Nomenclature for Factors of the HLA System

March 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the February 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence previously named A*23:19Q has now been shown to be non-expressed and has been renamed A*23:19N.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:178NM-475118KP768456Kristin Kipper, Martinsried, Germany
A*01:179NM-519601KP768457Kristin Kipper, Martinsried, Germany
A*02:01:1195321200815KJ847970Zhanhui Du, Qingdao, China
A*11:215NCB5580KP723553Yan Li, Guangzhou, China
A*24:305ZJCB20141123002KP861866Faming Zhu, Hangzhou, China
A*29:01:08114403KP828365Raquel Fabreti, Belo Horizonte, Brazil
A*29:01:09SCL140912_110269KP940469Oh-Joong Kwon, Seoul, South Korea
A*29:78NM-463652KP768454Kristin Kipper, Martinsried, Germany
B*07:252DKMS-LSL-B-302LN810111DKMS Life Sciences Lab, Dresden, Germany
B*07:253DKMS-LSL-B-326LN810132DKMS Life Sciences Lab, Dresden, Germany
B*07:254DKMS-LSL-B-327LN810133DKMS Life Sciences Lab, Dresden, Germany
B*07:255DKMS-LSL-B-333LN810139DKMS Life Sciences Lab, Dresden, Germany
B*08:143DKMS-LSL-B-300LN810109DKMS Life Sciences Lab, Dresden, Germany
B*08:144DKMS-LSL-B-301LN810110DKMS Life Sciences Lab, Dresden, Germany
B*08:145DKMS-LSL-B-306LN810113DKMS Life Sciences Lab, Dresden, Germany
B*08:146DKMS-LSL-B-321LN810128DKMS Life Sciences Lab, Dresden, Germany
B*08:14781130779KP835296Daniel Fuerst, Ulm, Germany
B*13:02:18DKMS-LSL-B-313LN810120DKMS Life Sciences Lab, Dresden, Germany
B*14:46DKMS-LSL-B-325LN810131DKMS Life Sciences Lab, Dresden, Germany
B*15:354DKMS-LSL-B-329LN810136DKMS Life Sciences Lab, Dresden, Germany
B*15:355M-532150KP768459Kristin Kipper, Martinsried, Germany
B*18:107DKMS-LSL-B-315LN810122DKMS Life Sciences Lab, Dresden, Germany
B*18:10813-3202KP780483Michele Curcio, Pisa, Italy
B*27:138IMR001KP777818Bee Tee Koay, Kuala Lumpur, Malaysia
B*35:01:45DKMS-LSL-B-324LN810130DKMS Life Sciences Lab, Dresden, Germany
B*35:285DKMS-LSL-B-308LN810115DKMS Life Sciences Lab, Dresden, Germany
B*35:286DKMS-LSL-B-323LN810158DKMS Life Sciences Lab, Dresden, Germany
B*37:01:10DKMS-LSL-B-318LN810124DKMS Life Sciences Lab, Dresden, Germany
B*38:01:08DKMS-LSL-B-316LN810123DKMS Life Sciences Lab, Dresden, Germany
B*40:303NGR0004HF969862Laura Bungener, Groningen, The Netherlands
B*40:304DKMS-LSL-B-320LN810127DKMS Life Sciences Lab, Dresden, Germany
B*44:02:37DKMS-LSL-B-304LN810112DKMS Life Sciences Lab, Dresden, Germany
B*44:02:38DKMS-LSL-B-330LN810137DKMS Life Sciences Lab, Dresden, Germany
B*44:03:27SMC201503KP940470Oh-Joong Kwon, Seoul, South Korea
B*44:218DKMS-LSL-B-309LN810116DKMS Life Sciences Lab, Dresden, Germany
B*49:01:08DKMS-LSL-B-322LN810129DKMS Life Sciences Lab, Dresden, Germany
B*51:56:03DKMS-LSL-B-307LN810114DKMS Life Sciences Lab, Dresden, Germany
B*51:188DKMS-LSL-B-299LN810155DKMS Life Sciences Lab, Dresden, Germany
B*51:189DKMS-LSL-B-317LN810157DKMS Life Sciences Lab, Dresden, Germany
B*55:73DKMS-LSL-B-331LN810160DKMS Life Sciences Lab, Dresden, Germany
B*56:47DKMS-LSL-B-319LN810125DKMS Life Sciences Lab, Dresden, Germany
C*03:02:14HG00009685KP310891Histogenetics, Ossining, USA
C*03:03:29HG00009682KP192452Histogenetics, Ossining, USA
C*03:04:47HG00009684KP192447Histogenetics, Ossining, USA
