Nomenclature for Factors of the HLA System
November 2014
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens (2015) 85:221-225
- Human Immunology (2015) 76:195-198
- International Journal of Immunogenetics (2015) 42:124-127
The following sequences have been submitted to the Nomenclature Committee since the October 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:166 | M-510668 | KM594523 | Kristin Kipper, Martinsried, Germany |
| A*01:167 | DKMS-LSL-A-267 | LN600118 | DKMS Life Sciences Lab, Dresden, Germany |
| A*01:168 | HG00009280 | KM405355 | Histogenetics, Ossining, USA |
| A*01:169 | HG00009281 | KM405341 | Histogenetics, Ossining, USA |
| A*02:545 | M-540158 | KM594524 | Kristin Kipper, Martinsried, Germany |
| A*02:546 | M-506906 | KM594525 | Kristin Kipper, Martinsried, Germany |
| A*02:547 | DKMS-LSL-A-288 | LN600129 | DKMS Life Sciences Lab, Dresden, Germany |
| A*02:548 | TTIL0002 | LN614585 | Valentina Cappuzzo, Palermo, Italy |
| A*02:548 | HG00009288 | KM081660 | Histogenetics, Ossining, USA |
| A*02:549 | HG00009284 | KM282207 | Histogenetics, Ossining, USA |
| A*02:550 | HG00009285 | KM586167 | Histogenetics, Ossining, USA |
| A*02:551 | HG00009286 | KM282213 | Histogenetics, Ossining, USA |
| A*02:552 | HG00009287 | KM454984 | Histogenetics, Ossining, USA |
| A*02:553 | HG00009292 | KM282215 | Histogenetics, Ossining, USA |
| A*02:554 | HG00009289 | KM454985 | Histogenetics, Ossining, USA |
| A*02:555 | HG00009290 | KM497455 | Histogenetics, Ossining, USA |
| A*03:01:53 | HG00009283 | KM282212 | Histogenetics, Ossining, USA |
| A*11:01:01:02 | H140454 | KM362862 | Faming Zhu, Hangzhou, China |
| A*11:01:66 | HG00009268 | KM405351 | Histogenetics, Ossining, USA |
| A*11:211 | HG00009269 | KM282217 | Histogenetics, Ossining, USA |
| A*23:01:16 | HG00009278 | KM282219 | Histogenetics, Ossining, USA |
| A*23:69 | 31667 | LN624391 | Maria Peixoto, Porto, Portugal |
| A*24:02:91 | DKMS-LSL-A-253 | LN600111 | DKMS Life Sciences Lab, Dresden, Germany |
| A*24:292 | HG00009276 | KM405345 | Histogenetics, Ossining, USA |
| A*24:293 | HG00009277 | KM405349 | Histogenetics, Ossining, USA |
| A*25:01:08 | HG00009267 | KM282218 | Histogenetics, Ossining, USA |
| A*25:30 | HG00009282 | KM405343 | Histogenetics, Ossining, USA |
| A*26:108 | HG00009271 | KM405353 | Histogenetics, Ossining, USA |
| A*29:02:15 | HG00009261 | KM405352 | Histogenetics, Ossining, USA |
| A*29:76 | HG00009263 | KM282209 | Histogenetics, Ossining, USA |
| A*30:02:01:03 | ZA3007335D | LN624505 | Ernette Du Toit, Cape Town, South Africa |
| A*30:02:16 | HG00009274 | KM586168 | Histogenetics, Ossining, USA |
| A*30:93 | DKMS-LSL-A-212 | LN600055 | DKMS Life Sciences Lab, Dresden, Germany |
| A*32:69 | DKMS-LSL-A-214 | LN600058 | DKMS Life Sciences Lab, Dresden, Germany |
| A*32:69 | HG00009279 | KM081658 | Histogenetics, Ossining, USA |
| A*33:03:28 | HG00009262 | KM405347 | Histogenetics, Ossining, USA |
| A*33:03:29 | HG00009264 | KM405350 | Histogenetics, Ossining, USA |
| A*66:20 | HG00009272 | KM282211 | Histogenetics, Ossining, USA |
