Nomenclature for Factors of the HLA System

October 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the September 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:27HN-7197691GQ180348Histogenetics, Ossining, USA
A*01:01:28HN-1663421GQ199703Histogenetics, Ossining, USA
A*01:01:29HN-3821296GU590941Histogenetics, Ossining, USA
A*01:01:30HN-3101256GU947043Histogenetics, Ossining, USA
A*01:01:31HN-76969-5GU551736Histogenetics, Ossining, USA
A*01:01:32HN-32372-3GU811769Histogenetics, Ossining, USA
A*01:82HN-3143984GQ240361Histogenetics, Ossining, USA
A*01:83HN-05811-0GU590947Histogenetics, Ossining, USA
A*01:84HN-81182-9GU811760Histogenetics, Ossining, USA
A*01:85HN-L20117566GU590951Histogenetics, Ossining, USA
A*02:05:04HN-55574-3GU590957Histogenetics, Ossining, USA
A*02:24:02HN-22822-9GU947041Histogenetics, Ossining, USA
A*02:283HN-19324-3GQ132033Histogenetics, Ossining, USA
A*02:284NHN-5884384GU947028Histogenetics, Ossining, USA
A*02:285HN-N286706GU811766Histogenetics, Ossining, USA
A*02:286HN-232197GU590950Histogenetics, Ossining, USA
A*02:287HN-N289445GU811777Histogenetics, Ossining, USA
A*02:288HN-75274-2GU947030Histogenetics, Ossining, USA
A*02:289HN-96641-6GU947038Histogenetics, Ossining, USA
A*02:290HN-3738532GU947034Histogenetics, Ossining, USA
A*02:291MOV002ANFR720326Steven GE Marsh, London, United Kingdom
A*03:23:02HN-60472-9GU551795Histogenetics, Ossining, USA
A*03:113HN-5144444GQ199687Histogenetics, Ossining, USA
A*03:114HN-73321-0GQ199645Histogenetics, Ossining, USA
A*03:115HN-76307-8GU811761Histogenetics, Ossining, USA
A*11:01:28FRFLY17083FR694930Dominique Masson, La Tronche, France
A*11:81HN-1966782GQ199707Histogenetics, Ossining, USA
A*11:82HN-2368533GQ132034Histogenetics, Ossining, USA
A*11:83HN-88810-5GQ149255Histogenetics, Ossining, USA
A*11:84HN-68882-0GU551748Histogenetics, Ossining, USA
A*11:85HN-96781-9GU551792Histogenetics, Ossining, USA
A*11:86FLY17172FR693366Dominique Masson, La Tronche, France
A*23:32HN-17351-9GU551742Histogenetics, Ossining, USA
A*24:02:41D10009328FR690485Jinghui Qu, Shenzhen, China
A*24:156HN-6462167GQ149253Histogenetics, Ossining, USA
A*24:157HN-33034-1GU811763Histogenetics, Ossining, USA
A*24:158NSZGSQ-7HQ334195Su-Qing Gao, Shenzhen, China
A*24:159FRFGR27366FR714914Dominique Masson, La Tronche, France
A*25:14HN-27934-4GQ240355Histogenetics, Ossining, USA
A*25:15HN-7227635GQ132020Histogenetics, Ossining, USA
A*26:01:19HN-202277GU590953Histogenetics, Ossining, USA
A*26:01:20HN-4432354GQ132046Histogenetics, Ossining, USA
A*26:01:21HN-3100587GU811774Histogenetics, Ossining, USA
A*26:57HN-46486-8GU551784Histogenetics, Ossining, USA
A*26:58HN-63880-9GU551738Histogenetics, Ossining, USA
A*26:59HN-24304-6GU551746Histogenetics, Ossining, USA
