Nomenclature for Factors of the HLA System

July 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the June 2015 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence A*03:194 has been shown to contain errors and be identical to A*03:213. The name A*03:194 has been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:190HG00010320KR677041Histogenetics, Ossining, USA
A*01:191HG00010324KR677037Histogenetics, Ossining, USA
A*01:192HG00010325KR270566Histogenetics, Ossining, USA
A*01:193HG00010431KT037033Histogenetics, Ossining, USA
A*01:194NT01221KT179784Carolyn K Hurley, Washington DC, USA
A*02:01:01:05NT01208, NT01209KT032064Carolyn K Hurley, Washington DC, USA
A*02:06:21381165KT119433Edward KL Yang, Hualien, Taiwan
A*02:581HG00010328KR270565Histogenetics, Ossining, USA
A*02:582HG00010435KR868775Histogenetics, Ossining, USA
A*02:583HG00010436KT037028Histogenetics, Ossining, USA
A*02:584HG00010437KR868772Histogenetics, Ossining, USA
A*02:585HG00010438KT037029Histogenetics, Ossining, USA
A*02:586373353KT119434Edward KL Yang, Hualien, Taiwan
A*02:58781135959 KT284904Daniel Fuerst, Ulm, Germany
A*02:58893101067KT284902Daniel Fuerst, Ulm, Germany
A*03:01:01:04NT01219, NT01239KT156722Carolyn K Hurley, Washington DC, USA
A*03:01:01:05NT01210, NT01211KT266701Carolyn K Hurley, Washington DC, USA
A*03:230HG00010326KR677039Histogenetics, Ossining, USA
A*11:224HG00010420KR868773Histogenetics, Ossining, USA
A*11:225HG00010421KT037030Histogenetics, Ossining, USA
A*11:226HG00010423KT162059Histogenetics, Ossining, USA
A*11:227HG00010424KT037027Histogenetics, Ossining, USA
A*11:25:02HG00010313KR607459Histogenetics, Ossining, USA
A*11:32:02HG00010422KT190994Histogenetics, Ossining, USA
A*24:02:01:04NT01222, NT01223KT266706Carolyn K Hurley, Washington DC, USA
A*24:02:01:05NT01212, NT01213, NT01214KT266703Carolyn K Hurley, Washington DC, USA
A*24:3151265940LN850315Jue Wang, Chengdu, China
A*24:316HG00010321KR677038Histogenetics, Ossining, USA
A*24:317HG00010322KR270561Histogenetics, Ossining, USA
A*24:318HG00010323KR270564Histogenetics, Ossining, USA
A*24:319HG00010428KR868776Histogenetics, Ossining, USA
A*24:320HG00010429KT162061Histogenetics, Ossining, USA
A*24:32115001315KR919686Antonio Balas, Madrid, Spain
A*24:90:02NHG00010427KT037025Histogenetics, Ossining, USA
A*29:81HG00010418KT162058Histogenetics, Ossining, USA
A*30:96HG00010426KT037031Histogenetics, Ossining, USA
A*31:100HG00010417KT037034Histogenetics, Ossining, USA
A*31:101JRC-D08-034LC066304Masahiro Satake, Tokyo, Japan
A*31:99HG00010308KR607455Histogenetics, Ossining, USA
A*32:75HG00010327KR677036Histogenetics, Ossining, USA
A*32:76HG00010432KR868774Histogenetics, Ossining, USA
A*32:77HG00010434KT162071Histogenetics, Ossining, USA
A*33:01:08HG00010309KR270568Histogenetics, Ossining, USA
A*33:103HG00010310KR607458Histogenetics, Ossining, USA
A*33:104HG00010311KR677042Histogenetics, Ossining, USA
A*34:13HG00010315KR270567Histogenetics, Ossining, USA
A*66:24HG00010314KR607456Histogenetics, Ossining, USA
A*68:112:02HG00010318, HG00010319KR677033, KR677034Histogenetics, Ossining, USA
A*68:135HG00010316KR677035Histogenetics, Ossining, USA
A*68:136HG00010317KR677040Histogenetics, Ossining, USA
A*68:137NT01234KT314251Carolyn K Hurley, Washington DC, USA
