Nomenclature for Factors of the HLA System

May 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the April 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The allele DQA1*01:07 has been renamed DQA1*01:07Q.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:70RMC29714LN830754Maria Loginova, Kirov, Russia
A*02:06:01:0211QB000147JN384010Janette Kwok, Pokfulam Road, Hong Kong
A*03:223DKMS-LSL-A-423LN832584DKMS Life Science Lab, Dresden, Germany
A*03:224DKMS-LSL-A-428LN832588DKMS Life Science Lab, Dresden, Germany
A*03:225CTM-5030893KR106299Antonio Balas, Madrid, Spain
A*11:218DKMS-LSL-A-424LN832585DKMS Life Science Lab, Dresden, Germany
A*24:309FI65999KR560053Michele Curcio, Pisa, Italy
A*24:310:01JRC-D36-037LC055186Kenji Tadokoro, Tokyo, Japan
A*26:01:01:02LUMC-A72bFR823454Jacqy DH Anholts, Leiden, The Netherlands
A*26:115DKMS-LSL-A-427LN832589DKMS Life Science Lab, Dresden, Germany
A*29:02:17DKMS-LSL-A-425LN832586DKMS Life Science Lab, Dresden, Germany
A*31:01:02:03NMDA0000168KJ755682Kai Cao, Houston, USA
A*68:43:02DKMS-LSL-A-426LN832587DKMS Life Science Lab, Dresden, Germany
B*07:256HG00010027KP792226Histogenetics, Ossining, USA
B*14:47HG00010029KP711755Histogenetics, Ossining, USA
B*15:360HG00010016KP711761Histogenetics, Ossining, USA
B*15:361HG00010017KP792202Histogenetics, Ossining, USA
B*15:362HG00010033KP342348Histogenetics, Ossining, USA
B*35:289HG00010022KP792199Histogenetics, Ossining, USA
B*35:290HG00010032KP711760Histogenetics, Ossining, USA
B*35:291800140419LC051139Florent Delbos, Creteil, France
B*35:292157820FMDAKR698076Maria Elisa Moraes, Rio de Janeiro, Brazil
B*38:01:09HG00010030KP711756Histogenetics, Ossining, USA
B*39:105HG00010031KP342349Histogenetics, Ossining, USA
B*40:02:24DURCHG530130Valerie Dubois, Lyon, France
B*40:307JRC-D36-034LC055187Kenji Tadokoro, Tokyo, Japan
B*42:02:01:02LUMC-A74FR823455Jacqy DH Anholts, Leiden, The Netherlands
B*42:21HG00010026KP665943Histogenetics, Ossining, USA
B*44:221HG00010023KP711764Histogenetics, Ossining, USA
B*48:04:02HG00010028KP711759Histogenetics, Ossining, USA
B*50:43HG00010025KP342347Histogenetics, Ossining, USA
B*51:190HG00006015KC991062Histogenetics, Ossining, USA
B*52:50DKMS-LSL-B-419LN832563DKMS Life Science Lab, Dresden, Germany
B*53:01:11HG00010021KP711763Histogenetics, Ossining, USA
B*54:01:07SZ101040HQ651232Jun He, Suzhou, China
B*56:48HG00010020KP665946Histogenetics, Ossining, USA
B*58:01:1993089917KP230537Daniel Fuerst, Ulm, Germany
C*01:02:36DKMS-LSL-C-407LN811517DKMS Life Science Lab, Dresden, Germany
C*01:110DKMS-LSL-C-404LN811515DKMS Life Science Lab, Dresden, Germany
C*02:102DKMS-LSL-C-361LN811476DKMS Life Science Lab, Dresden, Germany
C*02:103DKMS-LSL-C-395LN811507DKMS Life Science Lab, Dresden, Germany
C*02:104HG00010067KP711787Histogenetics, Ossining, USA
C*02:105N91948_20USP,
91855_75USP,
91826_137USP		KR698080,
KR698081,
 KR698082		Maria Elisa Moraes, Rio de Janeiro, Brazil
C*03:04:48DKMS-LSL-C-387LN811501DKMS Life Science Lab, Dresden, Germany
C*03:184:02HG00010077KP665948Histogenetics, Ossining, USA
C*03:288DKMS-LSL-C-389LN811502DKMS Life Science Lab, Dresden, Germany
C*03:289DKMS-LSL-C-403LN811514DKMS Life Science Lab, Dresden, Germany
C*03:290DKMS-LSL-C-418LN811529DKMS Life Science Lab, Dresden, Germany
