Nomenclature for Factors of the HLA System
November 2012
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2013 81:249-52
- Human Immunology. 2013 74:686-8
- International Journal of Immunogenetics. 2013 40:252-5
The following sequences have been submitted to the Nomenclature Committee since the October 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:124 | ULM39360 | JX974834 | Daniel Fuerst, Ulm, Germany |
| A*11:134 | 101121 | KC136768 | Chun-Ying Lin, Taipei, Taiwan |
| A*11:135 | HG00005191 | JX524834 | Histogenetics, Ossining, USA |
| A*11:136 | HG00005192 | JX524831 | Histogenetics, Ossining, USA |
| A*11:137N | HG00005193 | JX976732 | Histogenetics, Ossining, USA |
| A*11:138 | HG00005194 | JX524832 | Histogenetics, Ossining, USA |
| A*23:56 | HG00005205 | KC019942 | Histogenetics, Ossining, USA |
| A*24:02:64 | HG00005204 | JX842752 | Histogenetics, Ossining, USA |
| A*24:223 | HLA-153 | JX982105 | Hong-Yan Zou, Shenzhen, China |
| A*24:224 | 5431100791 | JQ899198 | Chuanfu Zhu, Jinan, China |
| A*24:225 | 5431100059 | JQ924283 | Chuanfu Zhu, Jinan, China |
| A*24:226 | HG00005200 | JX027031 | Histogenetics, Ossining, USA |
| A*24:227 | HG00005203 | JX842747 | Histogenetics, Ossining, USA |
| A*26:82 | 5431100858 | JQ913144 | Chuanfu Zhu, Jinan, China |
| A*26:83 | HG00005196 | JX842749 | Histogenetics, Ossining, USA |
| A*26:84 | HG00005197 | JX481997 | Histogenetics, Ossining, USA |
| A*29:49 | 5431000452 | JQ913141 | Chuanfu Zhu, Jinan, China |
| A*30:71 | HG00005199 | JX976736 | Histogenetics, Ossining, USA |
| A*31:01:17 | HG00005189 | KC019940 | Histogenetics, Ossining, USA |
| A*31:71 | 5431100454 | JQ913143 | Chuanfu Zhu, Jinan, China |
| A*32:01:15 | HG00005188 | JX667709 | Histogenetics, Ossining, USA |
| A*68:01:18 | HG00005195 | JX667710 | Histogenetics, Ossining, USA |
| A*68:97 | HG00005190 | JX992556 | Histogenetics, Ossining, USA |
| A*68:98 | HG00005198 | JN205180 | Histogenetics, Ossining, USA |
| B*07:177 | 35686 | HF549022 | Katia Gagne, Nantes, France |
| B*15:265 | ID-1645195 | KC109818 | Gisele Rampim, Sao Paulo, Brazil |
| B*18:84 | 23238524 | HF548849 | Thibaut Gervais, Brussels, Belgium |
| B*27:100 | 231200866 | JX880089 | Wei Mao, Chongqing, China |
| B*40:229 | F00809 | KC119398 | Keming Du, Shanghai, China |
| B*40:230 | 5431100476 | JQ913142 | Chuanfu Zhu, Jinan, China |
| B*44:167 | 34927 | HF549021 | Francoise Bonneville, Nantes, France |
| B*51:149N | BY00936 | JX674064 | Carolyn K Hurley, Washington DC, USA |
| B*57:61 | BY00950 | JX844222 | Carolyn K Hurley, Washington DC, USA |
| C*03:183 | 130504 | JX988608 | Runying Tian, Durham, USA |
| C*16:55 | CBRA59126072488 | HF548847 | Dominique Masson, La Tronche, France |
