Nomenclature for Factors of the HLA System
January 2015
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens (2015) 86:38-42
- Human Immunology (2015) 76:453-456
- International Journal of Immunogenetics (2015) 42:297-301
The following sequences have been submitted to the Nomenclature Committee since the December 2014 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:69 | HG00009538 | KP192425 | Histogenetics, Ossining, USA |
| A*01:171 | HG00009534 | KP310878 | Histogenetics, Ossining, USA |
| A*01:172 | HG00009535 | KP310877 | Histogenetics, Ossining, USA |
| A*01:173 | HG00009536 | KM987146 | Histogenetics, Ossining, USA |
| A*01:174 | HG00009537 | KP310874 | Histogenetics, Ossining, USA |
| A*01:175 | HG00009549 | KP192427 | Histogenetics, Ossining, USA |
| A*02:556 | HG00009551 | KP057090 | Histogenetics, Ossining, USA |
| A*02:557 | MDA0000171 | KP336674 | Kai Cao, Houston, USA |
| A*02:558 | 64223 | KP636794 | Jianping Li, Shenyang, Liaoning, China |
| A*02:559 | 66741 | KP636797 | Jianping Li, Shenyang, Liaoning, China |
| A*03:01:54 | BY01015 | KC801940 | Carolyn K Hurley, Washington DC, USA |
| A*03:210 | HG00009533 | KP256317 | Histogenetics, Ossining, USA |
| A*03:211 | HG00009539 | KP163927 | Histogenetics, Ossining, USA |
| A*03:212 | HG00009541 | KM987179 | Histogenetics, Ossining, USA |
| A*03:213 | HG00009542, HG00009543 | KP163935, KP227722 | Histogenetics, Ossining, USA |
| A*03:214 | HG00009544 | KP192423 | Histogenetics, Ossining, USA |
| A*03:215 | HG00009546 | KP057091 | Histogenetics, Ossining, USA |
| A*03:216 | HG00009547 | KP192430 | Histogenetics, Ossining, USA |
| A*03:217 | HG00009550 | KP057089 | Histogenetics, Ossining, USA |
| A*03:218 | RMC27310 | LN774772 | Maria Loginova, Kirov, Russia |
| A*11:212 | HG00009501 | KP131482 | Histogenetics, Ossining, USA |
| A*11:213 | HG00009504 | KM604671 | Histogenetics, Ossining, USA |
| A*11:214 | HG00009512 | KP131436 | Histogenetics, Ossining, USA |
| A*23:01:17 | BY01115 | KF482383 | Carolyn K Hurley, Washington DC, USA |
| A*23:01:18 | HG00009522 | KM987188 | Histogenetics, Ossining, USA |
| A*24:02:92 | HG00009529 | KM987181 | Histogenetics, Ossining, USA |
| A*24:295 | HG00009518 | KP227725 | Histogenetics, Ossining, USA |
| A*24:296 | HG00009523 | KP131484 | Histogenetics, Ossining, USA |
| A*24:297 | HG00009524, HG00009525 | KP057087, KP057088 | Histogenetics, Ossining, USA |
| A*24:298 | HG00009526 | KM670529 | Histogenetics, Ossining, USA |
| A*24:299 | HG00009527 | KP256313 | Histogenetics, Ossining, USA |
| A*24:300 | HG00009528 | KP163931 | Histogenetics, Ossining, USA |
| A*24:301 | HG00009530 | KM987185 | Histogenetics, Ossining, USA |
| A*24:302 | HG00009531 | KP192436 | Histogenetics, Ossining, USA |
| A*24:303N | BY01089 | KF278710 | Carolyn K Hurley, Washington DC, USA |
| A*25:19:02 | HG00009507 | KF790835 | Histogenetics, Ossining, USA |
| A*25:31 | HG00009502 | KP310872 | Histogenetics, Ossining, USA |
| A*26:01:38 | HG00009503 | KM987144 | Histogenetics, Ossining, USA |
| A*26:110 | HG00009505 | KP227726 | Histogenetics, Ossining, USA |
| A*29:01:07 | HG00009491 | KP256315 | Histogenetics, Ossining, USA |
| A*29:77 | HG00009497, HG00009498 | KP279707, KP310876 | Histogenetics, Ossining, USA |
| A*30:02:17 | BY01114 | KF482382 | Carolyn K Hurley, Washington DC, USA |
