Nomenclature for Factors of the HLA System

June 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the May 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:71BY01161KT119430Carolyn K Hurley, Washington DC, USA
A*01:01:72DKMS-LSL-A-436LN832594DKMS Life Science Lab, Dresden, Germany
A*01:187DKMS-LSL-A-434LN832592DKMS Life Science Lab, Dresden, Germany
A*01:188HG00010222KR047739Histogenetics, Ossining, USA
A*01:189HG00010225KR082288Histogenetics, Ossining, USA
A*02:64:02HG00010140KP996241Histogenetics, Ossining, USA
A*02:576HG00010139KP938978Histogenetics, Ossining, USA
A*02:577HG00010227KR153538Histogenetics, Ossining, USA
A*02:578HG00010228KR105352Histogenetics, Ossining, USA
A*02:579HG00010229KR047744Histogenetics, Ossining, USA
A*02:580HG00010231,
HG00010232		KR047743,
 KR153539		Histogenetics, Ossining, USA
A*03:226HG00010135KP996244Histogenetics, Ossining, USA
A*03:227DKMS-LSL-A-432LN832590DKMS Life Science Lab, Dresden, Germany
A*03:228HG00010226KR082285Histogenetics, Ossining, USA
A*03:229P09449KT004515Faming Zhu, Hangzhou, China
A*11:219HG00010126,
HG00010127		KP872783,
 KP872785		Histogenetics, Ossining, USA
A*11:220HG00010131KP938979Histogenetics, Ossining, USA
A*11:221DKMS-LSL-A-433LN832591DKMS Life Science Lab, Dresden, Germany
A*11:222DKMS-LSL-A-435LN832593DKMS Life Science Lab, Dresden, Germany
A*11:223HG00010217KR105351Histogenetics, Ossining, USA
A*24:21:03HG00010223KR047741Histogenetics, Ossining, USA
A*24:310:02HG00010134KP996243Histogenetics, Ossining, USA
A*24:311HG00010133KP843863Histogenetics, Ossining, USA
A*24:312NHG00010221KR105350Histogenetics, Ossining, USA
A*24:313AMC150407_32219306KR922441Oh-Joong Kwon, Seoul, South Korea
A*24:314RMC26417,
RMC29201,
RMC29248		LN830751Maria Loginova, Kirov, Russia
A*25:32HG00010130KP872781Histogenetics, Ossining, USA
A*26:116HG00010219KR082284Histogenetics, Ossining, USA
A*31:98HG00010216KR153540Histogenetics, Ossining, USA
A*33:100HG00010214KR082287Histogenetics, Ossining, USA
A*33:101HG00010215KR047742Histogenetics, Ossining, USA
A*33:102CHA15-216KR778882Ji Young Huh, Sungnam-si, South Korea
A*68:134HG00010220KR047740Histogenetics, Ossining, USA
B*13:84HG00010141KP938981Histogenetics, Ossining, USA
B*14:48HG00010156KP996250Histogenetics, Ossining, USA
B*14:491157277LN850313Jue Wang, Chengdu, China
B*15:363HG00010152KP872788Histogenetics, Ossining, USA
B*18:110HG00010143KP843866Histogenetics, Ossining, USA
B*18:111HG00010145KP843867Histogenetics, Ossining, USA
B*18:112HG00010146KP872791Histogenetics, Ossining, USA
B*18:113DKMS-LSL-B-442LN832567DKMS Life Science Lab, Dresden, Germany
B*27:141HG00010142KP843864Histogenetics, Ossining, USA
B*27:142HG00010242KR105357Histogenetics, Ossining, USA
B*35:293063533KP903401Jianping Li, Shenyang, Liaoning, China
B*35:2931265848LN850314Jue Wang, Chengdu, China
B*35:294HG00010150KP938983Histogenetics, Ossining, USA
B*35:295HG00010151KP872786Histogenetics, Ossining, USA
B*35:296DKMS-LSL-B-439LN832566DKMS Life Science Lab, Dresden, Germany
B*37:56HG00010243KR153545Histogenetics, Ossining, USA
B*40:06:12HG00010238,
HG00010239,
HG00010240		KR047749,
 KR105353,
 KR105354		Histogenetics, Ossining, USA
B*40:308HG00010237KR047747Histogenetics, Ossining, USA
B*40:309HG00010241KR082291Histogenetics, Ossining, USA
B*41:38HG00010235KR153544Histogenetics, Ossining, USA
