Nomenclature for Factors of the HLA System
May 2012
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2012 80:286-8
- Human Immunology.2012 73:977-9
- International Journal of Immunogenetics. 2012 39:538-40
The following sequences have been submitted to the Nomenclature Committee since the April 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:01:79 | SZ-45 | JN990986 | Hong-Yan Zou, Shenzhen, China |
| A*02:01:80 | FRFLY19674 | HE806305 | Dominique Masson, La Tronche, France |
| A*02:06:13 | F03225 | JQ979301 | Keming Du, Shanghai, China |
| A*02:40:02 | FRFGR30553 | HE806304 | Dominique Masson, La Tronche, France |
| A*02:371 | BY00925 | JQ896287 | Carolyn K Hurley, Washington DC, USA |
| A*02:372 | LUMC-A96 | HE804039 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*02:373N | 62110720177 | HE806315 | Dominique Masson, La Tronche, France |
| A*11:124 | LUMC-A92 | HE804038 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*11:125 | F02087 | JQ979298 | Keming Du, Shanghai, China |
| A*11:126 | F03380 | JQ979302 | Jianhao Yang, Shanghai, China |
| A*11:127N | 100270 | JX013637 | Chun-Ying Lin, Taipei, Taiwan |
| A*24:204 | FRFLY19795 | HE806306 | Dominique Masson, La Tronche, France |
| A*26:01:25 | Xi`an 55641 | JX045663 | Mengli Liu, Xi�an, China |
| A*29:39 | 10945719 | JQ963275 | Antonio Balas, Madrid, Spain |
| A*29:40 | CTM-9097572 | JQ963274 | Antonio Balas, Madrid, Spain |
| A*29:41 | 93063426 | JX020761 | Daniel Fuerst, Ulm, Germany |
| A*31:65 | 5331000359 | JN209959 | Chuanfu Zhu, Jinan, China |
| A*31:66 | F00015 | JQ979295 | Keming Du, Shanghai, China |
| A*66:17 | 14550504 | HE806307 | Dominique Masson, La Tronche, France |
| A*68:93 | BY00904 | JQ039996 | Carolyn K Hurley, Washington DC, USA |
| B*08:93 | LUMC-B90 | HE804040 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*13:58 | HG00003667 | JQ007634 | Histogenetics, Ossining, USA |
| B*15:01:29 | HG00003720 | JQ237625 | Histogenetics, Ossining, USA |
| B*15:248 | HG00003707 | JN119412 | Histogenetics, Ossining, USA |
| B*15:249 | HG00003708 | JN123815 | Histogenetics, Ossining, USA |
| B*15:250 | HG00003717 | JN123830 | Histogenetics, Ossining, USA |
| B*15:251 | HG00003725 | JN123823 | Histogenetics, Ossining, USA |
| B*15:252 | HG00003727 | JQ237626 | Histogenetics, Ossining, USA |
| B*15:253 | HG00003732 | JN406418 | Histogenetics, Ossining, USA |
| B*35:204 | HG00003693 | JN124222 | Histogenetics, Ossining, USA |
| B*35:205 | HG00003696 | JQ031231 | Histogenetics, Ossining, USA |
| B*35:206 | An203050 | HE804053 | Francesca Poli, Milano, Italy |
| B*39:01:01:03 | P4066 | HM543712 | Lixing Yan, Hangzhou, China |
| B*40:208 | F02591 | JQ979299 | Keming Du, Shanghai, China |
| B*40:209 | F03178 | JQ979300 | Keming Du, Shanghai, China |
| B*40:210 | F03461 | JQ979303 | Keming Du, Shanghai, China |
| B*40:211 | F03500 | JQ979304 | Keming Du, Shanghai, China |
| B*40:212 | Xi`an 56230 | JX036024 | Mengli Liu, Xi�an, China |
| B*44:02:25 | FRFVA39310 | HE806314 | Dominique Masson, La Tronche, France |
| B*44:03:16 | DE-FFM 151572 | HE793198 | Christian Seidl, Frankfurt am Main, Germany |
| B*44:126:02 | CBRA59119953797 | HE806309 | Dominique Masson, La Tronche, France |
| B*44:153 | HG00003679 | JQ048672 | Histogenetics, Ossining, USA |
| B*44:154 | HG00003681 | JQ007631 | Histogenetics, Ossining, USA |
| B*46:32 | HG00003706 | JQ007649 | Histogenetics, Ossining, USA |
| B*49:22 | 81115632 | JX050173 | Daniel Fuerst, Ulm, Germany |
| B*51:61:02 | BB0903012 | JX014319 | YaoJung Yeh, Taipei, Taiwan |
| B*51:134 | HG00003733 | JN119409 | Histogenetics, Ossining, USA |
| B*51:135 | HG00003734 | JQ007641 | Histogenetics, Ossining, USA |
| B*51:136 | HG00003736, HG00003737 | JN119385, JN119386 | Histogenetics, Ossining, USA |
| B*52:01:12 | HG00003699 | JQ007653 | Histogenetics, Ossining, USA |
| B*52:30 | HG00003698 | JQ237622 | Histogenetics, Ossining, USA |
| B*53:28 | HG00003703 | JQ048671 | Histogenetics, Ossining, USA |
| B*56:36 | HG00003668, HG00003669 |
JN123808, JN123812 | Histogenetics, Ossining, USA |
| B*57:58 | HG00003726 | JN418825 | Histogenetics, Ossining, USA |
| B*58:37 | HG00003704 | JN123828 | Histogenetics, Ossining, USA |
| C*02:59 | 14566087 | HE806310 | Dominique Masson, La Tronche, France |
| C*04:01:01:05 | CG040101 | JQ341055 | David Sayer, Perth, Australia |
| C*04:119 | 14581132 | HE806311 | Dominique Masson, La Tronche, France |