| A*66:21 | HG00009273 | KM405348 | Histogenetics, Ossining, USA |
| A*68:125 | HG00009265 | KM282208 | Histogenetics, Ossining, USA |
| A*68:126 | HG00009266 | KM405342 | Histogenetics, Ossining, USA |
| A*68:127 | HG00009270 | KM454986 | Histogenetics, Ossining, USA |
| B*07:237 | DKMS-LSL-B-207 | LN600050 | DKMS Life Sciences Lab, Dresden, Germany |
| B*08:01:31 | HG00009304 | KM497457 | Histogenetics, Ossining, USA |
| B*08:139 | DKMS-LSL-B-239 | LN600098 | DKMS Life Sciences Lab, Dresden, Germany |
| B*08:140 | HG00009302, HG00009303 | KM282221, KM405356 | Histogenetics, Ossining, USA |
| B*13:02:17 | DKMS-LSL-B-224 | LN600066 | DKMS Life Sciences Lab, Dresden, Germany |
| B*15:01:38 | DKMS-LSL-B-206 | LN600049 | DKMS Life Sciences Lab, Dresden, Germany |
| B*15:17:03 | DKMS-LSL-B-205 | LN600048 | DKMS Life Sciences Lab, Dresden, Germany |
| B*15:340 | DKMS-LSL-B-286 | LN600130 | DKMS Life Sciences Lab, Dresden, Germany |
| B*18:106 | HG00009301 | KM282222 | Histogenetics, Ossining, USA |
| B*27:134 | HG00009298 | KM405359 | Histogenetics, Ossining, USA |
| B*27:135 | HG00009299 | KM586171 | Histogenetics, Ossining, USA |
| B*35:270 | TMO26177 | KP089982 | Antonio Balas, Madrid, Spain |
| B*35:271 | DKMS-LSL-B-211 | LN600054 | DKMS Life Sciences Lab, Dresden, Germany |
| B*35:272 | M-532644 | KP019716 | Kristin Kipper, Martinsried, Germany |
| B*35:273 | 0018700 | KP099603 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| B*37:54 | HG00009300 | KM405368 | Histogenetics, Ossining, USA |
| B*40:297 | M-490619 | KM610238 | Kristin Kipper, Martinsried, Germany |
| B*40:298 | HG00009296 | KM282232 | Histogenetics, Ossining, USA |
| B*41:02:06 | HG00009294 | KM586170 | Histogenetics, Ossining, USA |
| B*41:35 | DKMS-LSL-B-269 | LN600100 | DKMS Life Sciences Lab, Dresden, Germany |
| B*44:02:35 | HG00009308 | KM282231 | Histogenetics, Ossining, USA |
| B*44:02:36 | HG00009309 | KM282220 | Histogenetics, Ossining, USA |
| B*44:214 | HG00009307 | KM405364 | Histogenetics, Ossining, USA |
| B*45:15 | HG00009297 | KM365103 | Histogenetics, Ossining, USA |
| B*49:04:02 | HG00009295 | KM405358 | Histogenetics, Ossining, USA |
| B*49:35 | M-535669 | KP019717 | Kristin Kipper, Martinsried, Germany |
| B*50:01:06 | UKTNGS001 | LC004127 | Alexandr Kuranov, T�bingen, Germany |
| B*50:42 | M-488122 | KP019700 | Kristin Kipper, Martinsried, Germany |
| B*51:01:01:02 | DKMS-LSL-B-218 | LN600062 | DKMS Life Sciences Lab, Dresden, Germany |
| B*52:43 | DKMS-LSL-B-210 | LN600053 | DKMS Life Sciences Lab, Dresden, Germany |
| B*55:01:14 | HG00009305 | KM405367 | Histogenetics, Ossining, USA |
| B*58:01:17 | DKMS-LSL-B-213 | LN600057 | DKMS Life Sciences Lab, Dresden, Germany |
| C*01:02:34 | D191689 | LN626693 | Edward KL Yang, Hualien, Taiwan |
| C*01:105 | M-516132 | KP019718 | Kristin Kipper, Martinsried, Germany |
| C*01:106 | DKMS-LSL-C-225 | LN600067 | DKMS Life Sciences Lab, Dresden, Germany |
| C*01:107 | BY01229 | KP116914 | Carolyn K Hurley, Washington DC, USA |
| C*02:90 | M-355587 | KP019702 | Kristin Kipper, Martinsried, Germany |
