Nomenclature for Factors of the HLA System
January 2013
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 81:471-3
- Human Immunology. 2013 74:888-9
- International Journal of Immunogenetics. 2013 40:335-7
The following sequences have been submitted to the Nomenclature Committee since the December 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence known as C*03:12 has been shown to be identical to the C*03:19 allele, consequently the designation C*03:12 has been abandoned.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:127 | 38071 | KC462570 | Jianping Li, Shenyang, Liaoning, China |
| A*02:404 | 20091 | KC405612 | Jianping Li, Shenyang, Liaoning, China |
| A*02:405 | 58063 | KC405614 | Jianping Li, Shenyang, Liaoning, China |
| A*02:406 | 58993 | KC405616 | Jianping Li, Shenyang, Liaoning, China |
| A*02:407 | 59859 | KC405617 | Jianping Li, Shenyang, Liaoning, China |
| A*02:408 | Chan001 | KC414222 | Niu Yang, Changsha, China |
| A*02:409 | BY00994 | KC488161 | Carolyn K Hurley, Washington DC, USA |
| A*02:410 | BY00995 | KC488162 | Carolyn K Hurley, Washington DC, USA |
| A*03:01:39 | 93085887 | KC213979 | Daniel Fuerst, Ulm, Germany |
| A*11:01:46 | 55492 | KC473555 | Jianping Li, Shenyang, Liaoning, China |
| A*11:140 | XianHaYa4807 | KC454399 | Jun Qi, Xian, China |
| A*23:57 | BY00973 | KC296447 | Carolyn K Hurley, Washington DC, USA |
| A*29:51 | 1219215 | HE819237 | John Crowley, Dublin, Eire |
| A*29:52 | BY00993 | KC488160 | Carolyn K Hurley, Washington DC, USA |
| A*30:72 | 58557 | KC473558 | Jianping Li, Shenyang, Liaoning, China |
| A*31:72 | 54111 | KC473552 | Jianping Li, Shenyang, Liaoning, China |
| A*31:73 | 59039 | KC473559 | Jianping Li, Shenyang, Liaoning, China |
| A*80:03 | 93334 | KC433572 | Raquel Fabreti, Belo Horizonte, Brazil |
| B*07:182N | BY00954 | JX844226 | Carolyn K Hurley, Washington DC, USA |
| B*13:64 | 52975 | KC473550 | Jianping Li, Shenyang, Liaoning, China |
| B*15:269 | 16797 | KC405611 | Jianping Li, Shenyang, Liaoning, China |
| B*15:270 | 55647 | KC473556 | Jianping Li, Shenyang, Liaoning, China |
| B*35:227 | H12607 | KC429788 | Faming Zhu, Hangzhou, China |
| B*38:43 | 7311211100 | KC414223 | Niu Yang, Changsha, China |
| B*40:06:07 | 43503-D | KC462572 | Jianping Li, Shenyang, Liaoning, China |
| B*46:01:08 | 55427 | KC473554 | Jianping Li, Shenyang, Liaoning, China |
| B*51:01:41 | 51718 | KC473549 | Jianping Li, Shenyang, Liaoning, China |
| B*54:01:04 | CB201200511 | KC414858 | Faming Zhu, Hangzhou, China |
| B*67:01:03 | 14669 | KC462567 | Jianping Li, Shenyang, Liaoning, China |
| C*05:88 | 0004079 | KC470079 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| C*07:300 | 38122 | HF549024 | Katia Gagne, Nantes, France |
| C*08:75 | 30433 | HF568778 | Carles Serra-Pages, Barcelona, Spain |
| C*08:76 | 31076 | HF568779 | Carles Serra-Pages, Barcelona, Spain |
| C*16:56 | 014639441 | HF545601 | Dominique Masson, La Tronche, France |
| DRB1*04:153 | 38737-D | KC462571 | Jianping Li, Shenyang, Liaoning, China |
| DRB1*07:23 | 218178 | HF568780 | Klaus Witter, M�nchen, Germany |
| DRB1*11:143 | 43005 | KC405613 | Jianping Li, Shenyang, Liaoning, China |