A*74:25HG00010433KT190992Histogenetics, Ossining, USA
B*07:02:48DKMS-LSL-B-346LN810152DKMS Life Sciences Lab, Dresden, Germany
B*08:152HG00010247KR047752Histogenetics, Ossining, USA
B*08:153HG00010335KR677047Histogenetics, Ossining, USA
B*08:154HG00010446KT037042Histogenetics, Ossining, USA
B*08:155NT01229KT314245Carolyn K Hurley, Washington DC, USA
B*13:8593016234KR611040Daniel Fuerst, Ulm, Germany
B*14:02:01:02NT01217KT156717Carolyn K Hurley, Washington DC, USA
B*14:50HG00010345KR270574Histogenetics, Ossining, USA
B*15:364HG00010341KR607440Histogenetics, Ossining, USA
B*15:365HG00010342KR818716Histogenetics, Ossining, USA
B*15:366HG00010343KR677046Histogenetics, Ossining, USA
B*15:367KNUH150410(4)_PSJKT200224Oh-Joong Kwon, Seoul, South Korea
B*18:114HG00010244KR047753Histogenetics, Ossining, USA
B*18:115HG00010245KR082289Histogenetics, Ossining, USA
B*18:116HG00010246KR105358Histogenetics, Ossining, USA
B*27:143HG00010334KR677051Histogenetics, Ossining, USA
B*27:144COMA784883LN867112James Kelleher, Dublin, Ireland
B*27:145HG00010443KT162062Histogenetics, Ossining, USA
B*35:297HG00010254KR153547Histogenetics, Ossining, USA
B*35:298BY01255KT156718Carolyn K Hurley, Washington DC, USA
B*37:19:02HG00010444KT037043Histogenetics, Ossining, USA
B*38:01:10HG00010349KR607441Histogenetics, Ossining, USA
B*39:106HG00010253KR047755Histogenetics, Ossining, USA
B*40:06:13HG00010333KR607439Histogenetics, Ossining, USA
B*40:06:14HG00010445KR868779Histogenetics, Ossining, USA
B*40:10:01:02NT01218KT156723Carolyn K Hurley, Washington DC, USA
B*40:310HG00010329, HG00010330KR270570, KR270573Histogenetics, Ossining, USA
B*40:311HG00010332KR607442Histogenetics, Ossining, USA
B*40:312HG00010440KT037041Histogenetics, Ossining, USA
B*40:313HG00010442KT037035Histogenetics, Ossining, USA
B*40:314NT01220KT156721Carolyn K Hurley, Washington DC, USA
B*44:224NT01230KT314244Carolyn K Hurley, Washington DC, USA
B*44:225NT01235KT321459Carolyn K Hurley, Washington DC, USA
B*45:17HG00010441KT162064Histogenetics, Ossining, USA
B*49:40HG00010439KT190997Histogenetics, Ossining, USA
B*52:51HG00010331KR677045Histogenetics, Ossining, USA
B*55:01:15HG00010251KR153543Histogenetics, Ossining, USA
B*58:73HG00010339KR677044Histogenetics, Ossining, USA
B*81:08HG00010347KR270576Histogenetics, Ossining, USA
C*01:112HG00010351KR677057Histogenetics, Ossining, USA
C*01:113HG00010352KR270579Histogenetics, Ossining, USA
C*01:49:02JRC-D78-065LC066305Masahiro Satake, Tokyo, Japan
C*02:107HG00010354KR677062Histogenetics, Ossining, USA
C*02:108HG00010364KR677054Histogenetics, Ossining, USA
C*03:298HG00010273KR105362Histogenetics, Ossining, USA
C*03:299HG00010274KR082293Histogenetics, Ossining, USA
C*03:300HG00010366KR818721Histogenetics, Ossining, USA
C*04:180:02HG00010278KR153556Histogenetics, Ossining, USA
C*04:207HG00010276, HG00010277KR105360, KR105361Histogenetics, Ossining, USA
C*04:208HG00010279KR153558Histogenetics, Ossining, USA
C*04:209HG00010281KR153549Histogenetics, Ossining, USA
C*04:210HG00010369KR818719Histogenetics, Ossining, USA
C*04:211HG00010370KR677058Histogenetics, Ossining, USA
C*04:212D236495KT156720Edward KL Yang, Hualien, Taiwan
C*06:165HG00010355KR818718Histogenetics, Ossining, USA
C*07:447HG00010259KR153553Histogenetics, Ossining, USA
C*07:448HG00010350KR818722Histogenetics, Ossining, USA