| C*02:91 | DKMS-LSL-C-237 | LN600093 | DKMS Life Sciences Lab, Dresden, Germany |
| C*02:92N | DKMS-LSL-C-279 | LN600110 | DKMS Life Sciences Lab, Dresden, Germany |
| C*03:03:28 | DKMS-LSL-C-248 | LN600094 | DKMS Life Sciences Lab, Dresden, Germany |
| C*03:271 | DKMS-LSL-C-275 | LN600095 | DKMS Life Sciences Lab, Dresden, Germany |
| C*04:01:66 | DKMS-LSL-C-250 | LN600083 | DKMS Life Sciences Lab, Dresden, Germany |
| C*04:186 | DKMS-LSL-C-228 | LN600069 | DKMS Life Sciences Lab, Dresden, Germany |
| C*04:187 | DKMS-LSL-C-232 | LN600072 | DKMS Life Sciences Lab, Dresden, Germany |
| C*04:188 | DKMS-LSL-C-245 | LN600080 | DKMS Life Sciences Lab, Dresden, Germany |
| C*04:189 | DKMS-LSL-C-285 | LN600126 | DKMS Life Sciences Lab, Dresden, Germany |
| C*04:190 | BY01236 | KP116921 | Carolyn K Hurley, Washington DC, USA |
| C*04:191N | DKMS-LSL-C-271 | LN600116 | DKMS Life Sciences Lab, Dresden, Germany |
| C*05:01:31 | BY01234 | KP116919 | Carolyn K Hurley, Washington DC, USA |
| C*05:109 | DKMS-LSL-C-235 | LN600073 | DKMS Life Sciences Lab, Dresden, Germany |
| C*05:110 | DKMS-LSL-C-259 | LN600088 | DKMS Life Sciences Lab, Dresden, Germany |
| C*05:111 | DKMS-LSL-C-268 | LN600091 | DKMS Life Sciences Lab, Dresden, Germany |
| C*05:112 | BY01233 | KP116918 | Carolyn K Hurley, Washington DC, USA |
| C*05:113N | DKMS-LSL-C-209 | LN600052 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:02:42 | DKMS-LSL-C-240 | LN600079 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:144 | M-465859 | KP019704 | Kristin Kipper, Martinsried, Germany |
| C*06:145 | M-499480 | KP019703 | Kristin Kipper, Martinsried, Germany |
| C*06:146 | NGR0012 | HG965220 | Laura Bungener, Groningen, The Netherlands |
| C*06:147 | DKMS-LSL-C-92 | LN600056 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:148 | M-518105 | KP019719 | Kristin Kipper, Martinsried, Germany |
| C*06:148 | DKMS-LSL-C-274 | LN600117 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:149 | DKMS-LSL-C-260 | LN600089 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:01:47 | DKMS-LSL-C-233 | LN600074 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:02:67 | DKMS-LSL-C-261 | LN600113 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:04:10 | DKMS-LSL-C-242 | LN600103 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:257:02 | M-433809 | KP019705 | Kristin Kipper, Martinsried, Germany |
| C*07:402 | DKMS-LSL-C-241 | LN600077 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:403 | DKMS-LSL-C-262 | LN600108 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:404 | BY01230 | KP116915 | Carolyn K Hurley, Washington DC, USA |
| C*07:405 | BY01231 | KP116916 | Carolyn K Hurley, Washington DC, USA |
| C*08:02:12 | DKMS-LSL-C-258 | LN600107 | DKMS Life Sciences Lab, Dresden, Germany |
| C*08:113 | ZA3007335D | LN624509 | Ernette Du Toit, Cape Town, South Africa |
| C*12:139 | DKMS-LSL-C-238 | LN600078 | DKMS Life Sciences Lab, Dresden, Germany |
| C*12:140 | DKMS-LSL-C-247 | LN600082 | DKMS Life Sciences Lab, Dresden, Germany |
