Nomenclature for Factors of the HLA System
August 2013
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 82:452-7
- Human Immunology. 2013 74:1713-6
- International Journal of Immunogenetics. 2013 40:533-7
The following sequences have been submitted to the Nomenclature Committee since the July 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
Sequence | Cell identification | Accession number | Submitting author |
---|---|---|---|
A*01:139 | 63700 | HG004399 | Jane Rowlands, Pontyclun, United Kingdom |
A*01:140 | BY01122 | KF482390 | Carolyn K Hurley, Washington DC, USA |
A*01:141 | D11037624 | KF418558 | Jinghui Qu, Shenzhen, China |
A*01:142 | D11022135 | KF418559 | Jinghui Qu, Shenzhen, China |
A*02:01:97 | D11048675 | KF418564 | Jinghui Qu, Shenzhen, China |
A*02:03:05 | D11043271 | KF418566 | Jinghui Qu, Shenzhen, China |
A*02:03:06 | D11023212 | KF418568 | Jinghui Qu, Shenzhen, China |
A*02:439N | BY01093 | KF318741 | Carolyn K Hurley, Washington DC, USA |
A*02:440Q | BY01097 | KF318737 | Carolyn K Hurley, Washington DC, USA |
A*02:441 | 271111662 | KF501489 | Wangxia Li, Wuhan, China |
A*02:442 | D11022869 | KF418560 | Jinghui Qu, Shenzhen, China |
A*02:443 | D11013527 | KF418561 | Jinghui Qu, Shenzhen, China |
A*02:444 | D11049071 | KF418562 | Jinghui Qu, Shenzhen, China |
A*02:445 | D11016259 | KF418563 | Jinghui Qu, Shenzhen, China |
A*02:446 | D11019201 | KF418565 | Jinghui Qu, Shenzhen, China |
A*02:447 | D11006287 | KF418567 | Jinghui Qu, Shenzhen, China |
A*11:01:51 | BY01094 | KF318740 | Carolyn K Hurley, Washington DC, USA |
A*11:151 | 90172837 | KC577585 | Daniel Fuerst, Ulm, Germany |
A*11:152 | 0271211454A | KF515273 | Wen Qiang, Wuhan, China |
A*31:78 | BY01123 | KF482388 | Carolyn K Hurley, Washington DC, USA |
A*31:79 | BY01119 | KF482387 | Carolyn K Hurley, Washington DC, USA |
A*32:59 | BY01124 | KF482389 | Carolyn K Hurley, Washington DC, USA |
A*33:73N | MDA0000156, MDA0000157 | KF442969, KF442970 | Kai Cao, Houston, USA |
A*33:74N | 101961 | KF515524 | Chun-Ying Lin, Taipei, Taiwan |
A*68:105 | PI12-3632 | KF460577 | Michele Curcio, Pisa, Italy |
A*68:106 | BY01120 | KF482392 | Carolyn K Hurley, Washington DC, USA |
A*74:18 | BY01096 | KF318738 | Carolyn K Hurley, Washington DC, USA |
A*74:19 | BY01116 | KF482384 | Carolyn K Hurley, Washington DC, USA |
B*07:200 | HG00006018 | KC875893 | Histogenetics, Ossining, USA |
B*07:201N | HG00006019 | KC959260 | Histogenetics, Ossining, USA |
B*07:202 | HG00006022 | KC991060 | Histogenetics, Ossining, USA |
B*07:203 | HG00006023 | KF015529 | Histogenetics, Ossining, USA |
B*07:204 | BY01113 | KF482402 | Carolyn K Hurley, Washington DC, USA |
B*08:113 | ERL_20095 | HG421893 | Juergen Zingsem, Erlangen, Germany |
B*14:01:04 | HG00006017 | KC959274 | Histogenetics, Ossining, USA |
B*15:284 | 4521100952 | KC701036 | Xin Li, Harbin, China |
B*15:285 | HG00006001 | KC904412 | Histogenetics, Ossining, USA |
B*15:286 | HG00006003 | KC875905 | Histogenetics, Ossining, USA |
B*15:287 | HG00006004 | KC904400 | Histogenetics, Ossining, USA |