| DRB1*04:05:16 | JMDP36K0186 | AB763379 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*04:147 | BY00960 | JX844230 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:137N | D10016961 | HE654765 | Jinghui Qu, Shenzhen, China |
| DRB1*15:87 | D10077185 | HE654769 | Jinghui Qu, Shenzhen, China |
| DRB1*15:88 | D10118635 | HE654770 | Jinghui Qu, Shenzhen, China |
| DRB1*15:89 | JMDP36K0198 | AB763380 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*16:20 | D10087486 | HE654771 | Jinghui Qu, Shenzhen, China |
| DQB1*02:01:07 | D10050431 | HE804185 | Jinghui Qu, Shenzhen, China |
| DQB1*02:01:08 | D10015984 | HE804187 | Jinghui Qu, Shenzhen, China |
| DQB1*02:08 | D10084698 | HE804186 | Jinghui Qu, Shenzhen, China |
| DQB1*02:09 | D10102057 | HE804188 | Jinghui Qu, Shenzhen, China |
| DQB1*02:10 | R49877 | HF545657 | Hien Tran, Heidelberg, Germany |
| DQB1*03:45 | 98511 | KC119454 | Runying Tian, Durham, USA |
| MICA*007:05 | 2382P07207725 | KC171730 | Daniel Fuerst, Ulm, Germany |
| MICA*007:06 | 45S09210470 | KC171732 | Daniel Fuerst, Ulm, Germany |
| MICA*008:05 | 1-G-02 | JX961659 | Zhanhui Du, Qingdao, China |
| MICA*073 | 46P | KC171729 | Daniel Fuerst, Ulm, Germany |
| MICA*074 | 2518S261788 | KC171731 | Daniel Fuerst, Ulm, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:04 | MDA0000043, MDA0000044 | KC117157 | Kai Cao, Houston, USA |
| A*02:14 | MDA0000045 | KC152638 | Kai Cao, Houston, USA |
| A*02:29 | MDA0000047 | KC152640 | Kai Cao, Houston, USA |
| A*03:01:03 | MDA0000046 | KC152639 | Kai Cao, Houston, USA |
| A*23:06 | MDA0000048 | KC152641 | Kai Cao, Houston, USA |
| B*39:75 | MDA0000038 | KC014608 | Kai Cao, Houston, USA |
| C*02:02:09 | HG00005115 | JQ824573 | Histogenetics, Ossining, USA |
| C*02:40 | HG00005112, HG00005113 | JQ911911, JQ824513 | Histogenetics, Ossining, USA |
| C*02:44 | HG00005114 | JQ824498 | Histogenetics, Ossining, USA |
| C*03:04:11 | HG00005120 | JQ824564 | Histogenetics, Ossining, USA |
| C*03:04:17 | HG00005116 | JQ867333 | Histogenetics, Ossining, USA |
| C*03:04:18 | HG00005119 | JQ911896 | Histogenetics, Ossining, USA |
| C*03:04:28 | HG00005125 | JQ824577 | Histogenetics, Ossining, USA |
| C*03:88 | HG00005117 | JQ824489 | Histogenetics, Ossining, USA |
| C*03:109 | HG00005121, HG00005122 | JQ867337, JQ824646 | Histogenetics, Ossining, USA |
| C*03:122 | HG00005118 | JQ964670 | Histogenetics, Ossining, USA |
| C*03:136 | HG00005123, HG00005124 | JQ824560, JQ824559 | Histogenetics, Ossining, USA |
| C*04:01:09 | HG00005131 | JQ824584 | Histogenetics, Ossining, USA |
| C*04:01:13 | HG00005135, HG00005136, HG00005137 | JQ824453, JQ824502, JQ824516 | Histogenetics, Ossining, USA |
| C*04:01:16 | HG00005129, HG00005130 | JQ824697, JQ824631 | Histogenetics, Ossining, USA |
| C*04:01:21 | HG00005127 | JQ824604 | Histogenetics, Ossining, USA |