C*03:282HG00009679KP131447Histogenetics, Ossining, USA
C*03:283HG00009680KM670532Histogenetics, Ossining, USA
C*03:284HG00009681KP256324Histogenetics, Ossining, USA
C*04:01:67HG00009687KP279717Histogenetics, Ossining, USA
C*04:196HG00009686KM987204Histogenetics, Ossining, USA
C*04:197HG00009688KP256329Histogenetics, Ossining, USA
C*07:314:02HG00009678KP057112Histogenetics, Ossining, USA
C*08:119HG00009689KP131452Histogenetics, Ossining, USA
C*15:02:22HG00009673KP057108Histogenetics, Ossining, USA
C*15:02:23HG00009674KP131446Histogenetics, Ossining, USA
C*15:02:24HG00009676KP310890Histogenetics, Ossining, USA
C*15:110HG00009671KP256325Histogenetics, Ossining, USA
C*15:111HG00009672KP227737Histogenetics, Ossining, USA
C*15:112HG00009675KP256328Histogenetics, Ossining, USA
C*15:113HG00009677KP192450Histogenetics, Ossining, USA
DRB1*01:01:29HG00009788KM987169Histogenetics, Ossining, USA
DRB1*01:20:02HG00009789KP310905Histogenetics, Ossining, USA
DRB1*01:68NHG00009790KM670540Histogenetics, Ossining, USA
DRB1*01:69HG00009791KM670547Histogenetics, Ossining, USA
DRB1*01:70HG00009792KM987222Histogenetics, Ossining, USA
DRB1*03:01:25HG00009774KP131457Histogenetics, Ossining, USA
DRB1*04:189HG00009758KP192462Histogenetics, Ossining, USA
DRB1*04:190HG00009759KM987220Histogenetics, Ossining, USA
DRB1*07:01:17HG00009402KM455005Histogenetics, Ossining, USA
DRB1*08:72HG00009769KP310904Histogenetics, Ossining, USA
DRB1*08:73HG00009770KP310906Histogenetics, Ossining, USA
DRB1*08:74HG00009771KP057135Histogenetics, Ossining, USA
DRB1*08:75HG00009772KM670545Histogenetics, Ossining, USA
DRB1*10:01:07HG00009760KM670554Histogenetics, Ossining, USA
DRB1*10:01:08HG00009761,
HG00009762,
HG00009763,
HG00009764,
HG00009765		KP163965,
 KP192463,
 KP192464,
 KP192465,
 KP192467		Histogenetics, Ossining, USA
DRB1*11:01:26HG00009773KP310903Histogenetics, Ossining, USA
DRB1*11:01:27HG00009778,
HG00009779		KP192469,
 KP192468		Histogenetics, Ossining, USA
DRB1*11:02:03HG00009782KP163966Histogenetics, Ossining, USA
DRB1*11:02:04HG00009783KP057134Histogenetics, Ossining, USA
DRB1*11:178HG00009780KM670548Histogenetics, Ossining, USA
DRB1*11:179HG00009784KM604695Histogenetics, Ossining, USA
DRB1*11:180HG00009786KP256336Histogenetics, Ossining, USA
DRB1*11:181HG00009787KM604692Histogenetics, Ossining, USA
DRB1*12:01:09HG00009766KP163963Histogenetics, Ossining, USA
DRB1*12:56HG00009767KP131456Histogenetics, Ossining, USA
DRB1*13:02:12HG00009777KM604693Histogenetics, Ossining, USA
DRB1*13:201HG00009775KM670541Histogenetics, Ossining, USA
DQA1*03:01:03CE596KP723544Antonio Balas, Madrid, Spain
DQB1*03:180GM53071213KP757873Susana G Marino, Chicago, USA
DQB1*06:01:15RG77011314KP966298Susana G Marino, Chicago, USA
DPB1*01:01:06HG00009811KM604700Histogenetics, Ossining, USA
DPB1*02:01:17HG00009802KP057141Histogenetics, Ossining, USA
DPB1*03:01:05HG00009815KP310916Histogenetics, Ossining, USA
DPB1*03:01:06HG00009817KP057152Histogenetics, Ossining, USA
DPB1*04:01:29HG00009793,
HG00009794		KP192476,
 KM670558		Histogenetics, Ossining, USA
DPB1*04:01:30HG00009798KP163968Histogenetics, Ossining, USA
DPB1*05:01:06HG00009796KP163975Histogenetics, Ossining, USA
DPB1*424:01HG00009795KP057145Histogenetics, Ossining, USA
