477KR868792Histogenetics, Ossining, USA
C*03:301HG00010479KT037052Histogenetics, Ossining, USA
C*04:01:69148024AMDSKT454776Maria Elisa Moraes, Rio de Janeiro, Brazil
C*04:213HG00010480KT037054Histogenetics, Ossining, USA
C*04:214HG00010481KR868787Histogenetics, Ossining, USA
C*04:215NHG00010482KR868784Histogenetics, Ossining, USA
C*04:216HG00010483KR868794Histogenetics, Ossining, USA
C*05:123HG00010473KT162069Histogenetics, Ossining, USA
C*06:04:02EA-AE194J-ZCKR920751Louis-Marie Yindom, Oxford, United Kingdom
C*06:04:02HG00010465KT037049Histogenetics, Ossining, USA
C*06:34:02HG00010466KR868786Histogenetics, Ossining, USA
C*07:29:02HG00010469KT162068Histogenetics, Ossining, USA
C*07:454HG00010467KT037053Histogenetics, Ossining, USA
C*07:455HG00010468KT037055Histogenetics, Ossining, USA
C*07:456HG00010470KR868789Histogenetics, Ossining, USA
C*07:457HG00010471KT037051Histogenetics, Ossining, USA
C*12:165HG00010475KR868788Histogenetics, Ossining, USA
C*12:16613900410KT334224Antonio Balas, Madrid, Spain
C*16:01:01:02EA-AA184U-ZCKR920753Louis-Marie Yindom, Oxford, United Kingdom
C*16:87HG00010474KR868791Histogenetics, Ossining, USA
DRB1*04:200HG00010508KT162077Histogenetics, Ossining, USA
DRB1*04:201CB456KT454779Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*07:65HG00010507KR868799Histogenetics, Ossining, USA
DRB1*07:66LUMC-DRB1-103LN867303Jacqy DH Anholts, Leiden, The Netherlands
DRB1*10:16HG00010509KR868798Histogenetics, Ossining, USA
DRB1*11:189HG00010513KT191012Histogenetics, Ossining, USA
DRB1*11:190HG00010514KT191011Histogenetics, Ossining, USA
DRB1*11:191HG00010515KT191013Histogenetics, Ossining, USA
DRB1*11:192P78.I.WNKR012875Constantina Sarri, Larissa, Greece
DRB1*13:207HG00010512KT162079Histogenetics, Ossining, USA
DRB1*13:208155964NRLKT454778Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*14:04:03HG00010510KT037065Histogenetics, Ossining, USA
DRB1*14:166NIME 794-15KT160424Manuela Testi, Rome, Italy
DRB1*14:167HG00010511KT037063Histogenetics, Ossining, USA
DRB1*15:02:16HG00010506KT162075Histogenetics, Ossining, USA
DRB1*15:127H150392KT337663Faming Zhu, Hangzhou, China
DRB1*16:01:09HG00010503KT037066Histogenetics, Ossining, USA
DRB1*16:37HG00010504, HG00010505KT191009, KT191010Histogenetics, Ossining, USA
DQB1*02:02:01:0200552658KT387605Jorge Martinez-Laso, Madrid, Spain
DQB1*03:201HG00010485KR868797Histogenetics, Ossining, USA
DQB1*03:202HG00010486KT037059Histogenetics, Ossining, USA
DQB1*03:203HG00010488KT191007Histogenetics, Ossining, USA
DQB1*03:204HG00010495, HG00010496KR868795, KR868796Histogenetics, Ossining, USA
DQB1*03:205HG00010498KT162074Histogenetics, Ossining, USA
DQB1*03:206IMD0001LN875780Sabine Schuett, Berlin, Germany
DQB1*04:31HG00010501KT162073Histogenetics, Ossining, USA
DQB1*04:3293100359KT305953Daniel Fuerst, Ulm, Germany
DQB1*05:109HG00010499KT162072Histogenetics, Ossining, USA
DQB1*06:191HG00010489, HG00010490, HG00010491, HG00010492KT191001, KT191002, KT191005, KT191004Histogenetics, Ossining, USA
DQB1*06:192HG00010502KT037057Histogenetics, Ossining, USA
DQB1*06:193N93100275KT305952Daniel Fuerst, Ulm, Germany
DPB1*484:01HG00010516KT191015Histogenetics, Ossining, USA
DPB1*485:01HG00010517KT037068Histogenetics, Ossining, USA
DPB1*486:01HG00010518KR868801Histogenetics, Ossining, USA
