Nomenclature for Factors of the HLA System

June 2014

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the May 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences Table 1) and confirmations of previously reported sequences Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence B*49:15 has been shown to be in error and be identical to the B*49:01:01 allele, consequently the designation B*49:15 has been abandoned.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided 2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:67DKMS-LSL-A-166LK021985Viviane Albrecht, Dresden, Germany
A*01:01:68DKMS-LSL-A-167LK021986Viviane Albrecht, Dresden, Germany
A*01:157DKMS-LSL-A-131LK021948Viviane Albrecht, Dresden, Germany
A*01:158HG00008587KJ749706Histogenetics, Ossining, USA
A*01:159HG00008601KJ749709Histogenetics, Ossining, USA
A*01:160NHG00008602KJ749701Histogenetics, Ossining, USA
A*01:161DKMS-LSL-A-165LK021984Viviane Albrecht, Dresden, Germany
A*02:01:110DKMS-LSL-A-128LK021945Viviane Albrecht, Dresden, Germany
A*02:01:111HG00008606KJ819834Histogenetics, Ossining, USA
A*02:01:112HG00008610KJ749705Histogenetics, Ossining, USA
A*02:03:08HG00008607KJ749707Histogenetics, Ossining, USA
A*02:06:17HG00008603KJ819845Histogenetics, Ossining, USA
A*02:525NDKMS-LSL-A-123LK021942Viviane Albrecht, Dresden, Germany
A*02:526DKMS-LSL-A-150LK021967Viviane Albrecht, Dresden, Germany
A*02:527HG00008604KJ749766Histogenetics, Ossining, USA
A*02:528HG00008605KJ749704Histogenetics, Ossining, USA
A*02:529HG00008608KJ819846Histogenetics, Ossining, USA
A*02:530HG00008609KJ749708Histogenetics, Ossining, USA
A*02:531HG00008611KJ749770Histogenetics, Ossining, USA
A*02:532DKMS-LSL-A-157LK021975Viviane Albrecht, Dresden, Germany
A*02:533DKMS-LSL-A-160LK021978Viviane Albrecht, Dresden, Germany
A*02:534DKMS-LSL-A-161LK021979Viviane Albrecht, Dresden, Germany
A*02:535DKMS-LSL-A-163LK021982Viviane Albrecht, Dresden, Germany
A*02:536DKMS-LSL-A-169LK021988Viviane Albrecht, Dresden, Germany
A*02:537DKMS-LSL-A-180LK021999Viviane Albrecht, Dresden, Germany
A*02:538MADA777080LK024171Steven GE Marsh, London, United Kingdom
A*03:198DKMS-LSL-A-134LK021950Viviane Albrecht, Dresden, Germany
A*03:199HG00008600KJ819835Histogenetics, Ossining, USA
A*03:200QDKMS-LSL-A-158LK021976Viviane Albrecht, Dresden, Germany
A*11:01:65HG00008593KJ749710Histogenetics, Ossining, USA
A*11:204HG00008591KJ749765Histogenetics, Ossining, USA
A*11:205HG00008592KJ749768Histogenetics, Ossining, USA
A*11:206DKMS-LSL-A-173LK021992Viviane Albrecht, Dresden, Germany
A*23:66HG00008597KJ749702Histogenetics, Ossining, USA
A*24:02:89DKMS-LSL-A-170LK021989Viviane Albrecht, Dresden, Germany
A*24:07:02HG00008599KJ819836Histogenetics, Ossining, USA
A*24:287360391LK021330Edward KL Yang, Hualien, Taiwan
A*24:288HG00008598KJ819844Histogenetics, Ossining, USA
A*26:104DKMS-LSL-A-126LK021943Viviane Albrecht, Dresden, Germany
A*26:105HG00008612KJ749767Histogenetics, Ossining, USA
A*30:88HG00008596KJ749769Histogenetics, Ossining, USA
A*30:89DKMS-LSL-A-181LK022000Viviane Albrecht, Dresden, Germany
A*30:90DKMS-LSL-A-199LK022017Viviane Albrecht, Dresden, Germany
A*31:89HG00008588KJ819847Histogenetics, Ossining, USA
