Nomenclature for Factors of the HLA System
October 2011
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2012 79:218-21
- Human Immunology. 2012 73:432-4
- International Journal of Immunogenetics. 2012 39:264-7
The following sequences have been submitted to the Nomenclature Committee since the September 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:102 | BY00844 | JN383950 | Carolyn K Hurley, Washington DC, USA |
| A*01:103 | CBRA59119911554 | HE601620 | Dominique Masson, La Tronche, France |
| A*03:134 | 10-72-9406 | HE589765 | Wendy Swelsen, Amsterdam, The Netherlands |
| A*31:57 | 10-333 | JN604508 | A-Hyun Lim, Seoul, South Korea |
| A*68:85 | BY00845 | JN383951 | Carolyn K Hurley, Washington DC, USA |
| B*07:144 | 11014150 | JN638447 | Daniel Fuerst, Ulm, Germany |
| B*44:138Q | SJ297/76 | AM285030 | Gottfried Fischer, Vienna, Austria |
| C*01:61 | p5594 | JN701458 | Lixing Yan, Hangzhou, China |
| C*02:55 | PRIChar | HE602370 | Sylvie Tourne, Strasbourg, France |
| C*03:04:25 | JMDP01K101 | AB671237 | Kenji Tadokoro, Tokyo, Japan |
| C*03:139 | 96023273 | JN638448 | Daniel Fuerst, Ulm, Germany |
| C*04:106 | 48209 | HE585126, HE585127, HE585128 | Thibaut Gervais, Brussels, Belgium |
| C*05:72 | 14194953 | HE601622 | Dominique Masson, La Tronche, France |
| C*06:02:19 | FRFSE03762 | HE601621 | Dominique Masson, La Tronche, France |
| C*08:55N | 96009890 | JN638449 | Daniel Fuerst, Ulm, Germany |
| C*08:56 | KTS02 | JN887337 | Simon Lank, Madison, USA |
| DRB1*03:77 | 345089 | HE605046 | Edward KL Yang, Hualien, Taiwan |
| DRB1*04:107 | BY00890 | JN383948 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:102:02 | BY00893 | JN383941 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:68 | BY00888 | JN383947 | Carolyn K Hurley, Washington DC, USA |
| MICB*005:06 | T65 | JN089769 | Wei Tian, Changsha, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:01:23 | HG00002377 | HQ850025 | Histogenetics, Ossining, USA |
| A*02:01:49 | HG00002372 | JF309385 | Histogenetics, Ossining, USA |
| A*02:01:51 | HG00002373 | JF309383 | Histogenetics, Ossining, USA |
| A*02:136 | JMDP01K105 | AB671232 | Kenji Tadokoro, Tokyo, Japan |
| A*02:161 | HG00002975, HG00002374, HG00002375, HG00002376 | HQ850021, HQ850024, JN123762, JN418808 | Histogenetics, Ossining, USA |
| A*02:64 | 60675721 | JN215464 | Antonio Balas, Madrid, Spain |
| A*11:01:17 | HG00002499 | JF292459 | Histogenetics, Ossining, USA |
| A*11:106 | HG00002498 | JN123761 | Histogenetics, Ossining, USA |
| A*11:12 | 10700243 | JN631813 | Antonio Balas, Madrid, Spain |
| A*24:138 | BY00860 | JN383953 | Carolyn K Hurley, Washington DC, USA |
| A*26:63 | ANSH734103AN | HE603108 | Steven GE Marsh, London, United Kingdom |
| A*31:36 | BY00859 | JN383952 | Carolyn K Hurley, Washington DC, USA |
| A*31:40 | HG00002497, HG00002672 | JN123976, JN123983 | Histogenetics, Ossining, USA |
| B*07:02:10 | HG00002482, HG00003097 | HQ906901, JN644967 | Histogenetics, Ossining, USA |
