Nomenclature for Factors of the HLA System
February 2014
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens (2014) 83:439-443
- Human Immunology (2014) 75:690-693
- International Journal of Immunogenetics (2014) 41:346-350
The following sequences have been submitted to the Nomenclature Committee since the January 2014 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:148 | HG00007174 | KF501497 | Histogenetics, Ossining, USA |
| A*01:149 | HG00007175 | KF501494 | Histogenetics, Ossining, USA |
| A*01:150 | HG00007176, HG00007177 | KF291263, KF291261 | Histogenetics, Ossining, USA |
| A*02:11:06 | HG00007187 | KF438195 | Histogenetics, Ossining, USA |
| A*02:484 | HG00007184 | KF535955 | Histogenetics, Ossining, USA |
| A*02:485 | HG00007185 | KF263492 | Histogenetics, Ossining, USA |
| A*02:486 | HG00007186 | KF291262 | Histogenetics, Ossining, USA |
| A*02:487 | HG00007188 | KF291260 | Histogenetics, Ossining, USA |
| A*02:488 | I031 | KJ205532 | Wangxia Li, Wuhan, China |
| A*03:01:45 | HG00007180 | KF415250 | Histogenetics, Ossining, USA |
| A*03:184 | HG00007178 | KF415249 | Histogenetics, Ossining, USA |
| A*03:185 | HG00007179 | KF312402 | Histogenetics, Ossining, USA |
| A*11:01:60 | HG00007154 | KF471684 | Histogenetics, Ossining, USA |
| A*11:01:61 | HG00007155 | KF535960 | Histogenetics, Ossining, USA |
| A*11:01:62 | HG00007162 | KF312406 | Histogenetics, Ossining, USA |
| A*11:183 | HG00006371 | KF036233 | Histogenetics, Ossining, USA |
| A*11:184 | HG00007159 | KF535957 | Histogenetics, Ossining, USA |
| A*11:185 | HG00007160 | KF381221 | Histogenetics, Ossining, USA |
| A*11:186 | HG00007161 | KF381218 | Histogenetics, Ossining, USA |
| A*11:187 | HG00007163 | KF263491 | Histogenetics, Ossining, USA |
| A*11:188 | sz13010552A | KJ185393 | Daming Wang, Shenzhen, China |
| A*24:275 | HG00007170 | KF381222 | Histogenetics, Ossining, USA |
| A*24:276 | HG00007172 | KF471695 | Histogenetics, Ossining, USA |
| A*24:277 | HG00007173 | KF381224 | Histogenetics, Ossining, USA |
| A*25:25 | HG00007166 | KF438193 | Histogenetics, Ossining, USA |
| A*29:01:06 | HG00007146 | KF535951 | Histogenetics, Ossining, USA |
| A*29:60 | D51775 | HG931084 | Odile Avinens, Montpellier, Cedex 5, France |
| A*30:82 | HG00007169 | KF312401 | Histogenetics, Ossining, USA |
| A*31:01:21 | HG00007149 | KF263494 | Histogenetics, Ossining, USA |
| A*31:01:22 | HG00007150 | KF415246 | Histogenetics, Ossining, USA |
| A*31:85 | HG00007147 | KF501496 | Histogenetics, Ossining, USA |
| A*31:86 | HG00007148 | KF312405 | Histogenetics, Ossining, USA |
| A*32:01:16 | HG00007183 | KF501493 | Histogenetics, Ossining, USA |
| A*32:62 | HG00007181 | KF381223 | Histogenetics, Ossining, USA |
| A*33:03:25 | HG00007151 | KF535952 | Histogenetics, Ossining, USA |
| A*33:86 | HG00007145 | KF535953 | Histogenetics, Ossining, USA |
| A*68:110 | HG00007153 | KF381220 | Histogenetics, Ossining, USA |
| A*68:111 | HG00007167 | KF438192 | Histogenetics, Ossining, USA |
