Nomenclature for Factors of the HLA System
March 2012
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2012 80:202-4
- Human Immunology. 2012 73:867-9
- International Journal of Immunogenetics. 2012 39:370-2
The following sequences have been submitted to the Nomenclature Committee since the Mayblank.html 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence DRB1*03:11:02 has been shown to be in error and the name has been abandoned.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:108 | 91954223 | HE680088 | Dominique Masson, La Tronche, France |
| A*01:109 | FRFGR17845 | HE680089 | Dominique Masson, La Tronche, France |
| A*02:357 | 7311120097 | JQ765600 | Min Dai, Yueyang, China |
| A*02:358 | 7311120607 | JQ765601 | Min Dai, Yueyang, China |
| A*03:143 | IME54-12T, IME56-12T | JQ712685 | Manuela Testi, Rome, Italy |
| A*11:121 | BY00916 | JQ670869 | Carolyn K Hurley, Washington DC, USA |
| A*11:122 | 7311121360 | JQ765602 | Min Dai, Yueyang, China |
| A*30:63 | BY00915 | JQ670868 | Carolyn K Hurley, Washington DC, USA |
| A*31:01:13 | CHA11-295 | JQ743704 | Ji Young Huh, Sungnam-si, South Korea |
| A*32:01:13 | 96004951 | JQ712688 | Daniel Fuerst, Ulm, Germany |
| A*32:41 | 7311123005 | JQ765603 | Min Dai, Yueyang, China |
| A*33:59 | BY00917 | JQ670870 | Carolyn K Hurley, Washington DC, USA |
| B*18:71 | 101516916 | HE680091 | Dominique Masson, La Tronche, France |
| B*35:05:03 | 11-72-2013 | HE650143 | Wendy Swelsen, Amsterdam, The Netherlands |
| B*35:199 | HG00002424 | HQ879826 | Histogenetics, Ossining, USA |
| B*35:200 | BY00918 | JQ670871 | Carolyn K Hurley, Washington DC, USA |
| B*39:39:02 | HG00003104 | JN604859 | Histogenetics, Ossining, USA |
| B*44:151 | 91152437 | HE680090 | Dominique Masson, La Tronche, France |
| B*44:152 | CTM-1012888 | JQ739211 | Antonio Balas, Madrid, Spain |
| B*52:29 | 10-72-3977 | HE664021 | Wendy Swelsen, Amsterdam, The Netherlands |
| B*57:01:13 | 11-93-0008 | HE664022 | Wendy Swelsen, Amsterdam, The Netherlands |
| C*03:146 | ANCB739361AN | HE687290 | Steven GE Marsh, London, United Kingdom |
| C*06:76 | CABO041243AN | HE687291 | Steven GE Marsh, London, United Kingdom |
| C*12:02:09 | HG00003183 | JN124421 | Histogenetics, Ossining, USA |
| C*12:18:02 | HG00003180 | JN124415 | Histogenetics, Ossining, USA |
| C*12:73 | HG00003179 | JN124433 | Histogenetics, Ossining, USA |
| C*12:74 | HG00003181 | JN124387 | Histogenetics, Ossining, USA |
| C*12:75 | HG00003187 | JN418830 | Histogenetics, Ossining, USA |
| C*12:76 | FRFLY19654 | HE680092 | Dominique Masson, La Tronche, France |
| C*14:37 | 90165693 | JQ712686 | Daniel Fuerst, Ulm, Germany |
| C*15:02:09 | HG00003192 | JN124392 | Histogenetics, Ossining, USA |
| C*15:02:10 | HG00003194 | JN124413 | Histogenetics, Ossining, USA |
| C*15:58 | HG00003189 | JN124429 | Histogenetics, Ossining, USA |
| C*15:59 | HG00003191 | JN124402 | Histogenetics, Ossining, USA |
| C*15:60 | HG00003193 | JN124440 | Histogenetics, Ossining, USA |
| E*01:03:05 | TMO1158 | JQ744563 | Erick Castelli, Ribeirao Preto, Sao Paulo, Brazil |
| DRB1*03:81 | BY00543 | GU066754 | Carolyn K Hurley, Washington DC, USA |
| DRB1*09:01:08 | 345638 | HE663455 | Edward KL Yang, Hualien, Taiwan |