| B*07:14 | 606756688 | JN202317 | Antonio Balas, Madrid, Spain |
| B*07:68:03 | HG00002474 | HQ879828 | Histogenetics, Ossining, USA |
| B*07:87 | HG00002479, HG00002480, HG00002481, HG00003095, HG00003096 | JN124231, JF309400, JN123822, JN124300, JN561726 | Histogenetics, Ossining, USA |
| B*07:88 | HG00002380, HG00002381, HG00002978 | JN123804, JN123827, JN124269 | Histogenetics, Ossining, USA |
| B*07:92 | HG00002484, HG00003101 | JN124325, JN182980 | Histogenetics, Ossining, USA |
| B*07:95 | HG00002483 | JN124296 | Histogenetics, Ossining, USA |
| B*07:98 | HG00002476, HG00002477 | JN124232, JN123805 | Histogenetics, Ossining, USA |
| B*07:102 | HG00002473 | JN124270 | Histogenetics, Ossining, USA |
| B*07:111N | HG00002472 | HQ879816 | Histogenetics, Ossining, USA |
| B*08:01:01 | CGM1 | D84394 | Hidetoshi Inoko, Isehara, Kanagawa, Japan |
| B*08:01:08 | HG00002401 | JN123817 | Histogenetics, Ossining, USA |
| B*08:52 | HG00002406, HG00002874, HG00002875, HG00002876 | HQ906903, JN124245, JN124263, JN124239 | Histogenetics, Ossining, USA |
| B*13:45 | HG00002410 | JN123835 | Histogenetics, Ossining, USA |
| B*14:23 | HG00002467 | JF309394 | Histogenetics, Ossining, USA |
| B*15:01:10 | HG00002436 | JN123838 | Histogenetics, Ossining, USA |
| B*15:01:16 | HG00002452, HG00003062 | HQ906907, JN418820 | Histogenetics, Ossining, USA |
| B*15:05:01 | 60675719 | JN202318 | Antonio Balas, Madrid, Spain |
| B*15:173 | HG00002453, HG00003064 | JN119419, JN124261 | Histogenetics, Ossining, USA |
| B*15:207 | HG00002435 | JN123842 | Histogenetics, Ossining, USA |
| B*15:208 | HG00002439, HG00003057 | JN124229, JN124276 | Histogenetics, Ossining, USA |
| B*15:236 | HG00002437, HG00002438 | JN124327, JN123833 | Histogenetics, Ossining, USA |
| B*18:34 | HG00002399, HG00003005, HG00003006 | JN124235, JN418823, JN124267 | Histogenetics, Ossining, USA |
| B*18:47 | HG00002400 | JN123854 | Histogenetics, Ossining, USA |
| B*18:61 | HG00002398 | JF309408 | Histogenetics, Ossining, USA |
| B*27:02:01 | CS00121 | JN703996 | Kai Cao, Los Angeles, USA |
| B*27:47 | HG00002389, HG00002858 | JN124250, JN124208 | Histogenetics, Ossining, USA |
| B*27:49 | HG00002391 | HQ906905 | Histogenetics, Ossining, USA |
| B*27:53 | HG00002392, HG00002393, HG00002394 | JF309391, JN123796, JF292470 | Histogenetics, Ossining, USA |
| B*27:73 | HG00002388 | JN124264 | Histogenetics, Ossining, USA |
| B*27:82 | HG00002390 | JN123856 | Histogenetics, Ossining, USA |
| B*27:85 | HG00002395, HG00002396 | HQ906908, HQ879833 | Histogenetics, Ossining, USA |
| B*35:01:15 | HG00002434 | JN124178 | Histogenetics, Ossining, USA |
| B*35:14:01 | CS00122 | JN703997 | Kai Cao, Los Angeles, USA |
| B*35:103 | HG00002445 | HQ906897 | Histogenetics, Ossining, USA |
| B*35:121 | HG00002425, HG00002426 | JN123799, JN119375 | Histogenetics, Ossining, USA |
| B*35:132 | HG00002427, HG00002895, HG00002428 | JN119376, JN123793, JN629068 | Histogenetics, Ossining, USA |
