Nomenclature for Factors of the HLA System
May 2013
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 82:224-8
- Human Immunology. 2013 74:1413-16
- International Journal of Immunogenetics. 2013 40:429-33
The following sequences have been submitted to the Nomenclature Committee since the April 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence named B*13:08Q has now been shown to be expressed and detectable on the cell surface, as such the Q suffix has been removed and the allele will be listed as B*13:08.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
Sequence | Cell identification | Accession number | Submitting author |
---|---|---|---|
A*02:01:89 | 249302 | HF968495 | Elena Longhi, Milano, Italy |
A*02:426 | H130157 | KC904969 | Faming Zhu, Hangzhou, China |
A*02:427 | frfgr31372 | HF951970 | Dominique Masson, La Tronche, France |
A*02:428 | MYS | KC978885 | Sung-Hee Han, Seoul, South Korea |
A*02:429 | BY01042 | KF028600 | Carolyn K Hurley, Washington DC, USA |
A*02:430 | BY01041 | KF028601 | Carolyn K Hurley, Washington DC, USA |
A*02:431 | SZ-154 | KF041480 | Hong-Yan Zou, Shenzhen, China |
A*02:432 | SZ-159 | KF059235 | Hong-Yan Zou, Shenzhen, China |
A*03:171 | BY01051 | KF028623 | Carolyn K Hurley, Washington DC, USA |
A*11:119:02 | 356647 | HF933200 | Edward KL Yang, Hualien, Taiwan |
A*24:02:65 | CBRA59126149705 | HF951979 | Dominique Masson, La Tronche, France |
A*24:241 | F04713 | KF039685 | Keming Du, Shanghai, China |
A*26:92 | 60659 | HF677706 | Jane Rowlands, Pontyclun, United Kingdom |
A*30:77 | 216723 | HF937075 | Elisabeth Keller, Munich, Germany |
A*30:78N | BY01022 | KF028619 | Carolyn K Hurley, Washington DC, USA |
A*68:01:20 | BY01043 | KF028630 | Carolyn K Hurley, Washington DC, USA |
A*68:101 | 93088886 | KC980910 | Daniel Fuerst, Ulm, Germany |
B*07:33:02 | BY01031 | KF028611 | Carolyn K Hurley, Washington DC, USA |
B*07:194 | HG00005805 | KC592323 | Histogenetics, Ossining, USA |
B*07:195 | HG00005806 | KC441491 | Histogenetics, Ossining, USA |
B*07:196 | HG00005808 | KC592317 | Histogenetics, Ossining, USA |
B*07:197 | HG00005809 | KC748287 | Histogenetics, Ossining, USA |
B*07:198 | HG00005810 | KC859251 | Histogenetics, Ossining, USA |
B*13:70 | LinC | KC493157 | Chunji Gao, Beijing, China |
B*14:34 | HG00005802 | KC424465 | Histogenetics, Ossining, USA |
B*14:35 | HG00005803 | KC424469 | Histogenetics, Ossining, USA |
B*14:36 | HG00005804 | KC592320 | Histogenetics, Ossining, USA |
B*14:37 | BY01036 | KF028606 | Carolyn K Hurley, Washington DC, USA |
B*15:01:33 | HG00005789 | KC537767 | Histogenetics, Ossining, USA |
B*15:277 | HG00005770, HG00005771, HG00005772, HG00005773, HG00005774, HG00005775, HG00005776, HG00005777, HG00005778 | KC748290, KC748291, KC603605, KC603598, KC603607, KC632162, KC603600, KC632163, KC748292 | Histogenetics, Ossining, USA |
