Nomenclature for Factors of the HLA System

March 2011

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the February 2011 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence previously named A*01:34N has now been shown to be expressed at low levels, and has been renamed A*01:01:38L, the name A*01:34N has now been abandoned. Three other alleles have the same mutation as that seen in A*01:01:38L, and consequently have ‘questionable’ expression levels, the suffix ‘Q’ has now been added to these alleles: A*02:01:14Q, A*24:02:03Q, A*33:03:03Q.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:38L37935FM209476Jane Rowlands, Pontyclun, United Kingdom
A*02:01:59LUMC-A76FR823456Jacqy DH Anholts, Leiden, The Netherlands
A*02:01:6081104817JF502561Daniel Fuerst, Ulm, Germany
A*02:31181107982JF502563Daniel Fuerst, Ulm, Germany
B*07:129LUMC-B83FR823460Jacqy DH Anholts, Leiden, The Netherlands
B*07:130205220FR824045Elisabeth Keller, Munich, Germany
B*08:7081107856JF693895Daniel Fuerst, Ulm, Germany
B*15:22346-B-10JF272517Yanling Zhang, Beijing, China
B*15:224JRC-D78-001AB617624Kenji Tadokoro, Tokyo, Japan
B*18:6396062167JF495081Daniel Fuerst, Ulm, Germany
B*35:01:26HG00000887HQ590440Histogenetics, Ossining, USA
B*35:12:03HG00000880HQ590407Histogenetics, Ossining, USA
B*35:163HG00000882HQ590418Histogenetics, Ossining, USA
B*40:164JRC-D01-016AB617623Kenji Tadokoro, Tokyo, Japan
B*44:02:18HG00000879HQ590450Histogenetics, Ossining, USA
B*44:03:14HG00000878HQ590431Histogenetics, Ossining, USA
B*56:32HG00000886HQ590432Histogenetics, Ossining, USA
B*58:34HG00000883HQ590413Histogenetics, Ossining, USA
C*01:55JRC-D01-021AB617626Kenji Tadokoro, Tokyo, Japan
C*04:90LUMC-C85FR839029Jacqy DH Anholts, Leiden, The Netherlands
C*07:186JRC-D01-014AB617625Kenji Tadokoro, Tokyo, Japan
C*07:18781107608JF502562Daniel Fuerst, Ulm, Germany
C*08:01:05JMDP36K107AB602445Kenji Tadokoro, Tokyo, Japan
DRB1*04:98scu13704JF430869Francisco de Paula Sanchez Gordo, Malaga, Spain
DRB1*11:108NT01154HM021748Carolyn K Hurley, Washington DC, USA
DRB1*15:01:16MUAL730474FR822200Steven GE Marsh, London, United Kingdom
DRB1*15:01:17LUMC-DRB75FR839024Jacqy DH Anholts, Leiden, The Netherlands
DRB3*02:28LUMC-DRB3n84FR839028Jacqy DH Anholts, Leiden, The Netherlands
DQB1*05:12LUMC-DQ80FR839025Jacqy DH Anholts, Leiden, The Netherlands
DPB1*133:01LUMC-DP81, 11d00511FR839026Jacqy DH Anholts, Leiden, The Netherlands
DPB1*134:01LUMC-DP82FR839027Jacqy DH Anholts, Leiden, The Netherlands

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:38L37935GQ281054Kai Cao, Los Angeles, USA
A*01:2532905FR799757Marcel GJ Tilanus, Maastricht, The Netherlands
A*02:96CS00072JF423318Kai Cao, Los Angeles, USA
A*02:125NLUMC-A70FR823452Jacqy DH Anholts, Leiden, The Netherlands
A*24:47CS00073JF706261Kai Cao, Los Angeles, USA
A*33:11JMDP36K106AB618604Kenji Tadokoro, Tokyo, Japan
A*74:1132876FR799755Marcel GJ Tilanus, Maastricht, The Netherlands
B*13:13JMDP01K075AB618606Kenji Tadokoro, Tokyo, Japan
B*15:11:02JMDP01K072AB618603Kenji Tadokoro, Tokyo, Japan
B*15:50JMDP01K103AB618651Kenji Tadokoro, Tokyo, Japan
B*27:20JMDP36K068AB618648Kenji Tadokoro, Tokyo, Japan
B*35:30JMDP36K077AB618649Kenji Tadokoro, Tokyo, Japan
B*35:121HG00000881HQ590435Histogenetics, Ossining, USA
B*39:14JMDP01K071AB618602Kenji Tadokoro, Tokyo, Japan
B*51:16JMDP01K076AB618645Kenji Tadokoro, Tokyo, Japan
B*52:05JMDP01K070AB618601Kenji Tadokoro, Tokyo, Japan
B*55:07JMDP01K079AB618646Kenji Tadokoro, Tokyo, Japan
B*78:02:02JMDP36K060AB618647Kenji Tadokoro, Tokyo, Japan
C*03:23JMDP01K094AB618605Kenji Tadokoro, Tokyo, Japan
C*03:28JMDP36K092AB618650Kenji Tadokoro, Tokyo, Japan
C*07:141NT01143HM021758Carolyn K Hurley, Washington DC, USA
C*07:17981107123JF495082Daniel Fuerst, Ulm, Germany
DRB1*04:05:10BY00662GU562426Carolyn K Hurley, Washington DC, USA
DRB1*08:17LUMC-DRB71FR823453Jacqy DH Anholts, Leiden, The Netherlands
DRB3*02:24TEMFN563145Jacqy DH Anholts, Leiden, The Netherlands
DQB1*05:10SZGSQ-9JF689816Su-Qing Gao, Shenzhen, China

Table 3: Recently Published Sequences


Sequence References
B*35:42:02 (3)
B*52:21 (4)
DRB1*01:01:01 (5)
DRB1*03:01:01:01 (5)
DRB1*04:01:01 (5)
DRB1*04:05:01 (5)
DRB1*04:06:01 (5)
DRB1*07:01:01:01 (5)
DRB1*08:03:02 (5)
DRB1*08:09 (5)
DRB1*09:01:02 (5)
DRB1*11:01:01 (5)
DRB1*12:01:01 (5)
DRB1*12:02:01 (5)
DRB1*13:01:01 (5)
DRB1*13:02:01 (5)
DRB1*13:12:01 (5)
DRB1*13:99 (6)
DRB1*14:04 (5)
DRB1*14:07:01 (5)
DRB1*14:54 (5)
DRB1*15:01:01:01 (5)
DRB1*15:02:01 (5)
DRB1*16:02:01 (5)
DQB1*05:06 (7)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Tang Z, H., Li GY, Wang ML, Liu YY, Li YR, Fang LH. Identification of a novel HLA-B*35:42:02 allele in a Chinese bone marrow donor. Tissue Antigens. 2011; 77: 341-2.
  4. Veiga TR, Rampim GF, Gerbase Delima M. Identification of a novel HLA-B*52 allele in a Brazilian individual: B*52:21. Tissue Antigens. 2011; 77: 342-3.
  5. Zhu F, He Y, Tao S, et al. Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population. Tissue Antigens. 2011; 77: 329-32.
  6. Ko SY, Oh HB, Heo YS, Jun JH, Kwon OJ. HLA-DRB1*13:99, a novel HLA-DRB1*13 allele identified by sequence-based typing. Tissue Antigens. 2011; 77: 343-4.
  7. Cho MC, Ko SY, Oh HB, Heo YS, Kwon OJ. HLA-DQB1*05:06, a novel HLA-DQB1*05 allele identified by sequence-based typing. Tissue Antigens. 2011; 77: 344-6.