C*03:291HG00010075KP665950Histogenetics, Ossining, USA
C*03:292HG00010076KP342352Histogenetics, Ossining, USA
C*03:293HG00010078KP342355Histogenetics, Ossining, USA
C*03:2940103076KR560068Chun-Ying Lin, Taipei, Taiwan
C*03:295JRC-D78-044LC055188Kenji Tadokoro, Tokyo, Japan
C*04:01:01:06DKMS-LSL-C-407LN811518DKMS Life Science Lab, Dresden, Germany
C*04:01:68DKMS-LSL-C-405LN811516DKMS Life Science Lab, Dresden, Germany
C*04:201DKMS-LSL-C-390LN811503DKMS Life Science Lab, Dresden, Germany
C*05:118DKMS-LSL-C-413LN811525DKMS Life Science Lab, Dresden, Germany
C*05:119HG00010061KP325454Histogenetics, Ossining, USA
C*05:120HG00010063KP792228Histogenetics, Ossining, USA
C*06:156DKMS-LSL-C-391LN811504DKMS Life Science Lab, Dresden, Germany
C*06:157HG00010036KP735530Histogenetics, Ossining, USA
C*06:158HG00010037KP711779Histogenetics, Ossining, USA
C*06:159HG00010058KP325455Histogenetics, Ossining, USA
C*07:01:49DKMS-LSL-C-373LN827802DKMS Life Science Lab, Dresden, Germany
C*07:02:69DKMS-LSL-C-401LN811513DKMS Life Science Lab, Dresden, Germany
C*07:78:02DKMS-LSL-C-392LN811505DKMS Life Science Lab, Dresden, Germany
C*07:424DKMS-LSL-C-393LN811531DKMS Life Science Lab, Dresden, Germany
C*07:425DKMS-LSL-C-414LN811526DKMS Life Science Lab, Dresden, Germany
C*07:426DKMS-LSL-C-417LN811533DKMS Life Science Lab, Dresden, Germany
C*07:427HG00010035KP792227Histogenetics, Ossining, USA
C*07:428HG00010038KP711776Histogenetics, Ossining, USA
C*07:429HG00010039,
HG00010040,
HG00010041,
HG00010042,
HG00010043,
HG00010044,
HG00010045,
HG00010046,
HG00010047,
HG00010048,
HG00010049		KP711780,
 KP792208,
KP792212,
 KP711784,
 KP711785,
 KP735532,
KP792213,
KP711781,
KP711782,
KP711783,
 KP735531		Histogenetics, Ossining, USA
C*07:430HG00010050KP342353Histogenetics, Ossining, USA
C*07:431HG00010051KP792230Histogenetics, Ossining, USA
C*07:432HG00010052KP792203Histogenetics, Ossining, USA
C*07:433HG00010054KP325458Histogenetics, Ossining, USA
C*07:434HG00010055KP711778Histogenetics, Ossining, USA
C*07:435HG00010056KP792205Histogenetics, Ossining, USA
C*07:436HG00010057KP792207Histogenetics, Ossining, USA
C*07:437N15208709KR534595Daniel Fuerst, Ulm, Germany
C*08:120HG00010062KP325456Histogenetics, Ossining, USA
C*08:121NUCLAXZ-0001KR269771Xiaohai Zhang, Los Angeles, USA
C*12:03:37DKMS-LSL-C-415LN811527DKMS Life Science Lab, Dresden, Germany
C*12:157HG00010064KP665949Histogenetics, Ossining, USA
C*12:158HG00010065KP665947Histogenetics, Ossining, USA
C*12:159HG00010066KP711786Histogenetics, Ossining, USA
C*12:16041614HG327125Marcel GJ Tilanus, Maastricht, The Netherlands
C*14:02:19DKMS-LSL-C-409LN811520DKMS Life Science Lab, Dresden, Germany
C*14:71DKMS-LSL-C-397LN811509DKMS Life Science Lab, Dresden, Germany
C*15:114HG00010070,
HG00010071,
HG00010072		KP735533,
 KP792209,
 KP735534		Histogenetics, Ossining, USA
C*15:115NHG00010074KP711775Histogenetics, Ossining, USA
C*16:8537383 37328HE981740Robert Collins, London, United Kingdom
C*17:30DKMS-LSL-C-396LN811508DKMS Life Science Lab, Dresden, Germany
DRB1*01:02:11HG00010111KP735537Histogenetics, Ossining, USA
DRB1*01:71HG00010110KP711798Histogenetics, Ossining, USA
DRB1*03:120HG00010101KP665958Histogenetics, Ossining, USA
DRB1*04:08:04HG00010099KP325463Histogenetics, Ossining, USA
