Nomenclature for Factors of the HLA System
October 2014
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens (2015) 85:218-220
- Human Immunology (2015) 76:192-194
- International Journal of Immunogenetics (2015) 42:121-123
The following sequences have been submitted to the Nomenclature Committee since the September 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.An additional 372 alleles were recently published but have not been included in Table 3 due to space considerations (2).
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (3). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*11:210N | CTM8026638 | KM657949 | Antonio Balas, Madrid, Spain |
| A*26:106 | 23462, RMC26119 | LN614521 | Maria Loginova, Kirov, Russia |
| A*26:107N | 9711052 | KM979288 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| A*29:75 | FRFGR33525 | LN558515 | Dominique Masson, La Tronche, France |
| A*31:01:02:02 | CTM 1026127 | KM879189 | Antonio Balas, Madrid, Spain |
| B*07:235 | BY01145 | KF649107 | Carolyn K Hurley, Washington DC, USA |
| B*07:236 | UKT NGS 002 | LC004128 | Alexandr Kuranov, T�bingen, Germany |
| B*08:138 | 81126682 | KM875664 | Daniel Fuerst, Ulm, Germany |
| B*49:34 | 14001440 | KJ941004 | Antonio Balas, Madrid, Spain |
| B*51:185 | 81127544 | KM875663 | Daniel Fuerst, Ulm, Germany |
| B*54:34 | P08700 | KM658169 | Faming Zhu, Hangzhou, China |
| B*55:02:01:02 | TU01 | AB679915 | Takashi Shiina, Isehara, Japan |
| B*56:01:01:02 | TU02 | AB679916 | Takashi Shiina, Isehara, Japan |
| B*58:67 | 7711106200 | KM609464 | Yan Liao, Nanning, China |
| C*05:108 | 49381 | KM657022 | Runying Tian, Durham, USA |
| C*16:77N | 93095106 | KM875665 | Daniel Fuerst, Ulm, Germany |
| DRB1*04:05:17 | D10075231 | HE654732 | Jinghui Qu, Shenzhen, China |
| DRB1*04:05:18 | DK1561 | LN609297 | Xiang Liu, Beijing, China |
| DRB1*08:03:05 | BE7610 | LN609290 | Xiang Liu, Beijing, China |
| DRB1*08:61 | DA8331 | LN609296 | Xiang Liu, Beijing, China |
| DRB1*08:62 | DV2595 | LN609298 | Xiang Liu, Beijing, China |
| DRB1*08:63 | CTJ-20255 | EU545182 | Lina Yan, Tianjin, China |
| DRB1*08:63 | D11050140 | KF270568 | Jinghui Qu, Shenzhen, China |
| DRB1*12:52 | BE7520 | LN609289 | Xiang Liu, Beijing, China |
| DRB1*13:194 | LIG 90004 | KM591601 | Maria Elisa Moraes, Rio de Janeiro, Brazil |
| DRB1*14:04:02 | D10049542 | HE654759 | Jinghui Qu, Shenzhen, China |
| DQB1*03:03:02:04 | MAT-92 | KM519596 | Jorge Martinez-Laso, Madrid, Spain |
| DQB1*05:87Q | B00910 | KC970437 | Keming Du, Shanghai, China |
| E*01:03:01:03 | 4395 | LM654512 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| E*01:08N | 4395 | LM654513 | Marcel GJ Tilanus, Maastricht, The Netherlands |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:01:74 | BY00906 | JQ040000 | Carolyn K Hurley, Washington DC, USA |
| A*02:486 | HG00009201 | KM198115 | Histogenetics, Ossining, USA |
| A*23:65 | HG00009200 | KM198204 | Histogenetics, Ossining, USA |
| A*24:248 | Beijing22607 | KC473543 | Xiaoyan Shan, Beijing, China |
| B*15:268 | HG00009208 | KF790850 | Histogenetics, Ossining, USA |
| B*15:332 | HG00009207 | KM051859 | Histogenetics, Ossining, USA |
