Nomenclature for Factors of the HLA System

July 2013

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the June 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at :

Table 1: New Sequences

Sequence Cell identification Accession number Submitting author
A*02:01:9690185817HG324057Christian Seidl, Frankfurt am Main, Germany
A*02:11:05HG00005973KC875889Histogenetics, Ossining, USA
A*24:02:71CALE747852HG007959Steven GE Marsh, London, United Kingdom
A*24:247SZGSQ 21KF304799Su-Qing Gao, Shenzhen, China
A*26:02:02JMDP36K0199AB829894Kenji Tadokoro, Tokyo, Japan
A*33:72BY01088KF278711Carolyn K Hurley, Washington DC, USA
A*68:103BY01084KF278715Carolyn K Hurley, Washington DC, USA
A*68:104BY01086KF278713Carolyn K Hurley, Washington DC, USA
B*07:199BY01056KF266789Carolyn K Hurley, Washington DC, USA
B*08:01:22HG00005989KC991056Histogenetics, Ossining, USA
B*08:112HG00005988KC748294Histogenetics, Ossining, USA
B*13:71HG00005990KC875907Histogenetics, Ossining, USA
B*15:283BY01082KF266791Carolyn K Hurley, Washington DC, USA
B*18:92HG00005980KF015527Histogenetics, Ossining, USA
B*18:93HG00005984KC959276Histogenetics, Ossining, USA
B*18:94NHG00005985KC603580Histogenetics, Ossining, USA
B*27:05:23HG00005977KC959277Histogenetics, Ossining, USA
B*27:05:24HG00005979KC991055Histogenetics, Ossining, USA
B*27:07:04HG00005978KC959291Histogenetics, Ossining, USA
B*35:234HG00005993KC904411Histogenetics, Ossining, USA
B*35:235HG00005994KC904405Histogenetics, Ossining, USA
B*35:236HG00005996KC904403Histogenetics, Ossining, USA
B*35:237HG00005997KC904409Histogenetics, Ossining, USA
B*35:238HG00005998KC959289Histogenetics, Ossining, USA
B*35:239BY01076KF266797Carolyn K Hurley, Washington DC, USA
B*35:240IME956-10TKF267447Manuela Testi, Rome, Italy
B*35:24135904HF970578Marcel GJ Tilanus, Maastricht, The Netherlands
B*37:38HG00005981KC959281Histogenetics, Ossining, USA
B*37:39HG00005982KC875900Histogenetics, Ossining, USA
B*37:40HG00005983KC875910Histogenetics, Ossining, USA
B*37:41HG00005987KC904401Histogenetics, Ossining, USA
B*40:247101762KF208638Chun-Ying Lin, Taipei, Taiwan
B*40:248BY01075KF266798Carolyn K Hurley, Washington DC, USA
B*41:29HG00005976KC959288Histogenetics, Ossining, USA
B*48:32BY01071KF266802Carolyn K Hurley, Washington DC, USA
B*50:34BY01074KF266799Carolyn K Hurley, Washington DC, USA
B*52:01:18HG00005999KC904419Histogenetics, Ossining, USA
B*52:32BY01081KF266792Carolyn K Hurley, Washington DC, USA
B*57:66BY01072KF266801Carolyn K Hurley, Washington DC, USA
B*58:01:14HG00005992KC959279Histogenetics, Ossining, USA
B*58:47HG00005991KC875906Histogenetics, Ossining, USA
C*01:02:20D10047948KF175394Jinghui Qu, Shenzhen, China
C*01:02:21D10057079KF175397Jinghui Qu, Shenzhen, China
C*01:02:22D10097769KF175399Jinghui Qu, Shenzhen, China
C*01:02:23D10092834KF175403Jinghui Qu, Shenzhen, China
C*01:79:02D10098667KF175396Jinghui Qu, Shenzhen, China
C*01:80D10066432KF175395Jinghui Qu, Shenzhen, China
C*01:81D10096758KF175398Jinghui Qu, Shenzhen, China
C*01:82D10111537KF175400Jinghui Qu, Shenzhen, China
C*01:83D10128630KF175401Jinghui Qu, Shenzhen, China
C*01:84D10075614KF175402Jinghui Qu, Shenzhen, China
C*02:6935767HF674389Marcel GJ Tilanus, Maastricht, The Netherlands
C*02:70D10050477KF175406Jinghui Qu, Shenzhen, China
C*02:71D10028882KF175404Jinghui Qu, Shenzhen, China
C*02:72D10025544KF175405Jinghui Qu, Shenzhen, China
C*03:03:22D10070263KF175415Jinghui Qu, Shenzhen, China
C*03:04:37D10064091KF175421Jinghui Qu, Shenzhen, China
C*03:04:38D10116860KF175422Jinghui Qu, Shenzhen, China
C*03:04:39D10074696KF175424Jinghui Qu, Shenzhen, China
C*03:04:40D10085847KF175426Jinghui Qu, Shenzhen, China
C*03:04:41D10047135KF175427Jinghui Qu, Shenzhen, China
C*03:13:02D10021653KF175431Jinghui Qu, Shenzhen, China
C*03:196JMDP36K0161AB829605Kenji Tadokoro, Tokyo, Japan
C*03:197D10098824KF175408Jinghui Qu, Shenzhen, China
C*03:198D10104742KF175409Jinghui Qu, Shenzhen, China
C*03:199D10072405KF175410Jinghui Qu, Shenzhen, China
C*03:200D10118127KF175411Jinghui Qu, Shenzhen, China
C*03:201ND10097621KF175412Jinghui Qu, Shenzhen, China
C*03:202D10095948KF175413Jinghui Qu, Shenzhen, China
C*03:203D10054540KF175414Jinghui Qu, Shenzhen, China