C*07:449HG00010353KR607443Histogenetics, Ossining, USA
C*07:450HG00010357KR818725Histogenetics, Ossining, USA
C*07:451NHG00010359KR270577Histogenetics, Ossining, USA
C*07:452NHG00010360KR677052Histogenetics, Ossining, USA
C*07:453Ua2015TP1363LN866280Mats Bengtsson, Uppsala, Sweden
C*08:124HG00010362KR818723Histogenetics, Ossining, USA
C*12:163HG00010361KR270580Histogenetics, Ossining, USA
C*12:164HG00010363KR677053Histogenetics, Ossining, USA
C*14:46:02HG00010367KR270578Histogenetics, Ossining, USA
C*14:72HG00010275KR047759Histogenetics, Ossining, USA
DPB1*09:01:04HG00010411KR818736Histogenetics, Ossining, USA
DPB1*10:01:02HG00010412KR818735Histogenetics, Ossining, USA
DPB1*155:01:02HG00010405, HG00010406, HG00010407KR677081, KR818740, KR607453Histogenetics, Ossining, USA
DPB1*236:01:02HG00010404KR270594Histogenetics, Ossining, USA
DPB1*465:01HG00010299KR153574Histogenetics, Ossining, USA
DPB1*466:01HG00010300KR153571Histogenetics, Ossining, USA
DPB1*467:01HG00010301, HG00010302KR153572, KR105368Histogenetics, Ossining, USA
DPB1*468:01HG00010303KR047765Histogenetics, Ossining, USA
DPB1*469:01HG00010304KR082308Histogenetics, Ossining, USA
DPB1*470:01HG00010305KR047768Histogenetics, Ossining, USA
DPB1*471:01HG00010306KR082307Histogenetics, Ossining, USA
DPB1*472:01HG00010307KR153570Histogenetics, Ossining, USA
DPB1*473:01HG00010397KR818739Histogenetics, Ossining, USA
DPB1*474:01HG00010398KR677070Histogenetics, Ossining, USA
DPB1*475:01HG00010400KR270596Histogenetics, Ossining, USA
DPB1*476:01HG00010401KR270593Histogenetics, Ossining, USA
DPB1*477:01HG00010403KR270590Histogenetics, Ossining, USA
DPB1*478:01HG00010409KR677073Histogenetics, Ossining, USA
DPB1*479:01HG00010410KR677080Histogenetics, Ossining, USA
DPB1*480:01HG00010413KR270592Histogenetics, Ossining, USA
DPB1*481:01HG00010414KR677076Histogenetics, Ossining, USA
DPB1*482:01HG00010415KR677072Histogenetics, Ossining, USA
DPB1*483:01HG00010416KR818733Histogenetics, Ossining, USA
DQB1*02:62DKMS-LSL-DQB1-462LN854601DKMS Life Sciences Lab, Dresden, Germany
DQB1*02:63DKMS-LSL-DQB1-474LN854612DKMS Life Sciences Lab, Dresden, Germany
DQB1*02:64DKMS-LSL-DQB1-487LN854625DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:01:31DKMS-LSL-DQB1-475LN854613DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:192HG00010282KR105366Histogenetics, Ossining, USA
DQB1*03:193HG00010372KR818728Histogenetics, Ossining, USA
DQB1*03:194HG00010373KR677065Histogenetics, Ossining, USA
DQB1*03:195DKMS-LSL-DQB1-463LN854602DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:196DKMS-LSL-DQB1-479LN854617DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:197QDKMS-LSL-DQB1-480LN854618DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:198DKMS-LSL-DQB1-481LN854619DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:199DKMS-LSL-DQB1-489LN854627DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:200AMC150521_22940184KT223821Oh-Joong Kwon, Seoul, South Korea
DQB1*04:02:10DKMS-LSL-DQB1-483LN854621DKMS Life Sciences Lab, Dresden, Germany
DQB1*04:30DKMS-LSL-DQB1-422LN854593DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:01:21DKMS-LSL-DQB1-461LN854600DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:01:22DKMS-LSL-DQB1-464LN854603DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:100HG00010377KR607447Histogenetics, Ossining, USA