| B*18:45 | HG00009204 | KF790851 | Histogenetics, Ossining, USA |
| B*35:144 | HG00009206 | KF790855 | Histogenetics, Ossining, USA |
| B*35:158 | HG00009205 | KF790852 | Histogenetics, Ossining, USA |
| B*40:130:02 | HG00009202 | KM198209 | Histogenetics, Ossining, USA |
| B*41:29 | 4307681 | HG934987 | Paul Dunn, Auckland, New Zealand |
| B*51:160 | BY01204 | KJ418364 | Carolyn K Hurley, Washington DC, USA |
| B*51:168 | HG00009209 | KM248726 | Histogenetics, Ossining, USA |
| B*57:73 | HG00009203 | KM216193 | Histogenetics, Ossining, USA |
| C*05:01:29 | HG00009215 | KJ749782 | Histogenetics, Ossining, USA |
| C*06:127:01 | HG00009210 | KM216197 | Histogenetics, Ossining, USA |
| C*06:133 | HG00009211 | KM198222 | Histogenetics, Ossining, USA |
| C*07:02:52 | HG00009213 | KM198146 | Histogenetics, Ossining, USA |
| C*07:02:63 | 120821109 | HG934781 | Dominique Masson, La Tronche, France |
| C*07:381 | HG00009214 | KM365111 | Histogenetics, Ossining, USA |
| C*07:397 | HG00009212 | KM216196 | Histogenetics, Ossining, USA |
| DRB1*03:01:20 | HG00009242 | KJ619556 | Histogenetics, Ossining, USA |
| DRB1*03:04:01 | 27895 | LM611904 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*04:14 | 38210 | HG974603 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*04:100 | D10002408 | HE654736 | Jinghui Qu, Shenzhen, China |
| DRB1*04:182 | HG00009241 | KM198167 | Histogenetics, Ossining, USA |
| DRB1*07:26N | DKMS-LSL-DRB1-41 | HF937425 | DKMS Life Sciences Lab, Dresden, Germany |
| DRB1*08:30:03 | D10071082 | HE654739 | Jinghui Qu, Shenzhen, China |
| DRB1*11:13:02 | 29585 | LM611905 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DRB1*12:48 | 8811000959 | KM382430 | Huafang Gao, Beijing, China |
| DRB1*14:17 | #15310-LN | HG974602 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| DQB1*02:41 | HG00009218, HG00009219 | KM198234, KM198151 | Histogenetics, Ossining, USA |
| DQB1*03:02:06 | HG00009224 | KM198157 | Histogenetics, Ossining, USA |
| DQB1*03:02:13 | HG00009222, HG00009223 | KM198228, KM454994 | Histogenetics, Ossining, USA |
| DQB1*03:139 | HG00009217 | KM198165 | Histogenetics, Ossining, USA |
| DQB1*05:03:14 | HG00009232 | KM454992 | Histogenetics, Ossining, USA |
| DQB1*05:11:02 | HG00009230, HG00009231 | KM248735, KM248734 | Histogenetics, Ossining, USA |
| DQB1*05:20 | HG00009228 | KJ190374 | Histogenetics, Ossining, USA |
| DQB1*05:49 | HG00009235 | KM365116 | Histogenetics, Ossining, USA |
| DQB1*05:52 | HG00009225, HG00009226, HG00009227 | KM248738, KM198154, KM248731 | Histogenetics, Ossining, USA |
| DQB1*05:69 | HG00009233, HG00009234 | KM454993, KM198155 | Histogenetics, Ossining, USA |
| DQB1*05:75 | HG00009229 | KM198161 | Histogenetics, Ossining, USA |
| DQB1*06:02:20 | HG00009239 | KM248732 | Histogenetics, Ossining, USA |
| DQB1*06:22:03 | HG00009238 | KM248739 | Histogenetics, Ossining, USA |
| DQB1*06:125 | HG00009237 | KM198150 | Histogenetics, Ossining, USA |
| DQB1*06:126 | HG00009240 | KM198163 | Histogenetics, Ossining, USA |
| DQB1*06:153 | HG00009216 | KM198164 | Histogenetics, Ossining, USA |
| DQB1*06:155 | HG00009220, HG00009221 | KM454995, KM198231 | Histogenetics, Ossining, USA |
