Nomenclature for Factors of the HLA System
September 2011
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2011 78:482-4
- Human Immunology. 2011 73:127-9
- International Journal of Immunogenetics. 2011 39:95-7
The following sequences have been submitted to the Nomenclature Committee since the August 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*02:07:02 | CNUHH-16583444 | JN580999 | Oh-Joong Kwon, Seoul, South Korea |
| A*02:76:02 | JRCKBCB2238 | AB646796 | Yukari Kuroda, Fukuoka, Japan |
| A*02:333 | JRC-D43-001 | AB645764 | Kenji Tadokoro, Tokyo, Japan |
| A*02:334 | DNA20112619 | HE585994 | Harald Schulze, Berlin, Germany |
| A*24:185N | Shanxi009 | JN133617, JN133617 | Demei Zhang, Taiyuan, China |
| A*24:186 | Shanxi010 | JN133618 | Demei Zhang, Taiyuan, China |
| A*31:56 | 54110001305 | JN695567 | Lixing Yan, Hangzhou, China |
| B*27:07:02 | An 201266 | HE575490 | Francesca Poli, Milano, Italy |
| B*27:86 | AS2001 | HE586330 | Edward KL Yang, Hualien, Taiwan |
| B*35:08:05 | BY00839 | JN132204 | Carolyn K Hurley, Washington DC, USA |
| B*35:185 | D09020777 | HM122197 | Jinghui Qu, Shenzhen, China |
| B*35:186 | 52763 | JN253376 | Jianping Li, Shenyang, Liaoning, China |
| B*40:178 | 7112444 | HE585573 | Jean-Marie Tiercy, Geneva, Switzerland |
| B*52:27 | BY00865 | JN383931 | Carolyn K Hurley, Washington DC, USA |
| DRB1*01:45 | FRFRE08600 | HE582401 | Dominique Masson, La Tronche (Grenoble), France |
| DRB1*03:76 | HG00001834 | HM594822 | Histogenetics, Ossining, USA |
| DRB1*08:03:03 | 48596 | HE585125 | Thibaut Gervais, Brussels, Belgium |
| DRB1*11:120 | DEMGuil | HE584532 | Sylvie Tourne, Strasbourg, France |
| DRB1*15:67 | BY00884 | JN383940 | Carolyn K Hurley, Washington DC, USA |
| DQB1*05:14 | R43510 | HE584761 | Hien Tran, Heidelberg, Germany |
| DPB1*135:01 | 30400 | FR775798 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| MICA*067 | POP95/150 | HE583590 | Gottfried Fischer, Vienna, Austria |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:09 | HG00002350, HG00002351 | HQ906893, JF309368 | Histogenetics, Ossining, USA |
| A*01:01:10 | HG00002327, HG00002328, HG00002329, HG00002330, HG00002763, HG00002764, HG00002765, HG00002766 | JN124066, JN124061, JN124065, HQ850027, JN182959, JN205183, JN561710, JN418810 | Histogenetics, Ossining, USA |
| A*01:01:42 | HG00002336 | JF292468 | Histogenetics, Ossining, USA |
| A*01:38 | HG00002326 | JN123786 | Histogenetics, Ossining, USA |
| A*01:40 | HG00002334, HG00002772, HG00002773 | JF309375, JN124058, JN124060 | Histogenetics, Ossining, USA |
| A*01:44 | HG00002333, HG00002771 | HQ879812, JN123982 | Histogenetics, Ossining, USA |
| A*01:51 | HG00002335 | JN123778 | Histogenetics, Ossining, USA |
| A*01:98 | HG00002331, HG00002332 | JN123785, JN123782 | Histogenetics, Ossining, USA |
| A*02:01:32 | HG00002359, HG00002814 | JN123767, JN124099 | Histogenetics, Ossining, USA |
| A*02:01:34 | HG00002366 | JN123777 | Histogenetics, Ossining, USA |
| A*02:01:37 | HG00002364, HG00002820, HG00002821, HG00002822 | HQ850020, JN124047, JN124004, JN124098 | Histogenetics, Ossining, USA |
| A*02:01:39 | HG00002370 | HQ850032 | Histogenetics, Ossining, USA |
| A*02:12 | CS00117 | JN662438 | Kai Cao, Los Angeles, USA |
| A*02:186 | HG00002355 | JN123741 | Histogenetics, Ossining, USA |
| A*02:194 | HG00002369 | JN123771 | Histogenetics, Ossining, USA |
| A*02:198 | HG00002361 | HQ850031 | Histogenetics, Ossining, USA |
| A*02:199 | HG00002371 | JN123755 | Histogenetics, Ossining, USA |
| A*02:233 | HG00002360 | JN124059 | Histogenetics, Ossining, USA |
| A*03:01:17 | HG00002344 | JN124091 | Histogenetics, Ossining, USA |
| A*03:01:19 | HG00002340, HG00002341, HG00002342, HG00002343 | HQ879803, JF309369, JF309378, JF309379 | Histogenetics, Ossining, USA |
| A*03:48 | HG00002349 | JN123765 | Histogenetics, Ossining, USA |
| A*03:74 | HG00002337, HG00002338, HG00002780 | JF292458, JF292462, JN124055 | Histogenetics, Ossining, USA |
| A*11:01:34 | HG00002354 | JF292464 | Histogenetics, Ossining, USA |
| A*11:47 | HG00002279, HG00002280, HG00002691, HG00002692 | JF309371, HQ906892, JN123980, JN242425 | Histogenetics, Ossining, USA |