DRB1*04:53:02HG00010098KP342366Histogenetics, Ossining, USA
DRB1*07:01:18150234_MMRP,
148907_MHDMB		KR698077,
KR698078		Maria Elisa Moraes, Rio de Janeiro, Brazil
DRB1*07:59HG00010096KP342368Histogenetics, Ossining, USA
DRB1*07:60HG00010097KP711801Histogenetics, Ossining, USA
DRB1*10:15HG00010100KP665960Histogenetics, Ossining, USA
DRB1*11:03:02HG00010108KP665959Histogenetics, Ossining, USA
DRB1*11:103:02HG00010107KP342367Histogenetics, Ossining, USA
DRB1*12:58HG00009768KM670542,
 KM670551		Histogenetics, Ossining, USA
DRB1*13:05:03HG00010109KP342365Histogenetics, Ossining, USA
DRB1*13:203HG00009776KM670543,
 KM670550		Histogenetics, Ossining, USA
DRB1*13:204256801KR138378Raquel Fabreti, Belo Horizonte, Brazil
DRB1*14:162HG00010102KP792216Histogenetics, Ossining, USA
DRB1*14:163HG00010103,
HG00010104		KP792218,
KP792219		Histogenetics, Ossining, USA
DRB1*15:124HG00010095KP792217Histogenetics, Ossining, USA
DRB1*16:35HG00010094KP711799Histogenetics, Ossining, USA
DRB1*16:36WP47KR131864Wu Jiang Dong, Shihezi, China
DRB4*01:09LUMC-DRB4-100LN849724Jacqy DH Anholts, Leiden, The Netherlands
DQB1*03:183HG00010083KP735536Histogenetics, Ossining, USA
DQB1*03:184HG00010085KP342360Histogenetics, Ossining, USA
DQB1*03:185HG00010087KP711795Histogenetics, Ossining, USA
DQB1*03:18693099719KR534593Daniel Fuerst, Ulm, Germany
DQB1*05:93HG00010082KP711792Histogenetics, Ossining, USA
DQB1*05:94HG00010088KP711790Histogenetics, Ossining, USA
DQB1*06:176HG00010080KP792231Histogenetics, Ossining, USA
DQB1*06:177HG00010081KP665952Histogenetics, Ossining, USA
DQB1*06:178HG00010091KP735535Histogenetics, Ossining, USA
DQB1*06:179NHG00010092,
HG00010093		KP325459,
KP325460		Histogenetics, Ossining, USA
DQB1*06:18015208356KR534592Daniel Fuerst, Ulm, Germany
DPB1*04:02:08HG00010117KP342375Histogenetics, Ossining, USA
DPB1*348:01:02HG00010122KP792222Histogenetics, Ossining, USA
DPB1*441:01HG00010112KP665969Histogenetics, Ossining, USA
DPB1*442:01HG00010113KP711807Histogenetics, Ossining, USA
DPB1*443:01HG00010115KP792221Histogenetics, Ossining, USA
DPB1*444:01HG00010116KP665968Histogenetics, Ossining, USA
DPB1*445:01HG00010118KP711805Histogenetics, Ossining, USA
DPB1*446:01HG00010119KP665964Histogenetics, Ossining, USA
DPB1*447:01HG00010120KP342371Histogenetics, Ossining, USA
DPB1*448:01HG00010123KP711804Histogenetics, Ossining, USA
DPB1*449:01HG00010125KP665966Histogenetics, Ossining, USA
DPB1*450:01NHG00010124KP711802Histogenetics, Ossining, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
B*08:56:02DKMS-LSL-B-420LN832564DKMS Life Science Lab, Dresden, Germany
C*01:107HG00010034KP792210Histogenetics, Ossining, USA
C*02:05:03HG00010068KP342356Histogenetics, Ossining, USA
C*02:35DKMS-LSL-C-411LN811523DKMS Life Science Lab, Dresden, Germany
C*02:6924922955LN833885Thibaut Gervais, Brussels, Belgium
C*02:87DKMS-LSL-C-416LN811528DKMS Life Science Lab, Dresden, Germany
C*03:192DKMS-LSL-C-412LN811524DKMS Life Science Lab, Dresden, Germany
C*03:251DKMS-LSL-C-399LN811511DKMS Life Science Lab, Dresden, Germany
C*04:42:02DKMS-LSL-C-400LN811512DKMS Life Science Lab, Dresden, Germany
C*06:142DKMS-LSL-C-394LN811506DKMS Life Science Lab, Dresden, Germany
C*07:172:02DKMS-LSL-C-388LN811530DKMS Life Science Lab, Dresden, Germany