A*26:60NHN-71684-6GU947027Histogenetics, Ossining, USA
A*29:02:08HN-49952-7GU590945Histogenetics, Ossining, USA
A*31:01:10D10008098FR690487Jinghui Qu, Shenzhen, China
A*31:47HN-20270-2GQ199644Histogenetics, Ossining, USA
A*32:01:07HN-12286-8GQ199642Histogenetics, Ossining, USA
A*32:01:08HN-36015-1GU947033Histogenetics, Ossining, USA
A*32:31HN-89523-4GU551731Histogenetics, Ossining, USA
A*33:35HN-6374826GQ180323Histogenetics, Ossining, USA
A*33:36HN-3743146GU551734Histogenetics, Ossining, USA
A*33:37HN-48888-3GU551790Histogenetics, Ossining, USA
A*33:38D10011031FR690488Jinghui Qu, Shenzhen, China
A*33:393130900758FR694904Zhongrem Shi, Hebei, China
A*34:02:02HN-2036874GQ132032Histogenetics, Ossining, USA
A*66:1614898HQ384433Maria Elisa Moraes, Rio de Janeiro, Brazil
A*68:01:01:027550801952HM595421Yunping Xu, Shenzhen, China
A*68:21:02HN-N283077GU590940Histogenetics, Ossining, USA
A*68:67HN-6149053GQ199662Histogenetics, Ossining, USA
A*68:68HN-32747-7GU590943Histogenetics, Ossining, USA
A*68:69HN-N288568GU811768Histogenetics, Ossining, USA
A*68:70HN-61022-1GU551796Histogenetics, Ossining, USA
A*74:15HN-4558139GU551763Histogenetics, Ossining, USA
B*07:11810219091HQ317402Daniel Fuerst, Ulm, Germany
B*07:119FRFVA35598FR714911Dominique Masson, La Tronche, France
B*13:415751000245HQ260746Lixing Yan, Hangzhou, China
B*13:423350900515FR694905Lujun He, Shijiazhuang, China
B*14:20HN-22892-3GU228814Histogenetics, Ossining, USA
B*14:21HN-78820-7GU551822Histogenetics, Ossining, USA
B*15:210HN-2834326GQ345037Histogenetics, Ossining, USA
B*15:211HN-1145013GQ245725Histogenetics, Ossining, USA
B*15:212SD193FR690489Jinghui Qu, Shenzhen, China
B*15:213D10010029FR690490Jinghui Qu, Shenzhen, China
B*15:214D10010450FR690491Jinghui Qu, Shenzhen, China
B*15:215D10009142FR690492Jinghui Qu, Shenzhen, China
B*18:53FRFGR28374FR714913Dominique Masson, La Tronche, France
B*27:05:16HN-78143-4GU289886Histogenetics, Ossining, USA
B*35:152HN-22362-6GU811787Histogenetics, Ossining, USA
B*35:153HN-36057-9GU947058Histogenetics, Ossining, USA
B*35:154HN-48587-8GU551844Histogenetics, Ossining, USA
B*35:1553180900066FR694907Xiaohu Liang, Hebei, China
B*38:01:05HN-1910648GQ254339Histogenetics, Ossining, USA
B*40:01:18HN-33446-5GU354097Histogenetics, Ossining, USA
B*40:27:02HN-1188252GQ254331Histogenetics, Ossining, USA
B*40:159D120153FR691747Edward KL Yang, Hualien, Taiwan
B*41:17CS00051HQ402926Kai Cao, Los Angeles, USA
B*44:02:15HN-1040901GU289889Histogenetics, Ossining, USA
B*44:116HN-33111-5GU811784Histogenetics, Ossining, USA
B*44:117493147FR694931Dominique Masson, La Tronche, France
B*46:01:06HN-2384009GQ279263Histogenetics, Ossining, USA
B*47:01:02FRFLY17407FR714912Dominique Masson, La Tronche, France