| C*04:01:33 | HG00005132 | JX458879 | Histogenetics, Ossining, USA |
| C*04:47 | HG00005128 | JQ824506 | Histogenetics, Ossining, USA |
| C*04:62 | HG00005126 | JQ824526 | Histogenetics, Ossining, USA |
| C*04:65 | HG00005133 | JQ911916 | Histogenetics, Ossining, USA |
| C*04:77 | HG00005134 | JQ824688 | Histogenetics, Ossining, USA |
| C*05:28 | HG00005111 | JQ824476 | Histogenetics, Ossining, USA |
| C*07:02:11 | HG00005094, HG00005095 | JQ997143, JQ867349 | Histogenetics, Ossining, USA |
| C*07:83 | HG00005073 | JQ964661 | Histogenetics, Ossining, USA |
| C*08:02:08 | HT-126 | JX988607 | Runying Tian, Durham, USA |
| C*08:53 | HG00005138 | JX267244 | Histogenetics, Ossining, USA |
| C*15:02:15 | DKM5961940 | JX974836 | Daniel Fuerst, Ulm, Germany |
| C*16:16Q | HG00005108 | JQ277303 | Histogenetics, Ossining, USA |
| C*17:01:03 | HG00005110 | JQ824550 | Histogenetics, Ossining, USA |
| C*17:01:04 | HG00005109 | JQ911905 | Histogenetics, Ossining, USA |
| DRB1*01:02:06 | HG00005181 | JX458898 | Histogenetics, Ossining, USA |
| DRB1*03:01:07 | HG00005166, HG00005167 | JQ824820, JQ935232 | Histogenetics, Ossining, USA |
| DRB1*03:01:15 | HG00005164, HG00005165 | JQ824817, JQ824800 | Histogenetics, Ossining, USA |
| DRB1*04:03:05 | HG00005162 | JQ824829 | Histogenetics, Ossining, USA |
| DRB1*04:05:09 | HG00005148 | JQ824786 | Histogenetics, Ossining, USA |
| DRB1*04:07:04 | HG00005159, HG00005160, HG00005161 | JQ824789, JQ824773, JQ824794 | Histogenetics, Ossining, USA |
| DRB1*04:17:02 | HG00005152, HG00005153, HG00005154, HG00005155, HG00005156, HG00005157, HG00005158 | JQ824792, JQ824795, JQ824796, JQ824797, JQ824775, JQ824777, JQ824798 | Histogenetics, Ossining, USA |
| DRB1*04:96 | HG00005149, HG00005150, HG00005151 | JQ824833, JQ824809, JQ824810 | Histogenetics, Ossining, USA |
| DRB1*11:01:10 | HG00005175, HG00005176 | JQ997122, JQ824806 | Histogenetics, Ossining, USA |
| DRB1*11:81 | HG00005177 | JQ824825 | Histogenetics, Ossining, USA |
| DRB1*11:103 | HG00005173, HG00005174 | JQ824769, JQ824770 | Histogenetics, Ossining, USA |
| DRB1*11:125 | HG00005178, HG00005179 | JX089379, JQ824733 | Histogenetics, Ossining, USA |
| DRB1*13:95 | HG00005180 | JQ824749 | Histogenetics, Ossining, USA |
| DRB1*13:111 | HG00005168, HG00005169, HG00005170 | JQ935230, JQ824811, JQ824761 | Histogenetics, Ossining, USA |
| DRB1*13:128 | HG00005182, HG00005183, HG00005184, HG00005185 | JX134274, JQ824743, JQ824745, GU551913 | Histogenetics, Ossining, USA |
| DRB1*14:87 | HG00005171, HG00005172 | JQ824768, JQ824760 | Histogenetics, Ossining, USA |
| DRB1*14:95 | HG00005163 | JQ824741 | Histogenetics, Ossining, USA |
| DRB1*15:01:11 | HG00005142, HG00005143 | JQ824725, JQ824726 | Histogenetics, Ossining, USA |