| DRB1*12:39 | BY00987 | KC296448 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:32:03 | 58761 | KC405615 | Jianping Li, Shenyang, Liaoning, China |
| DRB1*14:127:02 | 26309 | KC462568 | Jianping Li, Shenyang, Liaoning, China |
| DQB1*02:12 | D10018201 | HE804190 | Jinghui Qu, Shenzhen, China |
| DQB1*03:01:09 | D10023673 | HE804203 | Jinghui Qu, Shenzhen, China |
| DQB1*03:01:10 | D10022592 | HE804204 | Jinghui Qu, Shenzhen, China |
| DQB1*03:01:11 | D10052228 | HE804205 | Jinghui Qu, Shenzhen, China |
| DQB1*03:48 | 43567 | KC427090 | Runying Tian, Durham, USA |
| DQB1*03:49 | D10118557 | HE804199 | Jinghui Qu, Shenzhen, China |
| DQB1*03:50 | D10016942 | HE804200 | Jinghui Qu, Shenzhen, China |
| DQB1*03:51 | D10117434 | HE804202 | Jinghui Qu, Shenzhen, China |
| DQB1*04:10 | SH004 | AB773253 | Hiroshi Furukawa, Sagamihara, Japan |
| DQB1*06:04:04 | 10062712 | KC461183 | Manuela Testi, Rome, Italy |
| DPB1*142:01 | EDB | KC342219 | Antonio Balas, Madrid, Spain |
| MICA*076 | 2335PW | KC213978 | Daniel Fuerst, Ulm, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:06:01 | MDA0000050 | KC465060 | Kai Cao, Houston, USA |
| A*24:03:02 | MDA0000053, MDA0000054 | KC477655 | Kai Cao, Houston, USA |
| A*24:25 | MDA0000051 | KC465061 | Kai Cao, Houston, USA |
| A*24:81 | MDA0000052 | KC465062 | Kai Cao, Houston, USA |
| A*30:07 | MDA0000056 | KC477658 | Kai Cao, Houston, USA |
| A*30:10 | MDA0000058, MDA0000059 | KC495076 | Kai Cao, Houston, USA |
| A*34:05 | MDA0000055 | KC477657 | Kai Cao, Houston, USA |
| A*68:31 | MDA0000057 | KC477659 | Kai Cao, Houston, USA |
| B*13:47 | BY00997 | KC488163 | Carolyn K Hurley, Washington DC, USA |
| B*40:182 | 7311113807 | KC414224 | Niu Yang, Changsha, China |
| B*40:229 | Xian-4807 | KC454400 | Jun Qi, Xian, China |
| B*50:31 | 35871 | KC462569 | Jianping Li, Shenyang, Liaoning, China |
| C*03:19 | R428619 | HF547300 | Tatiana Lebedeva, Dedham, USA |
| DRB1*07:20 | BY00982 | KC296450 | Carolyn K Hurley, Washington DC, USA |
| DQB1*06:49 | 34921, 124219, 124435, 125231 | KC427091 | Runying Tian, Durham, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*24:02:17 | 3 |
| A*24:128 | 4 |
| B*07:55 | 5 |
| B*13:18 | 6 |
| C*04:112 | 7 |
| DRB1*09:20 | 8 |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Liu N, Zhang Z, Shan X, Ni L, Wang L. A novel HLA-A allele, A*24:02:17, identified by sequence-based typing. Tissue Antigens. 2013. 81:119-20.
- Wang L, Zhang Z, Cui S, Shan X. Identification of a novel HLA-A allele, A*24:128 in a Chinese individual. Tissue Antigens. 2013: 81:120-1.
- Liu N, Zhang Z, Shan X, Wang L, Cui S. A novel HLA-B allele, B*07:55, identified by sequence-based typing. Tissue Antigens. 2013: 81:121-3.
- Liu N, Zhang Z, Shan X, Cui S, Zhao B. A novel HLA-B allele, B*13:18, identified by sequence-based typing. Tissue Antigens. 2013: 81:123-4.
- Ferriola D, Heron S, Lind C, Monos DS. Characterization of a new HLA-C*04 allele, C*04:112. Tissue Antigens. 2013: 81:124-5.
- Hommel-Berrey GA, House KD, Backfish KA, Arnoff TS, Lobashevsky AL. Identification of a novel HLA-DRB1 allele, DRB1*09:20, by sequence-based typing in an unrelated bone marrow donor. Tissue Antigens. 2013. 81:125-6.
