Nomenclature for Factors of the HLA System
September 2013
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 82:458-61
- Human Immunology. 2013 74:1717-9
- International Journal of Immunogenetics. 2013 40:538-41
The following sequences have been submitted to the Nomenclature Committee since the August 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:01:98 | D11020516 | KF418545 | Jinghui Qu, Shenzhen, China |
| A*02:01:99 | CBRA59126148390 | HG427204 | Dominique Masson, La Tronche, France |
| A*02:06:15 | D11002394 | KF418570 | Jinghui Qu, Shenzhen, China |
| A*02:07:03 | D11033365 | KF418574 | Jinghui Qu, Shenzhen, China |
| A*02:243:02 | D11040246 | KF418577 | Jinghui Qu, Shenzhen, China |
| A*02:448 | D11042835 | KF418544 | Jinghui Qu, Shenzhen, China |
| A*02:449 | D11026799 | KF418546 | Jinghui Qu, Shenzhen, China |
| A*02:450 | D11018106 | KF418571 | Jinghui Qu, Shenzhen, China |
| A*02:451 | D11009197 | KF418572 | Jinghui Qu, Shenzhen, China |
| A*02:452 | D11026410 | KF418575 | Jinghui Qu, Shenzhen, China |
| A*02:453 | CD11001649 | KF418576 | Jinghui Qu, Shenzhen, China |
| A*02:454 | CD13000554 | KF564794 | Joan Feng, Beijing, China |
| A*02:455 | 39178 | HG327124 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| A*02:456 | 13217037 | KF611900 | Daniel Fuerst, Ulm, Germany |
| A*03:175 | D11049091 | KF418578 | Jinghui Qu, Shenzhen, China |
| A*11:01:52 | CD11001690 | KF418549 | Jinghui Qu, Shenzhen, China |
| A*11:01:53 | D11049441 | KF418581 | Jinghui Qu, Shenzhen, China |
| A*11:153 | D11032854 | KF418548 | Jinghui Qu, Shenzhen, China |
| A*11:154 | D11041376 | KF418550 | Jinghui Qu, Shenzhen, China |
| A*11:155 | D11003198 | KF418580 | Jinghui Qu, Shenzhen, China |
| A*11:156 | D11049397 | KF418582 | Jinghui Qu, Shenzhen, China |
| A*11:157 | D11007373 | KF418585 | Jinghui Qu, Shenzhen, China |
| A*11:158 | D11037371 | KF418588 | Jinghui Qu, Shenzhen, China |
| A*11:91:02 | D11047375 | KF418579 | Jinghui Qu, Shenzhen, China |
| A*24:248 | D11004858 | KF418551 | Jinghui Qu, Shenzhen, China |
| A*24:249 | D11032329 | KF418553 | Jinghui Qu, Shenzhen, China |
| A*24:250 | D11049011 | KF418554 | Jinghui Qu, Shenzhen, China |
| A*24:251 | D11014491 | KF418555 | Jinghui Qu, Shenzhen, China |
| A*24:252N | 93089062 | KF611901 | Daniel Fuerst, Ulm, Germany |
| A*29:02:14 | FRFGR31331 | HG427206 | Dominique Masson, La Tronche, France |
| A*66:01:02 | 41633 | HG327126 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*27:05:25 | 15646173 | HG004400 | Jane Rowlands, Pontyclun, United Kingdom |
| B*27:05:26 | FRFGR31371 | HG427207 | Dominique Masson, La Tronche, France |
| B*35:02:06 | 96073628 | KC788282 | Daniel Fuerst, Ulm, Germany |
| B*44:184 | S-25017 | AB847953 | Takashi Shiina, Isehara, Japan |
| B*56:43 | UD1036 | KF002484 | Arturas Jakubauskas, Vilnius, Lithuania |
| C*02:05:02 | BY01131 | KF551942 | Carolyn K Hurley, Washington DC, USA |