DPB1*425:01HG00009797KP192473Histogenetics, Ossining, USA
DPB1*426:01HG00009799KM670557Histogenetics, Ossining, USA
DPB1*427:01HG00009800KM987177Histogenetics, Ossining, USA
DPB1*428:01HG00009801KP310915Histogenetics, Ossining, USA
DPB1*429:01HG00009803KP057154Histogenetics, Ossining, USA
DPB1*430:01HG00009804KP057153Histogenetics, Ossining, USA
DPB1*431:01HG00009805KP279736Histogenetics, Ossining, USA
DPB1*432:01HG00009807KM987230Histogenetics, Ossining, USA
DPB1*433:01HG00009808KP310910Histogenetics, Ossining, USA
DPB1*434:01HG00009809KP310911Histogenetics, Ossining, USA
DPB1*435:01HG00009810KP057147Histogenetics, Ossining, USA
DPB1*436:01HG00009812KP057156Histogenetics, Ossining, USA
DPB1*437:01HG00009813KP163978Histogenetics, Ossining, USA
DPB1*438:01HG00009814KP192475Histogenetics, Ossining, USA
DPB1*439:01HG00009816KP057140Histogenetics, Ossining, USA
Y*01:01UCLA-1038,
UCLA-1132		AY344232Susana G Marino, Chicago, USA
Y*02:01NSM179AB012687Yoshihisa Watanabe, Shibuya, Tokyo, , Japan
Y*02:01NIHI6525,
NIHI6546		Y18651Derek Middleton, Liverpool, United Kingdom
Y*03:01UCLA-1139AY436316,
 AY436317		Susana G Marino, Chicago, USA

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:6571554LM654023Jane Rowlands, Pontyclun, United Kingdom
A*01:01:6616328744LM654024Jane Rowlands, Pontyclun, United Kingdom
A*02:01:114HG00009835KM405346Histogenetics, Ossining, USA
A*02:06:18HG00009833KM987182Histogenetics, Ossining, USA
A*02:460HG00009836KP279708Histogenetics, Ossining, USA
A*02:528HG00009834KM081659Histogenetics, Ossining, USA
A*02:541HG00009837KM987189Histogenetics, Ossining, USA
A*03:01:52HG00009832KP256319Histogenetics, Ossining, USA
A*03:176HG00009825KM282210Histogenetics, Ossining, USA
A*03:202HG00009826,
HG00009827,
HG00009828,
HG00009829,
HG00009830,
HG00009831		KP192432,
 KP192433,
 KP192431,
 KP192434,
 KP227723,
 KP192435		Histogenetics, Ossining, USA
A*03:220shanxi042KP716803Demei Zhang, Taiyuan, China
A*11:153:02HG00009820KP279705Histogenetics, Ossining, USA
A*11:208NHG00009819KF673191Histogenetics, Ossining, USA
A*11:211HG00009821KP131439Histogenetics, Ossining, USA
A*23:01:0121251LN813010Marcel GJ Tilanus, Maastricht, The Netherlands
A*24:275HG00009824KM497454Histogenetics, Ossining, USA
A*24:290HG00009823KF882427Histogenetics, Ossining, USA
A*33:03:16HG00009818KM405354Histogenetics, Ossining, USA
A*68:01:24HG00009822KP256316Histogenetics, Ossining, USA
B*07:206HG00009850KP163939Histogenetics, Ossining, USA
B*07:222HG00009848KP131445Histogenetics, Ossining, USA
B*07:238RG77011314KP644242Susana G Marino, Chicago, USA
B*08:01:30HG00009840KM987153Histogenetics, Ossining, USA
B*08:128DKMS-LSL-B-303LN810126DKMS Life Sciences Lab, Dresden, Germany
B*08:129121146KP828366Raquel Fabreti, Belo Horizonte, Brazil
B*08:135HG00009841KM081663Histogenetics, Ossining, USA
B*08:136DKMS-LSL-B-312LN810119DKMS Life Sciences Lab, Dresden, Germany
B*15:01:36HG00009847KM987198Histogenetics, Ossining, USA
B*15:03:05HG00009844,
HG00009845		KM987199,
 KP057100		Histogenetics, Ossining, USA
B*15:04:02DKMS-LSL-B-227LN810134DKMS Life Sciences Lab, Dresden, Germany
B*15:10824864819LN829411Thibaut Gervais, Brussels, Belgium
B*15:142DKMS-LSL-B-310LN810117DKMS Life Sciences Lab, Dresden, Germany