| DRB1*15:01:12 | HG00005146, HG00005147 | JQ824715, JQ824717 | Histogenetics, Ossining, USA |
| DRB1*15:03:02 | HG00005140, HG00005141 | JQ824720, JQ824721 | Histogenetics, Ossining, USA |
| DRB1*15:37:01 | HG00005144, HG00005145 | JQ824718, JQ824719 | Histogenetics, Ossining, USA |
| DRB1*15:40 | HG00005139 | JQ824729 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:335 | 3 |
| A*02:370 | 3 |
| A*03:143 | 4 |
| A*29:39 | 5 |
| A*29:40 | 5 |
| A*66:07 | 6 |
| B*35:11:03 | 7 |
| B*37:04:02 | 8 |
| B*37:34 | 9 |
| B*40:213 | 10 |
| B*42:01:03 | 7 |
| B*44:150 | 11 |
| B*44:152 | 9 |
| B*51:01:35 | 7 |
| DRB1*04:67 | 12 |
| DRB1*11:64 | 12 |
| DQA1*01:08 | 13 |
| DQA1*01:09 | 13 |
| DQA1*03:03:02 | 13 |
| DPB1*140:01 | 14 |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Tao SD, Zhang W, He J, Zhu FM, Lv HJ. HLA-A*02:335 and HLA-A*02:370 were identified by polymerase chain reaction sequence-based typing in Chinese individuals. Tissue Antigens. 2012: 80: 537-9.
- Testi M, Stellitano C, Di Luzio A, Battarra M, Andreani M. The novel HLA-A*03:143 allele, identified by sequence-based typing in an Italian family. Tissue Antigens. 2012: 80: 539-40.
- Santos S, Balas A, Garcia-Sanchez F, Vesga MA, Vicario JL. Sequencing of two novel HLA-A*29 alleles, A*29:39 and A*29:40. Tissue Antigens. 2012: 80: 541-2.
- Dongmei W, Li W, Wang L, Ni L, Zhixin Z. A novel HLA-A*66 allele, A*66:07. Tissue Antigens. 2012: 80: 542-3.
- Endres RO, Hoffman AD, Palmer P, Scott I, Souza S. Characterization of three novel HLA alleles with silent nucleotide substitutions. Tissue Antigens. 2012: 80: 536-7.
- Li JP, Li XF, Zhang X, Zhang KL, Liu XZ. Identification of a novel allele, HLA-B*37:04:02, from a registered donor of the China Marrow Donor Program. Tissue Antigens. 2012: 80: 543-5.
- Balas A, Sanchez-Gordo F, Gomez-Zumaquero JM, Prat I, Vicario JL. Description of two novel HLA-B alleles, B*37:34 and B*44:152. Tissue Antigens. 2012: 80: 545-6.
- Liu Y. Identification of a new allele HLA-B*40:213 by polymerase chain reaction sequence based typing in a Chinese patient suffering from chloroma. Tissue Antigens. 2012: 80: 547-8.
- Balas A, Gonzalez-Roiz C, Vargas ML, Garcia-Sanchez F, Vicario JL. Sequencing of the new HLA-B*44:150 allele suggests recombination between B*44:02:01:01 and B*07:02:01 alleles. Tissue Antigens. 2012: 80: 548-9.
- Wang D, Li W, Wang L, Xiaoyan S, Zhixin Z. Two new alleles, HLA-DRB1*11:64 and HLA-DRB1*04:67 identified in Chinese individuals. Tissue Antigens. 2012: 80: 553-4.
- Yan H, Dong XS, Li J, et al. Identification of three novel HLA-DQA1 alleles: DQA1*01:08, DQA1*01:09 and DQA1*03:03:02. Tissue Antigens. 2012: 80: 551-3.
- Deng ZH, Xu YP, Wang DM. Characterization of the novel HLA-DPB1*140:01 allele identified by sequence-based typing. Tissue Antigens. 2012: 80: 549-51.
