Nomenclature for Factors of the HLA System

February 2015

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence A*26:03:02 was shown to have been named in error and has been renamed as A*26:111. The name A*26:03:02 has been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:176shanxi031KP693406Demei Zhang, Taiyuan, China
A*01:177shanxi054KP716815Demei Zhang, Taiyuan, China
A*02:01:116HG00009553KP279709Histogenetics, Ossining, USA
A*02:01:117HG00009554KM987149Histogenetics, Ossining, USA
A*02:01:118HG00009559KP163932Histogenetics, Ossining, USA
A*02:02:03HG00009563KP192426Histogenetics, Ossining, USA
A*02:06:19shanxi044KP716805Demei Zhang, Taiyuan, China
A*02:07:08T102KP404443Wei Tian, Changsha, China
A*02:560HG00009552KP192424Histogenetics, Ossining, USA
A*02:561HG00009555KP192428Histogenetics, Ossining, USA
A*02:562HG00009556KM670530Histogenetics, Ossining, USA
A*02:563HG00009557KM987191Histogenetics, Ossining, USA
A*02:564HG00009558KM987145Histogenetics, Ossining, USA
A*02:565HG00009560KP163933Histogenetics, Ossining, USA
A*02:566HG00009561KM987190Histogenetics, Ossining, USA
A*02:567HG00009562KM987192Histogenetics, Ossining, USA
A*02:568HG00009564KP163930Histogenetics, Ossining, USA
A*02:569HG00009565KP192429Histogenetics, Ossining, USA
A*02:570368104LN795904Edward KL Yang, Hualien, Taiwan
A*02:571shanxi061KP716822Demei Zhang, Taiyuan, China
A*02:5725030215KP774530Antonio Balas, Madrid, Spain
A*02:573M-360736KP768458Kristin Kipper, Martinsried, Germany
A*03:219HG00009540KM987184Histogenetics, Ossining, USA
A*03:220shanxi024KP693399Demei Zhang, Taiyuan, China
A*03:221M-379127KP768447Kristin Kipper, Martinsried, Germany
A*11:01:67shanxi047KP716808Demei Zhang, Taiyuan, China
A*24:02:93shanxi043KP716804Demei Zhang, Taiyuan, China
A*24:02:94shanxi055KP716816Demei Zhang, Taiyuan, China
A*24:172:02shanxi046KP716807Demei Zhang, Taiyuan, China
A*24:304shanxi053KP716814Demei Zhang, Taiyuan, China
A*25:01:09HG00000090HQ226103Histogenetics, Ossining, USA
A*26:111JMDP01K090AB540607Kenji Tadokoro, Tokyo, Japan
A*26:112shanxi037KP693412Demei Zhang, Taiyuan, China
A*30:95shanxi018KP693392Demei Zhang, Taiyuan, China
A*31:95shanxi028KP693403Demei Zhang, Taiyuan, China
A*32:72M-352644KP768448Kristin Kipper, Martinsried, Germany
A*33:97ZJCB20140914006KP728939Faming Zhu, Hangzhou, China
A*68:119:02shanxi040KP716801Demei Zhang, Taiyuan, China
B*07:248shanxi22,
shanxi068		KP693397,
 KP716830		Demei Zhang, Taiyuan, China
B*07:249333765LN795906Edward KL Yang, Hualien, Taiwan
B*07:250shanxi052KP716813Demei Zhang, Taiyuan, China
B*07:251NM-184744KP294307Kristin Kipper, Martinsried, Germany
B*13:01:11shanxi030KP693405Demei Zhang, Taiyuan, China
B*15:11:07shanxi057KP716818Demei Zhang, Taiyuan, China
B*15:348shanxi019KP693393Demei Zhang, Taiyuan, China
B*15:349shanxi041KP716803Demei Zhang, Taiyuan, China
B*15:350shanxi049KP716810Demei Zhang, Taiyuan, China
B*15:351shanxi050KP716811Demei Zhang, Taiyuan, China
B*15:352shanxi066KP716828Demei Zhang, Taiyuan, China