B*15:278 | HG00005779, HG00005780, HG00005781, HG00005782, HG00005783, HG00005784, HG00005785, HG00005786, HG00005787, HG00005788 | KC603599, KC603606, KC859250, KC473871, KC592318, KC592319, KC748240, KC603604, KC632161, KC603597 | Histogenetics, Ossining, USA |
B*15:279 | HG00005790 | KC424467 | Histogenetics, Ossining, USA |
B*15:280 | HG00005792 | KC748288 | Histogenetics, Ossining, USA |
B*15:281 | BY01040 | KF028602 | Carolyn K Hurley, Washington DC, USA |
B*15:282 | BY01048 | KF028624 | Carolyn K Hurley, Washington DC, USA |
B*27:106 | BY01028 | KF028614 | Carolyn K Hurley, Washington DC, USA |
B*35:01:38 | HG00005768 | KC592310 | Histogenetics, Ossining, USA |
B*35:232 | BY01049 | KF028625 | Carolyn K Hurley, Washington DC, USA |
B*35:233 | 12A12308 | KF032077 | Carmen Alaez, Mexico, Mexico |
B*39:06:03 | HG00005811 | KC473869 | Histogenetics, Ossining, USA |
B*39:83 | ID-1615378 | KC565476 | Gisele Rampim, Sao Paulo, Brazil |
B*40:243 | F03868 | KC970433 | Keming Du, Shanghai, China |
B*40:244 | BY01034 | KF028608 | Carolyn K Hurley, Washington DC, USA |
B*40:245 | BY01029 | KF028613 | Carolyn K Hurley, Washington DC, USA |
B*40:246 | BY01025 | KF028616 | Carolyn K Hurley, Washington DC, USA |
B*44:177 | HG00005812 | KC592324 | Histogenetics, Ossining, USA |
B*44:178 | HG00005813 | KC503865 | Histogenetics, Ossining, USA |
B*44:179 | BY01039 | KF028603 | Carolyn K Hurley, Washington DC, USA |
B*44:180 | BY01052 | KF028622 | Carolyn K Hurley, Washington DC, USA |
B*44:181 | BY01044 | KF028629 | Carolyn K Hurley, Washington DC, USA |
B*46:40 | HG00005799 | KC632164 | Histogenetics, Ossining, USA |
B*46:41N | P13160 | KC970440 | Keming Du, Shanghai, China |
B*51:01:42 | HG00005800 | KC632166 | Histogenetics, Ossining, USA |
B*51:154 | HG00005798 | KC748242 | Histogenetics, Ossining, USA |
B*52:02:02 | F05242 | KC970442 | Keming Du, Shanghai, China |
B*53:31 | R51102 | HF952171 | Hien Tran, Heidelberg, Germany |
B*55:01:11 | HG00005797 | KC592315 | Histogenetics, Ossining, USA |
B*55:59 | HG00005794 | KC503867 | Histogenetics, Ossining, USA |
B*56:41 | HG00005793 | KC503866 | Histogenetics, Ossining, USA |
B*56:42 | BY01046 | KF028626 | Carolyn K Hurley, Washington DC, USA |
B*57:65 | HG00005791 | KC748245 | Histogenetics, Ossining, USA |
B*58:16:02 | HG00005769 | KC603608 | Histogenetics, Ossining, USA |
B*58:44 | 147723905 | HF951971 | Dominique Masson, La Tronche, France |
B*58:45 | 346597 | HF933202 | Edward KL Yang, Hualien, Taiwan |
B*58:46 | BY01038 | KF028605 | Carolyn K Hurley, Washington DC, USA |
C*01:02:19 | HG00005814 | KC424463 | Histogenetics, Ossining, USA |
C*01:77 | 14723883 | HF951973 | Dominique Masson, La Tronche, France |
C*01:78 | SZ-156 | KF049216 | Hong-Yan Zou, Shenzhen, China |
C*02:68 | HG00005837 | KC592338 | Histogenetics, Ossining, USA |
C*03:02:02:03 | BSM252 | KC788178 | Oh-Joong Kwon, Seoul, South Korea |
C*03:02:10 | HG00005836 | KC503871 | Histogenetics, Ossining, USA |