A*32:675711301209KJ831627Faming Zhu, Hangzhou, China
A*33:03:27HG00008589KJ749703Histogenetics, Ossining, USA
A*33:93HG00008590KJ819837Histogenetics, Ossining, USA
A*68:01:26HG00008595KJ819849Histogenetics, Ossining, USA
A*68:01:27DKMS-LSL-A-162LK021980Viviane Albrecht, Dresden, Germany
A*68:76:02HG00008594KJ819843Histogenetics, Ossining, USA
A*68:103:02DKMS-LSL-A-133LK022019Viviane Albrecht, Dresden, Germany
A*68:118DKMS-LSL-A-130LK021947Viviane Albrecht, Dresden, Germany
A*68:119DKMS-LSL-A-132LK021949Viviane Albrecht, Dresden, Germany
A*68:120NDKMS-LSL-A-159LK021977Viviane Albrecht, Dresden, Germany
A*68:121DKMS-LSL-A-168LK021987Viviane Albrecht, Dresden, Germany
B*07:225D11000574FR849756Jinghui Qu, Shenzhen, China
B*07:226DKMS-LSL-B-177LK021996Viviane Albrecht, Dresden, Germany
B*07:227DKMS-LSL-B-184LK022003Viviane Albrecht, Dresden, Germany
B*08:133DKMS-LSL-B-136LK021951Viviane Albrecht, Dresden, Germany
B*08:134DKMS-LSL-B-137LK021952Viviane Albrecht, Dresden, Germany
B*13:56:02NHG00008621KJ819850Histogenetics, Ossining, USA
B*13:81HG00008627KJ819867Histogenetics, Ossining, USA
B*15:3265751300414KJ831628Faming Zhu, Hangzhou, China
B*15:327350599LK021329Edward KL Yang, Hualien, Taiwan
B*15:328HG00008624KJ749773Histogenetics, Ossining, USA
B*15:329HG00008625KJ819864Histogenetics, Ossining, USA
B*27:130HG00008370KJ535559Histogenetics, Ossining, USA
B*27:131CLS00001KJ857482Jinguo Wang, Calgary, Canada
B*35:03:17DKMS-LSL-B-188LK022007Viviane Albrecht, Dresden, Germany
B*35:260HG00008623KJ819868Histogenetics, Ossining, USA
B*37:52DKMS-LSL-B-182LK022001Viviane Albrecht, Dresden, Germany
B*39:01:21DKMS-LSL-B-185LK022004Viviane Albrecht, Dresden, Germany
B*39:97N5741300629KJ859678Faming Zhu, Hangzhou, China
B*40:02:23HG00008617KJ819866Histogenetics, Ossining, USA
B*40:294HG00008615,
HG00008616		KJ749712,
KJ749774		Histogenetics, Ossining, USA
B*40:295HG00008618,
HG00008619,
HG00008620		KJ749772,
KJ749778,
KJ749779		Histogenetics, Ossining, USA
B*44:203SCU-19606KJ858683Antonio Balas, Madrid, Spain
B*44:204HG00008622KJ749777Histogenetics, Ossining, USA
B*46:60337797LK021328Edward KL Yang, Hualien, Taiwan
B*50:39HG00008614KJ749771Histogenetics, Ossining, USA
B*58:60HG00008613KJ749780Histogenetics, Ossining, USA
B*58:610281158414HG518111Jue Wang, Chengdu, China
C*01:02:29DKMS-LSL-C-138LK021953Viviane Albrecht, Dresden, Germany
C*01:100HG00008629KJ819873Histogenetics, Ossining, USA
C*02:85DKMS-LSL-C-151LK021968Viviane Albrecht, Dresden, Germany
C*02:86DKMS-LSL-C-87LK021971Viviane Albrecht, Dresden, Germany
C*03:260DKMS-LSL-C-178LK021997Viviane Albrecht, Dresden, Germany
C*03:261DKMS-LSL-C-193LK022013Viviane Albrecht, Dresden, Germany
C*03:262DKMS-LSL-C-195LK022015Viviane Albrecht, Dresden, Germany
C*04:176DKMS-LSL-C-146LK021964Viviane Albrecht, Dresden, Germany
C*04:177DKMS-LSL-C-191LK022011Viviane Albrecht, Dresden, Germany
C*05:09:03HG00008539KJ675419Histogenetics, Ossining, USA
C*06:02:39HG00008630KJ749728Histogenetics, Ossining, USA
C*06:02:40HG00008632KJ819880Histogenetics, Ossining, USA
C*06:134NDKMS-LSL-C-142LK021960Viviane Albrecht, Dresden, Germany
C*06:135DKMS-LSL-C-143LK021961Viviane Albrecht, Dresden, Germany
C*06:136DKMS-LSL-C-153LK021972Viviane Albrecht, Dresden, Germany