B*51:01:21HN-17486-0GU228811Histogenetics, Ossining, USA
B*51:01:22HN-37966-7GU811788Histogenetics, Ossining, USA
B*51:56:02HN-99587-7GU551843Histogenetics, Ossining, USA
B*51:107HN-2730706GQ449626Histogenetics, Ossining, USA
B*52:01:01:02P4325HM543719Lixing Yan, Hangzhou, China
B*52:01:07HN-33262-6GU947064Histogenetics, Ossining, USA
B*52:232010-2762FR686355Kremena Todorova, Berlin, Germany
B*53:17:0213078HQ338110Maria Elisa Moraes, Rio de Janeiro, Brazil
B*55:49PBMC-QD212HM777039JianQiong Zhang, Nanjing, China
B*56:3110G13HQ231327Arturas Jakubauskas, Vilnius, Lithuania
B*57:38HN-2141474GQ240385Histogenetics, Ossining, USA
B*58:323350900509FR694906Aihong Zhang, Shijiazhuang, China
B*59:01:01:029.00061E+12HQ267234Lixing Yan, Hangzhou, China
C*01:46SZBM1113HQ399496Zhihui Deng, ShenZhen, China
C*02:02:17FRFSE04323FR714916Dominique Masson, La Tronche, France
C*03:103FRFVA39645FR714917Dominique Masson, La Tronche, France
C*03:104FRFGR29398FR714918Dominique Masson, La Tronche, France
C*04:15:03HN-41273-6GQ180459Histogenetics, Ossining, USA
C*04:82LHLAS000678FN870187Jian Li, Shenzhen, China
C*04:83HN-04344-0GQ161037Histogenetics, Ossining, USA
C*04:84FRFVA39901FR714920Dominique Masson, La Tronche, France
C*05:52DURCHRIFR714834Sylvie Tourne, Strasbourg, France
C*06:56FRFGR28959FR694929Dominique Masson, La Tronche, France
C*07:02:22HN-76689-5GU017942Histogenetics, Ossining, USA
C*07:02:23FRFLY17162FR694927Dominique Masson, La Tronche, France
C*07:161FRFLY12157FR688113Dominique Masson, La Tronche, France
C*07:162HN-N92196GQ240468Histogenetics, Ossining, USA
C*07:163FRFGR24051FR693747Dominique Masson, La Tronche, France
C*07:164NFRFLY16990FR714926Dominique Masson, La Tronche, France
C*07:165FRFLY18217FR714922Dominique Masson, La Tronche, France
C*07:166FRFDI05043FR714923Dominique Masson, La Tronche, France
C*08:45CBRA59099756744FR714924Dominique Masson, La Tronche, France
C*12:03:15HN-15696-0GU017956Histogenetics, Ossining, USA
C*14:26FRFSE04706FR689739Dominique Masson, La Tronche, France
C*15:46HN-43473-4GU017951Histogenetics, Ossining, USA
C*15:47FRFSE06045FR714925Dominique Masson, La Tronche, France
C*16:02:06FRFCF04453FR693746Dominique Masson, La Tronche, France
E*01:03:02:02MCFCR936916Stephan Beck, London, United Kingdom
F*01:01:02:06SSTOBX005428Stephan Beck, London, United Kingdom
DRB1*03:01:10HN-52302-3GQ401235Histogenetics, Ossining, USA
DRB1*03:01:11HN-84974-4GU128066Histogenetics, Ossining, USA
DRB1*03:59HN-14520-0GQ401233Histogenetics, Ossining, USA
DRB1*04:93D10008512FR690498Jinghui Qu, Shenzhen, China
DRB1*04:94N5710903021HQ329096Lixing Yan, Hangzhou, China
DRB1*09:10D10007883FR690496Jinghui Qu, Shenzhen, China
