Nomenclature for Factors of the HLA System
March 2011
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2011 78:77-9
- Human Immunology. 2010 72:671-3
- International Journal of Immunogenetics. 2011 38:363-4
The following sequences have been submitted to the Nomenclature Committee since the February 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence previously named A*01:34N has now been shown to be expressed at low levels, and has been renamed A*01:01:38L, the name A*01:34N has now been abandoned. Three other alleles have the same mutation as that seen in A*01:01:38L, and consequently have ‘questionable’ expression levels, the suffix ‘Q’ has now been added to these alleles: A*02:01:14Q, A*24:02:03Q, A*33:03:03Q.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:38L | 37935 | FM209476 | Jane Rowlands, Pontyclun, United Kingdom |
| A*02:01:59 | LUMC-A76 | FR823456 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*02:01:60 | 81104817 | JF502561 | Daniel Fuerst, Ulm, Germany |
| A*02:311 | 81107982 | JF502563 | Daniel Fuerst, Ulm, Germany |
| B*07:129 | LUMC-B83 | FR823460 | Jacqy DH Anholts, Leiden, The Netherlands |
| B*07:130 | 205220 | FR824045 | Elisabeth Keller, Munich, Germany |
| B*08:70 | 81107856 | JF693895 | Daniel Fuerst, Ulm, Germany |
| B*15:223 | 46-B-10 | JF272517 | Yanling Zhang, Beijing, China |
| B*15:224 | JRC-D78-001 | AB617624 | Kenji Tadokoro, Tokyo, Japan |
| B*18:63 | 96062167 | JF495081 | Daniel Fuerst, Ulm, Germany |
| B*35:01:26 | HG00000887 | HQ590440 | Histogenetics, Ossining, USA |
| B*35:12:03 | HG00000880 | HQ590407 | Histogenetics, Ossining, USA |
| B*35:163 | HG00000882 | HQ590418 | Histogenetics, Ossining, USA |
| B*40:164 | JRC-D01-016 | AB617623 | Kenji Tadokoro, Tokyo, Japan |
| B*44:02:18 | HG00000879 | HQ590450 | Histogenetics, Ossining, USA |
| B*44:03:14 | HG00000878 | HQ590431 | Histogenetics, Ossining, USA |
| B*56:32 | HG00000886 | HQ590432 | Histogenetics, Ossining, USA |
| B*58:34 | HG00000883 | HQ590413 | Histogenetics, Ossining, USA |
| C*01:55 | JRC-D01-021 | AB617626 | Kenji Tadokoro, Tokyo, Japan |
| C*04:90 | LUMC-C85 | FR839029 | Jacqy DH Anholts, Leiden, The Netherlands |
| C*07:186 | JRC-D01-014 | AB617625 | Kenji Tadokoro, Tokyo, Japan |
| C*07:187 | 81107608 | JF502562 | Daniel Fuerst, Ulm, Germany |
| C*08:01:05 | JMDP36K107 | AB602445 | Kenji Tadokoro, Tokyo, Japan |
| DRB1*04:98 | scu13704 | JF430869 | Francisco de Paula Sanchez Gordo, Malaga, Spain |
| DRB1*11:108 | NT01154 | HM021748 | Carolyn K Hurley, Washington DC, USA |
| DRB1*15:01:16 | MUAL730474 | FR822200 | Steven GE Marsh, London, United Kingdom |
| DRB1*15:01:17 | LUMC-DRB75 | FR839024 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB3*02:28 | LUMC-DRB3n84 | FR839028 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*05:12 | LUMC-DQ80 | FR839025 | Jacqy DH Anholts, Leiden, The Netherlands |
| DPB1*133:01 | LUMC-DP81, 11d00511 | FR839026 | Jacqy DH Anholts, Leiden, The Netherlands |
| DPB1*134:01 | LUMC-DP82 | FR839027 | Jacqy DH Anholts, Leiden, The Netherlands |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:38L | 37935 | GQ281054 | Kai Cao, Los Angeles, USA |