| B*35:182 | HG00002451 | JF292473 | Histogenetics, Ossining, USA |
| B*38:01:04 | HG00002379 | JN124205 | Histogenetics, Ossining, USA |
| B*38:24 | HG00002488 | JN123857 | Histogenetics, Ossining, USA |
| B*39:57 | HG00002487 | JF309401 | Histogenetics, Ossining, USA |
| B*40:01:21 | HG00002382, HG00002383 | HQ906896, JN123839 | Histogenetics, Ossining, USA |
| B*40:107 | HG00002387 | HQ906898 | Histogenetics, Ossining, USA |
| B*41:11 | HG00002385 | HQ850034 | Histogenetics, Ossining, USA |
| B*44:73 | HG00002417 | HQ879834 | Histogenetics, Ossining, USA |
| B*44:74 | HG00002418, HG00003028, HG00003029 | JN124254, JN182977, JN604857 | Histogenetics, Ossining, USA |
| B*44:77 | HG00002413 | HQ850033 | Histogenetics, Ossining, USA |
| B*44:79 | HG00002414, HG00003021 | JF292471, JN406407 | Histogenetics, Ossining, USA |
| B*44:83 | HG00002431 | JN123792 | Histogenetics, Ossining, USA |
| B*44:86 | HG00002409, HG00002879, HG00002880 | JF309393, JN124176, JN124236 | Histogenetics, Ossining, USA |
| B*44:87 | HG00002412 | JF309403 | Histogenetics, Ossining, USA |
| B*44:96 | HG00002420, HG00002886 | JN123807, JN124197 | Histogenetics, Ossining, USA |
| B*44:98 | HG00002419, HG00003030 | HQ906902, JN205214 | Histogenetics, Ossining, USA |
| B*51:01:19 | HG00002465 | JN124298 | Histogenetics, Ossining, USA |
| B*51:117 | HG00002461, HG00002462, HG00002463 | JN123848, HQ879835, HQ879837 | Histogenetics, Ossining, USA |
| B*51:120 | HG00002457 | JF309399 | Histogenetics, Ossining, USA |
| B*51:24:04 | HG00002464 | HQ879827 | Histogenetics, Ossining, USA |
| B*51:65 | HG00002455 | JN124226 | Histogenetics, Ossining, USA |
| B*51:68 | HG00002408, HG00003013 | JF292476, JN242434 | Histogenetics, Ossining, USA |
| B*51:74 | HG00002454 | HQ906904 | Histogenetics, Ossining, USA |
| B*51:82 | HG00002458, HG00002459, HG00002460 | JF309397, JN123802, JN124280 | Histogenetics, Ossining, USA |
| B*52:08 | JMDP36K094 | AB671233 | Kenji Tadokoro, Tokyo, Japan |
| B*55:01:05 | HG00002447, HG00002448 | JN124230, JN124246 | Histogenetics, Ossining, USA |
| B*55:50 | CHA07-1649 | JN703285 | Ji Young Huh, Sungnam-si, Korea |
| B*56:25 | HG00002449 | JN124180 | Histogenetics, Ossining, USA |
| B*57:32 | HG00002442 | JN124237 | Histogenetics, Ossining, USA |
| C*01:17 | JMDP36K084 | AB671234 | Kenji Tadokoro, Tokyo, Japan |
| C*01:22 | JMDP01K100 | AB671235 | Kenji Tadokoro, Tokyo, Japan |
| C*01:59 | HG00002503, HG00003224 | HQ850043, JN644974 | Histogenetics, Ossining, USA |
| C*02:10 | 60676565 | JN227741 | Antonio Balas, Madrid, Spain |
| C*03:35 | JMDP36K115 | AB671236 | Kenji Tadokoro, Tokyo, Japan |
| C*06:02:07 | HG00002512, HG00003240, HG00003241 | JN124564, JN124557, JN182992 | Histogenetics, Ossining, USA |
| C*06:27 | HG00002513, HG00002514, HG00002515 | JN123871, HQ906914, JF292493 | Histogenetics, Ossining, USA |
| C*06:28 | HG00002507, HG00003230, HG00003231, HG00003232 | HQ906917, JN124509, JN124510, JN242448 | Histogenetics, Ossining, USA |