C*03:191 | HG00005815 | KC592332 | Histogenetics, Ossining, USA |
C*03:192 | HG00005846 | KC592327 | Histogenetics, Ossining, USA |
C*03:193 | HG00005847 | KC603577 | Histogenetics, Ossining, USA |
C*03:194 | HG00005848 | KC473874 | Histogenetics, Ossining, USA |
C*03:195 | FGR31384 | HF951975 | Dominique Masson, La Tronche, France |
C*04:01:52 | HG00005855 | KC748286 | Histogenetics, Ossining, USA |
C*04:03:02 | SZ-155 | KF049215 | Hong-Yan Zou, Shenzhen, China |
C*04:147 | HG00005838 | KC748248 | Histogenetics, Ossining, USA |
C*04:148 | HG00005851 | KC503870 | Histogenetics, Ossining, USA |
C*04:149 | HG00005853 | KC592330 | Histogenetics, Ossining, USA |
C*04:150 | HG00005854 | KC503874 | Histogenetics, Ossining, USA |
C*04:151 | HG00005856 | KC424462 | Histogenetics, Ossining, USA |
C*05:01:27 | HG00005829 | KC592334 | Histogenetics, Ossining, USA |
C*05:93 | NGR001 | HE995438 | Laura Bungener, Groningen, The Netherlands |
C*05:94 | 14729181 | HF951984 | Dominique Masson, La Tronche, France |
C*06:101 | HG00005817 | KC632168 | Histogenetics, Ossining, USA |
C*06:102 | HG00005820 | KC503869 | Histogenetics, Ossining, USA |
C*07:01:34 | HG00005827 | KC537769 | Histogenetics, Ossining, USA |
C*07:02:42 | HG00005824 | KC859254 | Histogenetics, Ossining, USA |
C*07:02:43 | HG00005828 | KC503873 | Histogenetics, Ossining, USA |
C*07:309 | HG00005816 | KC473873 | Histogenetics, Ossining, USA |
C*07:310 | HG00005821 | KC592331 | Histogenetics, Ossining, USA |
C*07:311 | HG00005823 | KC441496 | Histogenetics, Ossining, USA |
C*07:312 | HG00005825 | KC473877 | Histogenetics, Ossining, USA |
C*07:313 | HG00005826 | KC592328 | Histogenetics, Ossining, USA |
C*07:314 | M4791 | HF913728 | Vincent Elsermans, Lille cedex, France |
C*08:72:02 | HG00005830 | KC424461 | Histogenetics, Ossining, USA |
C*08:78 | BSB | KC978883 | Sung-Hee Han, Seoul, South Korea |
C*12:97 | HG00005831 | KC748280 | Histogenetics, Ossining, USA |
C*12:98 | HG00005833 | KC859253 | Histogenetics, Ossining, USA |
C*12:99 | HG00005834 | KC748257 | Histogenetics, Ossining, USA |
C*15:02:16 | HG00005841 | KC859255 | Histogenetics, Ossining, USA |
C*15:05:09 | HG00005849 | KC537770 | Histogenetics, Ossining, USA |
C*15:67 | HG00005839 | KC503876 | Histogenetics, Ossining, USA |
C*15:68 | HG00005840 | KC632170 | Histogenetics, Ossining, USA |
C*15:69 | HG00005843 | KC603578 | Histogenetics, Ossining, USA |
C*15:70 | HG00005844 | KC441497 | Histogenetics, Ossining, USA |
C*15:71 | HG00005845 | KC748249 | Histogenetics, Ossining, USA |
C*16:59 | HG00005832 | KC748254 | Histogenetics, Ossining, USA |
C*18:07N | HG00005818 | KC592325 | Histogenetics, Ossining, USA |
E*01:06 | CB0054 | KC894734 | Luciana Veiga-Castelli, Ribeirao Preto, Brazil |
DRB1*01:29:02 | DKMS-LSL-DRB1-36 | HF937407 | DKMS Life Science, Dresden, Germany |
DRB1*03:91 | DKMS-LSL-DRB1-38 | HF937409 | DKMS Life Science, Dresden, Germany |