| DPB1*04:01:14 | HG00009256, HG00009257 | KM198191, KM198182 | Histogenetics, Ossining, USA |
| DPB1*11:01:03 | HG00009259 | KM365122 | Histogenetics, Ossining, USA |
| DPB1*177:01 | HG00009247 | KM216213 | Histogenetics, Ossining, USA |
| DPB1*182:01 | HG00009249 | KM198192 | Histogenetics, Ossining, USA |
| DPB1*184:01 | HG00009251, HG00009252 | KM198186, KM198244 | Histogenetics, Ossining, USA |
| DPB1*210:01 | HG00009243 | KM198178 | Histogenetics, Ossining, USA |
| DPB1*218:01N | HG00009255 | KM198170 | Histogenetics, Ossining, USA |
| DPB1*301:01 | HG00009244 | KM198184 | Histogenetics, Ossining, USA |
| DPB1*309:01 | HG00009253 | KM198174 | Histogenetics, Ossining, USA |
| DPB1*329:01 | HG00009260 | KM365124 | Histogenetics, Ossining, USA |
| DPB1*357:01N | HG00009248 | KM248742 | Histogenetics, Ossining, USA |
| DPB1*365:01 | HG00009250 | KM198243 | Histogenetics, Ossining, USA |
| DPB1*369:01 | HG00009258 | KJ956777 | Histogenetics, Ossining, USA |
| DPB1*382:01N | HG00009254 | KM198168 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:05:01 | (4) |
| A*02:06:01 | (4) |
| A*11:101 | (5) |
| A*11:188 | (6) |
| A*11:192 | (7) |
| B*08:132 | (8) |
| B*15:325 | (9) |
| B*37:06:02 | (10) |
| B*55:50 | (11) |
| DRB1*15:02:11 | (12) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
- Hernandez-Frederick CJ, Cereb N, Giani AS, et al. Three hundred and seventy-two novel HLA class II alleles identified in potential hematopoietic stem cell donors from Germany, the United States, and Poland. Tissue Antigens. 2014; 84:497-502.
- Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res. 2013; 41:D1222-7.
- Zhang H, Xu YP. Genomic full-length sequence of two HLA-A alleles, A*02:05:01 and A*02:06:01 identified by cloning and sequencing. Tissue Antigens. 2014; 84:505-7.
- Zhang X, Li XF, Lin FQ, Zhang KL, Li JP. Identification of a novel HLA allele, HLA-A*11:101, in a platelet donor from China. Tissue Antigens. 2014; 84:508-9.
- Li Z, Lu L, Nie D, et al. HLA-A*11:188: a new allele identified by sequence-based typing in a Chinese blood donor. Tissue Antigens. 2014; 84:512-3.
- Todorova K, Zuber K, Neuwirt P, Arnold R, Schonemann C, Schulze H. Identification of the novel HLA-A*11:192 allele by HLA typing of a Caucasian individual. Tissue Antigens. 2014; 84:509-10.
- Papazoglou A, Gasiewski A, Huynh A, et al. Identification and characterization of a novel HLA-B hybrid allele, B*08:132 with Next Generation Sequencing. Tissue Antigens. 2014; 84:513-4.
- Ou G, Wang J, Wang C, Ji X, Chen Q. A novel HLA-B allele, HLA-B*15:325, is identified by sequence-based typing in a HIV infected individual. Tissue Antigens. 2014; 84:514-5.
- Li X, Zou H, Gu B, Zhu Y, Chen Q. A novel HLA allele, HLA-B*37:06:02, identified in a Chinese family. Tissue Antigens. 2014; 84:516-7.
- Zhang KL, Li XF, Zhang X, Lin FQ, Li JP. A novel HLA allele, HLA-B*55:50, was identified by sequence-based typing. Tissue Antigens. 2014; 84:517-8.
- Yang KL, Lee SK, Hung JH, Lin PY. HLA-DRB1*15:02:11, a variant of HLA-DRB1*15:02:01, revealed in a Taiwanese patient awaiting hematopoietic stem cell transplantation. Tissue Antigens. 2014; 84:519-20.
