Nomenclature for Factors of the HLA System
November 2011
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2012 79:222-9
- Human Immunology. 2012 73:320-5
- International Journal of Immunogenetics. 2012 39:268-74
The following sequences have been submitted to the Nomenclature Committee since the October 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence known previously as A*11:53 has now been shown to be identical to the corrected A*11:02:01 sequence, the name A*11:53 has now been abandoned.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:335 | P5655 | JQ002652 | Lixing Yan, Hangzhou, China |
| A*02:336 | 1-12805 | JN800501 | Carmen Alaez, Mexico, Mexico |
| A*11:110 | SZ-56 | FJ969874 | Hong-Yan Zou, Shenzhen, China |
| B*08:79 | 60662800 | JN696112 | Antonio Balas, Madrid, Spain |
| B*15:237 | BY00903 | JN629055 | Carolyn K Hurley, Washington DC, USA |
| B*40:179 | CHA11-281 | JN990107 | Ji Young Huh, Sungnam-si, South Korea |
| B*40:180 | BY00901 | JN629053 | Carolyn K Hurley, Washington DC, USA |
| B*44:139 | 93077940 | JQ027701 | Daniel Fuerst, Ulm, Germany |
| C*03:03:17 | CS00126 | JN987185 | Kai Cao, Los Angeles, USA |
| C*07:220 | 96065138 | JN862560 | Daniel Fuerst, Ulm, Germany |
| DRB1*04:06:05 | JMDP36K0131 | AB677524 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*09:17 | JMDP01K087 | AB677520 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*12:35 | JMDP01K029 | AB677839 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*11:121 | JMDP36K0151 | AB677525 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*13:135 | BY00899 | JN629051 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:44:03 | JMDP36K0130 | AB677523 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*14:121 | JMDP01K099 | AB677521 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*14:122 | BY00881, BY00897 | JN881333, JN629049 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:01:01:03 | 7551100020 | HQ840743 | Yunping Xu, Shenzhen, China |
| DRB1*15:01:01:04 | 7551100019 | JN157603 | Yunping Xu, Shenzhen, China |
| DRB1*15:69 | JMDP36K118 | AB677522 | Kenji Tadokoro, Tokyo, Japan |
| DPB1*04:01:03 | UA2011-tp-3909 | HE611275 | Mats Bengtsson, Uppsala, Sweden |
| DPB1*136:01 | 2011081803 | JN794564 | Adolfo Eiras, Santiago de Compostela, Spain |
| MICB*026 | T105 | JN983708 | Wei Tian, Changsha, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:335 | P5655 | JQ002652 | Lixing Yan, Hangzhou, China |
| A*02:336 | 1-12805 | JN800501 | Carmen Alaez, Mexico, Mexico |
| A*11:110 | SZ-56 | FJ969874 | Hong-Yan Zou, Shenzhen, China |
| B*08:79 | 60662800 | JN696112 | Antonio Balas, Madrid, Spain |
| B*15:237 | BY00903 | JN629055 | Carolyn K Hurley, Washington DC, USA |
| B*40:179 | CHA11-281 | JN990107 | Ji Young Huh, Sungnam-si, South Korea |
| B*40:180 | BY00901 | JN629053 | Carolyn K Hurley, Washington DC, USA |
| B*44:139 | 93077940 | JQ027701 | Daniel Fuerst, Ulm, Germany |
| C*03:03:17 | CS00126 | JN987185 | Kai Cao, Los Angeles, USA |
| C*07:220 | 96065138 | JN862560 | Daniel Fuerst, Ulm, Germany |