| A*69:03 | HG00007165 | KF438194 | Histogenetics, Ossining, USA |
| B*07:151:02 | HG00007237 | KF381233 | Histogenetics, Ossining, USA |
| B*07:211 | HG00007239 | KF291264 | Histogenetics, Ossining, USA |
| B*07:212 | Xian63062 | KF961695 | Jun Qi, Xian, China |
| B*07:33:03 | HG00007238 | KF291269 | Histogenetics, Ossining, USA |
| B*08:01:24 | HG00007210 | KF263501 | Histogenetics, Ossining, USA |
| B*08:117 | HG00007211 | KF415251 | Histogenetics, Ossining, USA |
| B*08:118 | HG00007212 | KF291265 | Histogenetics, Ossining, USA |
| B*08:119 | HG00007213 | KF535965 | Histogenetics, Ossining, USA |
| B*13:74 | HG00007214 | KF312408 | Histogenetics, Ossining, USA |
| B*13:75 | HG00007215 | KF438186 | Histogenetics, Ossining, USA |
| B*13:76N | 8811300178 | KJ137675 | Xiangming Zhu, Kunming, China |
| B*15:01:35 | HG00007228 | KF501499 | Histogenetics, Ossining, USA |
| B*15:308 | HG00007220 | KF381238 | Histogenetics, Ossining, USA |
| B*15:309 | HG00007227 | KF381228 | Histogenetics, Ossining, USA |
| B*15:310 | HG00007229 | KF471722 | Histogenetics, Ossining, USA |
| B*15:311 | HG00007231 | KF291266 | Histogenetics, Ossining, USA |
| B*15:312 | HG00007232 | KF381226 | Histogenetics, Ossining, USA |
| B*18:98 | HG00007208 | KF263496 | Histogenetics, Ossining, USA |
| B*18:99 | HG00007209 | KF471723 | Histogenetics, Ossining, USA |
| B*27:05:27 | HG00007206 | KF438187 | Histogenetics, Ossining, USA |
| B*27:119 | HG00007203 | KF471724 | Histogenetics, Ossining, USA |
| B*27:120 | HG00007204 | KF381237 | Histogenetics, Ossining, USA |
| B*27:121 | HG00007205 | KF381236 | Histogenetics, Ossining, USA |
| B*27:122 | HG00007207 | KF501505 | Histogenetics, Ossining, USA |
| B*35:08:07 | HG00007236 | KF263498 | Histogenetics, Ossining, USA |
| B*35:251 | HG00007222 | KF535967 | Histogenetics, Ossining, USA |
| B*35:252 | HG00007230 | KF438189 | Histogenetics, Ossining, USA |
| B*39:01:18 | HG00007240 | KF471719 | Histogenetics, Ossining, USA |
| B*39:89 | HG00007242 | KF471721 | Histogenetics, Ossining, USA |
| B*40:01:38 | HG00007193 | KF471720 | Histogenetics, Ossining, USA |
| B*40:01:39 | Xian57248 | KF955602 | Mengli Liu, Xi���an, China |
| B*40:273 | HG00007196 | KF501507 | Histogenetics, Ossining, USA |
| B*40:274 | HG00007198 | KF501504 | Histogenetics, Ossining, USA |
| B*40:275 | HG00007201 | KF501509 | Histogenetics, Ossining, USA |
| B*40:276 | HG00007202 | KF263502 | Histogenetics, Ossining, USA |
| B*40:35:02 | HG00007200 | KF381230 | Histogenetics, Ossining, USA |
| B*41:32 | HG00007194 | KF415252 | Histogenetics, Ossining, USA |
| B*44:188 | HG00007190, HG00007191 | KF312407, KF501502 | Histogenetics, Ossining, USA |
| B*44:189 | HG00007216 | KF501500 | Histogenetics, Ossining, USA |
| B*44:190 | HG00007217 | KF312413 | Histogenetics, Ossining, USA |
| B*44:191 | HG00007218 | KF381234 | Histogenetics, Ossining, USA |
| B*49:01:05 | HG00007192 | KF501508 | Histogenetics, Ossining, USA |