DPB1*487:01HG00010519KT162081Histogenetics, Ossining, USA
DPB1*488:01HG00010520KT037075Histogenetics, Ossining, USA
DPB1*489:01HG00010521KT037070Histogenetics, Ossining, USA
DPB1*490:01HG00010523KT037072Histogenetics, Ossining, USA
DPB1*491:01HG00010524KT191014Histogenetics, Ossining, USA
DPB1*492:01HG00010525KT191016Histogenetics, Ossining, USA
DPB1*493:01HG00010526KT037076Histogenetics, Ossining, USA
HFE*001:01:01pac222k22U91328John N Feder, Menlo Park, USA
HFE*001:01:02NIEHS1EU523119Deborah Nickerson, Seattle, USA
HFE*001:01:03ICRFy901D1223Z92910Werner Albig, Goettingen, Germany
HFE*002USP-FMRP0539KM263603Wagner Narciso de Campos, Ribeirao Preto, Brasil
HFE*003USP-FMRP0611KM263593Wagner Narciso de Campos, Ribeirao Preto, Brasil
HFE*004USP-FMRP100KM263589Wagner Narciso de Campos, Ribeirao Preto, Brasil
MICA*0863733S10208632KP835293Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:69HG00010536KP996245Histogenetics, Ossining, USA
A*02:06:18HG00010537KP996242Histogenetics, Ossining, USA
A*11:183HG00010532KP342334Histogenetics, Ossining, USA
A*11:223HG00010531KR270563Histogenetics, Ossining, USA
A*24:02:73HG00010535KP711766Histogenetics, Ossining, USA
A*24:21:03HG00010533KR270562Histogenetics, Ossining, USA
A*24:3060735541KT321295Antonio Balas, Madrid, Spain
A*24:5060729082KT321296Antonio Balas, Madrid, Spain
A*24:56NT01248KT387295Carolyn K Hurley, Washington DC, USA
A*24:293NT01253KT425097Carolyn K Hurley, Washington DC, USA
A*24:307HG00010534KR003368Histogenetics, Ossining, USA
A*25:0960730689KT321297Antonio Balas, Madrid, Spain
A*29:69HG00010529, HG00010530KP325446, KP325447Histogenetics, Ossining, USA
A*31:01:04NT01237KT321461Carolyn K Hurley, Washington DC, USA
A*31:36NT01237KT321462Carolyn K Hurley, Washington DC, USA
A*68:07NT01243KT367881Carolyn K Hurley, Washington DC, USA
B*07:05:08HG00010551KR047750Histogenetics, Ossining, USA
B*07:237HG00010550KR082292Histogenetics, Ossining, USA
B*08:60121146KP828366Raquel Fabreti, Belo Horizonte, Brazil
B*08:137HG00010541KP872789Histogenetics, Ossining, USA
B*15:39:0160737957KT334225Antonio Balas, Madrid, Spain
B*15:151NT01255KT425099Carolyn K Hurley, Washington DC, USA
B*15:332HG00010548KP872787Histogenetics, Ossining, USA
B*27:1260738867KT334226Antonio Balas, Madrid, Spain
B*27:134HG00010540KR047748Histogenetics, Ossining, USA
B*35:09:03NT01252KT425096Carolyn K Hurley, Washington DC, USA
B*35:262HG00010543KR607438Histogenetics, Ossining, USA
B*35:278HG00010549KR047751Histogenetics, Ossining, USA
B*39:92NT01241KT367882Carolyn K Hurley, Washington DC, USA
B*39:102HG00010552KR677043Histogenetics, Ossining, USA
B*40:113NT01245KT367884Carolyn K Hurley, Washington DC, USA
B*40:114:01NT01259KT454928Carolyn K Hurley, Washington DC, USA
B*44:02:34HG00010542KP792197Histogenetics, Ossining, USA
B*47:04SE1437120DLN870422Mats Bengtsson, Uppsala, Sweden
B*48:1360737786KT334227Antonio Balas, Madrid, Spain
B*50:40HG00010539KP735527Histogenetics, Ossining, USA
B*51:0560737654KT334228Antonio Balas, Madrid, Spain
B*51:09:01NT01240KT363117Carolyn K Hurley, Washington DC, USA
B*51:167HG00010538KP665941Histogenetics, Ossining, USA
B*51:18593099272KT305948Daniel Fuerst, Ulm, Germany
B*51:187HG00010553KT162063Histogenetics, Ossining, USA
B*52:01:23HG00010544KP711749Histogenetics, Ossining, USA