| A*30:02:18 | HG00009519 | KP163928 | Histogenetics, Ossining, USA |
| A*30:02:19 | HG00009520 | KP310873 | Histogenetics, Ossining, USA |
| A*30:94 | HG00009521 | KP163929 | Histogenetics, Ossining, USA |
| A*31:90 | HG00009490 | KP131437 | Histogenetics, Ossining, USA |
| A*31:91 | HG00009492 | KP057092 | Histogenetics, Ossining, USA |
| A*31:92 | HG00009493 | KP256314 | Histogenetics, Ossining, USA |
| A*31:93 | HG00009494 | KM987186 | Histogenetics, Ossining, USA |
| A*31:94 | HG00009495 | KP131479 | Histogenetics, Ossining, USA |
| A*32:01:22 | BY01024 | KF028618 | Carolyn K Hurley, Washington DC, USA |
| A*32:70 | M-328357 | KP294308 | Kristin Kipper, Martinsried, Germany |
| A*32:71 | HG00009548 | KM987180 | Histogenetics, Ossining, USA |
| A*33:03:30 | BY01007 | KC801947 | Carolyn K Hurley, Washington DC, USA |
| A*33:96N | HG00009496 | KP131435 | Histogenetics, Ossining, USA |
| A*66:01:03 | HG00009508 | KM604670 | Histogenetics, Ossining, USA |
| A*66:22 | HG00009509 | KP131476 | Histogenetics, Ossining, USA |
| A*68:01:29 | HG00009513 | KM987183 | Histogenetics, Ossining, USA |
| A*68:01:30 | HG00009514 | KM987187 | Histogenetics, Ossining, USA |
| A*68:01:31 | HG00009515 | KP256318 | Histogenetics, Ossining, USA |
| A*68:02:09 | HG00009499 | KP163936 | Histogenetics, Ossining, USA |
| A*68:128 | HG00009500 | KP163934 | Histogenetics, Ossining, USA |
| A*68:129 | HG00009510 | KM987148 | Histogenetics, Ossining, USA |
| A*68:130 | HG00009511 | KF790838 | Histogenetics, Ossining, USA |
| A*68:131 | HG00009516 | KP310871 | Histogenetics, Ossining, USA |
| A*68:132 | HG00009517 | KP163937 | Histogenetics, Ossining, USA |
| A*74:24 | HG00009532 | KP227724 | Histogenetics, Ossining, USA |
| B*07:02:46 | HG00009613 | KM670535 | Histogenetics, Ossining, USA |
| B*07:02:47 | HG00009619 | KM987193 | Histogenetics, Ossining, USA |
| B*07:242 | HG00009610 | KP163947 | Histogenetics, Ossining, USA |
| B*07:243 | HG00009611 | KP310879 | Histogenetics, Ossining, USA |
| B*07:244 | HG00009612 | KP163945 | Histogenetics, Ossining, USA |
| B*07:245 | HG00009614 | KP131441 | Histogenetics, Ossining, USA |
| B*07:246 | HG00009616 | KP057095 | Histogenetics, Ossining, USA |
| B*07:247 | HG00009618 | KP227728 | Histogenetics, Ossining, USA |
| B*08:141 | HG00009578 | KP057103 | Histogenetics, Ossining, USA |
| B*08:142 | HG00009579 | KP192438 | Histogenetics, Ossining, USA |
| B*13:01:10 | HG00009622 | KM987196 | Histogenetics, Ossining, USA |
| B*13:13:02 | HG00009582 | KM987200 | Histogenetics, Ossining, USA |
| B*14:02:13 | HG00009607 | KP057094 | Histogenetics, Ossining, USA |
| B*14:44 | HG00009608 | KP227732 | Histogenetics, Ossining, USA |
| B*14:45 | HG00009609 | KP256320 | Histogenetics, Ossining, USA |
| B*15:01:39 | 66522 | KP636796 | Jianping Li, Shenyang, Liaoning, China |
| B*15:344 | HG00009570 | KP227730 | Histogenetics, Ossining, USA |
| B*15:345 | HG00009583 | KP057104 | Histogenetics, Ossining, USA |
| B*15:346 | HG00009598 | KP227727 | Histogenetics, Ossining, USA |
| B*15:347 | HG00009602 | KP131442 | Histogenetics, Ossining, USA |
| B*18:01:21 | BY01000 | KC488167 | Carolyn K Hurley, Washington DC, USA |
| B*18:01:22 | HG00009575, HG00009576 | KP057097, KP057098 | Histogenetics, Ossining, USA |
| B*18:01:23 | HG00009577 | KM987155 | Histogenetics, Ossining, USA |