| B*49:01:06 | HG00007195 | KF312410 | Histogenetics, Ossining, USA |
| B*51:01:46 | HG00007233 | KF312412 | Histogenetics, Ossining, USA |
| B*51:08:02 | HG00007235 | KF381231 | Histogenetics, Ossining, USA |
| B*51:167 | HG00007189 | KF535962 | Histogenetics, Ossining, USA |
| B*51:168 | HG00007234 | KF438188 | Histogenetics, Ossining, USA |
| B*51:169 | DAGF | HG530131 | Valerie Dubois, Lyon, France |
| B*52:37 | HG00007225 | KF535966 | Histogenetics, Ossining, USA |
| B*53:01:10 | HG00007243 | KF381232 | Histogenetics, Ossining, USA |
| B*53:32 | HG00007221 | KF312409 | Histogenetics, Ossining, USA |
| B*53:33 | HG00007223, HG00007224 | KF291267, KF291268 | Histogenetics, Ossining, USA |
| B*58:59 | HG00007226 | KF535963 | Histogenetics, Ossining, USA |
| C*01:92 | HG00007244 | KF291280 | Histogenetics, Ossining, USA |
| C*03:240 | sz4176C | KJ185392 | Daming Wang, Shenzhen, China |
| C*06:125 | HG00007245 | KF471730 | Histogenetics, Ossining, USA |
| C*06:126 | HG00007249 | KF263507 | Histogenetics, Ossining, USA |
| C*06:127 | HG00007250 | KF535968 | Histogenetics, Ossining, USA |
| C*06:128N | HG00007256 | KF381239 | Histogenetics, Ossining, USA |
| C*07:01:40 | HG00007257 | KF438198 | Histogenetics, Ossining, USA |
| C*07:02:54 | HG00007247 | KF501517 | Histogenetics, Ossining, USA |
| C*07:355 | HG00007246 | KF263503 | Histogenetics, Ossining, USA |
| C*07:356 | HG00007248 | KF501520 | Histogenetics, Ossining, USA |
| C*07:357 | HG00007254 | KF291273 | Histogenetics, Ossining, USA |
| C*07:358 | HG00007255 | KF291275 | Histogenetics, Ossining, USA |
| C*07:359 | ABAL772993 | HG796222 | Steven GE Marsh, London, United Kingdom |
| C*07:76:02 | HG00007251 | KF501515 | Histogenetics, Ossining, USA |
| DRB1*03:96 | CG6408 | HG797651 | Xiang Liu, Beijing, China |
| DRB1*03:97 | D53384 | HG931083 | Odile Avinens, Montpellier, Cedex 5, France |
| DRB1*04:56:02 | 93087236 | KJ407396 | Daniel Fuerst, Ulm, Germany |
| DRB1*11:08:03 | ASUS286789 | HG796223 | Steven GE Marsh, London, United Kingdom |
| DRB1*11:154 | CH4408 | HG797655 | Xiang Liu, Beijing, China |
| DRB1*12:45 | CW5931 | HG797653 | Xiang Liu, Beijing, China |
| DRB1*12:46 | RUCH133143 | HG796224 | Steven GE Marsh, London, United Kingdom |
| DRB1*14:147 | AV8315 | HG797654 | Xiang Liu, Beijing, China |
| DRB1*15:01:23 | CV2407 | HG797652 | Xiang Liu, Beijing, China |
| DQA1*01:05:02 | 224036 | HG803546 | Klaus Witter, M?�nchen, Germany |
| DQB1*03:115 | CB7886 | HG797650 | Xiang Liu, Beijing, China |
| DPA1*02:02:06 | G993041 | KF555375 | Chen-Chung Chu, New Taipei City, Taiwan |
| DPB1*02:01:12 | HG00006346 | KF152908 | Histogenetics, Ossining, USA |
| DPB1*04:01:16 | HG00006343 | KF184352 | Histogenetics, Ossining, USA |
| DPB1*11:01:03 | HG00006350 | KF220355 | Histogenetics, Ossining, USA |
| DPB1*214:01 | HG00006340 | KF220354 | Histogenetics, Ossining, USA |
| DPB1*215:01 | HG00006341, HG00006342 | KF036208, KF128979 | Histogenetics, Ossining, USA |