B*15:332HG00009207KM081662Histogenetics, Ossining, USA
B*15:335HG00009843KP192441Histogenetics, Ossining, USA
B*15:347shanxi70KP693396Demei Zhang, Taiyuan, China
B*27:118DKMS-LSL-B-328LN810135DKMS Life Sciences Lab, Dresden, Germany
B*35:95DKMS-LSL-B-332LN810138DKMS Life Sciences Lab, Dresden, Germany
B*35:263DKMS-LSL-B-311LN810118DKMS Life Sciences Lab, Dresden, Germany
B*35:281DKMS-LSL-B-334LN810140DKMS Life Sciences Lab, Dresden, Germany
B*39:89HG00009849KM987197Histogenetics, Ossining, USA
B*40:02:23HG00009838KM405362Histogenetics, Ossining, USA
B*40:292HG00009839KP279710Histogenetics, Ossining, USA
B*41:01:03HG00009851KM987194Histogenetics, Ossining, USA
B*44:02:31HG00009842KM987150Histogenetics, Ossining, USA
B*51:158:02HG00009846KM405363Histogenetics, Ossining, USA
B*51:168HG00009209KM282229Histogenetics, Ossining, USA
B*51:187DKMS-LSL-B-305LN810156DKMS Life Sciences Lab, Dresden, Germany
B*56:01:01:02DKMS-LSL-B-314LN810121DKMS Life Sciences Lab, Dresden, Germany
C*01:103HG00009852KM405378Histogenetics, Ossining, USA
C*03:41:02HG00009683KP310892Histogenetics, Ossining, USA
C*04:182HG00009866KP279718Histogenetics, Ossining, USA
C*04:185HG00009163KM081666Histogenetics, Ossining, USA
C*05:01:28HG00009860KP310894Histogenetics, Ossining, USA
C*06:127:01HG00009854KP227733Histogenetics, Ossining, USA
C*06:138HG00009853KM670531Histogenetics, Ossining, USA
C*06:142HG00009855KM405371Histogenetics, Ossining, USA
C*07:339HG00009856KM405381Histogenetics, Ossining, USA
C*07:409HG00009857,
HG00009858,
HG00009859		KM604674,
 KP057113,
 KM987203		Histogenetics, Ossining, USA
C*12:02:13HG00009862KP163953Histogenetics, Ossining, USA
C*12:132HG00009861KM405380Histogenetics, Ossining, USA
C*14:66HG00009865KP310884Histogenetics, Ossining, USA
C*15:101HG00009864KP192453Histogenetics, Ossining, USA
C*15:102HG00009863KF602009Histogenetics, Ossining, USA
DRB1*03:115HG00009785KM604694Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*02:06:14(3)
A*02:488(4)
A*02:541(5)
A*23:17(6)
A*30:02:01:03(6)
B*08:01:01(6)
B*14:01:01(6)
B*49:34(7)
C*07:01:01:01(6)
C*08:113(6)
DRB1*09:12(8)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291-455.
  2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res 2013: 41: D1222-7.
  3. He J, Chen NY, Wang W, Han ZD, Zhu FM, Lv HJ. Identification of a novel HLA-A*02:06:14 allele by polymerase chain reaction sequence-based typing in a Chinese bone marrow donor. Tissue Antigens 2015: 85: 287-8.
  4. Li WX, Xia JA, Ma Y, Peng JS, Lu HX. A novel HLA-A allele, HLA-A*02:488, identified by sequence-based typing. Tissue Antigens 2015: 85: 288-9.
  5. Yang KL, Lee SK, Hung JH, Lin PY. HLA-A*02:541, a novel variant of HLA-A*02, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens 2015: 85: 290-1.
  6. Hayhurst JD, du Toit ED, Borrill V, Schlaphoff TE, Brosnan N, Marsh SGE. Two novel HLA alleles, HLA-A*30:02:01:03 and HLA-C*08:113, identified in a South African bone marrow donor. Tissue Antigens 2015: 85: 291-3.
  7. Azcarate M, Santos S, Balas A, Eguizabal C, Vicario JL. A new HLA-B allele, B*49:34, sequenced in a Spanish individual. Tissue Antigens 2015: 85: 293-4.
  8. Li JP, Li XF, Zhang X, Lin FQ, Zhang KL. A new human leukocyte antigen class II allele, DRB1*09:12. Tissue Antigens 2015: 85: 294-6.