Nomenclature for Factors of the HLA System

February 2012

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2012 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:44HG00002793,
HG00002794
JN604843,
JN604844
Histogenetics, Ossining, USA
A*01:01:45HG00002963JN561712Histogenetics, Ossining, USA
A*01:105HG00002760JN124029Histogenetics, Ossining, USA
A*01:106HG00002770JN604842Histogenetics, Ossining, USA
A*01:107WEIManoHE660039Sylvie Tourne, Strasbourg, France
A*02:01:67HG00002804JN124079Histogenetics, Ossining, USA
A*02:01:68HG00002817JN124031Histogenetics, Ossining, USA
A*02:01:69HG00002824JN123973Histogenetics, Ossining, USA
A*02:01:70HG00002827,
HG00002828
JN124101,
JN561711
Histogenetics, Ossining, USA
A*02:01:71HG00002832JN123752Histogenetics, Ossining, USA
A*02:01:7255486JQ429790Jianping Li, Shenyang, Liaoning, China
A*02:01:7393081372JQ645967Daniel Fuerst, Ulm, Germany
A*02:06:11HG00002798,
HG00002799
JN604840,
JN123996
Histogenetics, Ossining, USA
A*02:344HG00002797JN406393Histogenetics, Ossining, USA
A*02:345HG00002805JN584490Histogenetics, Ossining, USA
A*02:346HG00002806JN406433Histogenetics, Ossining, USA
A*02:347HG00002807JN124050Histogenetics, Ossining, USA
A*02:348HG00002812JN124083Histogenetics, Ossining, USA
A*02:349HG00002830JN124037Histogenetics, Ossining, USA
A*02:350NHG00002831JN119365Histogenetics, Ossining, USA
A*02:351HG00002833,
HG00002834
JN124094,
JN124076
Histogenetics, Ossining, USA
A*02:352HG00002840JN182958Histogenetics, Ossining, USA
A*02:353HG00002969JN182964Histogenetics, Ossining, USA
A*02:354HG00002973JN124127Histogenetics, Ossining, USA
A*02:3555381000333JN209961Chuanfu Zhu, Jinan, China
A*02:356NJRC-D01-092AB696719Kenji Tadokoro, Tokyo, Japan
A*03:01:32HG00002778JN123998Histogenetics, Ossining, USA
A*03:01:33HG00002786,
HG00002787
JN124088,
JN124089
Histogenetics, Ossining, USA
A*03:137HG00002759JN124002Histogenetics, Ossining, USA
A*03:138HG00002779JN124086Histogenetics, Ossining, USA
A*03:139HG00002781JN182956Histogenetics, Ossining, USA
A*03:140HG00002782JN124015Histogenetics, Ossining, USA
A*03:141HG00002966JN406434Histogenetics, Ossining, USA
A*03:142HG00002967JN584497Histogenetics, Ossining, USA
A*11:01:38HG00002700JN124082Histogenetics, Ossining, USA
A*11:01:39HG00002705,
HG00002706
JN418812,
JN629077
Histogenetics, Ossining, USA
A*11:01:40HG00002957JN124113Histogenetics, Ossining, USA
A*11:114HG00002698JN123992Histogenetics, Ossining, USA
A*11:115NHG00002699JN406502Histogenetics, Ossining, USA
A*11:116HG00002704JN124093Histogenetics, Ossining, USA
A*11:117HG00002709JN124100Histogenetics, Ossining, USA
A*11:118HG00002710JN124005Histogenetics, Ossining, USA
A*11:119HG00002953JN124109Histogenetics, Ossining, USA
A*11:12044461JQ365626Jianping Li, Shenyang, Liaoning, China
A*23:01:09HG00002749JN644950Histogenetics, Ossining, USA
A*23:5187738JQ661498Maria Elisa Moraes, Rio de Janeiro, Brazil
A*24:02:55GDY-1219JN590043Guolong Yu, Guanghzhou City, China
A*24:02:5655309JQ410444Jianping Li, Shenyang, Liaoning, China
A*24:192HG00002733JN406388Histogenetics, Ossining, USA
A*24:193HG00002735JN644953Histogenetics, Ossining, USA