| DPB1*216:01N | HG00006344 | KF220350 | Histogenetics, Ossining, USA |
| DPB1*217:01 | HG00006345 | KF128976 | Histogenetics, Ossining, USA |
| DPB1*218:01N | HG00006347 | KF220351 | Histogenetics, Ossining, USA |
| DPB1*219:01 | HG00006348 | KF220358 | Histogenetics, Ossining, USA |
| DPB1*220:01 | HG00006349 | KF152909 | Histogenetics, Ossining, USA |
| DPB1*221:01 | HG00006351 | KF152906 | Histogenetics, Ossining, USA |
| DPB1*222:01 | HG00006352 | KF128972 | Histogenetics, Ossining, USA |
| MICA*080 | 1189P249987 | KJ413140 | Daniel Fuerst, Ulm, Germany |
| MICA*081 | 1198P09205115 | KJ413141 | Daniel Fuerst, Ulm, Germany |
| MICA*082 | G20111107003 | HG931177 | Dabin Tang, Chengdu, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:407 | HG00007709 | KF749232 | Histogenetics, Ossining, USA |
| A*11:52Q | 120823772 | HG792591 | Dominique Masson, La Tronche, France |
| A*24:213 | HG00007953 | KF976733 | Histogenetics, Ossining, USA |
| A*24:248 | BJ1025 | KC473543 | Xiaoyan Shan, Beijing, China |
| A*68:99 | HG00007948, HG00007949 | KJ017980, KF951104 | Histogenetics, Ossining, USA |
| A*68:104 | HG00007693 | KF790833 | Histogenetics, Ossining, USA |
| B*15:01:31 | HG00007579, HG00007580 | KF381225, KF438185 | Histogenetics, Ossining, USA |
| B*15:07:03 | HG00007722 | KF804112 | Histogenetics, Ossining, USA |
| B*15:282 | HG00007725 | KF749238 | Histogenetics, Ossining, USA |
| B*35:01:35 | HG00007578 | KF577614 | Histogenetics, Ossining, USA |
| B*37:01:09 | HG00007577 | KF501506 | Histogenetics, Ossining, USA |
| B*40:130:02 | HG00007846 | KF882434 | Histogenetics, Ossining, USA |
| B*40:268 | HG00007715 | KF737192 | Histogenetics, Ossining, USA |
| B*46:01:18 | TMOI2014 | KJ011856 | Pei Yongfeng, Nanning, China |
| B*57:63 | HG00007975 | KF976737 | Histogenetics, Ossining, USA |
| C*12:94 | HG00007879 | KF840755 | Histogenetics, Ossining, USA |
| DRB1*04:01:12 | HG00007664 | KF501540 | Histogenetics, Ossining, USA |
| DRB1*12:02:01 | HG00007914 | KF925417 | Histogenetics, Ossining, USA |
| DRB1*13:158 | HG00007665 | KF263514 | Histogenetics, Ossining, USA |
| DQB1*02:27 | HG00007749 | KF737221 | Histogenetics, Ossining, USA |
| DQB1*02:29 | HG00007645, HG00007646 | KF501532, KF673225 | Histogenetics, Ossining, USA |
| DQB1*03:02:06 | HG00007634 | KF647800 | Histogenetics, Ossining, USA |
| DQB1*03:45 | HG00007635 | KF647802 | Histogenetics, Ossining, USA |
| DQB1*03:72 | HG00007648 | KF415268 | Histogenetics, Ossining, USA |
| DQB1*04:02:03 | HG00007649 | KF535977 | Histogenetics, Ossining, USA |
| DQB1*04:02:04 | HG00007650, HG00007651 | KF673220, KF471735 | Histogenetics, Ossining, USA |
| DQB1*04:11 | HG00007647 | KF647809 | Histogenetics, Ossining, USA |
| DQB1*05:01:04 | HG00007636 | KF535973 | Histogenetics, Ossining, USA |
| DQB1*05:01:05 | HG00007637, HG00007638 | KF577632, KF501527 | Histogenetics, Ossining, USA |
| DQB1*05:01:08 | HG00007639, HG00007640, HG00007641 | KF415260, KF501530, KF471742 | Histogenetics, Ossining, USA |