| C*06:83 | LUMC-C89 | HE804042 | Jacqy DH Anholts, Leiden, The Netherlands |
| C*07:01:27 | FRFG235 | FR716504 | Sylvie Tourne, Strasbourg, France |
| C*07:02:34 | 112561993 | HE806312 | Dominique Masson, La Tronche, France |
| C*07:245 | CBRA59119953797 | HE806308 | Dominique Masson, La Tronche, France |
| C*08:63 | An209953 | HE801913 | Francesca Poli, Milano, Italy |
| C*16:01:08 | 103357220 | HE806313 | Dominique Masson, La Tronche, France |
| DRB1*04:114 | Xi'an 56224 | JX045664 | Jun Qi, Xian, China |
| DRB1*09:01:09 | Shanxi007 | JN093308 | Jiangtao Zuo, Taiyuan, China |
| DRB1*09:19 | 7311122958 | JX040451 | Feng Liu, Yueyang, China |
| DRB1*11:129 | 11QB000316 | JN384011 | Janette Kwok, Pokfulam Road, Hong Kong |
| DRB1*12:03:03 | CHA11-760 | JX028302 | Ji Young Huh, Sungnam-si, South Korea |
| DRB1*13:26:02 | F01108 | JQ979296 | Keming Du, Shanghai, China |
| DRB1*14:126 | LAPA036289 | HE774681 | Steven GE Marsh, London, United Kingdom |
| DRB1*14:127 | F01116 | JQ979297 | Keming Du, Shanghai, China |
| DRB1*15:76 | 88018DMR160944 | JQ965806 | Maria Elisa Moraes, Rio de Janeiro, Brazil |
| DRB5*02:06 | LUMC-B5n88 | HE793380 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*02:07 | LUMC-DQB91 | HE798690 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*03:41 | LUMC-DQB97 | HE798691 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*03:42 | YC040208 | JX041850 | Yenhui Chang, St. Petersburg, USA |
| DQB1*06:52 | LUMC-DQB94 | HE798689 | Jacqy DH Anholts, Leiden, The Netherlands |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:44 | MDA0000008, MDA0000009, MDA0000010 |
JX046906, JX046907, JX046908 | Kai Cao, Houston, USA |
| A*02:338 | DE-FFM 168427 | HE794979 | Christian Seidl, Frankfurt am Main, Germany |
| A*24:137 | 349176 | HE800182 | Edward KL Yang, Hualien, Taiwan |
| A*80:01 | CUI-86 | JX009131 | Jorge Martinez-Laso, Madrid, Spain |
| B*40:97 | D159844 | HE681414 | Edward KL Yang, Hualien, Taiwan |
| B*40:178 | LUMC-B93 | HE804041 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*51:119 | LIGH92127 | JN039330 | Maria da Graca Bicalho, Curitiba, Brazil |
| C*04:108 | LUMC-C95 | HE804043 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB1*04:99 | Shanxi008 | JN093306 | Fei Wang, Taiyuan, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:328 | (3) |
| A*03:134 | (4) |
| A*33:49 | (5) |
| B*15:238 | (6) |
| B*51:01:29 | (7) |
| C*04:71 | (8) |
| C*07:195 | (9) |
| G*01:01:03:03 | (10) |
| G*01:01:21 | (10) |
| MICA*064N | (11) |
| DRB1*11:119 | (12) |
| DQB1*05:03:05 | (13) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Hong SS, Sung HY, Kang MS, Huh JY. HLA-A*02:328, a novel allele identified by sequence-based typing in cord blood from a Korean woman. Tissue Antigens. 2012 79:308.
- Swelsen WT, Poell B, Hartog KS, Lardy NM. Characterization of a new allele: HLA-A*03:134. Tissue Antigens. 2012 79:309-10.
- Sanchez-Gordo F, Balas A, Garcia-Sanchez F, Prat I, Vicario JL. Description of HLA-A*33:49 in a Spanish cord blood unit. Tissue Antigens. 2012 80:65-6.
- Parkner AM, Halm-Heinrich I, Hahn J, Heim MU. Detection of a new HLA-B*15 allele, HLA-B*15:238, in a voluntary stem cell donor. Tissue Antigens. 2012 80:66-7.
- Barbuti S, Fornaciari S, Mariotti ML, Curcio M, Scatena F. A novel HLA-B*51:01:29 allele identified by sequence-based typing. Tissue Antigens. 2012 79:310-1.
- Moraru M, Balas A, de Pablo R, Vicario JL, Vilches C. Allele-specific amplification of the complete HLA-C gene from genomic DNA - a novel Cw4 allele (C*04:71) with a Cw1 motif in the peptide-binding site. Tissue Antigens. 2012 79:291-4.
- Testi M, Battarra M, Troiano M, Condello R, Andreani M. Characterization of the novel HLA-C*07:195 allele in an Italian hematopoietic stem cell volunteer donor, detected by sequence-based typing. Tissue Antigens. 2012 80:67-8.
- Castelli EC, de Albuquerque RS, Veiga-Castelli LC, et al. Identification of two new HLA-G alleles, G*01:01:03:03 and G*01:01:21, in Brazilian individuals. Tissue Antigens. 2012 80:70-1.
- Zhang S, Wang J, Luo M, Li X, Chen Q. A novel allele: MICA*064N with a stop codon in exon 4. Tissue Antigens. 2012 79:313-4.
- Zhu FM, Zhang W, He J, Lv HJ, Yan LX. A novel allele HLA-DRB1*11:119 was identified by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2012 80:68-70.
- Zhang W, Wang W, Zhu FM, Lv HJ, Yan LX. Characterization of a novel allele, HLA-DQB1*05:03:05. Tissue Antigens. 2012 79:311-2.