| A*01:25 | 32905 | FR799757 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| A*02:96 | CS00072 | JF423318 | Kai Cao, Los Angeles, USA |
| A*02:125N | LUMC-A70 | FR823452 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*24:47 | CS00073 | JF706261 | Kai Cao, Los Angeles, USA |
| A*33:11 | JMDP36K106 | AB618604 | Kenji Tadokoro, Tokyo, Japan |
| A*74:11 | 32876 | FR799755 | Marcel GJ Tilanus, Maastricht, The Netherlands |
| B*13:13 | JMDP01K075 | AB618606 | Kenji Tadokoro, Tokyo, Japan |
| B*15:11:02 | JMDP01K072 | AB618603 | Kenji Tadokoro, Tokyo, Japan |
| B*15:50 | JMDP01K103 | AB618651 | Kenji Tadokoro, Tokyo, Japan |
| B*27:20 | JMDP36K068 | AB618648 | Kenji Tadokoro, Tokyo, Japan |
| B*35:30 | JMDP36K077 | AB618649 | Kenji Tadokoro, Tokyo, Japan |
| B*35:121 | HG00000881 | HQ590435 | Histogenetics, Ossining, USA |
| B*39:14 | JMDP01K071 | AB618602 | Kenji Tadokoro, Tokyo, Japan |
| B*51:16 | JMDP01K076 | AB618645 | Kenji Tadokoro, Tokyo, Japan |
| B*52:05 | JMDP01K070 | AB618601 | Kenji Tadokoro, Tokyo, Japan |
| B*55:07 | JMDP01K079 | AB618646 | Kenji Tadokoro, Tokyo, Japan |
| B*78:02:02 | JMDP36K060 | AB618647 | Kenji Tadokoro, Tokyo, Japan |
| C*03:23 | JMDP01K094 | AB618605 | Kenji Tadokoro, Tokyo, Japan |
| C*03:28 | JMDP36K092 | AB618650 | Kenji Tadokoro, Tokyo, Japan |
| C*07:141 | NT01143 | HM021758 | Carolyn K Hurley, Washington DC, USA |
| C*07:179 | 81107123 | JF495082 | Daniel Fuerst, Ulm, Germany |
| DRB1*04:05:10 | BY00662 | GU562426 | Carolyn K Hurley, Washington DC, USA |
| DRB1*08:17 | LUMC-DRB71 | FR823453 | Jacqy DH Anholts, Leiden, The Netherlands |
| DRB3*02:24 | TEM | FN563145 | Jacqy DH Anholts, Leiden, The Netherlands |
| DQB1*05:10 | SZGSQ-9 | JF689816 | Su-Qing Gao, Shenzhen, China |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| B*35:42:02 | (3) |
| B*52:21 | (4) |
| DRB1*01:01:01 | (5) |
| DRB1*03:01:01:01 | (5) |
| DRB1*04:01:01 | (5) |
| DRB1*04:05:01 | (5) |
| DRB1*04:06:01 | (5) |
| DRB1*07:01:01:01 | (5) |
| DRB1*08:03:02 | (5) |
| DRB1*08:09 | (5) |
| DRB1*09:01:02 | (5) |
| DRB1*11:01:01 | (5) |
| DRB1*12:01:01 | (5) |
| DRB1*12:02:01 | (5) |
| DRB1*13:01:01 | (5) |
| DRB1*13:02:01 | (5) |
| DRB1*13:12:01 | (5) |
| DRB1*13:99 | (6) |
| DRB1*14:04 | (5) |
| DRB1*14:07:01 | (5) |
| DRB1*14:54 | (5) |
| DRB1*15:01:01:01 | (5) |
| DRB1*15:02:01 | (5) |
| DRB1*16:02:01 | (5) |
| DQB1*05:06 | (7) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Tang Z, H., Li GY, Wang ML, Liu YY, Li YR, Fang LH. Identification of a novel HLA-B*35:42:02 allele in a Chinese bone marrow donor. Tissue Antigens. 2011; 77: 341-2.
- Veiga TR, Rampim GF, Gerbase Delima M. Identification of a novel HLA-B*52 allele in a Brazilian individual: B*52:21. Tissue Antigens. 2011; 77: 342-3.
- Zhu F, He Y, Tao S, et al. Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population. Tissue Antigens. 2011; 77: 329-32.
- Ko SY, Oh HB, Heo YS, Jun JH, Kwon OJ. HLA-DRB1*13:99, a novel HLA-DRB1*13 allele identified by sequence-based typing. Tissue Antigens. 2011; 77: 343-4.
- Cho MC, Ko SY, Oh HB, Heo YS, Kwon OJ. HLA-DQB1*05:06, a novel HLA-DQB1*05 allele identified by sequence-based typing. Tissue Antigens. 2011; 77: 344-6.