C*03:204D10051069KF175416Jinghui Qu, Shenzhen, China
C*03:205D10048588KF175417Jinghui Qu, Shenzhen, China
C*03:206D10118603KF175418Jinghui Qu, Shenzhen, China
C*03:207D10096862KF175419Jinghui Qu, Shenzhen, China
C*03:208ND10051727KF175420Jinghui Qu, Shenzhen, China
C*03:209D10109671KF175423Jinghui Qu, Shenzhen, China
C*03:210D10042999KF175425Jinghui Qu, Shenzhen, China
C*03:211D10029002KF175428Jinghui Qu, Shenzhen, China
C*03:212D10088501KF175429Jinghui Qu, Shenzhen, China
C*03:213D10073288KF175430Jinghui Qu, Shenzhen, China
C*04:01:53D10092900KF175434Jinghui Qu, Shenzhen, China
C*04:01:54D10048500KF175435Jinghui Qu, Shenzhen, China
C*04:153BY01064KF266814Carolyn K Hurley, Washington DC, USA
C*04:154D10021513KF175433Jinghui Qu, Shenzhen, China
C*05:95D10057122KF175438Jinghui Qu, Shenzhen, China
C*05:96D10059824KF175437Jinghui Qu, Shenzhen, China
C*06:02:28D10059708KF175443Jinghui Qu, Shenzhen, China
C*06:02:29D10109259KF175448Jinghui Qu, Shenzhen, China
C*06:02:30D10129772KF175449Jinghui Qu, Shenzhen, China
C*06:103P07264KF359943Faming Zhu, Hangzhou, China
C*06:103D10064622KF175444Jinghui Qu, Shenzhen, China
C*06:104D10059673KF175439Jinghui Qu, Shenzhen, China
C*06:105D10082769KF175440Jinghui Qu, Shenzhen, China
C*06:106:01D10053009KF175441Jinghui Qu, Shenzhen, China
C*06:106:02D10081329KF175442Jinghui Qu, Shenzhen, China
C*06:107D10061479KF175445Jinghui Qu, Shenzhen, China
C*06:108D10026251KF175446Jinghui Qu, Shenzhen, China
C*06:109D10127705KF175447Jinghui Qu, Shenzhen, China
C*06:110D10117867KF175450Jinghui Qu, Shenzhen, China
C*06:111D10023732KF175451Jinghui Qu, Shenzhen, China
C*07:02:44D10064815KF175454Jinghui Qu, Shenzhen, China
C*07:02:45D10044257KF175457Jinghui Qu, Shenzhen, China
C*07:02:46D10070500KF175460Jinghui Qu, Shenzhen, China
C*07:02:47D10128702KF175461Jinghui Qu, Shenzhen, China
C*07:02:48D10051528KF175462Jinghui Qu, Shenzhen, China
C*07:02:49D10097615KF175463Jinghui Qu, Shenzhen, China
C*07:02:50D10064431KF175464Jinghui Qu, Shenzhen, China
C*07:02:51D10057081KF175465Jinghui Qu, Shenzhen, China
C*07:316101355KF208637Chun-Ying Lin, Taipei, Taiwan
C*07:317BY01062KF266816Carolyn K Hurley, Washington DC, USA
C*07:318D10106275KF175455Jinghui Qu, Shenzhen, China
C*07:319D10109996KF175456Jinghui Qu, Shenzhen, China
C*07:320D10095664KF175458Jinghui Qu, Shenzhen, China
C*07:321D10103159KF175459Jinghui Qu, Shenzhen, China
C*07:322D10099231KF175466Jinghui Qu, Shenzhen, China
C*07:323D10116718KF175467Jinghui Qu, Shenzhen, China
C*07:324D10054705KF175468Jinghui Qu, Shenzhen, China
C*08:01:11D10067403KF175474Jinghui Qu, Shenzhen, China
C*08:01:12D10067254KF175475Jinghui Qu, Shenzhen, China
C*08:79D10083171KF175469Jinghui Qu, Shenzhen, China
C*08:80D10127194KF175470Jinghui Qu, Shenzhen, China
C*08:81D10109077KF175471Jinghui Qu, Shenzhen, China
C*08:82D10062302KF175473Jinghui Qu, Shenzhen, China
C*08:83D10126572KF175476Jinghui Qu, Shenzhen, China
C*08:84D10123391KF175477Jinghui Qu, Shenzhen, China
C*08:85D10089657KF175478Jinghui Qu, Shenzhen, China
C*08:86D10025458KF175479Jinghui Qu, Shenzhen, China
C*08:87D10075175KF175480Jinghui Qu, Shenzhen, China
C*08:88ND10102176KF175481Jinghui Qu, Shenzhen, China
C*08:89ND10028151KF175482Jinghui Qu, Shenzhen, China
C*14:53JMDP36K0181AB829606Kenji Tadokoro, Tokyo, Japan
C*14:54JMDP36K0182AB829607Kenji Tadokoro, Tokyo, Japan
DRB1*04:164BY01057KF266808Carolyn K Hurley, Washington DC, USA
DRB1*09:21TU11AB829527Takashi Shiina, Isehara, Japan
DRB1*11:148BY01058KF266807Carolyn K Hurley, Washington DC, USA
DQB1*03:03:08H130270KF376099Faming Zhu, Hangzhou, China
DQB1*03:90ND10088903KF270519Jinghui Qu, Shenzhen, China
DQB1*06:02:11D10047249HE804255Jinghui Qu, Shenzhen, China
DQB1*06:02:12D10115720HE804260Jinghui Qu, Shenzhen, China
DQB1*06:03:10D10048428HE804261Jinghui Qu, Shenzhen, China
DQB1*06:04:08D10116697HE804263Jinghui Qu, Shenzhen, China
DQB1*06:09:04D10110619HE804265Jinghui Qu, Shenzhen, China
DQB1*06:106D10084766HE804256Jinghui Qu, Shenzhen, China
DQB1*06:107D10074295HE804257Jinghui Qu, Shenzhen, China
DQB1*06:108D10111798HE804254Jinghui Qu, Shenzhen, China
DQB1*06:109D10043019HE804259Jinghui Qu, Shenzhen, China