B*15:288 | HG00006005 | KC632165 | Histogenetics, Ossining, USA |
B*15:289 | HG00006006 | KC959287 | Histogenetics, Ossining, USA |
B*15:290 | HG00006012 | KF015528 | Histogenetics, Ossining, USA |
B*15:291 | HG00006026 | KF015530 | Histogenetics, Ossining, USA |
B*27:107 | BY01125 | KF498960 | Carolyn K Hurley, Washington DC, USA |
B*37:42N | BY01104 | KF482393 | Carolyn K Hurley, Washington DC, USA |
B*38:44 | HG00006024 | KC875894 | Histogenetics, Ossining, USA |
B*38:45 | HG00006025 | KC904402 | Histogenetics, Ossining, USA |
B*40:249 | Xi`an 57428 | KF437296 | XiaoFang Wang, Xian, China |
B*44:182 | BY01112 | KF482401 | Carolyn K Hurley, Washington DC, USA |
B*44:183 | BY01106 | KF482395 | Carolyn K Hurley, Washington DC, USA |
B*44:84:02 | BY01109 | KF482397 | Carolyn K Hurley, Washington DC, USA |
B*46:43 | HG00006002 | KC875899 | Histogenetics, Ossining, USA |
B*51:01:43 | JMDP36K0203 | AB836681 | Kenji Tadokoro, Tokyo, Japan |
B*51:24:05 | HG00006014 | KC904404 | Histogenetics, Ossining, USA |
B*52:01:19 | HG00006000 | KC959272 | Histogenetics, Ossining, USA |
B*52:10:03 | HG00006016 | KC904420 | Histogenetics, Ossining, USA |
B*55:60 | HG00006011 | KC959286 | Histogenetics, Ossining, USA |
B*57:01:16 | HG00006008 | KC748293 | Histogenetics, Ossining, USA |
B*57:67 | HG00006007 | KC875915 | Histogenetics, Ossining, USA |
B*57:68 | HG00006009 | KC991061 | Histogenetics, Ossining, USA |
B*58:48 | BY01110 | KF482399 | Carolyn K Hurley, Washington DC, USA |
C*03:02:11 | HG00006086 | KC503875 | Histogenetics, Ossining, USA |
C*03:04:42 | HG00006076 | KC875935 | Histogenetics, Ossining, USA |
C*03:214 | HG00006083 | KF015538 | Histogenetics, Ossining, USA |
C*03:215 | HG00006084 | KC959295 | Histogenetics, Ossining, USA |
C*03:216 | HG00006087 | KC904431 | Histogenetics, Ossining, USA |
C*03:217 | HG00006089 | KC991068 | Histogenetics, Ossining, USA |
C*03:218 | MDA0000158 | KF498958 | Kai Cao, Houston, USA |
C*04:155 | HG00006092 | KC904442 | Histogenetics, Ossining, USA |
C*04:156 | HG00006093 | KC904443 | Histogenetics, Ossining, USA |
C*04:157 | HG00006094 | KC875928 | Histogenetics, Ossining, USA |
C*04:158 | 142149 | KF500544 | Elaine Hodges, Durham, USA |
C*05:97 | HG00006057 | KC875929 | Histogenetics, Ossining, USA |
C*06:02:01:03 | 2454 | JX512226 | Zahra Mehdizadeh Kashi, Beaverton, USA |
C*06:02:31 | HG00006031 | KC875918 | Histogenetics, Ossining, USA |
C*06:02:32 | HG00006033, HG00006034 | KC904421, KF015542 | Histogenetics, Ossining, USA |
C*06:02:33 | HG00006037 | KF015532 | Histogenetics, Ossining, USA |
C*06:02:34 | HG00006051, HG00006052, HG00006053, HG00006054 | KC875924, KC875925, KC875926, KC875927 | Histogenetics, Ossining, USA |
C*06:112 | HG00006035 | KF015546 | Histogenetics, Ossining, USA |
C*06:113 | HG00006036 | KC904433 | Histogenetics, Ossining, USA |
C*06:114 | HG00006038 | KF015543 | Histogenetics, Ossining, USA |
C*06:115 | HG00006050 | KC875916 | Histogenetics, Ossining, USA |
C*07:01:35 | HG00006040 | KC875939 | Histogenetics, Ossining, USA |