| B*27:136 | HG00009572 | KM987152 | Histogenetics, Ossining, USA |
| B*27:137 | HG00009573 | KM670536 | Histogenetics, Ossining, USA |
| B*35:01:44 | BY01045 | KF028628 | Carolyn K Hurley, Washington DC, USA |
| B*35:03:20 | HG00009592 | KP163938 | Histogenetics, Ossining, USA |
| B*35:03:21 | HG00009621 | KP163943 | Histogenetics, Ossining, USA |
| B*35:280 | HG00009569 | KP227731 | Histogenetics, Ossining, USA |
| B*35:281 | HG00009591 | KM987195 | Histogenetics, Ossining, USA |
| B*35:282 | HG00009593 | KM670533 | Histogenetics, Ossining, USA |
| B*37:55 | HG00009603 | KP163944 | Histogenetics, Ossining, USA |
| B*39:101 | HG00009574 | KP163941 | Histogenetics, Ossining, USA |
| B*39:102 | HG00009620 | KP227729 | Histogenetics, Ossining, USA |
| B*40:01:41 | zjcb20140821003 | KP347659 | Faming Zhu, Hangzhou, China |
| B*40:299 | MDA0000172 | KP336675 | Kai Cao, Houston, USA |
| B*41:36 | HG00009571 | KP057105 | Histogenetics, Ossining, USA |
| B*44:03:25 | HG00009584 | KP310882 | Histogenetics, Ossining, USA |
| B*44:03:26 | HG00009587 | KP131443 | Histogenetics, Ossining, USA |
| B*44:205:02 | HG00009581 | KP163942 | Histogenetics, Ossining, USA |
| B*44:215 | HG00009585 | KM987154 | Histogenetics, Ossining, USA |
| B*44:216 | HG00009590 | KM987151 | Histogenetics, Ossining, USA |
| B*44:217N | HG00009586 | KP192437 | Histogenetics, Ossining, USA |
| B*46:01:19 | 0103515 | KP281721 | Chun-Ying Lin, Taipei, Taiwan |
| B*47:10 | HG00009588, HG00009589 | KM604672, KP057099 | Histogenetics, Ossining, USA |
| B*48:37 | HG00009617 | KP163940 | Histogenetics, Ossining, USA |
| B*49:36 | HG00009567 | KP163946 | Histogenetics, Ossining, USA |
| B*49:37 | HG00009568 | KP057102 | Histogenetics, Ossining, USA |
| B*51:01:52 | HG00009604 | KP131440 | Histogenetics, Ossining, USA |
| B*51:01:53 | HG00009606 | KP279712 | Histogenetics, Ossining, USA |
| B*51:186 | HG00009605 | KF790860 | Histogenetics, Ossining, USA |
| B*51:187 | HG00009623 | KM987156 | Histogenetics, Ossining, USA |
| B*52:01:22 | HG00009580 | KP192440 | Histogenetics, Ossining, USA |
| B*52:01:23 | HG00009594 | KP192442 | Histogenetics, Ossining, USA |
| B*52:01:24 | 43951 | KP636793 | Jianping Li, Shenyang, Liaoning, China |
| B*52:06:03 | HG00009595 | KP131444 | Histogenetics, Ossining, USA |
| B*55:71 | 64420 | KP636795 | Jianping Li, Shenyang, Liaoning, China |
| B*56:46 | HG00009601 | KP256322 | Histogenetics, Ossining, USA |
| B*57:01:21 | BY01026 | KF028617 | Carolyn K Hurley, Washington DC, USA |
| B*57:01:22 | HG00009600 | KP057096 | Histogenetics, Ossining, USA |
| B*57:75 | HG00009597 | KP192439 | Histogenetics, Ossining, USA |
| B*57:76 | HG00009599 | KP310880 | Histogenetics, Ossining, USA |
| B*58:28:02 | HG00009596 | KP256321 | Histogenetics, Ossining, USA |
| B*59:09 | CHA14-489 | KP462886 | Ji Young Huh, Sungnam-si, South Korea |
| C*02:14:02 | MDA0000175 | KP336678 | Kai Cao, Houston, USA |
| C*03:278 | HG00009624 | KP163948 | Histogenetics, Ossining, USA |
| C*04:195 | MDA0000173, MDA0000174 | KP336676, KP336677 | Kai Cao, Houston, USA |
| C*06:150 | HG00009628 | KP131450 | Histogenetics, Ossining, USA |
| C*06:151 | HG00009629 | KP256323 | Histogenetics, Ossining, USA |
| C*06:152N | HG00009630 | KM987201 | Histogenetics, Ossining, USA |