Table 2: Confirmatory Sequences

Sequence Cell identification Accession number Submitting author
A*23:56BY01087KF278712Carolyn K Hurley, Washington DC, USA
A*24:164JMDP01K0145AB829609Kenji Tadokoro, Tokyo, Japan
A*24:206BY01085KF278714Carolyn K Hurley, Washington DC, USA
A*26:52JMDP36K0189AB829893Kenji Tadokoro, Tokyo, Japan
B*15:03:04BY01083KF266790Carolyn K Hurley, Washington DC, USA
B*15:241BY01070KF266803Carolyn K Hurley, Washington DC, USA
B*35:01:27BY01079KF266794Carolyn K Hurley, Washington DC, USA
B*35:11:03HG00005995KC991059Histogenetics, Ossining, USA
B*37:35BY01080KF266793Carolyn K Hurley, Washington DC, USA
B*40:06:075761200534KF206119Faming Zhu, Hangzhou, China
B*40:175BY01078KF266795Carolyn K Hurley, Washington DC, USA
B*40:86JMDP36K0195AB829608Kenji Tadokoro, Tokyo, Japan
B*44:146BY01050KF040405Carolyn K Hurley, Washington DC, USA
B*49:23BY01077KF266796Carolyn K Hurley, Washington DC, USA
B*51:127BY01073KF266800Carolyn K Hurley, Washington DC, USA
C*03:02:10D10017137KF175407Jinghui Qu, Shenzhen, China
C*03:86BY01066KF266812Carolyn K Hurley, Washington DC, USA
C*06:03:02BY01069KF266809Carolyn K Hurley, Washington DC, USA
C*06:101BY01063KF266815Carolyn K Hurley, Washington DC, USA
C*08:01:07BY01065KF266813Carolyn K Hurley, Washington DC, USA
C*08:01:10D10046648KF175472Jinghui Qu, Shenzhen, China
C*08:02:04BY01068KF266810Carolyn K Hurley, Washington DC, USA
DRB1*04:154BY01059KF266806Carolyn K Hurley, Washington DC, USA
DRB1*14:94BY01055KF266805Carolyn K Hurley, Washington DC, USA
DQB1*06:84D10080597HE804258Jinghui Qu, Shenzhen, China