C*07:01:36 | HG00006041 | KC904430 | Histogenetics, Ossining, USA |
C*07:01:37 | HG00006044 | KC904422 | Histogenetics, Ossining, USA |
C*07:325 | HG00006027 | KC904438 | Histogenetics, Ossining, USA |
C*07:326 | HG00006028 | KC875923 | Histogenetics, Ossining, USA |
C*07:327 | HG00006029 | KC875937 | Histogenetics, Ossining, USA |
C*07:328 | HG00006032 | KC959296 | Histogenetics, Ossining, USA |
C*07:329N | HG00006039 | KC959292 | Histogenetics, Ossining, USA |
C*07:330 | HG00006042 | KC904432 | Histogenetics, Ossining, USA |
C*07:331 | HG00006043 | KC959299 | Histogenetics, Ossining, USA |
C*07:332 | HG00006045 | KF015537 | Histogenetics, Ossining, USA |
C*07:333 | HG00006046 | KC904428 | Histogenetics, Ossining, USA |
C*07:334 | HG00006047 | KC875919 | Histogenetics, Ossining, USA |
C*07:335 | HG00006048 | KC959293 | Histogenetics, Ossining, USA |
C*07:336 | HG00006049 | KC959303 | Histogenetics, Ossining, USA |
C*07:337 | D10111441 | KF175453 | Jinghui Qu, Shenzhen, China |
C*08:90 | HG00006055 | KC959307 | Histogenetics, Ossining, USA |
C*08:91 | HG00006056 | KC959304 | Histogenetics, Ossining, USA |
C*08:92 | HG00006058 | KC904434 | Histogenetics, Ossining, USA |
C*08:93 | HG00006059 | KC959309 | Histogenetics, Ossining, USA |
C*12:02:10 | D10057658 | KF175486 | Jinghui Qu, Shenzhen, China |
C*12:03:26 | HG00006060 | KF015539 | Histogenetics, Ossining, USA |
C*12:03:27 | HG00006067 | KC904425 | Histogenetics, Ossining, USA |
C*12:03:28 | D10065867 | KF175489 | Jinghui Qu, Shenzhen, China |
C*12:100 | HG00006068 | KF015534 | Histogenetics, Ossining, USA |
C*12:101 | HG00006069, HG00006070 | KC904440, KC959324 | Histogenetics, Ossining, USA |
C*12:102 | HG00006071, HG00006072 | KC959315, KC959313 | Histogenetics, Ossining, USA |
C*12:103 | HG00006073 | KC959300 | Histogenetics, Ossining, USA |
C*12:104N | D10093103 | KF175483 | Jinghui Qu, Shenzhen, China |
C*12:105N | D10092617 | KF175484 | Jinghui Qu, Shenzhen, China |
C*12:106 | D10097830 | KF175485 | Jinghui Qu, Shenzhen, China |
C*12:107 | D10068520 | KF175487 | Jinghui Qu, Shenzhen, China |
C*12:108 | D10106688 | KF175488 | Jinghui Qu, Shenzhen, China |
C*12:109 | D10025823 | KF175490 | Jinghui Qu, Shenzhen, China |
C*12:110 | D10128214 | KF175491 | Jinghui Qu, Shenzhen, China |
C*12:111 | D10103042 | KF175492 | Jinghui Qu, Shenzhen, China |
C*14:02:13 | HG00006090 | KC959318 | Histogenetics, Ossining, USA |
C*14:02:14 | D10115904 | KF175494 | Jinghui Qu, Shenzhen, China |
C*14:02:15 | D10111022 | KF175496 | Jinghui Qu, Shenzhen, China |
C*14:55 | HG00006091 | KC904423 | Histogenetics, Ossining, USA |
C*14:56 | D10088662 | KF175493 | Jinghui Qu, Shenzhen, China |
C*14:57 | D10097204 | KF175495 | Jinghui Qu, Shenzhen, China |
C*14:58 | D10081884 | KF175497 | Jinghui Qu, Shenzhen, China |
C*15:02:17 | D10077717 | KF175498 | Jinghui Qu, Shenzhen, China |
C*15:02:18 | D10110834 | KF175500 | Jinghui Qu, Shenzhen, China |
C*15:02:19 | D10064532 | KF175504 | Jinghui Qu, Shenzhen, China |
C*15:10:03 | HG00006088 | KF015545 | Histogenetics, Ossining, USA |