C*06:137HG00008631KJ749738Histogenetics, Ossining, USA
C*07:01:45DKMS-LSL-C-145LK021963Viviane Albrecht, Dresden, Germany
C*07:02:63DKMS-LSL-C-148LK021970Viviane Albrecht, Dresden, Germany
C*07:02:64DKMS-LSL-C-149LK021966Viviane Albrecht, Dresden, Germany
C*07:381HG00008537KJ619515Histogenetics, Ossining, USA
C*07:382HG00008538KJ564313Histogenetics, Ossining, USA
C*07:383DKMS-LSL-C-139LK021954Viviane Albrecht, Dresden, Germany
C*07:384DKMS-LSL-C-140LK021958Viviane Albrecht, Dresden, Germany
C*07:385DKMS-LSL-C-201LK022020Viviane Albrecht, Dresden, Germany
C*07:386DKMS-LSL-C-154LK021973Viviane Albrecht, Dresden, Germany
C*07:387HG00008633KJ819889Histogenetics, Ossining, USA
C*07:388HG00008634KJ749726Histogenetics, Ossining, USA
C*07:389HG00008636KJ819882Histogenetics, Ossining, USA
C*07:390HG00008637KJ749732Histogenetics, Ossining, USA
C*07:391DKMS-LSL-C-190LK022009Viviane Albrecht, Dresden, Germany
C*07:392DKMS-LSL-C-194LK022014Viviane Albrecht, Dresden, Germany
C*08:112DKMS-LSL-C-88LK022010Viviane Albrecht, Dresden, Germany
C*12:129HG00008540KJ564312Histogenetics, Ossining, USA
C*15:96QDKMS-LSL-C-192LK022012Viviane Albrecht, Dresden, Germany
C*16:74HG00008541KJ675417Histogenetics, Ossining, USA
C*16:75DKMS-LSL-C-189LK022008Viviane Albrecht, Dresden, Germany
DRB1*01:44:02HG00008576KJ619525Histogenetics, Ossining, USA
DRB1*03:111HG00008570KJ675426Histogenetics, Ossining, USA
DRB1*03:112HG00008571KJ667136Histogenetics, Ossining, USA
DRB1*04:01:16HG00008569KJ675428Histogenetics, Ossining, USA
DRB1*04:180HG00008567KJ675429Histogenetics, Ossining, USA
DRB1*04:181HG00008568KJ667139Histogenetics, Ossining, USA
DRB1*11:01:24HG00008574KJ667137Histogenetics, Ossining, USA
DRB1*11:62:02HG00008573KJ619567Histogenetics, Ossining, USA
DRB1*13:186HG00008572KJ675427Histogenetics, Ossining, USA
DRB1*13:187HG00008575KJ585773Histogenetics, Ossining, USA
DQB1*03:150HG00008562KJ667125Histogenetics, Ossining, USA
DQB1*04:02:07HG00008564KJ667123Histogenetics, Ossining, USA
DQB1*04:02:08HG00008565KJ585766Histogenetics, Ossining, USA
DQB1*04:23DKMS-LSL-DQB1-197LK022016Viviane Albrecht, Dresden, Germany
DQB1*05:77HG00008561KJ619522Histogenetics, Ossining, USA
DQB1*06:159HG00008563KJ619521Histogenetics, Ossining, USA
DRB1*15:112HG00008566KJ667135Histogenetics, Ossining, USA
DPB1*354:01HG00008577KJ667147Histogenetics, Ossining, USA
DPB1*355:01HG00008578KJ675430Histogenetics, Ossining, USA
DPB1*356:01HG00008579KJ675431Histogenetics, Ossining, USA
DPB1*357:01NHG00008580KJ585782Histogenetics, Ossining, USA
DPB1*358:01HG00008581KJ564320Histogenetics, Ossining, USA
DPB1*359:01HG00008582KJ667146Histogenetics, Ossining, USA
DPB1*360:01HG00008583KJ585783Histogenetics, Ossining, USA
DPB1*361:01HG00008584KJ667148Histogenetics, Ossining, USA
DPB1*362:01HG00008585KJ667143Histogenetics, Ossining, USA
DPB1*363:010280943258HG328364Jue Wang, Chengdu, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:154DKMS-LSL-A-124LK021955Viviane Albrecht, Dresden, Germany
A*02:436DKMS-LSL-A-164LK021983Viviane Albrecht, Dresden, Germany
A*03:107DKMS-LSL-A-125LK021956Viviane Albrecht, Dresden, Germany
A*03:48DKMS-LSL-A-156LK021974Viviane Albrecht, Dresden, Germany
