Nomenclature for Factors of the HLA System

February 2013

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2013 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:128scu17121KC609748Francisco de Paula Sanchez Gordo, Malaga, Spain
A*02:06:14H13017KC526950Faming Zhu, Hangzhou, China
A*02:17:03242269HF586934Elena Longhi, Milano, Italy
A*02:41153425KC473551Jianping Li, Shenyang, Liaoning, China
A*02:412BY00998KC488165Carolyn K Hurley, Washington DC, USA
A*03:163BY00974KC296460Carolyn K Hurley, Washington DC, USA
A*11:02:04P12888KC441516Keming Du, Shanghai, China
A*11:1419361100173KC551790Guoying Li, Lanzhiu, China
A*23:5855051KC549668Sallyanne Fossey, Nashville, USA
A*24:2319381100036KC551792Guoying Li, Lanzhiu, China
A*33:03:14KS29KC540780Xin Ye, Guangzhou, China
A*34:11BY00975KC296459Carolyn K Hurley, Washington DC, USA
A*68:1009381100190KC551793Guoying Li, Lanzhiu, China
B*07:183HG00005366KC185429Histogenetics, Ossining, USA
B*07:184125904KC477770Raquel Fabreti, Belo Horizonte, Brazil
B*07:185toui-02AB753854Yasushi Kusunoki, Shimogyo-ku, Japan
B*14:01:03HG00005368KC300254Histogenetics, Ossining, USA
B*14:02:09DalkhonHF586904Paul Dunn, Auckland, New Zealand
B*15:01:32HG00005369KC253921Histogenetics, Ossining, USA
B*15:24:0290173750KC521471Daniel Fuerst, Ulm, Germany
B*15:2719431100105KC551791Guoying Li, Lanzhiu, China
B*27:10193088365KC521472Daniel Fuerst, Ulm, Germany
B*27:102202610KC477778Raquel Fabreti, Belo Horizonte, Brazil
B*27:1039341100057KC551789Guoying Li, Lanzhiu, China
B*39:82HG00005367KC253918Histogenetics, Ossining, USA
B*41:27109476KC477771Raquel Fabreti, Belo Horizonte, Brazil
B*42:19125981KC477777Raquel Fabreti, Belo Horizonte, Brazil
B*42:20215033KC477772Raquel Fabreti, Belo Horizonte, Brazil
B*44:17380818KC119453Runying Tian, Durham, USA
B*44:17490173922KC521469Daniel Fuerst, Ulm, Germany
B*46:01:0946995KC590321Yu Weijian, DaLian, China
B*49:26HG00005220KC019945Histogenetics, Ossining, USA
B*50:32218326KC477774Raquel Fabreti, Belo Horizonte, Brazil
B*51:151144888KC477775Raquel Fabreti, Belo Horizonte, Brazil
B*57:63102115KC477773Raquel Fabreti, Belo Horizonte, Brazil
B*57:64109716KC477776Raquel Fabreti, Belo Horizonte, Brazil
B*58:41P12926KC441517Keming Du, Shanghai, China
B*58:42216790KC477769Raquel Fabreti, Belo Horizonte, Brazil
B*58:436435KC503840Ma Luo, Winnipeg, Manitoba, Canada
C*01:76P12831KC441514Keming Du, Shanghai, China
C*02:02:26HG00005399JQ007685Histogenetics, Ossining, USA
C*03:03:20HG00005396KC300265Histogenetics, Ossining, USA
C*03:186HG00005394KC185438Histogenetics, Ossining, USA
C*03:187HG00005395KC209768Histogenetics, Ossining, USA
C*03:188HG00005397KC253912Histogenetics, Ossining, USA
C*03:189NHG00005398JQ007658Histogenetics, Ossining, USA
C*03:1901670KC503841Ma Luo, Winnipeg, Manitoba, Canada
C*04:01:49HG00005402KC185445Histogenetics, Ossining, USA
C*04:01:50HG00005403KC209767Histogenetics, Ossining, USA
C*04:01:51HG00005405KC209766Histogenetics, Ossining, USA
C*04:145HG00005370KC185448Histogenetics, Ossining, USA
C*05:64:02HG00005386JQ031244Histogenetics, Ossining, USA
C*05:89HG00005384JQ007682Histogenetics, Ossining, USA