B*15:353M-145230KP768449Kristin Kipper, Martinsried, Germany
B*27:04:05shanxi051KP716812Demei Zhang, Taiyuan, China
B*27:05:31RMC27381LN810554Maria Loginova, Kirov, Russia
B*35:283shanxi023KP693398Demei Zhang, Taiyuan, China
B*35:284shanxi026KP693401Demei Zhang, Taiyuan, China
B*39:103shanxi029KP693404Demei Zhang, Taiyuan, China
B*40:01:42shanxi048KP716809Demei Zhang, Taiyuan, China
B*40:300shanxi014KP693389Demei Zhang, Taiyuan, China
B*40:301SMC201410KP705145Oh-Joong Kwon, Seoul, South Korea
B*40:302BWU01KP723551Oh-Joong Kwon, Seoul, South Korea
B*41:01:04shanxi071KP716829Demei Zhang, Taiyuan, China
B*52:01:25shanxi033KP693408Demei Zhang, Taiyuan, China
B*52:01:26shanxi039KP716800Demei Zhang, Taiyuan, China
B*52:01:275801300025KP728940Faming Zhu, Hangzhou, China
B*52:45JRC-D01-170AB971355Kenji Tadokoro, Tokyo, Japan
B*52:46shanxi058KP716819Demei Zhang, Taiyuan, China
B*55:72shanxi025KP693400Demei Zhang, Taiyuan, China
B*58:70shanxi056KP716817Demei Zhang, Taiyuan, China
B*58:71shanxi059KP716820Demei Zhang, Taiyuan, China
C*01:108shanxi032KP693407Demei Zhang, Taiyuan, China
C*02:96HG00009662KP057110Histogenetics, Ossining, USA
C*02:97HG00009663KP192451Histogenetics, Ossining, USA
C*02:98HG00009664KP310886Histogenetics, Ossining, USA
C*02:99HG00009665KP310883Histogenetics, Ossining, USA
C*02:100HG00009666KP192446Histogenetics, Ossining, USA
C*03:279EVANIGLN794633Paul Dunn, Leicester, United Kingdom
C*03:280SMC201406KP705144Oh-Joong Kwon, Seoul, South Korea
C*03:281shanxi065KP716826Demei Zhang, Taiyuan, China
C*05:115HG00009646KM987202Histogenetics, Ossining, USA
C*05:116HG00009651KP256326Histogenetics, Ossining, USA
C*06:70:02shanxi069KP716827Demei Zhang, Taiyuan, China
C*07:417HG00009641KP057114Histogenetics, Ossining, USA
C*07:418HG00009642KP131488Histogenetics, Ossining, USA
C*07:419MAWI795220LN795900Steven GE Marsh, London, United Kingdom
C*08:01:19HG00009650KP192449Histogenetics, Ossining, USA
C*08:117HG00009649KP057109Histogenetics, Ossining, USA
C*08:118shanxi035KP693410Demei Zhang, Taiyuan, China
C*12:03:35HG00009653,
HG00009654		KP163950,
 KP131494		Histogenetics, Ossining, USA
C*12:150HG00009658KP310893Histogenetics, Ossining, USA
C*12:151HG00009659KM987206Histogenetics, Ossining, USA
C*12:152HG00009660KP192445Histogenetics, Ossining, USA
C*14:70shanxi064KP716825Demei Zhang, Taiyuan, China
C*15:04:02HG00009668,
HG00009669		KP163952,
 KP163951		Histogenetics, Ossining, USA
C*15:107HG00009645KP256327Histogenetics, Ossining, USA
C*15:108HG00009667KP227738Histogenetics, Ossining, USA
C*15:109HG00009670KM604673Histogenetics, Ossining, USA
C*16:81HG00009655KP131498Histogenetics, Ossining, USA
C*16:82HG00009656KP310889Histogenetics, Ossining, USA
C*16:83HG00009657KP279715Histogenetics, Ossining, USA
C*17:29HG00009661KP310888Histogenetics, Ossining, USA
DRB1*03:119shanxi020KP693395Demei Zhang, Taiyuan, China
DRB1*04:06:06shanxi063KP716824Demei Zhang, Taiyuan, China