DRB1*04:159 | DKMS-LSL-DRB1-35 | HF937406 | DKMS Life Science, Dresden, Germany |
DRB1*04:160 | DKMS-LSL-DRB1-40 | HF937411 | DKMS Life Science, Dresden, Germany |
DRB1*07:01:05 | DKMS-LSL-DRB1-42 | HF937412 | DKMS Life Science, Dresden, Germany |
DRB1*07:01:06 | DKMS-LSL-DRB1-44 | HF937414 | DKMS Life Science, Dresden, Germany |
DRB1*07:01:07 | 245626 | HF968493 | Elena Longhi, Milano, Italy |
DRB1*07:25 | DKMS-LSL-DRB1-43 | HF937413 | DKMS Life Science, Dresden, Germany |
DRB1*07:26N | DKMS-LSL-DRB1-41 | HF937425 | DKMS Life Science, Dresden, Germany |
DRB1*08:54 | CBRA59126099138 | HF951974 | Dominique Masson, La Tronche, France |
DRB1*10:01:04 | DKMS-LSL-DRB1-45 | HF937415 | DKMS Life Science, Dresden, Germany |
DRB1*10:06 | DKMS-LSL-DRB1-46 | HF937416 | DKMS Life Science, Dresden, Germany |
DRB1*11:23:02 | 281160141 | HF937365 | Jue Wang, Chengdu, China |
DRB1*13:162 | DKMS-LSL-DRB1-37 | HF937408 | DKMS Life Science, Dresden, Germany |
DRB1*13:163 | DKMS-LSL-DRB1-39 | HF937410 | DKMS Life Science, Dresden, Germany |
DRB1*13:164 | BY01054 | KF028632 | Carolyn K Hurley, Washington DC, USA |
DRB1*15:95 | DKMS-LSL-DRB1-48 | HF937417 | DKMS Life Science, Dresden, Germany |
DRB1*15:96 | DKMS-LSL-DRB1-51 | HF937420 | DKMS Life Science, Dresden, Germany |
DRB1*16:01:04 | DKMS-LSL-DRB1-52 | HF937421 | DKMS Life Science, Dresden, Germany |
DRB1*16:01:05 | DKMS-LSL-DRB1-3 | HF937422 | DKMS Life Science, Dresden, Germany |
DRB1*16:24 | DKMS-LSL-DRB1-49 | HF937418 | DKMS Life Science, Dresden, Germany |
DQB1*02:30 | HG00005867 | KC473883 | Histogenetics, Ossining, USA |
DQB1*02:31 | HG00005868 | KC503878 | Histogenetics, Ossining, USA |
DQB1*03:01:17 | HG00005859 | KC537776 | Histogenetics, Ossining, USA |
DQB1*03:01:18 | HG00005865 | KC537782 | Histogenetics, Ossining, USA |
DQB1*03:03:07 | D10104809 | HE804208 | Jinghui Qu, Shenzhen, China |
DQB1*03:74 | HG00005860 | KC632182 | Histogenetics, Ossining, USA |
DQB1*03:75 | HG00005861 | KC441501 | Histogenetics, Ossining, USA |
DQB1*03:76 | HG00005862 | KC473880 | Histogenetics, Ossining, USA |
DQB1*03:77 | HG00005864 | KC748263 | Histogenetics, Ossining, USA |
DQB1*03:78 | HG00005866 | KC592341 | Histogenetics, Ossining, USA |
DQB1*03:79 | D10125259 | HE804213 | Jinghui Qu, Shenzhen, China |
DQB1*03:80 | D10040708 | HE804214 | Jinghui Qu, Shenzhen, China |
DQB1*04:13 | D10116459 | HE804221 | Jinghui Qu, Shenzhen, China |
DQB1*06:85 | HG00005858 | KC592352 | Histogenetics, Ossining, USA |
DQB1*06:86 | D10016840 | HE804264 | Jinghui Qu, Shenzhen, China |
DQB1*06:87 | D10060249 | HE804262 | Jinghui Qu, Shenzhen, China |
DQB1*06:88 | D10109075 | HE804266 | Jinghui Qu, Shenzhen, China |
DQB1*06:89 | 40763103 | KC879155 | Paul Hoertnagl, Innsbruck, Austria |
Table 2: Confirmatory Sequences
Sequence | Cell identification | Accession number | Submitting author |
---|---|---|---|