| C*06:50 | HG00002511 | JF309413 | Histogenetics, Ossining, USA |
| C*06:66 | HG00002516 | HQ879821 | Histogenetics, Ossining, USA |
| C*07:101 | HG00002508, HG00003236 | JN123949, JN242453 | Histogenetics, Ossining, USA |
| C*14:27 | FRFGR29900 | HE588129 | Dominique Masson, La Tronche, France |
| C*15:52 | FRFDI01935 | HE601623 | Dominique Masson, La Tronche, France |
| DRB1*01:01:01 | 7551100014, 7551100028 |
JN157601 | Yunping Xu, Shenzhen, China |
| DRB1*01:02:06 | BY00883 | JN383945 | Carolyn K Hurley, Washington DC, USA |
| DRB1*01:02:06 | BY00882, BY00885, BY00887, |
JN383946, JN383943, JN383944 | Carolyn K Hurley, Washington DC, USA |
| DRB1*04:02:01 | CS00123 | JN703998 | Kai Cao, Los Angeles, USA |
| DRB1*09:01:06 | BY00894 | JN383949 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:04:01 | CS00124 | JN703999 | Kai Cao, Los Angeles, USA |
| DRB1*16:02:01 | 7551100013 | JN157602 | Yunping Xu, Shenzhen, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*11:90 | (3) |
| B*15:189 | (4) |
| B*35:01:25 | (5) |
| B*44:130 | (6) |
| B*46:13:03 | (4) |
| B*48:01:03 | (7) |
| C*04:06 | (8) |
| C*07:108 | (9) |
| DRB3*01:15 | (10) |
| DQB1*03:02:05 | (11) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010; 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Yang KL, Lee SK, Lin CC, et al. Oriental HLA-A*11:90 detected in a Taiwanese cord blood sample and the haplotype in association with A*11:90 allele. International journal of immunogenetics. 2011; 38: 543-6.
- Yang KL, Lee SK, Lin CC, et al. Discovery of two novel HLA-B alleles, B*46:13:03 and B*15:189, in two Taiwanese volunteer bone marrow donors by sequence-based typing. International journal of immunogenetics. 2011; 38: 539-42.
- Lee MY, Oh SH, Kim HR, Park N, Jun JH. Identification of a novel HLA-B allele, B*35:01:25
BY sequence-based typing in a Korean individual. Tissue antigens. 2011; 78: 400-1. - Planelles D, Balas A, Montoro JA, Roig R, Vicario JL. Sequencing of a single HLA-B genotype including two rare alleles allows the detection of a new allele, B*44:130. Tissue antigens. 2011; 78: 398-9.
- Kang JE, Hwang SH, Song EJ, Kwon OJ, Kim HH. A novel HLA-B*48 allele, B*48:01:03, identified by sequence-based typing. Tissue antigens. 2011; 78: 401-2.
- Xu Y, Sun Y, He L, Deng Z. Characterization of the genomic full-length sequence of C*04:03 and C*04:06 in Chinese Han individuals. Tissue antigens. 2011; 78: 402-3.
- Todorova K, Schulze H, Hartmann S, Arnold R, Salama A, Schonemann C. A new HLA-C*07 variant allele, C*07:108, identified by sequence-based typing. Tissue antigens. 2011; 78: 403-4.
- Schiller JJ, Gaba SM, Hasse TR, Fisher TL, Ellis TM. A novel HLA allele derived from a likely DRB1/DRB3 gene conversion event: HLA-DRB3*01:15. Tissue antigens. 2011; 78: 405-7.
- Todorova K, Schulze H, Diederich G, Ebell W, Salama A, Schoenemann C. A novel HLA-DQB1*03:02 variant designated DQB1*03:02:05. Tissue antigens. 2011; 78: 404-5.