| C*07:01:48 | HG00009635 | KP057106 | Histogenetics, Ossining, USA |
| C*07:02:68 | HG00009638 | KM987208 | Histogenetics, Ossining, USA |
| C*07:257:03 | HG00009636 | KP227736 | Histogenetics, Ossining, USA |
| C*07:410 | HG00009632 | KM987210 | Histogenetics, Ossining, USA |
| C*07:411 | HG00009633 | KP057107 | Histogenetics, Ossining, USA |
| C*07:412 | HG00009634 | KP131451 | Histogenetics, Ossining, USA |
| C*07:413 | HG00009625 | KP131497 | Histogenetics, Ossining, USA |
| C*07:414 | HG00009631 | KP227734 | Histogenetics, Ossining, USA |
| C*07:415 | HG00009639 | KP227735 | Histogenetics, Ossining, USA |
| C*07:416 | HG00009640 | KP163954 | Histogenetics, Ossining, USA |
| C*08:116 | HG00009644 | KP192444 | Histogenetics, Ossining, USA |
| C*12:149 | HG00009643 | KP310885 | Histogenetics, Ossining, USA |
| C*15:02:01:03 | AMC-YJS | KP284181 | Oh-Joong Kwon, Seoul, South Korea |
| C*15:02:21 | A1327 | KM982933 | Mingrui Huo, Beijing, China |
| C*16:80 | HG00009626 | KP310887 | Histogenetics, Ossining, USA |
| DRB1*08:69 | ZJ20140926003 | KP676075 | Faming Zhu, Hangzhou, China |
| DRB1*13:197 | HG00009463 | KM497479 | Histogenetics, Ossining, USA |
| DRB1*13:198 | HG00009466 | KM586188 | Histogenetics, Ossining, USA |
| DRB1*14:160 | HG00009467 | KM497490 | Histogenetics, Ossining, USA |
| DQA1*01:01:03 | 41828 | LN736034 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DQB1*03:168 | 0103499 | KP276161 | Chun-Ying Lin, Taipei, Taiwan |
| DQB1*03:169 | ua2014tp4216 | LN794216 | Mats Bengtsson, Uppsala, Sweden |
| DQB1*05:02:12 | 0103531 | KP326322 | Chun-Ying Lin, Taipei, Taiwan |
| DQB1*05:90N | M-545678 | KP294309 | Kristin Kipper, Martinsried, Germany |
| DPA1*01:13 | Ua2014tp4006 | LN717038 | Mats Bengtsson, Uppsala, Sweden |
| DPB1*04:01:28 | HG00009473 | KM365121 | Histogenetics, Ossining, USA |
| DPB1*05:01:05 | HG00009481 | KM282275 | Histogenetics, Ossining, USA |
| DPB1*418:01 | HG00009474 | KM454998 | Histogenetics, Ossining, USA |
| DPB1*419:01 | HG00009475 | KM586221 | Histogenetics, Ossining, USA |
| DPB1*420:01 | HG00009476 | KM081673 | Histogenetics, Ossining, USA |
| DPB1*421:01 | HG00009477 | KM405383 | Histogenetics, Ossining, USA |
| DPB1*422:01 | HG00009478 | KM405408 | Histogenetics, Ossining, USA |
| DPB1*423:01 | HG00009479, HG00009480 | KM455003, KM586223 | Histogenetics, Ossining, USA |
| MICB*030 | WM18 | KP301503 | Wei Tian, Changsha, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:02 | MDA0000169 | KP336672 | Kai Cao, Houston, USA |
| A*02:01:04 | MDA0000170 | KP336673 | Kai Cao, Houston, USA |
| A*03:197N | HG00009545 | KP163926 | Histogenetics, Ossining, USA |
| A*25:27:02 | HG00009506 | KM987147 | Histogenetics, Ossining, USA |
| A*26:103 | 69907 | LM654025 | Jane Rowlands, Pontyclun, United Kingdom |
| A*68:01:26 | BY01009 | KC801945 | Carolyn K Hurley, Washington DC, USA |
| B*07:237 | HG00009615 | KP057101 | Histogenetics, Ossining, USA |
| B*27:05:27 | BY01005 | KC801938 | Carolyn K Hurley, Washington DC, USA |
| C*06:136 | HG00009627 | KP057111 | Histogenetics, Ossining, USA |
| C*06:138 | MDA0000176 | KP336679 | Kai Cao, Houston, USA |
| C*07:108:02 | HG00009637 | KP131448 | Histogenetics, Ossining, USA |
| C*08:112 | HG00009647 | KP279719 | Histogenetics, Ossining, USA |
| C*08:115 | HG00009648 | KP279714 | Histogenetics, Ossining, USA |