C*05:90HG00005385KC300262Histogenetics, Ossining, USA
C*05:91NHG00005387JQ007656Histogenetics, Ossining, USA
C*06:02:26HG00005375JQ007684Histogenetics, Ossining, USA
C*06:43:02HG00005374JQ031246Histogenetics, Ossining, USA
C*06:97HG00005373KC348384Histogenetics, Ossining, USA
C*06:98HG00005376HM125858Histogenetics, Ossining, USA
C*07:02:40HG00005371KC185443Histogenetics, Ossining, USA
C*07:02:41HG00005380KC185442Histogenetics, Ossining, USA
C*07:301HG00005372JQ007671Histogenetics, Ossining, USA
C*07:302HG00005377KC209765Histogenetics, Ossining, USA
C*07:303HG00005378KC300256Histogenetics, Ossining, USA
C*07:304HG00005379JN695263Histogenetics, Ossining, USA
C*07:305HG00005381KC185444Histogenetics, Ossining, USA
C*07:306HG00005382KC209764Histogenetics, Ossining, USA
C*08:02:10HG00005389KC348383Histogenetics, Ossining, USA
C*08:77HG00005388JQ935224Histogenetics, Ossining, USA
C*12:95HG00005391KC185447Histogenetics, Ossining, USA
C*12:96B01209KC441515Keming Du, Shanghai, China
C*14:50HG00005400JQ007687Histogenetics, Ossining, USA
C*14:51HG00005401KC185441Histogenetics, Ossining, USA
C*16:57HG00005390KC185446Histogenetics, Ossining, USA
DRB1*01:01:24HG00005417KC253924Histogenetics, Ossining, USA
DRB1*01:01:25HG00005418KC209774Histogenetics, Ossining, USA
DRB1*01:57HG00005322JX458899Histogenetics, Ossining, USA
DRB1*01:58HG00005419KC185456Histogenetics, Ossining, USA
DRB1*03:01:22HG00005410KC253931Histogenetics, Ossining, USA
DRB1*03:90HG00005414JN119521Histogenetics, Ossining, USA
DRB1*04:11:03213742KC433573Raquel Fabreti, Belo Horizonte, Brazil
DRB1*04:154HG00005407KC300275Histogenetics, Ossining, USA
DRB1*04:155HG00005408KC185458Histogenetics, Ossining, USA
DRB1*04:156HG00005409KC253930Histogenetics, Ossining, USA
DRB1*04:157N84001684KC521470Daniel Fuerst, Ulm, Germany
DRB1*04:158NDEF!753198HF566380Steven GE Marsh, London, United Kingdom
DRB1*07:24CHAR752218HE981734Steven GE Marsh, London, United Kingdom
DRB1*10:05227245KC438413Raquel Fabreti, Belo Horizonte, Brazil
DRB1*11:144HG00005416KC253929Histogenetics, Ossining, USA
DRB1*11:14512226272KC521468Daniel Fuerst, Ulm, Germany
DRB1*13:159HG00005412KC209777Histogenetics, Ossining, USA
DRB1*13:160HG00005415KC253927Histogenetics, Ossining, USA
DRB1*15:93HG00005406KC209778Histogenetics, Ossining, USA
DRB1*15:94226693KC438414Raquel Fabreti, Belo Horizonte, Brazil
DRB1*16:22214440KC438412Raquel Fabreti, Belo Horizonte, Brazil
DQB1*02:01:09HG00005464KC019959Histogenetics, Ossining, USA
DQB1*02:01:10HG00005470,
HG00005471,
HG00005472,
HG00005473,
HG00005474		KC300273,
JX842726,
JX885893,
JX976756,
JX970505		Histogenetics, Ossining, USA
DQB1*02:01:11HG00005483JX992598Histogenetics, Ossining, USA
DQB1*02:13HG00005457KC019992Histogenetics, Ossining, USA
DQB1*02:14HG00005459,
HG00005460,
HG00005461,
HG00005462		JX992581,
JX992579,
KC185454,
KC020001		Histogenetics, Ossining, USA
DQB1*02:15HG00005463JX992595Histogenetics, Ossining, USA
DQB1*02:16HG00005465KC019989Histogenetics, Ossining, USA
DQB1*02:17HG00005466KC136256Histogenetics, Ossining, USA
DQB1*02:18NHG00005467JX992567Histogenetics, Ossining, USA
DQB1*02:19HG00005468KC020010Histogenetics, Ossining, USA
DQB1*02:20NHG00005475,