| C*03:219 | 33639 | HG327128 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| C*03:220 | BY01133 | KF551940 | Carolyn K Hurley, Washington DC, USA |
| C*04:159 | D10117687 | KF175432 | Jinghui Qu, Shenzhen, China |
| C*04:160 | COH11-07628 | KF158235 | Jean Garcia-Gomez, Duarte, USA |
| C*04:161 | 39556 | HG327127 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| C*06:116N | D10042658 | KF175452 | Jinghui Qu, Shenzhen, China |
| C*06:117 | BY01090 | KF551944 | Carolyn K Hurley, Washington DC, USA |
| C*08:94 | BY01130 | KF551943 | Carolyn K Hurley, Washington DC, USA |
| C*17:22 | BY01127, BY01128 | KF551946, KF551945 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:149 | D11043751 | KF270571 | Jinghui Qu, Shenzhen, China |
| DRB1*13:02:09 | HG00005917 | KC441509 | Histogenetics, Ossining, USA |
| DQB1*03:01:21 | D11027419 | KF270526 | Jinghui Qu, Shenzhen, China |
| DQB1*03:02:11 | D11045730 | KF270531 | Jinghui Qu, Shenzhen, China |
| DQB1*03:02:12 | D11044953 | KF270532 | Jinghui Qu, Shenzhen, China |
| DQB1*03:03:09 | D11047173 | KF270535 | Jinghui Qu, Shenzhen, China |
| DQB1*03:03:10 | D11022652 | KF270537 | Jinghui Qu, Shenzhen, China |
| DQB1*03:91Q | D10130180 | JX402006 | Jinghui Qu, Shenzhen, China |
| DQB1*03:92 | D11006238 | KF270527 | Jinghui Qu, Shenzhen, China |
| DQB1*03:93 | D11003655 | KF270528 | Jinghui Qu, Shenzhen, China |
| DQB1*03:94 | D11003905 | KF270530 | Jinghui Qu, Shenzhen, China |
| DQB1*03:95N | D11013249 | KF270533 | Jinghui Qu, Shenzhen, China |
| DQB1*03:96 | D11030299 | KF270534 | Jinghui Qu, Shenzhen, China |
| DQB1*03:97 | D11002442 | KF270536 | Jinghui Qu, Shenzhen, China |
| DQB1*03:98 | D11020045 | KF270538 | Jinghui Qu, Shenzhen, China |
| DQB1*03:99Q | D11036370 | KF270539 | Jinghui Qu, Shenzhen, China |
| DQB1*03:100 | D11039987 | KF270540 | Jinghui Qu, Shenzhen, China |
| DQB1*04:02:05 | D11012067 | KF270541 | Jinghui Qu, Shenzhen, China |
| DQB1*05:45 | D11034672 | KF270542 | Jinghui Qu, Shenzhen, China |
| DQB1*05:46 | D11036513 | KF270544 | Jinghui Qu, Shenzhen, China |
| DQB1*05:47 | D11035974 | KF270546 | Jinghui Qu, Shenzhen, China |
| DQB1*06:51:02 | BY01138 | KF551938 | Carolyn K Hurley, Washington DC, USA |
| DQB1*06:112N | D11017873 | KF270552 | Jinghui Qu, Shenzhen, China |
| DQB1*06:113 | D11050711 | KF270553 | Jinghui Qu, Shenzhen, China |
| DQB1*06:114 | D11002709 | KF270554 | Jinghui Qu, Shenzhen, China |
| DQB1*06:115 | D11036899 | KF270557 | Jinghui Qu, Shenzhen, China |
| DQB1*06:116 | D11023603 | KF270558 | Jinghui Qu, Shenzhen, China |
| DQB1*06:117 | RD11001476 | KF270559 | Jinghui Qu, Shenzhen, China |
| DQB1*06:118 | D11024299 | KF270560 | Jinghui Qu, Shenzhen, China |
| DQB1*06:119 | BY01135 | KF551939 | Carolyn K Hurley, Washington DC, USA |
| DPB1*167:01 | 5711102248 | KF557650 | Faming Zhu, Hangzhou, China |
| DPB1*168:01 | 5771201075 | KF656733 | Faming Zhu, Hangzhou, China |
| MICA*012:04 | 390O07218601 | KF611903 | Daniel Fuerst, Ulm, Germany |