DRB1*04:11:04HG00009755KP192461Histogenetics, Ossining, USA
DRB1*04:131:02HG00009756KM987221Histogenetics, Ossining, USA
DRB1*04:187HG00009754KM987219Histogenetics, Ossining, USA
DRB1*04:188HG00009757KM987218Histogenetics, Ossining, USA
DRB1*07:01:09HG00009382KM455037Histogenetics, Ossining, USA
DRB1*07:01:10HG00009392KM586215Histogenetics, Ossining, USA
DRB1*07:01:11HG00009394KM455009Histogenetics, Ossining, USA
DRB1*07:01:12HG00009395KM455038Histogenetics, Ossining, USA
DRB1*07:01:13HG00009397KM455008Histogenetics, Ossining, USA
DRB1*07:01:14HG00009401KM455033Histogenetics, Ossining, USA
DRB1*07:01:15HG00009415KM455017Histogenetics, Ossining, USA
DRB1*07:01:16HG00009748KP163964Histogenetics, Ossining, USA
DRB1*07:36HG00009379KM455004Histogenetics, Ossining, USA
DRB1*07:37HG00009380KM455041Histogenetics, Ossining, USA
DRB1*07:38HG00009381KM455010Histogenetics, Ossining, USA
DRB1*07:39HG00009383,
HG00009384,
HG00009385,
HG00009386		KM455028,
 KM455029,
 KM455039,
 KM586207		Histogenetics, Ossining, USA
DRB1*07:40HG00009393KM455011Histogenetics, Ossining, USA
DRB1*07:41HG00009396KM455006Histogenetics, Ossining, USA
DRB1*07:42HG00009403,
HG00009404		KM455022,
 KM455023		Histogenetics, Ossining, USA
DRB1*07:43HN-60278-8KM586195Histogenetics, Ossining, USA
DRB1*07:44HG00009405,
HG00009406,
HG00009407,
HG00009408		KM455024,
 KM455012,
 KM455013,
 KM455026		Histogenetics, Ossining, USA
DRB1*07:45HG00009409KM455036Histogenetics, Ossining, USA
DRB1*07:46HG00009422,
HG00009423		KM586211,
 KM455043		Histogenetics, Ossining, USA
DRB1*07:47HG00009424KM455046Histogenetics, Ossining, USA
DRB1*07:48HG00009425,
HG00009426,
HG00009427		KM455047,
 KM455018,
 KM455035		Histogenetics, Ossining, USA
DRB1*07:49HG00009428KM586202Histogenetics, Ossining, USA
DRB1*07:50HG00009429KM455007Histogenetics, Ossining, USA
DRB1*07:51HG00009430,
HG00009431,
HG00009432		KM455048,
 KM455045,
 KM586209		Histogenetics, Ossining, USA
DRB1*07:52HG00009433KM455014Histogenetics, Ossining, USA
DRB1*07:53HG00009742KM604682Histogenetics, Ossining, USA
DRB1*07:54HG00009743KM604691Histogenetics, Ossining, USA
DRB1*07:55HG00009744KM604683Histogenetics, Ossining, USA
DRB1*07:56HG00009745KP256334Histogenetics, Ossining, USA
DRB1*07:57HG00009746KM670552Histogenetics, Ossining, USA
DRB1*07:58NHG00009747KM604680Histogenetics, Ossining, USA
DRB1*08:70CTM 0025844KP693696Antonio Balas, Madrid, Spain
DRB1*08:71376806LN795907Edward KL Yang, Hualien, Taiwan
DRB1*09:01:11HG00009749KM604686Histogenetics, Ossining, USA
DRB1*09:25shanxi027KP693402Demei Zhang, Taiyuan, China
DRB1*11:29:02shanxi045,
shanxi062		KP716806,
 KP716823		Demei Zhang, Taiyuan, China
DRB1*11:177shanxi038KP693413Demei Zhang, Taiyuan, China
DRB1*13:199HG00009753KP163967Histogenetics, Ossining, USA
DRB1*13:200NHG00007919KF925413Histogenetics, Ossining, USA
DRB1*14:161shanxi060KP716821Demei Zhang, Taiyuan, China
DRB1*15:118HG00009732,
HG00009733		KP057133,
 KP192466		Histogenetics, Ossining, USA
DRB1*15:119HG00009739KP163962Histogenetics, Ossining, USA