A*24:194HG00002740JN629076Histogenetics, Ossining, USA
A*24:195HG00002741JN242427Histogenetics, Ossining, USA
A*24:196HG00002742JN123987Histogenetics, Ossining, USA
A*24:197HG00002744JN124052Histogenetics, Ossining, USA
A*24:19855031JQ392563Jianping Li, Shenyang, Liaoning, China
A*24:199An 209308HE614129Francesca Poli, Milano, Italy
A*25:01:06HG00002954JN584502Histogenetics, Ossining, USA
A*25:01:07HG00002801JN124096Histogenetics, Ossining, USA
A*26:01:23HG00002719JN418807Histogenetics, Ossining, USA
A*26:01:24HG00002721JN182952Histogenetics, Ossining, USA
A*26:73HG00002955JN124115Histogenetics, Ossining, USA
A*26:745371000179JN209960Chuanfu Zhu, Jinan, China
A*29:02:11HG00002677JN205179Histogenetics, Ossining, USA
A*29:33HG00002676JN205169Histogenetics, Ossining, USA
A*29:34HG00002945JN561715Histogenetics, Ossining, USA
A*29:35HG00002946,
HG00002947
JN124155,
JN584499
Histogenetics, Ossining, USA
A*30:60HG00002723JN123991Histogenetics, Ossining, USA
A*30:61HG00002724,
HG00002725
JN124039,
JN205178
Histogenetics, Ossining, USA
A*30:6255160JQ392564Jianping Li, Shenyang, Liaoning, China
A*31:01:12HG00002675JN124013Histogenetics, Ossining, USA
A*31:62VAUGuilHE660040Sylvie Tourne, Strasbourg, France
A*32:38HG00002789JN124022Histogenetics, Ossining, USA
A*32:39HG00002791JN418804Histogenetics, Ossining, USA
A*32:40HG00002796JN561708Histogenetics, Ossining, USA
A*33:32:02HG00002669JN124067Histogenetics, Ossining, USA
A*33:56HG00002667JN123994Histogenetics, Ossining, USA
A*33:57HG00002670JN182957Histogenetics, Ossining, USA
A*33:58HG00002673,
HG00002674
JN123974,
JN123993
Histogenetics, Ossining, USA
A*34:02:03HG00002716JN205172Histogenetics, Ossining, USA
A*68:01:12HG00002718JN561705Histogenetics, Ossining, USA
A*68:01:13HG00002722JN124040Histogenetics, Ossining, USA
A*68:01:14HG00002956JN119373Histogenetics, Ossining, USA
A*68:01:15HG00002958JN561714Histogenetics, Ossining, USA
A*68:02:05HG00002697JN418806Histogenetics, Ossining, USA
A*68:86HG00002696JN182949Histogenetics, Ossining, USA
A*68:87HG00002717JN629080Histogenetics, Ossining, USA
A*68:8896009895JQ645966Daniel Fuerst, Ulm, Germany
B*07:02:31HG00002928JN124184Histogenetics, Ossining, USA
B*07:02:32HG00003088JN604856Histogenetics, Ossining, USA
B*07:149HG00002924,
HG00002925,
HG00002926
JN124242,
JN124243,
JN124294
Histogenetics, Ossining, USA
B*07:150HG00002927JN124174Histogenetics, Ossining, USA
B*07:151HG00002932JN124191Histogenetics, Ossining, USA
B*07:152HG00003087JN124258Histogenetics, Ossining, USA
B*07:153HG00003093JN182976Histogenetics, Ossining, USA
B*07:154HG00003098JN406455Histogenetics, Ossining, USA
B*08:01:17HG00002873JN406450Histogenetics, Ossining, USA
B*08:86NHG00002871JN406503Histogenetics, Ossining, USA
B*08:87HG00002872JN124202Histogenetics, Ossining, USA
B*08:88HG00002878JN124218Histogenetics, Ossining, USA
B*13:53HG00003016JN205203Histogenetics, Ossining, USA
B*13:54HG00003017JN205210Histogenetics, Ossining, USA
B*14:30HG00002923JN561720Histogenetics, Ossining, USA
B*14:31HG00003083JN124289Histogenetics, Ossining, USA
B*14:32HG00003106JN124299Histogenetics, Ossining, USA