HG00005476		KC300266,
KC019950		Histogenetics, Ossining, USA
DQB1*02:21HG00005484JX842727Histogenetics, Ossining, USA
DQB1*02:22HG00005485JX992611Histogenetics, Ossining, USA
DQB1*02:23HG00005486KC019998Histogenetics, Ossining, USA
DQB1*02:24HG00005487JX842725Histogenetics, Ossining, USA
DQB1*02:25HG00005488KC019997Histogenetics, Ossining, USA
DQB1*02:26HG00005489,
HG00005490,
HG00005491,
HG00005492,
HG00005493,
HG00005494		KC136255,
JX992600,
KC209769,
JX992585,
KC019955,
KC019964		Histogenetics, Ossining, USA
DQB1*03:01:12D10114013HE804198Jinghui Qu, Shenzhen, China
DQB1*03:01:13HG00005442KC019960Histogenetics, Ossining, USA
DQB1*03:01:14HG00005444JX976755Histogenetics, Ossining, USA
DQB1*03:01:15HG00005449KC300271Histogenetics, Ossining, USA
DQB1*03:01:16HG00005456KC209771Histogenetics, Ossining, USA
DQB1*03:02:06HG00005535JX842721Histogenetics, Ossining, USA
DQB1*03:02:07HG00005542KC019979Histogenetics, Ossining, USA
DQB1*03:03:05HG00005529,
HG00005530		JX992575,
JX842715		Histogenetics, Ossining, USA
DQB1*03:03:06HG00005533JX976761Histogenetics, Ossining, USA
DQB1*03:14:02HG00005450,
HG00005451,
HG00005452,
HG00005453,
HG00005454		JX992618,
JX992619,
JX992620,
JX992621,
JX667736		Histogenetics, Ossining, USA
DQB1*03:52HG00005420JX970508Histogenetics, Ossining, USA
DQB1*03:53HG00005434,
HG00005435,
HG00005436		KC019994,
KC019995,
JX970507		Histogenetics, Ossining, USA
DQB1*03:54HG00005439JX992586Histogenetics, Ossining, USA
DQB1*03:55HG00005440,
HG00005441		KC019957,
KC019965		Histogenetics, Ossining, USA
DQB1*03:56HG00005443KC348388Histogenetics, Ossining, USA
DQB1*03:57HG00005445JX976753Histogenetics, Ossining, USA
DQB1*03:58HG00005446KC348390Histogenetics, Ossining, USA
DQB1*03:59HG00005447,
HG00005448		KC019977,
JX842717		Histogenetics, Ossining, USA
DQB1*03:60HG00005455JX992627Histogenetics, Ossining, USA
DQB1*03:61HG00005495KC136262Histogenetics, Ossining, USA
DQB1*03:62HG00005497,
HG00005498		KC020008,
KC020007		Histogenetics, Ossining, USA
DQB1*03:63HG00005524,
HG00005525		KC019990,
JX992615		Histogenetics, Ossining, USA
DQB1*03:64HG00005526,
HG00005527,
HG00005528		KC019974,
JX992608,
KC155592		Histogenetics, Ossining, USA
DQB1*03:65HG00005531,
HG00005532		KC019983,
KC019978		Histogenetics, Ossining, USA
DQB1*03:66NHG00005534JX992569Histogenetics, Ossining, USA
DQB1*03:67HG00005536,
HG00005537		JX842718,
KC019967		Histogenetics, Ossining, USA
DQB1*03:68HG00005539KC019970Histogenetics, Ossining, USA
DQB1*03:69HG00005543KC019956Histogenetics, Ossining, USA
DQB1*03:70HG00005438JX842719Histogenetics, Ossining, USA
DQB1*05:01:04HG00005548,
HG00005549		JX842716,
KC185455		Histogenetics, Ossining, USA
DQB1*05:01:05HG00005551,
HG00005552		KC019988,
JX992605		Histogenetics, Ossining, USA
DQB1*05:01:06HG00005553KC019969Histogenetics, Ossining, USA
DQB1*05:01:07HG00005554JX992614Histogenetics, Ossining, USA
DQB1*05:20HG00005545,
HG00005546		KC020014,
JX992610		Histogenetics, Ossining, USA
DQB1*05:21HG00005547KC019966Histogenetics, Ossining, USA
DQB1*05:22HG00005550KC136252Histogenetics, Ossining, USA
DQB1*06:01:07HG00005421JX667738Histogenetics, Ossining, USA
DQB1*06:01:08HG00005424,