DRB1*15:120HG00009740KP057129Histogenetics, Ossining, USA
DRB1*15:121shanxi015KP693394Demei Zhang, Taiyuan, China
DRB1*16:01:07HG00009735,
HG00009736		KM987165,
 KM987166		Histogenetics, Ossining, USA
DRB1*16:01:08HG00009737KP227744Histogenetics, Ossining, USA
DRB1*16:30HG00009731KM987168Histogenetics, Ossining, USA
DRB1*16:31HG00009734KM987167Histogenetics, Ossining, USA
DRB1*16:32HG00009738KP057132Histogenetics, Ossining, USA
DRB1*16:33HG00009741KP057131Histogenetics, Ossining, USA
DRB1*16:34M-543109KP768452Kristin Kipper, Martinsried, Germany
DRB3*01:16IME 2230-14,
IME 2231-14		KP784418Manuela Testi, Rome, Italy
DQB1*02:01:20HG00009697KM604679Histogenetics, Ossining, USA
DQB1*02:01:21HG00009701KP310901Histogenetics, Ossining, USA
DQB1*02:01:22HG00009703KP279725Histogenetics, Ossining, USA
DQB1*02:01:23HG00009719KP057128Histogenetics, Ossining, USA
DQB1*02:54HG00009698,
HG00009699,
HG00009700		KP057123,
 KP227742,
 KP279724		Histogenetics, Ossining, USA
DQB1*02:55HG00009702KP057122Histogenetics, Ossining, USA
DQB1*02:56HG00009704KP192460Histogenetics, Ossining, USA
DQB1*02:57HCV151KP743137Faming Zhu, Hangzhou, China
DQB1*02:58N140917029LN810062Vicky Van Sandt, Mechelen, Belgium
DQB1*03:01:29HG00009695KM987163Histogenetics, Ossining, USA
DQB1*03:02:18HG00009716KM604676Histogenetics, Ossining, USA
DQB1*03:02:19HG00009718KP131460Histogenetics, Ossining, USA
DQB1*03:170HG00009691KP227740Histogenetics, Ossining, USA
DQB1*03:171HG00009692KP131462Histogenetics, Ossining, USA
DQB1*03:172HG00009693KM987161Histogenetics, Ossining, USA
DQB1*03:173HG00009694KP057126Histogenetics, Ossining, USA
DQB1*03:174HG00009696KP310902Histogenetics, Ossining, USA
DQB1*03:175HG00009712KM987215Histogenetics, Ossining, USA
DQB1*03:176HG00009713KP192457Histogenetics, Ossining, USA
DQB1*03:177HG00009714,
HG00009715		KM987217,
 KM987164		Histogenetics, Ossining, USA
DQB1*03:178HG00009717KP279726Histogenetics, Ossining, USA
DQB1*03:179M-427700KP768453Kristin Kipper, Martinsried, Germany
DQB1*04:02:09HG00009726KP192456Histogenetics, Ossining, USA
DQB1*04:28HG00009724KP192458Histogenetics, Ossining, USA
DQB1*04:29HG00009725KP310900Histogenetics, Ossining, USA
DQB1*05:01:20HG00009720KP279721Histogenetics, Ossining, USA
DQB1*05:02:13HG00009723KP131459Histogenetics, Ossining, USA
DQB1*05:03:17shanxi034KP693409Demei Zhang, Taiyuan, China
DQB1*05:91HG00009721KP057121Histogenetics, Ossining, USA
DQB1*05:92HG00009722KP310896Histogenetics, Ossining, USA
DQB1*06:02:24HG00009727KM987159Histogenetics, Ossining, USA
DQB1*06:03:19HG00009708KM987212Histogenetics, Ossining, USA
DQB1*06:168HG00009690KP256330Histogenetics, Ossining, USA
DQB1*06:169HG00009705KP256331Histogenetics, Ossining, USA
DQB1*06:170HG00009706,
HG00009707		KM987160,
 KP163956		Histogenetics, Ossining, USA
DQB1*06:171HG00009709,
HG00009710		KP279723,
 KP279722		Histogenetics, Ossining, USA
DQB1*06:172HG00009711KP279720Histogenetics, Ossining, USA