| DRB1*04:06:05 | JMDP36K0131 | AB677524 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*09:17 | JMDP01K087 | AB677520 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*12:35 | JMDP01K029 | AB677839 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*11:121 | JMDP36K0151 | AB677525 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*13:135 | BY00899 | JN629051 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:44:03 | JMDP36K0130 | AB677523 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*14:121 | JMDP01K099 | AB677521 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*14:122 | BY00881, BY00897 | JN881333, JN629049 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:01:01:03 | 7551100020 | HQ840743 | Yunping Xu, Shenzhen, China |
| DRB1*15:01:01:04 | 7551100019 | JN157603 | Yunping Xu, Shenzhen, China |
| DRB1*15:69 | JMDP36K118 | AB677522 | Kenji Tadokoro, Tokyo, Japan |
| DPB1*04:01:03 | UA2011-tp-3909 | HE611275 | Mats Bengtsson, Uppsala, Sweden |
| DPB1*136:01 | 2011081803 | JN794564 | Adolfo Eiras, Santiago de Compostela, Spain |
| MICB*026 | T105 | JN983708 | Wei Tian, Changsha, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*29:28 | (3) |
| B*40:162 | (4) |
| B*44:127 | (5) |
| B*52:23 | (6) |
| C*02:02:09 | (7) |
| C*07:02:25 | (8) |
| C*08:43 | (9) |
| DRB1*01:33N | (10) |
| DRB1*04:98:01 | (11) |
| DRB1*12:27 | (12) |
| DRB1*14:99 | (13) |
| DQB1*06:43 | (14) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Isabey EP, Pham HM, Peterson TA, Brunham RC, Luo M, Plummer FA. Identification of a novel HLA-A allele, A*29:28, in an East African population. Tissue antigens. 2011; 78: 451-2.
- Jiao SX, Feng ZH, Hu B, Chi XY, Zhao L. Identification of a novel HLA-B*40 allele, B*40:162, in a Chinese individual. Tissue antigens. 2011; 78: 452-4.
- Jiao SX, Chi XY, Hu B, Feng ZH, Zhao L. A novel HLA-B44 allele, B*44:127, was identified by sequencing-based typing. Tissue antigens. 2011; 78: 454-5.
- Todorova K, Schulze H, Ciroki J, Uharek L, Salama A, Schonemann C. A new HLA-B*52 allele, B*52:23, detected in a patient before bone marrow transplantation. Tissue antigens. 2011; 78: 455-6.
- Todorova K, Schulze H, Dautert C, Arnold R, Salama A, Schoenemann C. Identification of a novel HLA-C*02 allele, HLA-C*02:02:09. Tissue antigens. 2011; 78: 456-7.
- Tao SD, Zhang W, Zhu FM, Lv HJ, Yan LX. Identification of a novel HLA-C*07:02:25 allele by polymerase chain reaction sequence-based typing in a Chinese leukemia patient. Tissue antigens. 2011; 78: 457-9.
- Cao K, Street J, Johnson J, Wang Q, Lau M, Darke C. A new HLA-C allele, C*08:43, identified during a UCLA Immunogenetics Centre cell exchange. Tissue antigens. 2011; 78: 459-60.
- Zimmerman A, Spruit LS, Herczyk W, Marino SR. A single nucleotide deletion in exon 2 produces a novel null allele, HLA-DRB1*01:33N. Tissue antigens. 2011; 78: 463-4.
- Balas A, Sanchez-Gordo F, Garcia-Sanchez F, Prat I, Vicario JL. Sequencing of a new HLA-DRB1*04:98 allele in a Spanish donor. Tissue antigens. 2011; 78: 462-3.
- He YM, Zhang W, Zhu FM, Lv HJ, Yan LX. Identification of a novel HLA-DRB1 allele, HLA-DRB1*12:27, in a Chinese individual. Tissue antigens. 2011; 78: 465-6.
- Todorova K, Schulze H, Lassahn A, Galicki L, Salama A, Schoenemann C. Identification of a new HLA-DRB1* 14 allele, DRB1*14:99
BY HLA typing of an Asian individual. Tissue antigens. 2011; 78: 466-7. - Tao SD, Wang W, Zhu FM, Lv HJ, Yan LX. Sequence-based HLA high-resolution typing of a bone marrow donor/recipient pair shows the novel HLA allele DQB1*06:43. Tissue antigens. 2011; 78: 461-2.