DQB1*05:101HG00010378KR607445Histogenetics, Ossining, USA
DQB1*05:102DKMS-LSL-DQB1-459LN854598DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:103DKMS-LSL-DQB1-467LN854605DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:104DKMS-LSL-DQB1-478LN854616DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:105DKMS-LSL-DQB1-485LN854623DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:106DKMS-LSL-DQB1-488LN854626DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:107DKMS-LSL-DQB1-431LN854595DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:108DKMS-LSL-DQB1-440LN854596DKMS Life Sciences Lab, Dresden, Germany
DQB1*05:97HG00010284KR047762Histogenetics, Ossining, USA
DQB1*05:98HG00010285KR153563Histogenetics, Ossining, USA
DQB1*05:99HG00010376KR270582Histogenetics, Ossining, USA
DQB1*06:02:25DKMS-LSL-DQB1-472LN854610DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:03:20DKMS-LSL-DQB1-458LN854597DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:03:21DKMS-LSL-DQB1-468LN854606DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:183HG00010287KR105365Histogenetics, Ossining, USA
DQB1*06:184HG00010374KR677063Histogenetics, Ossining, USA
DQB1*06:185DKMS-LSL-DQB1-460LN854599DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:186DKMS-LSL-DQB1-473LN854611DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:187DKMS-LSL-DQB1-476LN854614DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:188DKMS-LSL-DQB1-482LN854620DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:189DKMS-LSL-DQB1-484LN854622DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:19093100111KT284903Daniel Fuerst, Ulm, Germany
DQB1*06:32:02HG00010283KR082299Histogenetics, Ossining, USA
DRB1*03:122HG00010293KR153565Histogenetics, Ossining, USA
DRB1*03:123HG00010388KR818730Histogenetics, Ossining, USA
DRB1*03:124LUMC--DRB1-102LN867302Jacqy DH Anholts, Leiden, The Netherlands
DRB1*03:71:02HG00010294KR082303Histogenetics, Ossining, USA
DRB1*04:195HG00010291KR105367Histogenetics, Ossining, USA
DRB1*04:196HG00010292KR153566Histogenetics, Ossining, USA
DRB1*04:197HG00010386KR818732Histogenetics, Ossining, USA
DRB1*04:198HG00010387KR818731Histogenetics, Ossining, USA
DRB1*04:199C1640LN868514Kremena Todorova, Berlin, Germany
DRB1*07:62HG00010197KP872807Histogenetics, Ossining, USA
DRB1*07:63HG00010290KR047764Histogenetics, Ossining, USA
DRB1*07:64HG00010379KR677069Histogenetics, Ossining, USA
DRB1*08:7728460LN854575Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*11:12:03HG00010393KR607448Histogenetics, Ossining, USA
DRB1*11:185HG00010295KR082302Histogenetics, Ossining, USA
DRB1*11:186HG00010296KR047763Histogenetics, Ossining, USA
DRB1*11:187HG00010390KR270586Histogenetics, Ossining, USA
DRB1*11:188HG00010394KR607449Histogenetics, Ossining, USA
DRB1*13:205HG00010389KR270585Histogenetics, Ossining, USA
DRB1*13:206HG00010391, HG00010392KR677066, KR270584Histogenetics, Ossining, USA
DRB1*14:164HG00010202KP872811Histogenetics, Ossining, USA
DRB1*14:165HG00010395KR270589Histogenetics, Ossining, USA
DRB1*15:01:27HG00010288KR153567Histogenetics, Ossining, USA
DRB1*15:02:14HG00010289KR153569Histogenetics, Ossining, USA
DRB1*15:02:15HG00010382KR677068Histogenetics, Ossining, USA
