Nomenclature for Factors of the HLA System

December 2011

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the November 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:104HG00002325JN123774Histogenetics, Ossining, USA
A*01:104UA2011tp4076HE614291Mats Bengtsson, Uppsala, Sweden
A*03:02:03BY00908JQ039998Carolyn K Hurley, Washington DC, USA
A*03:135HG00002339HQ879801Histogenetics, Ossining, USA
A*11:111HG00002284JN123760Histogenetics, Ossining, USA
A*11:112BY00909JQ040001Carolyn K Hurley, Washington DC, USA
A*23:48HG00002297,
HG00002298		JF309387,
JN123776		Histogenetics, Ossining, USA
A*23:49HG00002322,
HG00002323		HQ850029,
JF309373		Histogenetics, Ossining, USA
A*23:50Sep-19JQ219673Dimitri Monos, Philadelphia, USA
A*24:187HG00002303HQ850019Histogenetics, Ossining, USA
A*24:188HG00002306,
HG00002307		HQ850022,
HQ906891		Histogenetics, Ossining, USA
A*24:189HG00002268JN123744Histogenetics, Ossining, USA
A*24:190HG00002310HQ879805Histogenetics, Ossining, USA
A*26:71NHG00002283HQ850018Histogenetics, Ossining, USA
A*26:72BY00907JQ039997Carolyn K Hurley, Washington DC, USA
A*29:32HG00002275JN123749Histogenetics, Ossining, USA
A*30:56HG00002294JN123747Histogenetics, Ossining, USA
A*30:57HG00002295HQ879800Histogenetics, Ossining, USA
A*30:58HG00002296JF292469Histogenetics, Ossining, USA
A*31:58HG00002269JN123781Histogenetics, Ossining, USA
A*31:59p5668JQ085481Lixing Yan, Hangzhou, China
A*33:54HG00002271,
HG00002272		JF309366,
JF309367		Histogenetics, Ossining, USA
B*08:80HG00001517HM159313Histogenetics, Ossining, USA
B*15:238DEMBG-5014953JQ048546Andreas Parkner, Magdeburg, Germany
C*03:03:1893080794JQ241149Daniel Fuerst, Ulm, Germany
C*04:107SZ-46JN990987Hong-Yan Zou, Shenzhen, China
DRB1*16:19SZ-44JN626224Hong-Yan Zou, Shenzhen, China
DQA1*03:03:022208JF895477Fang Han, Beijing, China
DQB1*03:39SZ-47JQ063039Hong-Yan Zou, Shenzhen, China
DQB1*06:47P5646JQ085482Lixing Yan, Hangzhou, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*23:01:03BY00905JQ039999Carolyn K Hurley, Washington DC, USA
B*44:139HG00003015JN124274Histogenetics, Ossining, USA
C*01:52HG00003226JN242445Histogenetics, Ossining, USA
C*02:02:09HG00003326JN124480Histogenetics, Ossining, USA
C*02:30HG00003324JN124524Histogenetics, Ossining, USA
C*03:03:08HG00003338JN205229Histogenetics, Ossining, USA
C*03:19CS00127JQ068145Kai Cao, Los Angeles, USA
C*03:82HG00003207JN406464Histogenetics, Ossining, USA
C*03:88HG00003196,
HG00003197,
HG00003198,
HG00003199,
HG00003200,
HG00003201		JN124378,
JN124379,
JN124416,
JN629061,
JN124549,
JN124550		Histogenetics, Ossining, USA
C*03:113HG00003346JN205226Histogenetics, Ossining, USA
C*03:122HG00003337JN124482Histogenetics, Ossining, USA
C*03:136HG00003350JN119433Histogenetics, Ossining, USA
C*04:01:30HG00003211JN124391Histogenetics, Ossining, USA
C*04:01:33HG00003212JN124383Histogenetics, Ossining, USA
C*04:45HG00003369JN242447Histogenetics, Ossining, USA
C*04:47HG00003362JN406475Histogenetics, Ossining, USA
C*04:52HG00003210JN124380Histogenetics, Ossining, USA
C*04:54HG00003216JN242441Histogenetics, Ossining, USA
C*04:56HG00003371,
HG00003372		JN124534,
JN124521		Histogenetics, Ossining, USA
C*04:59QHG00003214JN124396Histogenetics, Ossining, USA
C*04:65HG00003366,
HG00003367		JN205232,
JN242456		Histogenetics, Ossining, USA
C*04:69HG00003370JN205230Histogenetics, Ossining, USA
C*05:22:02HG00003288JN561746Histogenetics, Ossining, USA
C*05:26HG00003283,
HG00003284,
HG00003285		JN406427,
JN406425,
JN406428		Histogenetics, Ossining, USA