| MICA*077 | 376P266445 | KF611902 | Daniel Fuerst, Ulm, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:77 | CBRA59126130334 | HG427205 | Dominique Masson, La Tronche, France |
| A*02:426 | D11042756 | KF418573 | Jinghui Qu, Shenzhen, China |
| A*02:83N | FRFY20850 | HG427210 | Dominique Masson, La Tronche, France |
| A*11:01:27 | HG00006366 | JN123773 | Histogenetics, Ossining, USA |
| A*11:01:43 | HG00006367, HG00006368 | JX970490, JN123780 | Histogenetics, Ossining, USA |
| A*11:105 | HG00006390, HG00006391 | KC209748, JQ824423 | Histogenetics, Ossining, USA |
| A*11:112 | D11010292 | KF418584 | Jinghui Qu, Shenzhen, China |
| A*11:117 | HG00006373 | JQ739470 | Histogenetics, Ossining, USA |
| A*11:135 | HG00006364 | KF184335 | Histogenetics, Ossining, USA |
| A*11:54 | HG00006369, HG00006370 | JQ622192, JQ668157 | Histogenetics, Ossining, USA |
| A*11:74 | HG00006393 | JQ687293 | Histogenetics, Ossining, USA |
| A*11:81 | HG00006372 | JQ687296 | Histogenetics, Ossining, USA |
| A*23:01:06 | HG00006413 | KC632157 | Histogenetics, Ossining, USA |
| A*23:01:10 | HG00006405 | KC592297 | Histogenetics, Ossining, USA |
| A*23:28 | HG00006408 | JQ867310 | Histogenetics, Ossining, USA |
| A*24:02:18 | HG00006417 | JQ277282 | Histogenetics, Ossining, USA |
| A*24:02:49 | HG00006409 | JX174600 | Histogenetics, Ossining, USA |
| A*24:02:53 | HG00006415, HG00006416 | JX027030, JX227998 | Histogenetics, Ossining, USA |
| A*24:02:59 | HG00006411 | KC748269 | Histogenetics, Ossining, USA |
| A*24:107 | HG00006414 | JQ768428 | Histogenetics, Ossining, USA |
| A*24:129 | HG00006406, HG00006407 | JQ436603, JQ436604 | Histogenetics, Ossining, USA |
| A*24:157 | HG00006412 | JQ359462 | Histogenetics, Ossining, USA |
| A*24:160 | HG00006418 | JQ581009 | Histogenetics, Ossining, USA |
| A*24:173 | HG00006410 | JQ668179 | Histogenetics, Ossining, USA |
| A*24:192 | HG00006403, HG00006404 | KC959241, JX390627 | Histogenetics, Ossining, USA |
| A*24:197 | HG00006419 | JQ797367 | Histogenetics, Ossining, USA |
| A*24:205 | HG00006402 | JX481996 | Histogenetics, Ossining, USA |
| A*24:234 | D11017171 | KF418552 | Jinghui Qu, Shenzhen, China |
| A*25:01:06 | HG00006376, HG00006377, HG00006378, HG00006379, HG00006380, HG00006381 | JX842746, JQ668160, JQ581005, JQ622190, KC603575, JX441338 | Histogenetics, Ossining, USA |
| A*25:12N | HG00006375 | JQ436586 | Histogenetics, Ossining, USA |
| A*25:16 | HG00006384 | JQ739491 | Histogenetics, Ossining, USA |
| A*25:19 | HG00006382, HG00006383 | KC603573, KC748272 | Histogenetics, Ossining, USA |
| A*26:01:23 | HG00006388, HG00006389 | JX089350, KC424458 | Histogenetics, Ossining, USA |
| A*26:59 | HG00006365 | JQ713615 | Histogenetics, Ossining, USA |
| A*26:74 | HG00006385 | JQ911867 | Histogenetics, Ossining, USA |
| A*26:75 | HG00006386, HG00006387 | JX089359, KC991051 | Histogenetics, Ossining, USA |
| A*29:02:09 | HG00006360, HG00006361, HG00006362 | KC859246, JQ997116, JQ964643 | Histogenetics, Ossining, USA |
| A*29:32 | HG00006359 | JX885885 | Histogenetics, Ossining, USA |