DRB1*11:04:07HN-28901-6GQ468264Histogenetics, Ossining, USA
DRB1*11:99HN-21509-0GQ994091Histogenetics, Ossining, USA
DRB1*11:100HN-81971-0GQ345105Histogenetics, Ossining, USA
DRB1*11:101D10003009FR690500Jinghui Qu, Shenzhen, China
DRB1*11:1013130900323FN824366Lujun He, Shijiazhuang, China
DRB1*13:12:02HN-23447-5GQ401232Histogenetics, Ossining, USA
DRB1*13:23:02HN-25391-6GU017969Histogenetics, Ossining, USA
DRB1*13:104HN-37846-2GQ468265Histogenetics, Ossining, USA
DRB1*13:105HN-30519-5GU017970Histogenetics, Ossining, USA
DRB1*13:106HN-63634-6FJ766008Histogenetics, Ossining, USA
DRB1*13:107HN-64540-3GQ994092Histogenetics, Ossining, USA
DRB1*13:108HN-78858-5GQ254399Histogenetics, Ossining, USA
DRB1*13:109HN-62395-1GQ401236Histogenetics, Ossining, USA
DRB1*13:110HN-64316-5GQ900587Histogenetics, Ossining, USA
DRB1*13:111HN-47205-9GU128069Histogenetics, Ossining, USA
DRB1*13:112HN-N93453GQ245758Histogenetics, Ossining, USA
DRB1*14:101HN-22119-4GU128076Histogenetics, Ossining, USA
DRB1*14:101FRFGR23357FR693748Dominique Masson, La Tronche, France
DRB1*14:102HN-5649855GU590986Histogenetics, Ossining, USA
DRB1*14:103D10011384FR690499Jinghui Qu, Shenzhen, China
DRB1*14:104BB1008205HQ331237YaoJung Yeh, Taipei, Taiwan
DRB1*14:10593071249HQ378504Daniel Fuerst, Ulm, Germany
DQB1*02:01:04405/2010HQ257218David Smillie, Sheffield, United Kingdom
DQB1*05:09D10013025FR690493Jinghui Qu, Shenzhen, China
DQB1*05:10D10007476FR690495Jinghui Qu, Shenzhen, China
DPB1*130:01ua2010tp2355FR695061Mats Bengtsson, Uppsala, Sweden
DPB1*131:013534FR714837Carlos Rojo, Houston, USA
MICA*063NGZP2084HM856619Xin Ye, Guangzhou, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:10HN-31462-1GU551756Histogenetics, Ossining, USA
A*01:01:22FRFVA39390FR714915Dominique Masson, La Tronche, France
A*02:01:01:01MCFCR759762Stephan Beck, London, United Kingdom
A*02:01:01:01DBBCR388220Stephan Beck, London, United Kingdom
A*02:13CS00041HQ386850Kai Cao, Los Angeles, USA
A*02:154HN-53574-9GQ132023Histogenetics, Ossining, USA
A*02:87CS00040HQ336044Kai Cao, Los Angeles, USA
A*03:88HN-73272-6GU551788Histogenetics, Ossining, USA
A*11:37HN-28610-0GQ345107Histogenetics, Ossining, USA
A*11:48HN-6435GU551757Histogenetics, Ossining, USA
A*23:21HN-3445296GQ254314Histogenetics, Ossining, USA
A*24:110HN-28167-6GQ149280Histogenetics, Ossining, USA
A*24:132NSZGSQ-8HQ404232Su-Qing Gao, Shenzhen, China
A*30:04:02HN-25713-5GQ345108Histogenetics, Ossining, USA
B*07:02:14HN-004384GQ345042Histogenetics, Ossining, USA
B*07:98HN-75374-4GU017933Histogenetics, Ossining, USA
B*07:102HN-12658-3GQ468251Histogenetics, Ossining, USA
B*14:10HN-35509-6GQ345062Histogenetics, Ossining, USA
B*14:19HN-03083-8GQ254344Histogenetics, Ossining, USA