| DRB1*11:05 | FH39 | HG974586 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*12:01:04 | XIAN029026788 | HQ677627 | Mengli Liu, Xian, China |
| DRB1*13:10 | 13976036 | HG974587 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*15:07:01 | UBM12218693 | HG974600 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DQB1*06:05:01 | W556R | U83585 | Lee Ann Baxter-Lowe, Novato, USA |
| DPB1*02:01:02 | DKMS-LSL-DPB1-219 | LN680989 | DKMS Life Sciences Lab, Dresden, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*01:25 | (3) |
| A*11:86 | (4) |
| A*24:287 | (5) |
| A*24:289 | (6) |
| A*80:01:01:01 | (7) |
| B*40:210 | (8) |
| B*44:203 | (9) |
| C*03:219 | (10) |
| C*07:02:60 | (11) |
| C*07:51 | (12) |
| DRB1*04:178N | (13) |
| DRB1*11:106 | (14) |
| DRB1*15:93 | (15) |
| DQB1*05:27 | (16) |
| DQB1*06:33 | (17) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291-455.
- Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res 2013: 41: D1222-7.
- Street J, Johnson J, Harvey C, Darke C. HLA-A*01:25 - a further example with observations on the specificity and genetics. International Journal of Immunogenetics 2014: 41: 433.
- Street J, Cook E, Johnson J, Darke C. Further examples of HLA-A*11:86 - genetics and serology. International Journal of Immunogenetics 2014: 41: 433.
- Yang KL, Lee SK, Hung JH, Lin PY. HLA-A*24:287, a novel variant of HLA-A*24:02:01:01, discovered in a Taiwanese hematopoietic stem cell donor. Tissue Antigens 2015: 85: 68-9.
- Wang J, Ji X, Ou GJ, Liu Z. Identification of a novel HLA-A*24 allele, A*24:289, in a Chinese individual. Tissue Antigens 2015: 85: 69-71.
- Cervera I, Herraiz MA, Vidart J, Ortega S, Martinez-Laso J. Different patterns of A*80:01:01:01 allele generation based on exon or intron sequences. Tissue Antigens 2015: 85: 58-67.
- Tang QJ, Guo ZH, Jiang YQ, et al. Identification of a novel HLA-B*40 allele, HLA-B*40:210, in a Chinese individual. Tissue Antigens 2015: 85: 71-2.
- Sanchez-Gordo F, Balas A, Gomez-Zumaquero JM, Prat I, Vicario JL. A new HLA-B allele, B*44:203, sequenced in a Spanish Caucasian cord blood unit. Tissue Antigens 2015: 85: 72-3.
- Crijns VB, Palusci F, Schouten HC, Voorter CE, Tilanus MG. The full length genomic sequence of a novel HLA-C*03 allele: HLA-C*03:219. Tissue Antigens 2015: 85: 75-6.
- Testi M, Andreani M, Galluccio T, Guagnano A, Paladini E. HLA-C*07:02:60, a variant of HLA-C*07 found in an unrelated volunteer stem cell donor. Tissue Antigens 2015: 85: 77-8.
- Street J, Williams L, Harvey C, Darke C. A further example of HLA-C*07:51. International Journal of immunogenetics 2014: 41: 433-4.
- Yang KL, Lee SK, Hung JH, Lin PY. Identification of a novel HLA-DRB1*04 null allele, HLA-DRB1*04:178N. Tissue Antigens 2015: 85: 78-9.
- Lin FQ, Li XF, Zhang X, Zhang KL, Li JP. HLA-DRB1*11:106, a variant of HLA-DRB1*11, discovered in a Chinese bone marrow donor. Tissue Antigens 2015: 85: 79-80.
- Street J, Johnson J, Cook E, Darke C. The second example of HLA-DRB1*15:93. International Journal of Immunogenetics 2014: 41: 435.
- Street J, Cook E, Lemin J, Darke C. Two further examples of HLA-DQB1*05:27. International Journal of Immunogenetics 2014: 41: 434.
- Street J, Cook E, Lemin J, Darke C. Some observations on HLA-DQB1*06:33. International Journal of Immunogenetics 2014: 41: 434-5.