C*05:34HG00003290,
HG00003291		JN124488,
JN406465		Histogenetics, Ossining, USA
C*06:02:08HG00003245JN418836Histogenetics, Ossining, USA
C*06:54HG00003243,
HG00003244		JN561743,
JN561744		Histogenetics, Ossining, USA
C*06:57HG00003246JN406471Histogenetics, Ossining, USA
C*06:60HG00003234JN119429Histogenetics, Ossining, USA
C*07:76HG00003265JN418837Histogenetics, Ossining, USA
C*07:79HG00003276JN124455Histogenetics, Ossining, USA
C*07:83HG00003260JN124541Histogenetics, Ossining, USA
C*07:91HG00003255JN124537Histogenetics, Ossining, USA
C*07:93HG00003252,
HG00003253		JN124543,
JN561748		Histogenetics, Ossining, USA
C*07:96HG00003336JN242455Histogenetics, Ossining, USA
C*07:100HG00003275JN604873Histogenetics, Ossining, USA
C*07:120HG00003257,
HG00003258,
HG00003259		JN124485,
JN242451,
JN205227		Histogenetics, Ossining, USA
C*07:137:02HG00003269JN119432Histogenetics, Ossining, USA
C*07:180HG00003279JN406422Histogenetics, Ossining, USA
C*07:202HG00003238JN406472Histogenetics, Ossining, USA
C*12:03:10HG00003313JN124539Histogenetics, Ossining, USA
C*12:27HG00003307,
HG00003308		JN242452,
JN182991		Histogenetics, Ossining, USA
C*12:47HG00003188JN418831Histogenetics, Ossining, USA
C*12:50HG00003310JN124476Histogenetics, Ossining, USA
C*14:17HG00003358JN584524Histogenetics, Ossining, USA
C*14:33HG00003373JN205222Histogenetics, Ossining, USA
C*15:05:06HG00003190JN205217Histogenetics, Ossining, USA
C*15:39HG00003332JN242449Histogenetics, Ossining, USA
C*16:15:01HG00003311JN406469Histogenetics, Ossining, USA
C*16:24HG00003302JN124555Histogenetics, Ossining, USA
C*16:26HG00003301JN119426Histogenetics, Ossining, USA
C*16:35HG00003303JN561741Histogenetics, Ossining, USA
C*16:39HG00003286JN418833Histogenetics, Ossining, USA
C*17:01:03HG00003321,
HG00003322,
HG00003323		JN124511,
JN124517,
JN418834		Histogenetics, Ossining, USA
DRB1*01:01:17HG00003450JN119484Histogenetics, Ossining, USA
DRB1*01:01:18HG00003446JN644981Histogenetics, Ossining, USA
DRB1*03:76HG00003408JN119547Histogenetics, Ossining, USA
DRB1*04:83HG00003403JN205243Histogenetics, Ossining, USA
DRB1*04:96HG00003393JN119555Histogenetics, Ossining, USA
DRB1*04:98:02N-779906HE613270Rainer Blasczyk, Hannover, Germany
DRB1*11:01:09HG00003439JN205241Histogenetics, Ossining, USA
DRB1*11:27:03HG00003429JN119518Histogenetics, Ossining, USA
DRB1*11:58:02HG00003425JN205237Histogenetics, Ossining, USA
DRB1*11:75HG00003440JN119520Histogenetics, Ossining, USA
DRB1*11:83HG00003406JN584532Histogenetics, Ossining, USA
DRB1*11:105HG00003428JN119527Histogenetics, Ossining, USA
DRB1*11:108HG00003438JN119548Histogenetics, Ossining, USA
DRB1*13:89HG00003427JN584534Histogenetics, Ossining, USA
DRB1*13:106HG00003421JN119549Histogenetics, Ossining, USA
DRB1*13:111HG00003419JN629074Histogenetics, Ossining, USA
DRB1*13:128HG00003452JN205242Histogenetics, Ossining, USA
DRB1*14:06:02HG00003454JN561765Histogenetics, Ossining, USA
DRB1*14:61CS00128JQ068146Kai Cao, Los Angeles, USA
DRB1*14:90HG00003423,
HG00003424		JN406489,
JN561763		Histogenetics, Ossining, USA
DRB1*14:95HG00003410,
HG00003411		JN119524,
JN119525		Histogenetics, Ossining, USA
DRB1*14:101HG00003422JN406488Histogenetics, Ossining, USA
DRB1*15:01:07HG00003387JN119504Histogenetics, Ossining, USA
DRB1*15:01:12HG00003386JN418843Histogenetics, Ossining, USA
DRB1*15:37HG00003381,
HG00003382,
HG00003383		JN119503,
JN119490,
JN119489		Histogenetics, Ossining, USA
DRB1*15:40HG00003375JN629073Histogenetics, Ossining, USA