B*41:39HG00010236KR105355Histogenetics, Ossining, USA
B*44:222HG00010147KP843865Histogenetics, Ossining, USA
B*44:223HG00010149KR003369Histogenetics, Ossining, USA
B*45:16HG00010234KR082290Histogenetics, Ossining, USA
B*46:01:20354080LN831881Edward KL Yang, Hualien, Taiwan
B*46:40:021376683LN850316Jue Wang, Chengdu, China
B*55:75HG00010155KP872792Histogenetics, Ossining, USA
B*56:49HG00010154KP996247Histogenetics, Ossining, USA
B*57:79NBY01253KT119432Carolyn K Hurley, Washington DC, USA
B*58:72N351464LN831882Edward KL Yang, Hualien, Taiwan
C*01:111NHG00010159KP996251Histogenetics, Ossining, USA
C*02:106IME 1778-14KR857277Manuela Testi, Rome, Italy
C*03:296HG00010171KP996253Histogenetics, Ossining, USA
C*03:297HG00010173KP843869Histogenetics, Ossining, USA
C*04:202HG00010174,
HG00010175		KP872800,
 KR003371		Histogenetics, Ossining, USA
C*04:203NHG00010176KP996252Histogenetics, Ossining, USA
C*04:204HG00010177KP872797Histogenetics, Ossining, USA
C*04:205NHG00010178KP938984Histogenetics, Ossining, USA
C*04:206HG00010179KP996255Histogenetics, Ossining, USA
C*05:121HG00010267KR153555Histogenetics, Ossining, USA
C*05:122HG00010268KR082297Histogenetics, Ossining, USA
C*06:160DKMS-LSL-C-89LN811521DKMS Life Science Lab, Dresden, Germany
C*06:161HG00010161KP996254Histogenetics, Ossining, USA
C*06:162HG00010163KP872798Histogenetics, Ossining, USA
C*06:163HG00010258KR153548Histogenetics, Ossining, USA
C*06:164HG00010260KR047756Histogenetics, Ossining, USA
C*07:01:50DKMS-LSL-C-429LN832568DKMS Life Science Lab, Dresden, Germany
C*07:01:51DKMS-LSL-C-438LN832570DKMS Life Science Lab, Dresden, Germany
C*07:02:01:06DKMS-LSL-C-358LN811474DKMS Life Science Lab, Dresden, Germany
C*07:438HG00010160KR003374Histogenetics, Ossining, USA
C*07:439HG00010165KP996257Histogenetics, Ossining, USA
C*07:440HG00010166KP843868Histogenetics, Ossining, USA
C*07:441HG00010257KR047757Histogenetics, Ossining, USA
C*07:442HG00010262KR153552Histogenetics, Ossining, USA
C*07:443HG00010263KR082296Histogenetics, Ossining, USA
C*07:444HG00010264KR153550Histogenetics, Ossining, USA
C*07:445800110579LC052674Florent Delbos, Creteil, France
C*07:4463083KT003575Chun-Ying Lin, Taipei, Taiwan
C*08:122HG00010265KR047758Histogenetics, Ossining, USA
C*08:123HG00010266KR153551Histogenetics, Ossining, USA
C*12:161DKMS-LSL-C-431LN832569DKMS Life Science Lab, Dresden, Germany
C*12:162HG00010270KR082294Histogenetics, Ossining, USA
C*15:116HG00010170KR003372Histogenetics, Ossining, USA
C*15:117HG00010272KR082298Histogenetics, Ossining, USA
C*16:86HG00010256KR105363Histogenetics, Ossining, USA
DRB1*03:41:02HG00010203KP996266Histogenetics, Ossining, USA
DRB1*03:121HG00010201KP996264Histogenetics, Ossining, USA
DRB1*04:192HG00010193KP872806Histogenetics, Ossining, USA
DRB1*04:193HG00010198KP938988Histogenetics, Ossining, USA
DRB1*04:194HG00010199KP938987Histogenetics, Ossining, USA
DRB1*07:61HG00010195,
HG00010196		KP843876,
 KP872809		Histogenetics, Ossining, USA
DRB1*11:183HG00010105KP735538Histogenetics, Ossining, USA
DRB1*11:184HG00010106KP711797Histogenetics, Ossining, USA
DRB1*15:02:13HG00010194KP872808Histogenetics, Ossining, USA
DRB1*16:02:05Xian61626KR604697Tianju Wang, Xi`an, China
DQB1*02:60HG00010185KP843874Histogenetics, Ossining, USA
DQB1*02:61HG00010186KP872804Histogenetics, Ossining, USA