A*23:19Q33185HG974606Marcel GJ Tilanus, Maastricht, The Netherlands
A*24:238DKMS-LSL-A-171LK021990Viviane Albrecht, Dresden, Germany
A*24:36NDKMS-LSL-A-202LK022021Viviane Albrecht, Dresden, Germany
B*08:01:29DKMS-LSL-B-175LK021994Viviane Albrecht, Dresden, Germany
B*08:110DKMS-LSL-B-135LK021957Viviane Albrecht, Dresden, Germany
B*18:94NDKMS-LSL-B-174LK021993Viviane Albrecht, Dresden, Germany
B*40:32DKMS-LSL-B-204LK022024Viviane Albrecht, Dresden, Germany
B*49:01:01BY00735HQ127355Carolyn K Hurley, Washington DC, USA
B*49:01:01HG00001981GQ254329Histogenetics, Ossining, USA
B*51:158:01HG00008626KJ819851Histogenetics, Ossining, USA
B*55:66DKMS-LSL-B-176LK021995Viviane Albrecht, Dresden, Germany
C*03:192DKMS-LSL-C-152LK021969Viviane Albrecht, Dresden, Germany
C*06:23DKMS-LSL-C-147LK021965Viviane Albrecht, Dresden, Germany
C*07:342HG00008635KJ749787Histogenetics, Ossining, USA
C*07:359331307LK021331Edward KL Yang, Hualien, Taiwan
C*12:113DKMS-LSL-C-200LK022018Viviane Albrecht, Dresden, Germany
C*12:99DKMS-LSL-C-141LK021959Viviane Albrecht, Dresden, Germany
C*17:03DKMS-LSL-C-155LK021981Viviane Albrecht, Dresden, Germany
DRB1*04:2518072HG974573Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*09:01:105771300444KJ831629Faming Zhu, Hangzhou, China
DRB1*11:06:0128410HG974579Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:0422584HG974577Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*13:26:015845HG974571Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*14:0820193HG974576Marcel GJ Tilanus, Maastricht, The Netherlands
DRB1*16:0719050HG974574Marcel GJ Tilanus, Maastricht, The Netherlands

Table 3: Recently Published Sequences


Sequence References
A*01:01:01:013
A*01:033
A*02:4664
A*11:1655
A*24:2246
A*24:225:016
A*24:2576
B*15:2767
B*40:02:188
B*54:299
C*03:24010
C*04:03:0211

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Lu L, Xu YP. Genomic full-length sequence of two HLA-A alleles, A*01:01:01:01 and A*01:03, identified by cloning and sequencing. Tissue Antigens. 2014 83: 423-4.
  4. Yang KL, Lee SK, Lin PY. HLA-A*02:466, a variant of HLA-A*02, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2014 83: 424-5.
  5. Yang KL, Lee SK, Lin PY. HLA-A*11:165, a variant of HLA-A*11, discovered in a Taiwanese unrelated hematopoietic stem cell donor. Tissue Antigens. 2014 83: 425-7.
  6. Zhu C, Zhang HW, Zhang Y, Nie XM. Three novel HLA-A*24 alleles identified in Chinese Han individuals. Tissue Antigens. 2014 83: 427-8.
  7. Barbuti S, Sciarrino R, Mariotti M, Curcio M, Scatena F. Identification of a novel HLA-B*15 variant allele, HLA-B*15:276, in an umbilical cord blood donor. Tissue Antigens. 2014 83: 428-9.
  8. Ko SY, Oh HB, Jun JH, Kwon OJ. HLA-B*40:02:18, a new HLA-B*40 allele. Tissue Antigens. 2014 83: 429-30.
  9. He JJ, Wang W, He J, Zhu FM, Lv HJ. A novel allele, HLA-B*54:29, identified by sequence-based typing in a Chinese bone marrow donor. Tissue Antigens. 2014 83: 430-2.
  10. Wang D, Wu J, Nie D, Zhang H, Zhen J, Zou H. Identification of the novel HLA-C*03:240 allele. Tissue Antigens. 2014 83: 432-3.
  11. He L, Wang D, Zou H. Characterization of a novel variant allele, HLA-C*04:03:02, identified in a Chinese Han individual. Tissue Antigens. 2014 83: 433-4.