DPB1*10:0112005HE603611Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*16:0111994HE603612Marcel GJ Tilanus, Maastricht, The Netherlands
DPB1*39:0117677HE614586Marcel GJ Tilanus, Maastricht, The Netherlands

Table 3: Recently Published Sequences


Sequence References
A*01:01:20(3)
A*01:66(3)
A*02:230 (4)
A*02:263(3)
A*02:267(3)
A*02:271(3)
A*03:88(3)
A*03:89(3)
A*03:132 (5)
A*11:70(3)
A*23:01:04(3)
A*23:30(3)
A*23:31(3)
A*23:31(3)
A*23:38N (6)
A*24:131(3)
A*29:02:01:02 (7)
A*29:11 (8)
A*30:01:02 (8)
A*30:02:02 (8)
A*30:44(3)
A*31:01:08(3)
A*31:40(3)
A*68:01:01:02 (7)
A*68:03:03(3)
A*68:27 (8)
A*68:54(3)
B*07:114(3)
B*07:115(3)
B*08:66(3)
B*13:50 (9)
B*15:220 (10)
B*15:228 (11)
B*18:54(3)
B*35:03:06(3)
B*35:113(3)
B*35:115(3)
B*35:117(3)
B*35:135(3)
B*35:136(3)
B*35:148(3)
B*35:149(3)
B*35:150(3)
B*35:156(3)
B*40:74 (12)
B*40:110(3)
B*40:110(3)
B*40:130(3)
B*40:134(3)
B*40:135(3)
B*40:135(3)
B*40:136(3)
B*40:148(3)
B*40:157(3)
B*41:14(3)
B*41:15(3)
B*41:16(3)
B*42:06 (8)
B*44:43:02(3)
B*44:108N(3)
B*44:111(3)
B*44:114(3)
B*45:07 (8)
B*49:15(3)
B*51:101(3)
B*53:24(3)
C*03:94(3)
C*06:44(3)
C*06:47(3)
C*06:58 (13)
C*07:140(3)
C*07:141(3)
C*07:141(3)
C*07:150Q(3)
C*07:151(3)
C*08:35(3)
C*08:42(3)
C*12:44(3)
C*12:44(3)
C*15:36(3)
C*15:36(3)
C*16:27(3)
DRB1*03:05:03 (14)
DRB1*03:60(3)
DRB1*04:95(3)
DRB1*07:20(3)
DRB1*07:21(3)
DRB1*08:04:06(3)
DRB1*08:42(3)
DRB1*11:10:02 (14)
DRB1*11:102:01(3)
DRB1*14:86 (14)
DRB1*14:106(3)
DRB1*14:107(3)
DRB1*14:108(3)
DRB1*14:109(3)
DRB1*16:18(3)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Lazaro AM, Henry J, Ng J, Hurley CK, Posch PE. Increased HLA class I and II diversity as 72 novel alleles are identified in volunteers for the National Marrow Donor Program Registry in 2010. Tissue antigens. 2012; 79: 50-7.
  4. Nie DM, Zou HY. Full-length sequence of a novel HLA-A*02:230 allele. Tissue antigens. 2012; 79: 68-9.
  5. Endres RO, Hoffman AD, Scott I. Characterization of a novel allele, HLA-A*03:132. Tissue antigens. 2012; 79: 69-71.
  6. Joannes MO, Voorter CE, Agis F, Tilanus MG. Full-length sequence of a novel null allele HLA-A*23:38N identified in an individual from Guadeloupe. Tissue antigens. 2012; 79: 71-2.
  7. Xu Y, Li Z, Zou H, Deng Z. Two novel HLA-A alleles, A*29:02:01:02 and A*68:01:01:02, were identified by genomic full-length cloning and sequencing. Tissue antigens. 2012; 79: 72-4.
  8. Paximadis M, Mathebula TY, Gentle NL, et al. Human leukocyte antigen class I (A, B, C) and II (DRB1) diversity in the black and Caucasian South African population. Human immunology. 2012; 73: 80-92.
  9. Shen M, Loh MF, Zulaimi MN, Chan SH, Ren EC. B*13:50, a novel HLA-B*13 allele, identified by sequence-based typing. Tissue antigens. 2012; 79: 74-5.
  10. Joannes MO, Voorter CE, Agis F, Tilanus MG. Full-length sequence of a novel HLA-B*15:220 allele identified in an individual from Guadeloupe. Tissue antigens. 2012; 79: 75-6.
  11. Endres RO, Hoffman AD, Scott I. Characterization of a novel allele, HLA-B*15:228. Tissue antigens. 2012; 79: 77-8.
  12. Li JP, Li XF, Zhang KL, Zhang X, Liu XZ. A novel HLA-B*40 allele, HLA-B*40:74, detected in a Chinese individual. Tissue antigens. 2012; 79: 78-80.
  13. Testi M, Troiano M, Di Luzio A, Stellitano C, Andreani M. The novel HLA-C*06:58 allele, identified by sequence-based typing in an Italian family. Tissue antigens. 2012; 79: 80-1.
  14. Frison S, Longhi E, Mantovani M, et al. Three novel alleles at the HLA-DRB1 locus identified by sequence-based typing. Human immunology. 2012; 73: 67-9.