HG00005425,
HG00005426,
HG00005427,
HG00005428		JX992584,
JX992587,
JX992603,
JX992604,
KC020005		Histogenetics, Ossining, USA
DQB1*06:03:03HG00005496JX992578Histogenetics, Ossining, USA
DQB1*06:03:04HG00005510KC020012Histogenetics, Ossining, USA
DQB1*06:03:05HG00005514KC020009Histogenetics, Ossining, USA
DQB1*06:03:06HG00005516JX992609Histogenetics, Ossining, USA
DQB1*06:03:07HG00005521,
HG00005522		JX992612,
JX970509		Histogenetics, Ossining, USA
DQB1*06:04:05HG00005458KC019953Histogenetics, Ossining, USA
DQB1*06:04:06HG00005511JX667737Histogenetics, Ossining, USA
DQB1*06:09:02HG00005517,
HG00005518		JX992616,
KC155591		Histogenetics, Ossining, USA
DQB1*06:09:03HG00005520JX992594Histogenetics, Ossining, USA
DQB1*06:53HG00005422KC019980Histogenetics, Ossining, USA
DQB1*06:54NHG00005423JX992568Histogenetics, Ossining, USA
DQB1*06:55HG00005429,
HG00005430		JX992606,
JX992607		Histogenetics, Ossining, USA
DQB1*06:56HG00005431KC020016Histogenetics, Ossining, USA
DQB1*06:57HG00005432,
HG00005433		JX667739,
KC020015		Histogenetics, Ossining, USA
DQB1*06:58HG00005437KC019982Histogenetics, Ossining, USA
DQB1*06:59HG00005499,
HG00005500		KC019993,
KC136257		Histogenetics, Ossining, USA
DQB1*06:60HG00005501JX992617Histogenetics, Ossining, USA
DQB1*06:61HG00005502KC019971Histogenetics, Ossining, USA
DQB1*06:62HG00005503,
HG00005504,
HG00005505		KC019986,
KC019987,
KC019984		Histogenetics, Ossining, USA
DQB1*06:63HG00005506JX992582Histogenetics, Ossining, USA
DQB1*06:64HG00005512,
HG00005513		KC019975,
KC019976		Histogenetics, Ossining, USA
DQB1*06:65HG00005515KC348387Histogenetics, Ossining, USA
DQB1*06:66HG00005519JX667741Histogenetics, Ossining, USA
DQB1*06:67HG00005544KC348391Histogenetics, Ossining, USA
DPA1*01:122914KC525951Ma Luo, Winnipeg, Manitoba, Canada

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*02:07:01MDA0000065KC595886Kai Cao, Houston, USA
A*02:08MDA0000061KC517062Kai Cao, Houston, USA
A*02:97:0123307299HF570922Thibaut Gervais, Brussels, Belgium
A*03:103BY00999KC488166Carolyn K Hurley, Washington DC, USA
A*11:04MDA0000064KC590091Kai Cao, Houston, USA
A*24:11NMDA0000063KC590090Kai Cao, Houston, USA
A*24:28MDA0000066KC595887Kai Cao, Houston, USA
A*29:10MDA0000062KC577599Kai Cao, Houston, USA
A*30:04:01MDA0000060KC517061Kai Cao, Houston, USA
B*07:04MDA0000067KC595888Kai Cao, Houston, USA
B*07:09MDA0000068, MDA0000069KC601846,
KC601847		Kai Cao, Houston, USA
B*07:10MDA0000070KC601848Kai Cao, Houston, USA
B*14:02:02MDA0000071KC601849Kai Cao, Houston, USA
B*15:266BY01001KC488168Carolyn K Hurley, Washington DC, USA
B*35:167BY01003KC488170Carolyn K Hurley, Washington DC, USA
B*46:21:01BY01002KC488169Carolyn K Hurley, Washington DC, USA
B*53:01:06BY00996KC488164Carolyn K Hurley, Washington DC, USA
C*01:18BY01004KC594867Carolyn K Hurley, Washington DC, USA
C*02:49HG00005393KC185440Histogenetics, Ossining, USA
C*03:0923411221HF677507Thibaut Gervais, Brussels, Belgium
C*04:49HG00005404HM562330Histogenetics, Ossining, USA
C*06:76:01HG00005392KC300259Histogenetics, Ossining, USA
C*07:264NHG00005383KC348380Histogenetics, Ossining, USA
DRB1*11:98HG00005413JN205238Histogenetics, Ossining, USA