C*07:371DKMS-LSL-C-402LN811532DKMS Life Science Lab, Dresden, Germany
C*08:103DKMS-LSL-C-408LN811519DKMS Life Science Lab, Dresden, Germany
C*12:03:29DKMS-LSL-C-398LN811510DKMS Life Science Lab, Dresden, Germany
C*14:02:12DKMS-LSL-C-410LN811522DKMS Life Science Lab, Dresden, Germany
DRB1*03:11270449LN846903Jane Rowlands, Pontyclun, United Kingdom
DRB1*13:45HG00009781KM670544,
 KM670549		Histogenetics, Ossining, USA
DRB1*15:11216240383LN846904Jane Rowlands, Pontyclun, United Kingdom
DQA1*01:07QKMPFN796494Bouke Hepkema, Groningen, The Netherlands
DQB1*03:02:1670417LN846902Jane Rowlands, Pontyclun, United Kingdom
DQB1*03:105148035_SDCFGKR698079Maria Elisa Moraes, Rio de Janeiro, Brazil

Table 3: Recently Published Sequences


Sequence References
A*02:455(3)
A*02:548(4)
A*31:01:02:02(5)
B*15:01:37(6)
B*15:263(7)
B*15:327(8)
B*44:220(9)
B*58:63(10)
C*01:02:34(11)
C*15:02:21(12)
DRB1*10:07(13)
DRB1*15:115N(14)
DQB1*03:03:08(15)
DQB1*03:03:13(15)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
  2. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh SGE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res. 2015; 43: D423-31.
  3. Crijns VB, Groeneweg M, Schouten HC, Voorter CE, Tilanus MG. Features of a new full length HLA allele: A*02:455. Tissue Antigens. 2015; 86:53-5.
  4. Cappuzzo V, Ingrassia F, Bavetta R, Mistretta S, Marceno R. Characterization of a new HLA allele: A*02:548. Tissue Antigens. 2015; 86:55-6.
  5. Balas A, Garcia-Sanchez F, Vicario JL. HLA-A allele dropout in sequence-specific oligonucleotide probe typing due to intronic polymorphism in the novel A*31:01:02:02 allele. Tissue Antigens. 2015; 86:56-7.
  6. Yang KL, Hung JH, Lin PY. Detection of a novel HLA-B*15 variant, HLA-B*15:01:37, in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2015; 86:57-8.
  7. Park BG, Park Y, Yoon CE, Kwon OJ, Kim HS. A new HLA-B*15 allele, HLA-B*15:263, identified in a Korean individual. Tissue Antigens. 2015; 86:58-9.
  8. Yang KL, Lee SK, Hung JH, Lin PY. HLA-B*15:327, a novel variant of HLA-B*15, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2015; 86:60-1.
  9. Hayward DR, Bultitude WP, Mayor NP, Madrigal JA, Marsh SGE. The novel HLA-B*44 allele, HLA-B*44:220, identified by Single Molecule Real-Time DNA sequencing in a British Caucasoid male. Tissue Antigens. 2015; 86:61-3.
  10. Ji X, Wang J, Ou GJ, Wang CY, Liu Z. HLA-B*58:63, a novel allele identified by sequence-based typing in a Chinese bone marrow voluntary donor. Tissue Antigens. 2015; 85:73-5.
  11. Yang KL, Hung JH, Lin PY. A single nucleotide replacement in exon 2 produces a novel HLA-C*01:02 variant, HLA-C*01:02:34. Tissue Antigens. 2015; 86:63-5.
  12. Huo MR, Yu Y, Xi B, Li D. Identification of a novel HLA-C*15 allele, HLA-C*15:02:21. Tissue Antigens. 2015; 86:65-6.
  13. He JJ, Zhang W, Wang W, He J, Zhu FM, Lv HJ. A novel allele, HLA-DRB1*10:07 was identified in a Chinese individual. Tissue Antigens. 2015; 86:68-9.
  14. Li X, Zou H, Li M, Chen Q. A novel null HLA allele, HLA-DRB1*15:115N, identified in a Chinese family. Tissue Antigens. 2015; 86:69-70.
  15. Zhang W, Wang W, Han ZD, et al. Two novel HLA-DQB1*03:03 alleles, HLA-DQB1*03:03:08 and DQB1*03:03:13, were identified in Chinese individuals. Tissue Antigens. 2015; 86:66-8.