Table 3: Recently Published Sequences

Sequence References
A*01:128 (3)
A*02:356N (4)
A*02:425 (5)
A*24:183N (4)
A*24:215 (6)
A*24:223 (7)
A*33:44 (8)
B*08:57 (9)
B*15:139 (10)
B*27:07:02 (11)
B*35:206 (11)
B*35:226 (12)
B*40:06:06 (13)
B*40:221 (14)
B*40:223 (12)
B*58:01:12 (15)
B*58:43 (16)
C*03:190 (16)
C*05:88 (3)
DRB1*04:05:14 (17)
DRB1*04:05:15 (18)
DRB1*09:01:07 (19)
DRB1*13:26:02 (20)
DQB1*04:10 (21)
DQB1*05:19 (22)
DQB1*06:48 (23)
DPA1*01:12 (16)
MICB*005:07 (24)
MICB*005:08 (24)
MICB*027 (24)
MICB*028 (24)
MICB*029 (24)


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  4. Shimizu M, Nakajima F, Okazaki H, Satake M, Tadokoro K. Two novel null HLA-A alleles with identical exon 4 nonsense mutations: HLA-A*24:183N and A*02:356N. Tissue Antigens. 2013: 82: 136-7.
  5. Huo MR, Yu Y, Xi B, Li D. Identification of a novel HLA-A*02 allele, HLA-A*02:425, by sequence-based typing. Tissue Antigens. 2013: 82: 135-6.
  6. Plaisier L, Geerts N, van Ginkel W, van der Weerd R, Spierings E. The novel HLA-A*24:215 allele, identified by sequencing-based typing of a stem cell transplant patient and the sibling donor. Tissue Antigens. 2013: 82: 138-9.
  7. Wang D, Xu Y, Zou H, Deng Z. A novel HLA-A allele detected by sequence-based typing: HLA-A*24:223. Tissue Antigens. 2013: 82: 139-40.
  8. Ye X, Ding H, Huang YF, Tan Y, Xia W, Bei C. HLA-A*33:44: a new allele identified by sequence-based typing in a Chinese blood donor. Tissue Antigens. 2013: 82: 140-2.
  9. Zhang X, Li XF, Lin FQ, Zhang KL, Li JP. Detection of the new HLA-B*08:57 allele in a voluntary platelet donor. Tissue Antigens. 2013: 82: 144-5.
  10. Zhang WD, Wang LJ, Zhang KY, Shan XY, Jia YJ. Characterization of a novel allele, HLA-B*15:139. Tissue Antigens. 2013: 82: 145-6.
  11. Frison S, Longhi E, Mantovani M, et al. Two novel alleles at HLA-B locus identified in two volunteer bone marrow donors by sequence-based typing. International Journal of Immunogenetics. 2013: 40: 328-30.
  12. Luo J, Yang N, Cao LQ, Xu ZX. Two new alleles, HLA-B*35:226 and HLA-B*40:233 identified by sequence-based typing in Chinese individuals. Tissue Antigens. 2013: 82: 147-8.
  13. Zou HY, Jin SZ, Li Z. HLA-B*40:06:06, a novel allele, which has arisen by silent mutation in codon 45. Tissue Antigens. 2013: 82: 142-4.
  14. Yang KL, Lee SK, Lin PY. Identification of the novel HLA-B*40:221 allele in a Taiwanese hematopoietic stem cell donor using a sequence-based typing method. International Journal of Immunogenetics. 2013: 40: 320-1.
  15. Yang KL, Lee SK, Kao RH, Lin CL, Lin PY. A novel HLA-B allele, B*58:01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method. International Journal of Immunogenetics. 2013: 40: 324-5.
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  17. Yang KL, Lee SK, Kao RH, Lin CL, Lin PY. Discovery of the novel HLA-DRB1*04:05:14 allele in a Taiwanese unrelated haematopoietic stem cell donor by a sequence-based typing method. International Journal of Immunogenetics. 2013: 40: 326-7.
  18. Yang KL, Lee SK, Lin PY. Discovery of a novel HLA-DRB1*04:05 variant, DRB1*04:05:15, in a Taiwanese and the probable HLA haplotype in association with DRB1*04:05:15. International Journal of Immunogenetics. 2013: 40: 396-7.
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  20. Zheng JW, Yang JH, Xie JH, et al. Characterization of the novel HLA-DRB1*13:26:02 allele. Tissue Antigens. 2013: 82: 152-3.
  21. Oka S, Furukawa H, Kashiwase K, Tsuchiya N, Tohma S. A novel HLA-DQB1*04 allele, DQB1*04:10, identified in a Japanese individual. Tissue Antigens. 2013: 82: 148-9.
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