B*15:03:03HN-38630-9GQ279272Histogenetics, Ossining, USA
B*15:162HN-207431GQ491086Histogenetics, Ossining, USA
B*15:208HN-98823-0GU128009Histogenetics, Ossining, USA
B*27:04:01CS00042HQ386851Kai Cao, Los Angeles, USA
B*27:61HN-002621GQ132052Histogenetics, Ossining, USA
B*35:06CS00043HQ386852Kai Cao, Los Angeles, USA
B*35:28CS00044HQ386853Kai Cao, Los Angeles, USA
B*40:94HN-61365-9GQ180221Histogenetics, Ossining, USA
B*40:102HN-21617-2GQ279275Histogenetics, Ossining, USA
B*40:114HN-63324-5GQ859543Histogenetics, Ossining, USA
B*40:12922195HQ384434Maria Elisa Moraes, Rio de Janeiro, Brazil
B*44:15CS00045HQ386854Kai Cao, Los Angeles, USA
B*44:64:02HN-59070-0GQ161023Histogenetics, Ossining, USA
B*44:107HN-15066-6GU017934Histogenetics, Ossining, USA
B*46:01:01H10030P4395HM543715Lixing Yan, Hangzhou, China
B*46:01:017550800757HM484301Yunping Xu, Shenzhen, China
B*51:69HN-90668-2GQ401194Histogenetics, Ossining, USA
B*57:24HN-7611622GQ859530Histogenetics, Ossining, USA
B*59:01:01:019.00061E+12HM543723Lixing Yan, Hangzhou, China
C*01:02:07HN-64160-4GQ345095Histogenetics, Ossining, USA
C*01:17HN-20086-2GQ240396Histogenetics, Ossining, USA
C*01:44FRFLY17162FR694928Dominique Masson, La Tronche, France
C*02:02:08HN-22943-9GQ180271Histogenetics, Ossining, USA
C*02:27:02HN-85994-0GQ149304Histogenetics, Ossining, USA
C*02:40HN-02501-9GQ180455Histogenetics, Ossining, USA
C*03:04:18HN-75737-9GU128025Histogenetics, Ossining, USA
C*03:08CS00046HQ396524Kai Cao, Los Angeles, USA
C*03:14CS00053HQ402928Kai Cao, Los Angeles, USA
C*03:88HN-8929468GQ180464Histogenetics, Ossining, USA
C*04:01:08HN-68489-5GQ240500Histogenetics, Ossining, USA
C*04:01:13HN-39452-9FJ997996Histogenetics, Ossining, USA
C*04:01:21HN-N268296GU128020Histogenetics, Ossining, USA
C*04:26CS00054HQ402929Kai Cao, Los Angeles, USA
C*04:59QHN-30834-8GU354138Histogenetics, Ossining, USA
C*05:09CS00047HQ386855Kai Cao, Los Angeles, USA
C*05:19HN-18457-3GQ161085Histogenetics, Ossining, USA
C*05:29HN-25544-7GQ240488Histogenetics, Ossining, USA
C*05:34HN-25925-0GU128040Histogenetics, Ossining, USA
C*06:18HN-67130-3GQ254398Histogenetics, Ossining, USA
C*06:47IME1086-10THQ318721Manuela Testi, Rome, Italy
C*07:40HN-23636-1GQ240425Histogenetics, Ossining, USA
C*07:54HN-75808-7GQ240454Histogenetics, Ossining, USA
C*07:108HN-12235-2GQ161046Histogenetics, Ossining, USA
C*07:12681103333HQ292779Daniel Fuerst, Ulm, Germany
C*08:15:01HN-04393-4GQ240436Histogenetics, Ossining, USA
C*08:28HN-49599-5GQ345096Histogenetics, Ossining, USA
C*12:03:04HN-90472-3GQ240443Histogenetics, Ossining, USA
C*12:03:10HN-04362-1GU128041Histogenetics, Ossining, USA
C*14:04CS00048HQ386856Kai Cao, Los Angeles, USA
C*15:30HN-78962-1GQ180432Histogenetics, Ossining, USA