| C*12:141 | DKMS-LSL-C-289 | LN614589 | DKMS Life Sciences Lab, Dresden, Germany |
| C*12:142 | BY01232 | KP116917 | Carolyn K Hurley, Washington DC, USA |
| C*14:69 | DKMS-LSL-C-272 | LN600092 | DKMS Life Sciences Lab, Dresden, Germany |
| C*15:02:01:02 | DKMS-LSL-C-215 | LN600059 | DKMS Life Sciences Lab, Dresden, Germany |
| C*15:104 | DKMS-LSL-C-281 | LN600121 | DKMS Life Sciences Lab, Dresden, Germany |
| C*15:105Q | CNUHH-17981533 | JN412101 | Oh-Joong Kwon, Seoul, South Korea |
| C*16:04:03 | DKMS-LSL-C-256 | LN600086 | DKMS Life Sciences Lab, Dresden, Germany |
| C*16:78 | M-499432 | KP019706 | Kristin Kipper, Martinsried, Germany |
| DRB1*01:66 | P111281 | KJ001130 | Hyewon Park, Seoul, South Korea |
| DRB1*01:67 | M-499199 | KP019707 | Kristin Kipper, Martinsried, Germany |
| DRB1*03:116 | M-504783 | KP019708 | Kristin Kipper, Martinsried, Germany |
| DRB1*03:117 | M-436653 | KP019709 | Kristin Kipper, Martinsried, Germany |
| DRB1*08:64 | M-474844 | KP019712 | Kristin Kipper, Martinsried, Germany |
| DRB1*08:65 | M-506876 | KP019713 | Kristin Kipper, Martinsried, Germany |
| DRB1*10:08 | M-443892 | KP019710 | Kristin Kipper, Martinsried, Germany |
| DRB1*11:172 | M-444093 | KP019711 | Kristin Kipper, Martinsried, Germany |
| DRB1*12:01:06 | 379766 | LN626694 | Edward KL Yang, Hualien, Taiwan |
| DRB1*15:116 | 379755 | LN626695 | Edward KL Yang, Hualien, Taiwan |
| DQB1*02:49 | M-358023 | KP019714 | Kristin Kipper, Martinsried, Germany |
| DQB1*03:01:26 | 23264 | LN651357 | Maria Loginova, Kirov, Russia |
| DQB1*05:02:11 | DKMS-LSL-DQB1-221 | LN600063 | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*06:02:23 | DKMS-LSL-DQB1-231 | LN600075 | DKMS Life Sciences Lab, Dresden, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| HLA Allele | Cell identification | Accession number | Submitting author |
| A*02:01:10 | DKMS-LSL-A-244 | LN600104 | DKMS Life Sciences Lab, Dresden, Germany |
| A*02:541 | HG00009291 | KM282214 | Histogenetics, Ossining, USA |
| A*23:17 | ZA3007335D | LN624506 | Ernette Du Toit, Cape Town, South Africa |
| A*29:03 | DKMS-LSL-A-222 | LN600064 | DKMS Life Sciences Lab, Dresden, Germany |
| A*30:80 | HG00009275 | KM405340 | Histogenetics, Ossining, USA |
| A*68:101 | HG00009293 | KF263493 | Histogenetics, Ossining, USA |
| B*07:208 | HG00009325, HG00009326 | KM282236, KM282237 | Histogenetics, Ossining, USA |
| B*08:01:01 | ZA3007335D | LN624507 | Ernette Du Toit, Cape Town, South Africa |
| B*08:132 | DKMS-LSL-B-234 | LN600124 | DKMS Life Sciences Lab, Dresden, Germany |
| B*14:01:01 | ZA3007335D | LN624508 | Ernette Du Toit, Cape Town, South Africa |
| B*15:272N | DKMS-LSL-B-208 | LN600051 | DKMS Life Sciences Lab, Dresden, Germany |
| B*15:319 | HG00009306 | KM405365 | Histogenetics, Ossining, USA |
| B*35:228 | DKMS-LSL-B-273 | LN600102 | DKMS Life Sciences Lab, Dresden, Germany |
| B*51:185 | M-492418 | KP019701 | Kristin Kipper, Martinsried, Germany |
| C*01:67 | DKMS-LSL-C-246 | LN600081 | DKMS Life Sciences Lab, Dresden, Germany |
| C*01:99 | DKMS-LSL-C-226 | LN600068 | DKMS Life Sciences Lab, Dresden, Germany |