B*52:06:03HG00010545, HG00010546KP735528, KP711751Histogenetics, Ossining, USA
B*56:01:01:02NT01240KT363118Carolyn K Hurley, Washington DC, USA
B*58:62HG00010547KR607437Histogenetics, Ossining, USA
C*01:02:32HG00010554KR153564Histogenetics, Ossining, USA
C*02:97HG00010563KR677061Histogenetics, Ossining, USA
C*02:104HG00010562KR153557Histogenetics, Ossining, USA
C*03:87:02HG00010567KR677060Histogenetics, Ossining, USA
C*03:258HG00010568KP342354Histogenetics, Ossining, USA
C*03:272HG00010566KP843870Histogenetics, Ossining, USA
C*04:01:01:06NT01254KT425098Carolyn K Hurley, Washington DC, USA
C*04:01:01:06NT01257KT454931Carolyn K Hurley, Washington DC, USA
C*04:15:02NT01242KT367880Carolyn K Hurley, Washington DC, USA
C*05:104HG00010557, HG00010558KR270581, KP843871Histogenetics, Ossining, USA
C*06:139HG00010555KP792204Histogenetics, Ossining, USA
C*07:311HG00010556KP131492Histogenetics, Ossining, USA
C*08:12NT01257KT454932Carolyn K Hurley, Washington DC, USA
C*12:03:35HG00010559KP792214Histogenetics, Ossining, USA
C*12:132HG00010560KR677056Histogenetics, Ossining, USA
C*12:159HG00010561KT162067Histogenetics, Ossining, USA
C*15:02:23HG00010564, HG00010565KR868785, KP872795Histogenetics, Ossining, USA
C*18:02EA-AE144K-ZCKR920752Louis-Marie Yindom, Oxford, United Kingdom
DRB1*01:01:29HG00010608KP711800Histogenetics, Ossining, USA
DRB1*01:02:09HG00010607KP325464Histogenetics, Ossining, USA
DRB1*07:01:15HG00010595, HG00010596, HG00010597KM604690, KP938989, KP872812Histogenetics, Ossining, USA
DRB1*07:29HG00010598KM604688Histogenetics, Ossining, USA
DRB1*07:39HG00010592KT162078Histogenetics, Ossining, USA
DRB1*07:40HG00010593, HG00010594KM670553, KM604689Histogenetics, Ossining, USA
DRB1*07:48HG00010599KR003378Histogenetics, Ossining, USA
DRB1*10:01:08HG00010601, HG00010602, HG00010603, HG00010604, HG00010605KR677067, KR082304, KR270587, KT162076 , KP996265Histogenetics, Ossining, USA
DRB1*13:199HG00010600KP325462Histogenetics, Ossining, USA
DRB1*14:163HG00010606KR003377Histogenetics, Ossining, USA
DRB1*15:01:25HG00010590, HG00010591KT191008, KR153568Histogenetics, Ossining, USA
DRB1*15:118HG00010588KP843877Histogenetics, Ossining, USA
DRB1*16:01:08HG00010589KP938991Histogenetics, Ossining, USA
DRB1*16:25HG00010587KP872810Histogenetics, Ossining, USA
DRB5*01:01:01NT01249NT01250NT01251KT387294Carolyn K Hurley, Washington DC, USA
DQB1*02:01:23HG00010583KR153559Histogenetics, Ossining, USA
DQB1*02:42HG00010575KT037061Histogenetics, Ossining, USA
DQB1*02:46HG00010576, HG00010577KR153561, KR153562Histogenetics, Ossining, USA
DQB1*02:51HG00010574KP342362Histogenetics, Ossining, USA
DQB1*03:01:27HG00010570, HG00010571KR082300, KR082301Histogenetics, Ossining, USA
DQB1*03:02:19HG00010581, HG00010582KP665956, KP711793Histogenetics, Ossining, USA
DQB1*03:109HG00010572, HG00010573KP325461, KP342364Histogenetics, Ossining, USA
DQB1*03:170HG00010569KR677064Histogenetics, Ossining, USA
DQB1*04:01:01LKT3AB715383Shigeki Mitsunaga, Tokyo, Japan
DQB1*05:18153832RCPKT454777Maria Elisa Moraes, Rio de Janeiro, Brazil
DQB1*05:51HG00010578KP342358Histogenetics, Ossining, USA
DQB1*05:80HG00010584KP792215Histogenetics, Ossining, USA
DQB1*05:88HG00010585KR818727Histogenetics, Ossining, USA
DQB1*06:162HG00010586KP872802Histogenetics, Ossining, USA