DRB1*13:120HG00005411KC348392Histogenetics, Ossining, USA
DQB1*02:01:05HG00005469JX992574Histogenetics, Ossining, USA
DQB1*02:07HG00005477,
HG00005478,
HG00005479,
HG00005480,
HG00005481,
HG00005482		JX976754,
JX976762,
JX842723,
JX976758,
JX976759,
JX970506		Histogenetics, Ossining, USA
DQB1*03:1123411294HF677506Thibaut Gervais, Brussels, Belgium
DQB1*03:37HG00005523KC136261Histogenetics, Ossining, USA
DQB1*03:40HG00005540,
HG00005541		KC136253,
JX842720		Histogenetics, Ossining, USA
DQB1*03:45HG00005538KC019968Histogenetics, Ossining, USA
DQB1*06:07:02HG00005507,
HG00005508,
HG00005509		KC136260,
KC136266,
KC136267		Histogenetics, Ossining, USA

Table 3: Recently Published Sequences


Sequence References
A*02:127 3
A*02:324 4
A*02:357 5
A*23:20 3
A*24:199 4
A*31:65 6
B*27:44 7
B*40:01:06 8
B*44:55 9
B*46:34 10
B*49:24 11
B*58:21 12
C*05:26 13
C*07:56:01 14
DRB1*03:64 11
DRB1*09:01:08 15

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55:280-7.
  3. Wang D, Liu N, Wang L, Li W, Zhang Z. Two new HLA alleles, HLA-A*23:20 and HLA-A*02:127 identified in Chinese individuals. Tissue Antigens. 2013. 81:172-3.
  4. Mantovani M, Frison S, Longhi E, et al. Identification of two novel HLA-A alleles: A*24:199 and A*02:324. Int J Immunogenet. 2013. 40:151-3.
  5. Dai M, Su YP, Sun A, Su XH, Liu F, Chen M. Identification of a novel HLA-A allele, A*02:357, in a Chinese individual. Tissue Antigens. 2013. 81:171-2.
  6. Chen YF, Yang L, Zhuang YL, Nie XM, Zhu CF. A novel HLA-A allele, A*31:65, was identified by sequence-based typing in a Chinese potential donor. Tissue Antigens. 2013. 81:173-5.
  7. Gong Z, Zhang Z, Shan X, Mei W, Li D. HLA-B*27:44, a novel allele identified by sequence-based typing, is a well-documented allele in China. Tissue Antigens. 2013. 81:175-6.
  8. Gong Z, Zhang Z, Shan X, Li W, Liu N. A novel HLA-B allele, B*40:01:06, identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2013. 81:176-7.
  9. Yang KL, Lee SK, Kao RH, Lin CL, Lin PY. Recognition of a Caucasoid HLA-B locus allele, B*44:55, in a Taiwanese/Chinese bone marrow stem cell donor. Int J Immunogenet. 2013. 40:154-5.
  10. Shen CM, Wang HD, Deng YJ, et al. Identification of a novel human leukocyte antigen allele B *46:34. Hum Immunol. 2013. 74:261-2.
  11. Planelles D, Balas A, Nagore E, Vicario JL. Sequencing of the novel HLA-B*49:24 and HLA-DRB1*03:64 alleles. Tissue Antigens. 2013. 81:177-8.
  12. Tischer S, Bunse C, Figueiredo C, Immenschuh S, Blasczyk R, Eiz-Vesper B. The new HLA-B*58:21 allele is predicted to be functionally similar to the B*58:01P group of alleles. Tissue Antigens. 2013. 81:178-9.
  13. Zilian E, Figueiredo C, Eiz-Vesper B, Blasczyk R, Immenschuh S. The new HLA-C variant HLA-C*05:26 is likely to be structurally identical to the C*05:01P alleles. Tissue Antigens. 2013. 81:179-80.
  14. Wang D, Liu N, Wang L, Ni L, Zhang Z. Characterization of a novel HLA-C*07 allele, HLA-C*07:56:01. Tissue Antigens. 2013. 81:181-2.
  15. Yang KL, Lee SK, Yang SY, Kao RH, Lin CL, Lin PY. Discovery of the novel HLA-DRB1*09:01:08 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08. Int J Immunogenet. 2013. 40:149-50.