B*15:01:28HG00003053JN406412Histogenetics, Ossining, USA
B*15:47:02HG00002913JN124213Histogenetics, Ossining, USA
B*15:240HG00002904JN124196Histogenetics, Ossining, USA
B*15:241HG00002905JN124179Histogenetics, Ossining, USA
B*15:242HG00002915JN124211Histogenetics, Ossining, USA
B*15:243HG00003065JN604858Histogenetics, Ossining, USA
B*15:244HG00003066JN205194Histogenetics, Ossining, USA
B*18:01:01:0218.1HM161847David Sayer, Perth, Australia
B*18:01:15HG00002863JN182974Histogenetics, Ossining, USA
B*18:01:16HG00003007JN182978Histogenetics, Ossining, USA
B*18:69HG00002861JN561723Histogenetics, Ossining, USA
B*18:70HG00002979JN119421Histogenetics, Ossining, USA
B*27:05:18HG00002865,
HG00002866
JN124183,
JN124244
Histogenetics, Ossining, USA
B*27:88HG00002857JN123810Histogenetics, Ossining, USA
B*27:89HG00002995JN584513Histogenetics, Ossining, USA
B*35:01:30HG00002893JN644964Histogenetics, Ossining, USA
B*35:01:31HG00003043JN418824Histogenetics, Ossining, USA
B*35:03:11HG00003045JN406457Histogenetics, Ossining, USA
B*35:190HG00002894JN644966Histogenetics, Ossining, USA
B*35:191HG00002897,
HG00002898
JN124192,
JN406449
Histogenetics, Ossining, USA
B*35:192HG00002911JN205187Histogenetics, Ossining, USA
B*35:193HG00003014JN406451Histogenetics, Ossining, USA
B*35:194HG00003033JN205195Histogenetics, Ossining, USA
B*35:195HG00003036JN182979Histogenetics, Ossining, USA
B*35:196HG00003046JN124271Histogenetics, Ossining, USA
B*35:197HG00003085JN124291Histogenetics, Ossining, USA
B*35:19829524JQ627828Maria Elisa Moraes, Rio de Janeiro, Brazil
B*37:33NHG00003001JN123788Histogenetics, Ossining, USA
B*38:01:07HG00003115JN406408Histogenetics, Ossining, USA
B*38:39HG00003084JN124283Histogenetics, Ossining, USA
B*38:40HG00003086JN584506Histogenetics, Ossining, USA
B*39:70HG00002937JN124207Histogenetics, Ossining, USA
B*39:71HG00002938JN604854Histogenetics, Ossining, USA
B*39:72HG00002942JN242432Histogenetics, Ossining, USA
B*39:73HG00003107,
HG00003108,
HG00003109,
HG00003110
JN406452,
JN584509,
JN584510,
JN584512
Histogenetics, Ossining, USA
B*40:02:13HG00002854JN124241Histogenetics, Ossining, USA
B*40:02:14HG00002991JN205212Histogenetics, Ossining, USA
B*40:02:15HG00002992JN406411Histogenetics, Ossining, USA
B*40:06:05HG00002856JN124195Histogenetics, Ossining, USA
B*40:182HG00002847JN604851Histogenetics, Ossining, USA
B*40:183HG00002849,
HG00002850
JN124221,
JN124312
Histogenetics, Ossining, USA
B*40:184HG00002855JN182972Histogenetics, Ossining, USA
B*40:185HG00002980JN418822Histogenetics, Ossining, USA
B*40:186HG00002981JN124306Histogenetics, Ossining, USA
B*40:186HYTJQ407773Oh-Joong Kwon, Seoul, South Korea
B*40:187HG00002982JN406454Histogenetics, Ossining, USA
B*40:188HG00002987JN119423Histogenetics, Ossining, USA
B*40:189HG00002989JN124275Histogenetics, Ossining, USA
B*40:190HG00002990JN124313Histogenetics, Ossining, USA
B*40:191HG00003116JN124262Histogenetics, Ossining, USA
B*40:192D252JQ316451Daniel Fuerst, Ulm, Germany
B*40:193JRC-D01-063AB696716Kenji Tadokoro, Tokyo, Japan
B*41:20HG00002846JN123809Histogenetics, Ossining, USA
B*44:02:23HG00002883JN124181Histogenetics, Ossining, USA