A*01:132 | 14729113 | HF951977 | Dominique Masson, La Tronche, France |
A*02:08 | FRFLY20522 | HF951978 | Dominique Masson, La Tronche, France |
A*02:66 | CBRA59126119805 | HF951976 | Dominique Masson, La Tronche, France |
A*68:02:01:03 | BY01021 | KF028620 | Carolyn K Hurley, Washington DC, USA |
B*08:101 | 14729148 | HF951980 | Dominique Masson, La Tronche, France |
B*13:08 | 63878 | HF937220 | Jane Rowlands, Pontyclun, United Kingdom |
B*14:08 | 56468 | HF937221 | Jane Rowlands, Pontyclun, United Kingdom |
B*15:47:02 | BY01047 | KF028627 | Carolyn K Hurley, Washington DC, USA |
B*18:77 | BY01033 | KF028609 | Carolyn K Hurley, Washington DC, USA |
B*35:227 | F02956 | KC970441 | Keming Du, Shanghai, China |
B*38:15 | 348734 | HF933201 | Edward KL Yang, Hualien, Taiwan |
B*40:175 | BY01027 | KF028615 | Carolyn K Hurley, Washington DC, USA |
B*40:197 | BY01053 | KF028621 | Carolyn K Hurley, Washington DC, USA |
B*44:03:18 | CBRA59126134474 | HF951981 | Dominique Masson, La Tronche, France |
B*44:37:01 | 23546353 | HF952207 | Thibaut Gervais, Brussels, Belgium |
B*44:146 | BY01032 | KF028610 | Carolyn K Hurley, Washington DC, USA |
B*51:01:34 | BY01035 | KF028607 | Carolyn K Hurley, Washington DC, USA |
B*52:01:12 | BY01037 | KF028604 | Carolyn K Hurley, Washington DC, USA |
B*53:17:02 | BY01030 | KF028612 | Carolyn K Hurley, Washington DC, USA |
B*55:54 | HG00005796 | KC592311 | Histogenetics, Ossining, USA |
C*03:101 | 14729130 | HF951982 | Dominique Masson, La Tronche, France |
C*04:23 | FRFGR31452 | HF951983 | Dominique Masson, La Tronche, France |
C*06:93 | FRFLY20440 | HF951973 | Dominique Masson, La Tronche, France |
C*07:09 | HG00005822 | KC632172 | Histogenetics, Ossining, USA |
C*14:47N | 14729172 | HF951985 | Dominique Masson, La Tronche, France |
C*15:02:08 | HG00005842 | KC441499 | Histogenetics, Ossining, USA |
DRB1*08:03:03 | HG00005908 | KC473887 | Histogenetics, Ossining, USA |
DRB1*08:20 | 6005041 | HF952622 | Katherine Mounsey, Leeds, United Kingdom |
DRB1*14:138 | HG00005906, HG00005907 | KC748266, KC748267 | Histogenetics, Ossining, USA |
DRB1*15:78 | BY01023 | KF028631 | Carolyn K Hurley, Washington DC, USA |
DRB1*15:94 | HG00005898 | KC473888 | Histogenetics, Ossining, USA |
DQB1*03:01:08 | HG00005863 | KC592355 | Histogenetics, Ossining, USA |
DQB1*03:13 | D261617 | HE995409 | Edward KL Yang, Hualien, Taiwan |
DQB1*06:46 | HG00005894, HG00005895 | KC632185, KC473884 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
Sequence | References |
---|---|
A*33:03:11 | 3 |
B*07:162 | 4 |
B*15:257 | 5 |
B*54:01:03 | 6 |
B*54:01:04 | 6 |
C*01:02:18 | 7 |
C*06:45 | 8 |
C*08:75 | 9 |
C*08:76 | 10 |
C*15:02:04 | 11 |
DRB1*01:50 | 12 |
DRB1*01:54 | 13 |
DQB1*02:01:06 | 14 |
DQB1*05:18 | 12 |
DQB1*06:04:04 | 15 |
DQB1*06:47 | 16 |
DPA1*01:11 | 17 |
DPA1*02:02:04 | 18 |
References:
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