DQB1*06:173HG00009729KP310898Histogenetics, Ossining, USA
DQB1*06:174HG00009730KP057119Histogenetics, Ossining, USA
DQB1*06:175M-505196KP768455Kristin Kipper, Martinsried, Germany
MICA*0851RomKP262025Daniel Fuerst, Ulm, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:01:102HG00009566KP310875Histogenetics, Ossining, USA
A*02:43663111004591727830Zhanhui Du, Qingdao, China
A*11:183HN-013007HQ226081Histogenetics, Ossining, USA
A*24:02:6163111001561726223Zhanhui Du, Qingdao, China
A*24:225:0153511000551726168Zhi-Hui Feng, Qingdao, China
A*24:287386135LN795905Edward KL Yang, Hualien, Taiwan
A*26:74HN-75759-0HQ226095Histogenetics, Ossining, USA
A*66:22MG98070813KP262055Susana G Marino, Chicago, USA
B*15:347shanxi021,
shanxi067		KP693396,
 KP716829		Demei Zhang, Taiyuan, China
B*40:249shanxi016KP693390Demei Zhang, Taiyuan, China
B*58:59shanxi017KP693391Demei Zhang, Taiyuan, China
C*02:0610201,
50452		KP765600Runying Tian, Durham, USA
C*07:374shanxi036KP693411Demei Zhang, Taiyuan, China
C*08:95HG00009652KM987205Histogenetics, Ossining, USA
DRB1*07:01:08HG00009410,
HG00009411,
HG00009412,
HG00009413,
HG00009414		KM455030,
 KM455027,
 KM455015,
 KM455016,
 KM455025		Histogenetics, Ossining, USA
DRB1*07:29HG00009416,
HG00009417,
HG00009418,
HG00009419,
HG00009420,
HG00009421		KM455032,
 KM455019,
 KM455020,
 KM455021,
 KM586201,
 KM586198		Histogenetics, Ossining, USA
DRB1*07:30HG00009387,
HG00009388,
HG00009389,
HG00009390,
HG00009391		KM455044,
 KM586208,
 KM586205,
 KM455040,
 KM455042		Histogenetics, Ossining, USA
DRB1*07:32HG00009398,
HG00009399,
HG00009400		KM455031,
 KM455034,
 KM586203		Histogenetics, Ossining, USA
DRB1*09:23HG00009750,
HG00009751,
HG00009752		KM604685,
 KM604684,
 KM604687		Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*01:123N(3)
A*23:19N(4)
B*27:105(5)
B*35:231(3)
B*41:21(3)
B*53:31(3)
C*07:294(3)
DRB1*12:51(6)
DQA1*01:12(3)
DQB1*02:10(3)
DQB1*03:03:02:04(7)
DPB1*363:01(8)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291-455.
  2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res 2013: 41: D1222-7.
  3. Adamek M, Klages C, Bauer M, et al. Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity: description of the new alleles and review of the literature. Hum Immunol 2015: 76: 30-5.
  4. Gerritsen KE, Voorter CE, Joannes MO, et al. RNA and protein expression of HLA-A( *)23:19Q. Hum Immunol 2015: 76: 286-91.
  5. He J, He YM, Zhang W, Wang W, Zhu FM, Lv HJ. Identification a novel HLA-B*27:105 allele in a Chinese bone marrow donor by polymerase chain reaction sequence-based typing. Tissue Antigens 2015: 85: 212-3.
  6. Li Y, Tang XW, Wu JY, Huang YN, Liao C. Identification of a novel HLA-DRB1 allele, HLA-DRB1*12:51, in a Chinese Cord Blood Donor. Tissue Antigens 2015: 85: 216-7.
  7. Cervera I, Herraiz MA, Vidart J, Ortega S, Martinez-Laso J. Identification of the novel HLA-DQB1*03:03:02:04 allele in a Spanish individual. Tissue Antigens 2015: 85: 215-6.
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