C*15:72 | HG00006077 | KC959320 | Histogenetics, Ossining, USA |
C*15:73 | HG00006078 | KC959316 | Histogenetics, Ossining, USA |
C*15:74 | HG00006079 | KC959319 | Histogenetics, Ossining, USA |
C*15:75 | HG00006080 | KC959308 | Histogenetics, Ossining, USA |
C*15:76 | HG00006081 | KC875932 | Histogenetics, Ossining, USA |
C*15:77 | HG00006082 | KF015544 | Histogenetics, Ossining, USA |
C*15:78 | D10093291 | KF175499 | Jinghui Qu, Shenzhen, China |
C*15:79 | D10124011 | KF175501 | Jinghui Qu, Shenzhen, China |
C*15:80 | D10122209 | KF175502 | Jinghui Qu, Shenzhen, China |
C*15:81 | D10029837 | KF175503 | Jinghui Qu, Shenzhen, China |
C*15:82 | D10105562 | KF175505 | Jinghui Qu, Shenzhen, China |
C*16:01:14 | HG00006064 | KC592339 | Histogenetics, Ossining, USA |
C*16:01:15 | HG00006065 | KC904429 | Histogenetics, Ossining, USA |
C*16:02:10 | HG00006062 | KC904426 | Histogenetics, Ossining, USA |
C*16:02:11 | HG00006063 | KC875930 | Histogenetics, Ossining, USA |
C*16:60 | HG00006061 | KC904439 | Histogenetics, Ossining, USA |
C*17:01:01:03 | 2454 | JX512225 | Zahra Mehdizadeh Kashi, Beaverton, USA |
C*17:20 | HG00006030 | KC959323 | Histogenetics, Ossining, USA |
C*17:21 | HG00006074 | KC959314 | Histogenetics, Ossining, USA |
DRB1*01:60 | BY01098 | KF482403 | Carolyn K Hurley, Washington DC, USA |
DRB1*04:95:02 | BY01103 | KF482408 | Carolyn K Hurley, Washington DC, USA |
DRB1*07:27 | D11024371 | KF270566 | Jinghui Qu, Shenzhen, China |
DRB1*07:28 | D11032796 | KF270567 | Jinghui Qu, Shenzhen, China |
DRB1*09:01:10 | D11026285 | KF270569 | Jinghui Qu, Shenzhen, China |
DRB1*09:22 | D11017395 | KF270570 | Jinghui Qu, Shenzhen, China |
DRB1*12:16:03 | D11048765 | KF270576 | Jinghui Qu, Shenzhen, China |
DRB1*12:41 | D11026433 | KF270572 | Jinghui Qu, Shenzhen, China |
DRB1*12:42 | D11010719 | KF270573 | Jinghui Qu, Shenzhen, China |
DRB1*12:43 | D11014850 | KF270575 | Jinghui Qu, Shenzhen, China |
DRB1*14:143 | 13061928 | KF413408 | Mingrui Huo, Beijing, China |
DRB1*14:144 | D11035687 | KF270577 | Jinghui Qu, Shenzhen, China |
DRB1*15:100 | BY01099 | KF482404 | Carolyn K Hurley, Washington DC, USA |
DRB1*15:99 | BY01100 | KF482405 | Carolyn K Hurley, Washington DC, USA |
DQB1*03:02:10 | 13202937 | KC788284 | Daniel Fuerst, Ulm, Germany |
DQB1*05:44 | D10075685 | HE804226 | Jinghui Qu, Shenzhen, China |
DQB1*06:110 | BBMR donor | KF280209 | Zareen Goburdhun, London, United Kingdom |
DQB1*06:111 | 101888 | KF515523 | Chun-Ying Lin, Taipei, Taiwan |
DPB1*166:01 | T1D9 | JX524133 | Yann-Jinn Lee, Taipei County, Taiwan |
Table 2: Confirmatory Sequences
Sequence | Cell identification | Accession number | Submitting author |
---|---|---|---|
A*02:377 | BY01095 | KF318739 | Carolyn K Hurley, Washington DC, USA |
A*02:419 | D11021516 | KF418569 | Jinghui Qu, Shenzhen, China |
A*02:437 | Xi`an 57500 | KF413873 | Tianju Wang, Xi`an, China |
A*03:162N | 64362 | HG417079 | Jane Rowlands, Pontyclun, United Kingdom |
A*24:46 | BY01121 | KF482391 | Carolyn K Hurley, Washington DC, USA |