| A*29:44 | HG00006358 | KF015523 | Histogenetics, Ossining, USA |
| A*30:02:06 | HG00006395, HG00006396, HG00006397 | KC748236, KC348372, KC959240 | Histogenetics, Ossining, USA |
| A*30:30 | HG00006398, HG00006399, HG00006400 | JQ668154, JQ768432, JQ935210 | Histogenetics, Ossining, USA |
| A*30:56 | HG00006394 | JX174601 | Histogenetics, Ossining, USA |
| A*30:71 | HG00006401 | KC155587 | Histogenetics, Ossining, USA |
| A*31:43 | HG00006355 | JQ687288 | Histogenetics, Ossining, USA |
| A*31:68 | HG00006353, HG00006354 | KF036236, KC904392 | Histogenetics, Ossining, USA |
| A*33:03:07 | HG00006356 | JQ359457 | Histogenetics, Ossining, USA |
| A*33:57 | HG00006357 | JQ997105 | Histogenetics, Ossining, USA |
| A*68:54 | HG00006363 | JQ277280 | Histogenetics, Ossining, USA |
| A*68:72 | HG00006374 | JQ964638 | Histogenetics, Ossining, USA |
| A*68:91 | HG00006392 | JX481998 | Histogenetics, Ossining, USA |
| B*48:02:03 | FRFGR31967 | HG427208 | Dominique Masson, La Tronche, France |
| C*02:65 | FRFVA41067 | HG427209 | Dominique Masson, La Tronche, France |
| C*04:155 | 33180 | HG327123 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| C*04:82 | D10044420 | KF175436 | Jinghui Qu, Shenzhen, China |
| C*06:103 | BY01126 | KF551947 | Carolyn K Hurley, Washington DC, USA |
| C*12:60 | BY01132 | KF551941 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:141 | D11031172 | KF270564 | Jinghui Qu, Shenzhen, China |
| DQB1*03:01:08 | D11037441 | KF270529 | Jinghui Qu, Shenzhen, China |
| DQB1*05:02:07 | D11009799 | KF270545 | Jinghui Qu, Shenzhen, China |
| DQB1*06:01:10 | D11047535 | KF270551 | Jinghui Qu, Shenzhen, China |
| DQB1*06:02:11 | D11031581 | KF270555 | Jinghui Qu, Shenzhen, China |
| DQB1*06:88 | D11039053 | KF270561 | Jinghui Qu, Shenzhen, China |
| DQB1*06:103 | D11014041 | KF270549 | Jinghui Qu, Shenzhen, China |
| DQB1*06:107 | D11013674 | KF270556 | Jinghui Qu, Shenzhen, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*26:79 | (3) |
| A*30:01:01 | (4) |
| A*30:04:01 | (4) |
| B*51:153 | (5) |
| DRB1*11:131 | (6) |
| DQB1*05:01:05 | (6) |
| DPA1*02:05 | (7) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
- Zhang W, He YM, He J, Zhu FM, Lv HJ. Identification of the novel HLA-A*26:79 allele by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2013: 82: 294
- Li Z, Xu YP. Genomic full-length sequence of two HLA-A alleles, A*30:01:01 and A*30:04:01, identified by cloning and sequencing. Tissue Antigens. 2013: 82: 295-6.
- Planelles D, Balas A, Sanz GF, Rodriguez-Cebria M, Vicario JL. Sequencing of a novel HLA-B allele, B*51:153, in a Spanish individual. Tissue Antigens. 2013: 82: 297.
- Jakubauskas A, Valatkaite B, Griskevicius L. Two novel HLA class II alleles, DRB1*11:131 and DQB1*05:01:05, identified by sequence-based typing. Tissue Antigens. 2013: 82: 299-300.
- Xu Y, Deng Z, He L. Characterization of the novel HLA-DPA1*02:05 allele identified by sequence-based typing. Tissue Antigens. 2013: 82: 298-9.