B*44:02:24HG00002885JN123801Histogenetics, Ossining, USA
B*44:03:15HG00003019JN124295Histogenetics, Ossining, USA
B*44:37:02HG00003031JN584507Histogenetics, Ossining, USA
B*44:144HG00002884JN182970Histogenetics, Ossining, USA
B*44:145HG00002888JN584503Histogenetics, Ossining, USA
B*44:146HG00003022JN124282Histogenetics, Ossining, USA
B*44:147HG00003023JN124253Histogenetics, Ossining, USA
B*44:148HG00003025,
HG00003026
JN119382,
JN584508
Histogenetics, Ossining, USA
B*44:149NHG00003032JN119369Histogenetics, Ossining, USA
B*44:1502011090109JQ413256Antonio Balas, Madrid, Spain
B*45:14HG00002986JN124256Histogenetics, Ossining, USA
B*50:16HG00002851JN124187Histogenetics, Ossining, USA
B*51:01:31HG00002916JN124238Histogenetics, Ossining, USA
B*51:01:32HG00002918JN584504Histogenetics, Ossining, USA
B*51:01:33HG00002921JN124219Histogenetics, Ossining, USA
B*51:01:34HG00003077JN124315Histogenetics, Ossining, USA
B*51:129HG00002845JN644965Histogenetics, Ossining, USA
B*51:130HG00003069JN124255Histogenetics, Ossining, USA
B*51:131HG00003076JN124249Histogenetics, Ossining, USA
B*52:01:11HG00003050JN205196Histogenetics, Ossining, USA
B*52:28HG00002899JN124194Histogenetics, Ossining, USA
B*53:01:06HG00002891JN182973Histogenetics, Ossining, USA
B*53:01:07HG00003034JN406456Histogenetics, Ossining, USA
B*54:265301000921JN209963Chuanfu Zhu, Jinan, China
B*55:01:09HG00002922JN124177Histogenetics, Ossining, USA
B*55:56HG00003060JN124265Histogenetics, Ossining, USA
B*56:34HG00003061JN124273Histogenetics, Ossining, USA
B*56:35JRC-D78-004AB696718Kenji Tadokoro, Tokyo, Japan
B*57:56HG00003052JN561730Histogenetics, Ossining, USA
B*57:57MOCEricHE650819Sylvie Tourne, Strasbourg, France
B*58:01:10HG00002900JN604852Histogenetics, Ossining, USA
B*58:01:11HG00002901JN124234Histogenetics, Ossining, USA
C*01:66HG00003123JN205215Histogenetics, Ossining, USA
C*03:02:09HG00003124,
HG00003125
JN124428,
JN124445
Histogenetics, Ossining, USA
C*03:04:26JRC-D01-078AB696717Kenji Tadokoro, Tokyo, Japan
C*04:112Nov-42JQ437409Dimitri Monos, Philadelphia, USA
C*06:74HG00003129JN124399Histogenetics, Ossining, USA
C*06:75HG00003154JN561734Histogenetics, Ossining, USA
C*07:02:01:04TU05AB679917Takashi Shiina, Isehara, Japan
C*07:02:01:05TU07AB679918Takashi Shiina, Isehara, Japan
C*07:02:30HG00003126JN629058Histogenetics, Ossining, USA
C*07:228HG00003127JN124373Histogenetics, Ossining, USA
C*07:229HG00003133JN124381Histogenetics, Ossining, USA
C*07:230HG00003134JN584519Histogenetics, Ossining, USA
C*07:231HG00003138JN124410Histogenetics, Ossining, USA
C*07:232HG00003150JN561736Histogenetics, Ossining, USA
C*07:233HG00003151JN124418Histogenetics, Ossining, USA
C*07:234HG00003153JN205216Histogenetics, Ossining, USA
C*07:235FRF2373HE653003Sylvie Tourne, Strasbourg, France
C*08:16:02HG00003158JN406420Histogenetics, Ossining, USA
C*08:60HG00003165JN124424Histogenetics, Ossining, USA
C*12:71HG00003157JN124382Histogenetics, Ossining, USA
C*12:72HG00003178JN629060Histogenetics, Ossining, USA
C*15:02:0890169129JQ511980Daniel Fuerst, Ulm, Germany
C*16:45HG00003176JN124408Histogenetics, Ossining, USA