| A*11:73 | HG00002285 | JN123772 | Histogenetics, Ossining, USA |
| A*23:01:06 | HG00002304, HG00002305 | JN123739, JN123742 | Histogenetics, Ossining, USA |
| A*23:47 | HG00002311 | JN124156 | Histogenetics, Ossining, USA |
| A*24:02:23 | HG00002319, HG00002320, HG00002755, HG00002756, HG00002757 | JF292455, JN123746, JN123979, JN644952, JN584496 | Histogenetics, Ossining, USA |
| A*24:02:24 | HG00002308 | JN124044 | Histogenetics, Ossining, USA |
| A*24:02:35 | HG00002265, HG00002267, HG00002266, HG00002736 | JN123977, JN123763, JN123990, JN242428 | Histogenetics, Ossining, USA |
| A*24:106 | HG00002316, HG00002317, HG00002318, HG00002753, HG00002754 | JF292463, JN123769, HQ879810, JN182960, JN124038 | Histogenetics, Ossining, USA |
| A*24:110 | HG00002312, HG00002313, HG00002752 | JN123758, JN124034, JN124062 | Histogenetics, Ossining, USA |
| A*24:118 | HG00002300, HG00002301 | HQ850030, JN123770 | Histogenetics, Ossining, USA |
| A*24:123 | HG00002324 | HQ879802 | Histogenetics, Ossining, USA |
| A*24:169 | HG00002299 | HQ879799 | Histogenetics, Ossining, USA |
| A*24:182 | HG00002315 | HQ879813 | Histogenetics, Ossining, USA |
| A*25:01:03 | HG00002286 | JN123759 | Histogenetics, Ossining, USA |
| A*26:01:11 | HG00002291, HG00002292 | JN123740, JF292457 | Histogenetics, Ossining, USA |
| A*26:39 | HG00002287, HG00002288, HG00002289 | HQ850026, JF309376, HQ906894 | Histogenetics, Ossining, USA |
| A*26:59 | HG00002282 | HQ906889 | Histogenetics, Ossining, USA |
| A*26:68 | HG00002290 | JF292461 | Histogenetics, Ossining, USA |
| A*26:69 | Shanxi012 | JN133619 | Demei Zhang, Taiyuan, China |
| A*31:01:04 | HG00002278, HG00002684, HG00002685, HG00002686, HG00002687 | JF292456, JN561716, JN124007, JN124008, JN584491 | Histogenetics, Ossining, USA |
| A*32:27N | HG00002348, HG00002790 | HQ906888, JN119366 | Histogenetics, Ossining, USA |
| A*32:28 | HG00002346 | JF292466 | Histogenetics, Ossining, USA |
| A*33:26 | HG00002277, HG00002678, HG00002679, HG00002680, HG00002681, HG00002682, HG00002683 | JF309381, JN406444, JN584495, JN406443, JN182962, JN406391, JN406439 | Histogenetics, Ossining, USA |
| A*33:27 | HG00002273 | HQ906890 | Histogenetics, Ossining, USA |
| A*68:02:04 | HG00002281, HG00002693 | JF309380, JN561704 | Histogenetics, Ossining, USA |
| A*68:55 | HG00002293 | HQ850023 | Histogenetics, Ossining, USA |
| B*15:35 | CS00119 | JN673552 | Kai Cao, Los Angeles, USA |
| B*15:39:01 | CS00114, CS00115 |
JN641865 | Kai Cao, Los Angeles, USA |
| B*27:25 | D000868 | HE586329 | Edward KL Yang, Hualien, Taiwan |
| B*35:17 | CS00113 | JN616270 | Kai Cao, Los Angeles, USA |
| B*44:03:02 | CS00120 | JN673553 | Kai Cao, Los Angeles, USA |
| B*44:10 | CS00116 | JN651492 | Kai Cao, Los Angeles, USA |
| B*49:18 | FRFLY19257 | HE588128 | Dominique Masson, La Tronche (Grenoble), France |
| B*51:09:01 | CS00118 | JN673551 | Kai Cao, Los Angeles, USA |
| B*51:11N | 5958027 | HE575207 | Katherine Poole, Leeds, United Kingdom |
| B*56:27 | DEAKB_330835 | FR828536 | Rainer Blasczyk, Hannover, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*01:01:38L | (3) |
| A*26:20 | (4) |
| A*31:30 | (4) |
| DRB1*03:55 | (5) |
| DRB1*04:92 | (5) |
| DRB1*11:46:02 | (5) |
| MICB*023 | (6) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Dunn PP, Hammond L, Coates E, Street J, Griner L, Darke C. A "silent" nucleotide substitution in exon 4 is responsible for the "alternative expression" of HLA-A*01:01:38L through aberrant splicing. Hum Immunol. 2011; 72: 717-22.
- Yang KL, Lee SK, Lin CC, et al. Detection of two HLA-A alleles, A*31:30 and A*26:20, in two Taiwanese volunteer bone marrow donors by sequence-based typing. Int J Immunogenet. 2011; 38: 437-40.
- Balas A, Garcia-Sanchez F, Vicario JL. Characterization of three novel HLA-DRB1 alleles, DRB1*03:55, *11:46:02 and *04:92
BY exon 2, 3 and 4 sequencing-based typing. Int J Immunogenet. 2011; 38: 435-6. - Liu X, Tian W, Li L, Cai J. Characterization of the major histocompatibility complex class I chain-related gene B (MICB) polymorphism in a northern Chinese Han population: The identification of a new MICB allele, MICB*023. Hum Immunol. 2011; 72: 727-32.