C*15:40HN-99485-5GQ240496Histogenetics, Ossining, USA
C*16:01:04HN-14518-5GQ180452Histogenetics, Ossining, USA
C*17:01:04HN-86918-0GQ254382Histogenetics, Ossining, USA
DRB1*01:01:12HN-60180-9GU128075Histogenetics, Ossining, USA
DRB1*01:32HN-40625-2GQ900588Histogenetics, Ossining, USA
DRB1*03:47HN-52293-4GQ994094Histogenetics, Ossining, USA
DRB1*03:50HN-58353-0GQ449666Histogenetics, Ossining, USA
DRB1*10:01:01p4812HQ267233Lixing Yan, Hangzhou, China
DRB1*11:01:123350900107FN824367Lujun He, Shijiazhuang, China
DRB1*11:2430818FR714869Thibaut Gervais, Brussels, Belgium
DRB1*11:58:02HN-58253-8GU017967Histogenetics, Ossining, USA
DRB1*11:78HN-27110-2GQ859585Histogenetics, Ossining, USA
DRB1*11:81HN-61224-4GQ994093Histogenetics, Ossining, USA
DRB1*13:38HN-96345-4GQ149339Histogenetics, Ossining, USA
DRB1*13:92HN-39135-1GU017966Histogenetics, Ossining, USA
DRB1*13:95HN-39652-8GQ401234Histogenetics, Ossining, USA
DRB1*14:24CS00049HQ396525Kai Cao, Los Angeles, USA
DRB1*14:89HN-27188-3GU128067Histogenetics, Ossining, USA
DRB1*14:90HN-99377-6GU128072Histogenetics, Ossining, USA
DRB1*14:99HN-67814-6GU128070Histogenetics, Ossining, USA
DRB1*15:36HN-13966-3GQ132055Histogenetics, Ossining, USA
DRB1*15:40HN-71872-3GQ345106Histogenetics, Ossining, USA
DRB1*16:05:02CS00052HQ402927Kai Cao, Los Angeles, USA
DQB1*06:10CS00050HQ396526Kai Cao, Los Angeles, USA

Table 3: Recently Published Sequences


Sequence References
A*11:01:10 (3)
B*13:01:03 (4)
B*14:10 (5)
B*35:137 (6)
B*40:123 (7)
B*42:12 (8)
DQB1*03:26 (9)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Gao SM, Wang L, Zhang ZX. A novel allele, HLA-A*11:01:10, identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2010; 76: 495.
  4. Chu CC, Lee KC, Lee HL, Lai SK, Lin M. Identification of the novel allele HLA-B*13:01:03 by sequence-based typing method in a Taiwanese individual. Tissue Antigens. 2010; 76: 496-7.
  5. Emmerich F, Daskalakis M, Niemeyer C. A novel HLA-B allele, B*14:10, identified by haplotype-specific sequencing. Tissue Antigens. 2010; 76: 497-8.
  6. Zhu FM, He J, Wang W, Lv HJ, Yan LX. Identification of a novel allele HLA-B*35:137 in a Chinese leukemia patient. Tissue Antigens. 2010; 76: 498-9.
  7. Lee KW. A novel HLA-B allele, B*40:123, carrying a nucleotide substitution at a conserved codon. Tissue Antigens. 2010; 76: 499-500.
  8. Mattar SB, Uehara CJ, Ribas F, et al. A new allele, HLA-B*4212, identified in a Brazilian volunteer bone marrow donors by sequence-based typing. Int J Immunogenet. 2010; 37: 517-8.
  9. Chen MJ, Chu CC, Shyr MH, Lin CL, Lin PY, Yang KL. Identification of a novel HLA-DQB1 allele, DQB1*0326, in a College of American Pathologists 2009 survey specimen. Int J Immunogenet. 2010; 37: 455-7.