DRB1*03:805461000145JF896313Chuanfu Zhu, Jinan, China
DRB1*12:16:022011-1659JQ629933A-Hyun Lim, Seoul, South Korea
DRB1*14:54:02NT01153,
NT01207
HQ189133,
JQ253896
Carolyn K Hurley, Washington DC, USA
DRB3*02:29NLUMC-DRB3N79,
10D05530
FR823459Jacqy DH Anholts, Leiden, The Netherlands
MICA*070USAPET3JQ522969Effie Petersdorf, Seattle, USA
MICA*071SZGSQ-14JQ619159Su-Qing Gao, Shenzhen, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:37DALE740378ANHE646286Steven GE Marsh, London, United Kingdom
A*02:31555360JQ410445Jianping Li, Shenyang, Liaoning, China
B*40:17209-72-6890HE650145Wendy Swelsen, Amsterdam, The Netherlands
B*46:305331000343JN209964Chuanfu Zhu, Jinan, China
C*05:55Ua2010tp2515HE651324Mats Bengtsson, Uppsala, Sweden
DRB1*04:01:0222685461HE654651Thibaut Gervais, Brussels, Belgium
DRB1*14:765993312HE603109Katherine Poole, Leeds, United Kingdom

Table 3: Recently Published Sequences


Sequence References
A*02:330(3)
A*11:108(3)
A*31:53(4)
A*66:14(5)
B*08:01:08(6)
B*15:01:18(7)
B*35:87(8)
B*40:175(3)
B*40:176(3)
B*44:110(7)
B*51:63(9)
C*04:01:22(7)
DQB1*03:03:04(10)
DQB1*05:14(7)
DPB1*06:01(11)
DPB1*10:01(11)
DPB1*11:01:01(11)
DPB1*16:01(11)
DPB1*17:01(11)
DPB1*18:01(11)
DPB1*21:01(11)
DPB1*26:01:02(11)
DPB1*27:01(11)
DPB1*39:01(11)
DPB1*131:01(11)
DPB1*135:01(11)
MICA*010:02 (12)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Endres RO, Hoffman AD, Scott I. Characterization of four novel HLA alleles, including two in the same haplotype. Tissue Antigens. 2012. 79: 204-5.
  4. Witter K, Kutsch M, Zahn R, Albert T, Dick A, Kauke T. Sequence-based typing confirmed a new HLA-A allele, A*31:53, in a liver recipient patient. Tissue Antigens. 2012. 79: 206-7.
  5. Wowk PF, Mattar SB, Rodrigues F, da Graca Bicalho M. A novel allele, HLA-A*66:14, identified in a Brazilian volunteer bone marrow donor. Tissue Antigens. 2012. 79: 207-8.
  6. Schlahsa L, Immenschuh S, Eiz-Vesper B, Blasczyk R, Figueiredo C. HLA-B*08:01:08- joining the fold of silent alpha-1 proline mutations in HLA-B. Tissue Antigens. 2012. 79: 208-9.
  7. Heyder J, Heinold A, Fiedler G, Opelz G, Tran TH. Characterization of four new HLA alleles: HLA-B*15:01:18, HLA-B*44:110, HLA-C*04:01:22 and HLA-DQB1*05:14. Tissue Antigens. 2012. 79: 209-10.
  8. Buddaseth S, Muller K, Bade-Doeding C, Blasczyk R, Huyton T. The new allele HLA-B*35:87 was generated by recombination between HLA-B*35:01 and B*08:01 in intron 2. Tissue Antigens. 2012. 79: 211-2.
  9. Dong Z, Yan LN, Xie JH, An SP, Yuan YH. A novel allele HLA-B*51:63 was identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2012. 79: 212-4.
  10. He YM, Zhang W, Zhu FM, Lv HJ, Yan LX. Identification of a novel HLA-DQB1*03:03:04 allele by polymerase chain reaction sequence-based typing in a Chinese leukemia patient. Tissue Antigens. 2012. 79: 214-5.
  11. Lauterbach N, Voorter CE, Stallinga CM, Groeneweg M, Wieten L, Tilanus MG. Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin. Tissue Antigens. 2012. 79: 165-73.
  12. Zhang S, Wang J, Luo M, Li X, Chen Q. Identification of a novel allele MICA*010:02. Tissue Antigens. 2012. 79: 216-7.