| DRB1*13:139 | RAFJean | HE681415 | Sylvie Tourne, Strasbourg, France |
| DQB1*03:40 | MDA0000001 | JQ694164 | Kai Cao, Houston, USA |
| DQB1*06:49 | DNA20110145 | HE774674 | Harald Schulze, Berlin, Germany |
| DPB1*138:01 | Rome778/11 | JQ686672 | Manuela Testi, Rome, Italy |
| DPB1*139:01 | 7550800968 | JQ740763 | Yunping Xu, Shenzhen, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:02 | Sep-67 | JQ771778 | Dimitri Monos, Philadelphia, USA |
| A*02:180 | HG00003569 | JQ007621 | Histogenetics, Ossining, USA |
| A*02:206 | HG00003574 | JQ007602 | Histogenetics, Ossining, USA |
| A*02:245 | HG00003576, HG00003577 | JN406401, JQ031227 | Histogenetics, Ossining, USA |
| A*03:97 | HG00003542 | JN124168 | Histogenetics, Ossining, USA |
| A*23:19Q | MDA0000002 | JQ793890 | Kai Cao, Houston, USA |
| A*24:02:27 | HG00003521 | JQ085351 | Histogenetics, Ossining, USA |
| A*24:129 | HG00003506 | JN124123 | Histogenetics, Ossining, USA |
| A*25:01:01 | 08-1621 | JQ771871 | Dimitri Monos, Philadelphia, USA |
| A*26:01:15 | HG00003487 | JQ031220 | Histogenetics, Ossining, USA |
| A*26:42 | HG00003493 | JN182954 | Histogenetics, Ossining, USA |
| A*30:42 | HG00003502 | JQ031216 | Histogenetics, Ossining, USA |
| A*36:01 | Sep-29 | JQ771779 | Dimitri Monos, Philadelphia, USA |
| A*68:03:01 | Sep-11 | JQ771782 | Dimitri Monos, Philadelphia, USA |
| A*74:01 | Sep-11 | JQ771780 | Dimitri Monos, Philadelphia, USA |
| B*07:110 | HG00003764 | JQ007652 | Histogenetics, Ossining, USA |
| B*08:53 | HG00003661 | JN561733 | Histogenetics, Ossining, USA |
| B*15:10:01 | Aug-48 | JQ771783 | Dimitri Monos, Philadelphia, USA |
| B*15:16:01 | Sep-64 | JQ771784 | Dimitri Monos, Philadelphia, USA |
| B*18:50 | HG00003648 | JQ048689 | Histogenetics, Ossining, USA |
| B*35:24:02 | HG00003682 | JQ007636 | Histogenetics, Ossining, USA |
| B*35:149 | HG00003705 | JN123795 | Histogenetics, Ossining, USA |
| B*38:37 | HG00003774 | JN124215 | Histogenetics, Ossining, USA |
| B*39:06:02 | Sep-04 | JQ771785 | Dimitri Monos, Philadelphia, USA |
| B*39:07 | 60682163 | JQ683080 | Antonio Balas, Madrid, Spain |
| B*39:68 | HG00003771 | JN124220 | Histogenetics, Ossining, USA |
| B*40:119 | BY00919 | JQ670872 | Carolyn K Hurley, Washington DC, USA |
| B*41:10 | HG00003619 | JN123820 | Histogenetics, Ossining, USA |
| B*41:16 | HG00003626 | JN123794 | Histogenetics, Ossining, USA |
| B*44:03:08 | HG00003742 | JQ085348 | Histogenetics, Ossining, USA |
| B*44:03:11 | HG00003613 | JN119402 | Histogenetics, Ossining, USA |
| B*44:55 | 342418 | HE687289 | Edward KL Yang, Hualien, Taiwan |
| B*51:01:33 | 12203200 | JQ712687 | Daniel Fuerst, Ulm, Germany |
| B*56:01:03 | HG00003721 | JN119393 | Histogenetics, Ossining, USA |
| B*57:03:01 | Sep-64 | JQ771786 | Dimitri Monos, Philadelphia, USA |
| B*81:01 | Sep-98 | JQ771787 | Dimitri Monos, Philadelphia, USA |
| B*81:05 | HG00003763 | JQ007642 | Histogenetics, Ossining, USA |
| C*01:45 | HG00003864 | JQ007696 | Histogenetics, Ossining, USA |
| C*02:02:11 | HG00003987 | JN123889 | Histogenetics, Ossining, USA |
| C*02:10 | 06-0678 | JQ771788 | Dimitri Monos, Philadelphia, USA |