| DQB1*05:03:08 | HG00007644 | KF673217 | Histogenetics, Ossining, USA |
| DQB1*05:19 | HG00007758 | KF804122 | Histogenetics, Ossining, USA |
| DQB1*05:23 | HG00007642, HG00007643 | KF501524, KF263511 | Histogenetics, Ossining, USA |
| DQB1*05:43 | HG00007905 | KF882449 | Histogenetics, Ossining, USA |
| DQB1*06:02:07 | HG00007652 | KF673227 | Histogenetics, Ossining, USA |
| DQB1*06:03:07 | HG00007633 | KF415263 | Histogenetics, Ossining, USA |
| DQB1*06:03:09 | HG00007630 | KF602018 | Histogenetics, Ossining, USA |
| DQB1*06:09:02 | HG00007631, HG00007632 | KF602021, KF602023 | Histogenetics, Ossining, USA |
| DQB1*06:11:01 | 24019938 | HG915713 | Thibaut Gervais, Brussels, Belgium |
| DQB1*06:15:02 | HG00007655, HG00007656 | KF673224, KF602016 | Histogenetics, Ossining, USA |
| DQB1*06:22:02 | HG00007653 | KF673222 | Histogenetics, Ossining, USA |
| DQB1*06:71 | HG00007654 | KF602026 | Histogenetics, Ossining, USA |
| DQB1*06:74 | HG00007657 | KF501533 | Histogenetics, Ossining, USA |
| DQB1*06:78 | HG00007658 | KF312422 | Histogenetics, Ossining, USA |
| DQB1*06:81 | HG00007659, HG00007660, HG00007661, HG00007662, HG00007663 | KF501523, KF535982, KF602019, KF381256, KF471737 | Histogenetics, Ossining, USA |
| DQB1*06:93 | HG00007629 | KF291285 | Histogenetics, Ossining, USA |
| DPB1*02:01:09 | HG00007673 | KF673246 | Histogenetics, Ossining, USA |
| DPB1*04:01:06 | HG00007666, HG00007667, HG00007668, HG00007669, HG00007670 | KF263522, KF415276, KF471759, KF501542, KF501558 | Histogenetics, Ossining, USA |
| DPB1*04:01:07 | HG00007671 | KF560463 | Histogenetics, Ossining, USA |
| DPB1*04:01:15 | HG00007927 | KF882487 | Histogenetics, Ossining, USA |
| DPB1*09:01:02 | HG00007677, HG00007678, HG00007679, HG00007680 | KF535996, KF647813, KF471747, KF415275 | Histogenetics, Ossining, USA |
| DPB1*13:01:02 | HG00007682, HG00007683, HG00007684 | KF577637, KF560452, KF560455 | Histogenetics, Ossining, USA |
| DPB1*150:01 | HG00007672 | KF438219 | Histogenetics, Ossining, USA |
| DPB1*155:01 | HG00007674, HG00007675, HG00007676 | KF673232, KF647812, KF577646 | Histogenetics, Ossining, USA |
| DPB1*158:01 | HG00007681 | KF535991 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*03:168N | (3) |
| B*08:113 | (4) |
| B*44:184 | (5) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
- Abad ML, Balas A, Andersen I, Rodriguez-Calvo MI, Eiras A, Vicario JL. A new non-expressed allele HLA-A*03:168N, identified by serological and sequence-based typing in a voluntary Norwegian hematopoietic stem cell donor. Tissue Antigens. 2014; 83:195-6.
- Strobel J, Ringwald J, Hauck-Dlimi B, Eckstein R, Zingsem J. The novel allele, HLA-B*08:113, identified in a German cord blood donor and his mother. Tissue Antigens. 2014; 83:197-8.
- Wada A, Shiina T, Michino J, Yasumura S, Sugiyama T. A novel HLA-B allele, HLA-B*44:184, identified by super high-resolution single-molecule sequence-based typing in a Japanese individual. Tissue Antigens. 2014; 83:198-9.