DRB1*15:125HG00010380KR270583Histogenetics, Ossining, USA
DRB1*15:126HG00010381KR818729Histogenetics, Ossining, USA
E*01:0941138LN846937Marcel GJ Tilanus, Maastricht, The Netherlands
G*01:19T49KT248538Wei Tian, Changsha, China
MICB*031TIM13AKT248539Wei Tian, Changsha, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:71HG00010430KT190993Histogenetics, Ossining, USA
A*02:193NT01228KT314246Carolyn K Hurley, Washington DC, USA
A*03:213DKMS-LSL-A-100HG973324DKMS Life Sciences Lab, Dresden, Germany
A*24:02:01:02LCS00075JN034032Kai Cao, Houston, USA
A*24:02:01:02LMDA0000049KC152642Kai Cao, Houston, USA
A*31:01:24NT01227KT314247Carolyn K Hurley, Washington DC, USA
A*34:02:01NT01224, NT01225, NT01226KT279359Carolyn K Hurley, Washington DC, USA
B*07:05:08HG00010308KR270571Histogenetics, Ossining, USA
B*08:145HG00010249KR153546Histogenetics, Ossining, USA
B*13:02:17HG00010337KR270575Histogenetics, Ossining, USA
B*15:315NT01217KT156716Carolyn K Hurley, Washington DC, USA
B*18:68NT01233KT314250Carolyn K Hurley, Washington DC, USA
B*18:69DKMS-LSL-B-421LN854592DKMS Life Sciences Lab, Dresden, Germany
B*35:296HG00010338KR818712Histogenetics, Ossining, USA
B*35:34NT01231KT314248Carolyn K Hurley, Washington DC, USA
B*38:11NT01232KT314249Carolyn K Hurley, Washington DC, USA
C*04:01:01:06NT01216KT156719Carolyn K Hurley, Washington DC, USA
DQB1*02:50DKMS-LSL-DQB1-470LN854608DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:138DKMS-LSL-DQB1-486LN854624DKMS Life Sciences Lab, Dresden, Germany
DQB1*03:26D302797LN864493Edward KL Yang, Hualien, Taiwan
DQB1*05:02:11DKMS-LSL-DQB1-471LN854609DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:125DKMS-LSL-DQB1-469LN854607DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:44DKMS-LSL-DQB1-430LN854594DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:58DKMS-LSL-DQB1-465LN854604DKMS Life Sciences Lab, Dresden, Germany
DQB1*06:62DKMS-LSL-DQB1-477LN854615DKMS Life Sciences Lab, Dresden, Germany

Table 3: Recently Published Sequences


Sequence References
B*27:138(3)
B*46:01:11(4)
B*51:01:39(4)
B*59:09(5)
C*15:02:01:03(6)
DRB1*12:01:06(7)
DRB1*15:116(8)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens . 2010 75: 291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res . 2015 43: D423-31.
  3. Koay BT, Norfarhana KF, Norhafizi MY, Lee YY, Dhaliwal JS. A novel HLA-B*27 allele, B*27:138, identified by sequence-based typing. Tissue Antigens . 2015 86: 143-4.
  4. Tao SD, Chen NY, Dong LN, He J, Zhu FM, Lv HJ. Two novel alleles, HLA-B*46:01:11 and HLA-B*51:01:39 were identified in Chinese bone marrow donors. Tissue Antigens . 2015 86: 144-5.
  5. Hong SS, Han OJ, Kang MS, Huh JY. HLA-B*59:09, a novel allele identified by sequence-based typing in a cord blood donated by a Korean woman. Tissue Antigens . 2015 86: 146-7.
  6. Park BG, Oh HB, Jun JH, Yoon CE, Kwon OJ. Identification of the novel allele, HLA-C*15:02:01:03, by full-length genomic sequencing. Tissue Antigens . 2015 86: 147-8.
  7. Yang KL, Hung JH, Lin PY. The novel HLA-DRB1*12:01:06 allele detected in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens . 2015 86: 148-9.
  8. Yang KL, Hung JH, Lin PY. A novel HLA allele, HLA-DRB1*15:116, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens . 2015 86: 149-50.