| C*02:26:02 | HG00003995, HG00003996 | JN123936, JN418841 | Histogenetics, Ossining, USA |
| C*02:44 | HG00003979, HG00003980, HG00003981 | JN123892, JN123893, JN123897 | Histogenetics, Ossining, USA |
| C*02:55 | HG00003990 | JN406477 | Histogenetics, Ossining, USA |
| C*03:04:19 | HG00004005 | JN675288 | Histogenetics, Ossining, USA |
| C*03:05 | Sep-61 | JQ771789 | Dimitri Monos, Philadelphia, USA |
| C*03:55 | HG00004001 | JN124504 | Histogenetics, Ossining, USA |
| C*03:81 | HG00003998 | JN124465 | Histogenetics, Ossining, USA |
| C*04:09N | Oct-40 | JQ771790 | Dimitri Monos, Philadelphia, USA |
| C*04:42 | HG00003925 | JN119443 | Histogenetics, Ossining, USA |
| C*04:46 | HG00003850 | JN182987 | Histogenetics, Ossining, USA |
| C*05:42 | HG00003821 | JN124434 | Histogenetics, Ossining, USA |
| C*06:32 | HG00003796 | JN242443 | Histogenetics, Ossining, USA |
| C*06:37 | HG00003881 | JN124554 | Histogenetics, Ossining, USA |
| C*06:38 | HG00003792 | JQ085357 | Histogenetics, Ossining, USA |
| C*07:102 | HG00003929 | JN119468 | Histogenetics, Ossining, USA |
| C*07:116 | HG00003897 | JQ048680 | Histogenetics, Ossining, USA |
| C*07:147 | HG00003923, HG00003924 | JN123941, JQ031254 | Histogenetics, Ossining, USA |
| C*08:04:01 | 06-0678 | JQ771791 | Dimitri Monos, Philadelphia, USA |
| C*08:37 | HG00003867 | JN119455 | Histogenetics, Ossining, USA |
| C*12:03:12 | HG00003940 | JN123894 | Histogenetics, Ossining, USA |
| C*12:38 | HG00003952 | JN123918 | Histogenetics, Ossining, USA |
| C*15:44 | HG00003736, HG00003737 | JN119436, JN119437 | Histogenetics, Ossining, USA |
| C*16:02:01 | 08-1552 | JQ771792 | Dimitri Monos, Philadelphia, USA |
| C*16:07:02 | HG00003824 | JQ031248 | Histogenetics, Ossining, USA |
| C*16:16Q | HG00003826, HG00003827 | JN123861, JN123909 | Histogenetics, Ossining, USA |
| DRB1*04:03:05 | HG00004055, HG00004056 | JN418848, JN406498 | Histogenetics, Ossining, USA |
| DRB1*13:97 | HG00004068 | JN119529 | Histogenetics, Ossining, USA |
| DRB1*15:68 | HG00004040 | JN119508 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*02:328 | (3) |
| A*03:134 | (4) |
| B*51:01:29 | (5) |
| C*04:71 | (6) |
| DQB1*05:03:05 | (7) |
| MICA*064N | (8) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000. 55: 280-7.
- Hong SS, Sung HY, Kang MS, Huh JY. HLA-A*02:328, a novel allele identified by sequence-based typing in cord blood from a Korean woman. Tissue Antigens. 2012. 79: 308.
- Swelsen WT, Poell B, Hartog KS, Lardy NM. Characterization of a new allele: HLA-A*03:134. Tissue Antigens. 2012. 79: 309-10.
- Barbuti S, Fornaciari S, Mariotti ML, Curcio M, Scatena F. A novel HLA-B*51:01:29 allele identified by sequence-based typing. Tissue Antigens. 2012. 79: 310-1.
- Moraru M, Balas A, de Pablo R, Vicario JL, Vilches C. Allele-specific amplification of the complete HLA-C gene from genomic DNA - a novel Cw4 allele (C*04:71) with a Cw1 motif in the peptide-binding site. Tissue Antigens. 2012. 79: 291-4.
- Zhang W, Wang W, Zhu FM, Lv HJ, Yan LX. Characterization of a novel allele, HLA-DQB1*05:03:05. Tissue Antigens. 2012. 79: 311-2.
- Zhang S, Wang J, Luo M, Li X, Chen Q. A novel allele: MICA*064N with a stop codon in exon 4. Tissue Antigens. 2012. 79: 313-4.