| C*02:87 | DKMS-LSL-C-284 | LN600125 | DKMS Life Sciences Lab, Dresden, Germany |
| C*03:140 | DKMS-LSL-C-276 | LN600096 | DKMS Life Sciences Lab, Dresden, Germany |
| C*03:243 | DKMS-LSL-C-278 | LN600123 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:02:31 | DKMS-LSL-C-282 | LN600122 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:103 | DKMS-LSL-C-252 | LN600085 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:120 | DKMS-LSL-C-266 | LN600115 | DKMS Life Sciences Lab, Dresden, Germany |
| C*06:127:01 | BY01237 | KP116922 | Carolyn K Hurley, Washington DC, USA |
| C*07:01:01:01 | ZA3007335D | LN624510 | Ernette Du Toit, Cape Town, South Africa |
| C*07:02:63 | DKMS-LSL-C-255 | LN600106 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:89 | BY01238 | KP116923 | Carolyn K Hurley, Washington DC, USA |
| C*07:205 | DKMS-LSL-C-264 | LN600114 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:340 | DKMS-LSL-C-236 | LN600076 | DKMS Life Sciences Lab, Dresden, Germany |
| C*07:351 | DKMS-LSL-C-265 | LN600109 | DKMS Life Sciences Lab, Dresden, Germany |
| C*08:02:11 | DKMS-LSL-C-263 | LN600090 | DKMS Life Sciences Lab, Dresden, Germany |
| C*08:28 | DKMS-LSL-C-277 | LN600119 | DKMS Life Sciences Lab, Dresden, Germany |
| C*08:73 | DKMS-LSL-C-223 | LN600065 | DKMS Life Sciences Lab, Dresden, Germany |
| C*08:90 | DKMS-LSL-C-249 | LN600105 | DKMS Life Sciences Lab, Dresden, Germany |
| C*08:94 | DKMS-LSL-C-257 | LN600087 | DKMS Life Sciences Lab, Dresden, Germany |
| C*12:73 | DKMS-LSL-C-283 | LN600097 | DKMS Life Sciences Lab, Dresden, Germany |
| C*14:02:17 | DKMS-LSL-C-251 | LN600084 | DKMS Life Sciences Lab, Dresden, Germany |
| C*16:02:01 | DKMS-LSL-C-216 | LN600060 | DKMS Life Sciences Lab, Dresden, Germany |
| C*17:08 | BY01235 | KP116920 | Carolyn K Hurley, Washington DC, USA |
| C*17:17 | DKMS-LSL-C-217 | LN600061 | DKMS Life Sciences Lab, Dresden, Germany |
| DRB1*03:110 | HG00009452 | KM586204 | Histogenetics, Ossining, USA |
| DRB1*04:99 | D10028956 | HE654735 | Jinghui Qu, Shenzhen, China |
| DRB1*11:160 | HG00009461 | KM497476 | Histogenetics, Ossining, USA |
| DQB1*03:119 | 66494 | HG518397 | Jane Rowlands, Pontyclun, United Kingdom |
| DQB1*03:162 | HG00009362 | KM586177 | Histogenetics, Ossining, USA |
| DQB1*04:02:03 | DKMS-LSL-DQB1-287 | LN600128 | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*05:57 | DKMS-LSL-DQB1-229 | LN600070 | DKMS Life Sciences Lab, Dresden, Germany |
| DQB1*05:80 | HG00009236 | KJ923286 | Histogenetics, Ossining, USA |
| DQB1*06:90 | DKMS-LSL-DQB1-196 | LN600127 | DKMS Life Sciences Lab, Dresden, Germany |
| DPB1*214:01 | HG00009245, HG00009246 | KM198196, KM198180 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*68:105 | (3) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
- Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Research. 2013; 41:D1222-7.
- Curcio M, Presciuttini S, Sciarrino R, Fornaciari S, Mariotti ML, Scatena F. Identification and characterization of a novel HLA-A allele, HLA-A*68:105, by genomic sequencing. Int J Immunogenet. 2014; 41:484-5.