DQB1*03:01:3086009327KP835295Daniel Fuerst, Ulm, Germany
DQB1*03:187HG00010182KP938985Histogenetics, Ossining, USA
DQB1*03:188HG00010183,
HG00010184		KP996263,
 KP872805		Histogenetics, Ossining, USA
DQB1*03:189HG00010188KP938986Histogenetics, Ossining, USA
DQB1*03:190DKMS-LSL-DQB1-441LN832595DKMS Life Science Lab, Dresden, Germany
DQB1*03:191DKMS-LSL-DQB1-444LN832596DKMS Life Science Lab, Dresden, Germany
DQB1*05:95HG00010190KP996261Histogenetics, Ossining, USA
DQB1*05:96DKMS-LSL-DQB1-443LN832597DKMS Life Science Lab, Dresden, Germany
DQB1*06:181HG00010181KP872801Histogenetics, Ossining, USA
DQB1*06:182HG00009728KP843873Histogenetics, Ossining, USA
DPA1*02:01:08OMWKP774799Paul Norman, Stanford, USA
DPB1*03:01:08DKMS-LSL-DPB1-453LN832583DKMS Life Science Lab, Dresden, Germany
DPB1*04:01:31DKMS-LSL-DPB1-457LN832571DKMS Life Science Lab, Dresden, Germany
DPB1*451:01HG00010114KP711806Histogenetics, Ossining, USA
DPB1*452:01HG00010205KP872817Histogenetics, Ossining, USA
DPB1*453:01HG00010206KR003379Histogenetics, Ossining, USA
DPB1*454:01HG00010207KP872819Histogenetics, Ossining, USA
DPB1*455:01NHG00010208KP872813Histogenetics, Ossining, USA
DPB1*456:01HG00010209KP843879Histogenetics, Ossining, USA
DPB1*457:01HG00010210KP872814Histogenetics, Ossining, USA
DPB1*458:01HG00010213KP938992Histogenetics, Ossining, USA
DPB1*459:01DKMS-LSL-DPB1-445LN832576DKMS Life Science Lab, Dresden, Germany
DPB1*460:01DKMS-LSL-DPB1-446LN832577DKMS Life Science Lab, Dresden, Germany
DPB1*461:01DKMS-LSL-DPB1-448LN832578DKMS Life Science Lab, Dresden, Germany
DPB1*462:01DKMS-LSL-DPB1-448LN832579DKMS Life Science Lab, Dresden, Germany
DPB1*463:01DKMS-LSL-DPB1-455LN832574DKMS Life Science Lab, Dresden, Germany
DPB1*464:01DKMS-LSL-DPB1-456LN832572DKMS Life Science Lab, Dresden, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:13162971LN850752Jane Rowlands, Pontyclun, United Kingdom
A*23:19N33185LN813009Marcel GJ Tilanus, Maastricht, The Netherlands
A*23:6870975LN850750Jane Rowlands, Pontyclun, United Kingdom
A*26:112P09445KT004514Faming Zhu, Hangzhou, China
A*33:4449197LN850751Jane Rowlands, Pontyclun, United Kingdom
B*35:271DKMS-LSL-B-437LN832565DKMS Life Science Lab, Dresden, Germany
B*37:10NT0125KT119431Carolyn K Hurley, Washington DC, USA
B*57:78HG00010153KP872790Histogenetics, Ossining, USA
C*12:139HG00010271KR082311Histogenetics, Ossining, USA
C*16:04:03HG00010167KP996256Histogenetics, Ossining, USA
DPB1*16:01:01DKMS-LSL-DPB1-455LN832573DKMS Life Science Lab, Dresden, Germany
DPB1*136:01DKMS-LSL-DPB1-452LN832582DKMS Life Science Lab, Dresden, Germany
DPB1*257:01DKMS-LSL-DPB1-451LN832581DKMS Life Science Lab, Dresden, Germany
DPB1*398:01DKMS-LSL-DPB1-449LN832575DKMS Life Science Lab, Dresden, Germany
DPB1*440:01DKMS-LSL-DPB1-450LN832580DKMS Life Science Lab, Dresden, Germany

Table 3: Recently Published Sequences


Sequence References
B*38:55Q(3)
MICB*030(4)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010; 75: 291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res. 2015; 43: D423-31.
  3. Fusco C, Azzarone R, Penta R, et al. HLA-B*38:55Q: a new alternatively expressed allele identified in a three-generation Italian family. Int J Immunogenet. 2015; 42: 294-6.
  4. Wang WY, Wang F, Tian W. Identification of a novel MICB allele, MICB*030, by cloning and sequencing. Int J Immunogenet. 2015; 42: 292-3.