A*30:02:06 | BY01117 | KF482385 | Carolyn K Hurley, Washington DC, USA |
A*68:86 | BY01118 | KF482386 | Carolyn K Hurley, Washington DC, USA |
B*15:03:04 | HG00006013 | KC959268 | Histogenetics, Ossining, USA |
B*15:141 | JMDP01K0166 | AB836683 | Kenji Tadokoro, Tokyo, Japan |
B*38:01:06 | BY01105 | KF482394 | Carolyn K Hurley, Washington DC, USA |
B*40:81 | 102073 | KF515525 | Chun-Ying Lin, Taipei, Taiwan |
B*46:40 | 271211808 | KF515274 | Yuanyan Zhu, Wuhan, China |
B*50:17 | BY01111 | KF482400 | Carolyn K Hurley, Washington DC, USA |
B*51:126 | BY01108 | KF482398 | Carolyn K Hurley, Washington DC, USA |
B*57:61 | HG00006010 | KC875897 | Histogenetics, Ossining, USA |
C*02:02:13 | HG00006827 | JQ824461 | Histogenetics, Ossining, USA |
C*02:49 | HG00006826 | KC748285 | Histogenetics, Ossining, USA |
C*03:139 | HG00006085 | KC875936 | Histogenetics, Ossining, USA |
C*07:314 | HG00006075 | KC904435 | Histogenetics, Ossining, USA |
C*12:41 | BY01092 | KF318743 | Carolyn K Hurley, Washington DC, USA |
C*12:60 | HG00006066 | KF015540 | Histogenetics, Ossining, USA |
C*16:45 | BY01091 | KF318742 | Carolyn K Hurley, Washington DC, USA |
DRB1*03:88 | BY01102 | KF482407 | Carolyn K Hurley, Washington DC, USA |
DRB1*08:30:03 | BY01101 | KF482406 | Carolyn K Hurley, Washington DC, USA |
DRB1*11:23:02 | Xi`an 57977 | KF412898 | Mengli Liu, Xi�an, China |
DRB1*14:136 | 13-77 | KF432139, KF432140 | A-Hyun Lim, Seoul, South Korea |
DQB1*02:01:08 | D11013102 | KF270524 | Jinghui Qu, Shenzhen, China |
DQB1*02:12 | D11045606 | KF270525 | Jinghui Qu, Shenzhen, China |
Table 3: Recently Published Sequences
Sequence | References |
---|---|
A*02:393 | (3) |
B*13:68 | (4) |
B*39:01:16 | (5) |
B*40:211 | (6) |
B*40:227 | (7) |
B*48:19 | (8) |
E*01:06 | (9) |
DRB1*13:154 | (10) |
DRB1*14:05:04 | (11) |
DRB1*14:130 | (11) |
DRB1*14:131 | (11) |
DRB1*14:137N | (11) |
DRB1*15:01:21 | (11) |
DRB1*15:37:02 | (11) |
DRB1*15:81 | (11) |
DRB1*15:87 | (11) |
DRB1*15:88 | (11) |
DRB1*16:20 | (11) |
DQB1*02:01:07 | (11) |
DQB1*02:01:08 | (11) |
DQB1*02:02:02 | (11) |
DQB1*02:08 | (11) |
DQB1*02:09 | (11) |
DQB1*02:11 | (11) |
DQB1*02:12 | (11) |
DQB1*03:01:07 | (11) |
DQB1*03:01:08 | (11) |
DQB1*03:01:09 | (11) |
DQB1*03:01:10 | (11) |
DQB1*03:01:11 | (11) |
DQB1*03:39 | (12 |
DQB1*03:46 | (11) |
DQB1*03:47 | (11) |
DQB1*03:49 | (11) |
DQB1*03:50 | (11) |
DQB1*03:51 | (11) |
DQB1*04:09 | (13) |
DPB1*142:01 | (14) |
MICA*008:05 | (15) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
- Longa LA, Perotti L, Piovano F, Prucca M, Menardi G, Peano G. A novel HLA allele, HLA-A*02:393, identified in a two generation Italian family. Tissue Antigens. 2013: 82: 203-4.
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- Jin SZ, Zou HY. Identification of a new HLA-DQB1*03 variant, DQB1*03:39, by sequence-based typing in a Chinese Han individual. Tissue Antigens. 2013: 82: 213-4.
- Testi M, Troiano M, Guagnano A, Testa G, Andreani M. A new allele, HLA-DQB1*04:09. Tissue Antigens. 2013: 82: 215-6.
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