DQB1*06:164HG00010579KP711791Histogenetics, Ossining, USA
DQB1*06:172HG00010580KR003375Histogenetics, Ossining, USA
DPA1*03:01C54.I.WNKR012868Constantina Sarri, Larissa, Greece
DPB1*02:01:12HG00010631KP342378Histogenetics, Ossining, USA
DPB1*02:01:15HG00010626KT162083Histogenetics, Ossining, USA
DPB1*04:01:13HG00010636KP325469Histogenetics, Ossining, USA
DPB1*04:02:07HG00010622KR868800Histogenetics, Ossining, USA
DPB1*177:01HG00010616KP342369Histogenetics, Ossining, USA
DPB1*184:01HG00010624KP325468Histogenetics, Ossining, USA
DPB1*189:01HG00010627KP325465Histogenetics, Ossining, USA
DPB1*340:01HG00010628, HG00010629, HG00010630KP342372, KP342373, KP342374Histogenetics, Ossining, USA
DPB1*365:01HG00010623KT037077Histogenetics, Ossining, USA
DPB1*375:01HG00010612KP792220Histogenetics, Ossining, USA
DPB1*377:01HG00010620, HG00010621KR047767, KR270591Histogenetics, Ossining, USA
DPB1*384:01HG00010637KR677075Histogenetics, Ossining, USA
DPB1*390:01HG00010644KR082305Histogenetics, Ossining, USA
DPB1*392:01HG00010647KR677071Histogenetics, Ossining, USA
DPB1*393:01HG00010641KR082306Histogenetics, Ossining, USA
DPB1*394:01HG00010527KT037074Histogenetics, Ossining, USA
DPB1*396:01HG00010615KP843878Histogenetics, Ossining, USA
DPB1*398:01HG00010617, HG00010618, HG00010619KP872818, KR677074, KR818734Histogenetics, Ossining, USA
DPB1*412:01HG00010642, HG00010643KP872816, KR818738Histogenetics, Ossining, USA
DPB1*413:01HG00010645, HG00010646KR868803, KR082310Histogenetics, Ossining, USA
DPB1*422:01HG00010625KT037073Histogenetics, Ossining, USA
DPB1*423:01HG00010634, HG00010635KM604698, KM987226Histogenetics, Ossining, USA
DPB1*424:01HG00010610, HG00010611KR270595, KP325470Histogenetics, Ossining, USA
DPB1*433:01HG00010632, HG00010633KR153573, KR818737Histogenetics, Ossining, USA
DPB1*441:01HG00010613, HG00010614KR677077, KR868804Histogenetics, Ossining, USA
DPB1*445:01HG00010638, HG00010639, HG00010640KR868802, KT162080, KT037069Histogenetics, Ossining, USA
DPB1*452:01HG00010609KT037067Histogenetics, Ossining, USA
HFE*001:01:01USP-FMRP1439KM263597Wagner Narciso de Campos, Ribeirao Preto, Brasil
HFE*001:01:01IGDR1AF115265Jean Mosser, Rennes, France

Table 3: Recently Published Sequences


Sequence References
A*02:01:119(3)
A*02:570(4)
B*14:41N(5)
B*18:108(6)
B*27:133(7)
B*58:66(8)
DRB1*08:71(9)
DQB1*03:113(10)
DQB1*05:48(11)
DQB1*06:02:15(10)
DQB1*06:129(10)

References:

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  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res . 2015 43: D423-31.
  3. Feng ZH, Chi XY, Han B, Jiao SX, Wang MM. A new HLA-A allele, HLA-A* 02:01:119, identified in a Chinese individual. Tissue Antigens . 2015 86: 205-6.
  4. Yang EK, Hung JH, Lin PY. Detection of a novel variant of HLA-A*02, HLA-A*02:570, in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens . 2015 86: 206-7.
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  6. Curcio M, Sciarrino R, Biagini C, et al. Characterization of a novel HLA-B allele (HLA-B*18:108) by intron-exon sequencing of the HLA-B locus. Tissue Antigens . 2015 86: 209-10.
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  8. Zhu X, Yang T, Tan R, Su P, Luo Z, Gao H. A novel HLA-B allele, HLA-B*58:66. Tissue Antigens . 2015 86: 213-5.
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