Nomenclature for Factors of the HLA System
September 2010
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2011 77:268-70
- Human Immunology. 2011 72:103-5
- International Journal of Immunogenetics. 2011 38:171-3
The following sequences have been submitted to the Nomenclature Committee since the August 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:26 | FRFLY16610 | FR691049 | Dominique Masson, La Tronche, France |
| A*01:78 | D10006910 | FR690475 | Jinghui Qu, Shenzhen, China |
| A*01:79 | FRFVA38971 | FR690873 | Dominique Masson, La Tronche, France |
| A*01:80 | FRFLY18286 | FR691048 | Dominique Masson, La Tronche, France |
| A*01:81 | CBRA59099746263, 014090619 |
FR691050 | Dominique Masson, La Tronche, France |
| A*02:280 | D09014985 | FR690476 | Jinghui Qu, Shenzhen, China |
| A*02:281 | CD10001668 | FR690477 | Jinghui Qu, Shenzhen, China |
| A*02:282 | D10011091 | FR690478 | Jinghui Qu, Shenzhen, China |
| A*02:79:02 | D10012888 | FR690479 | Jinghui Qu, Shenzhen, China |
| A*11:78N | P4754, P4755 | HQ214055 | Lixing Yan, Hangzhou, China |
| A*11:79 | D10008666 | FR690480 | Jinghui Qu, Shenzhen, China |
| A*11:80 | D10012897 | FR690481 | Jinghui Qu, Shenzhen, China |
| A*24:153 | D10010022 | FR690482 | Jinghui Qu, Shenzhen, China |
| A*24:154 | D10008340 | FR690483 | Jinghui Qu, Shenzhen, China |
| A*24:155N | D10007032 | FR690484 | Jinghui Qu, Shenzhen, China |
| A*26:56 | D10011797 | FR690486 | Jinghui Qu, Shenzhen, China |
| A*29:02:07 | FRFGR28281 | FR690871 | Dominique Masson, La Tronche, France |
| A*29:26 | FRFVA39523 | FR690872 | Dominique Masson, La Tronche, France |
| A*29:27 | FRFVA39950 | FR690874 | Dominique Masson, La Tronche, France |
| A*68:66 | A825 | HQ201391 | Annelies Muehlbacher, Innsbruck, Austria |
| B*08:66 | BY00730 | HQ127359 | Carolyn K Hurley, Washington DC, USA |
| B*14:02:06 | 13200305 | FR688111 | Dominique Masson, La Tronche, France |
| B*15:25:03 | 5760900236 | HQ171091 | Lixing Yan, Hangzhou, China |
| B*35:03:07 | SDBC-07D | GU145554 | Chuanfu Zhu, Jinan, China |
| B*38:26 | BJ082378 | HM347431 | Yanjun Jia, Beijing, China |
| B*40:155N | RC070832, RC076867 |
HM140623 | Oh-Joong Kwon, Seoul, South Korea |
| B*40:156 | 1094-10 | FR682859 | Florian Emmerich, Freiburg, Germany |
| B*40:157 | BY00733 | HQ127357 | Carolyn K Hurley, Washington DC, USA |
| B*40:158 | M1233197 | FR667574 | Edward KL Yang, Hualien, Taiwan |
| B*44:114 | BY00734 | HQ127356 | Carolyn K Hurley, Washington DC, USA |
| B*44:115 | FRFLY18407 | FR687370 | Dominique Masson, La Tronche, France |
| B*44:43:02 | BY00732 | HQ127358 | Carolyn K Hurley, Washington DC, USA |
| B*51:106 | N0005 | FN687185 | Mei Luo, Chengdu, China |
| B*53:24 | BY00729 | HQ127360 | Carolyn K Hurley, Washington DC, USA |
| B*57:37 | FRFVA40153 | FR687369 | Dominique Masson, La Tronche, France |
| C*01:02:13 | D10007074 | FR690462 | Jinghui Qu, Shenzhen, China |
| C*01:45 | FRFGR25834 | FR687364 | Dominique Masson, La Tronche, France |
| C*03:101 | FRFDI04440 | FR686901 | Dominique Masson, La Tronche, France |
| C*03:102 | D10009386 | FR690463 | Jinghui Qu, Shenzhen, China |
| C*04:81 | D10008515 | FR690464 | Jinghui Qu, Shenzhen, China |
| C*05:01:15 | FRFLY18331 | FR689740 | Dominique Masson, La Tronche, France |
| C*05:51Q | ANCB693337AN | FR671159 | Steven GE Marsh, London, United Kingdom |
| C*06:55 | D10012700 | FR690465 | Jinghui Qu, Shenzhen, China |
| C*07:137:02 | DED390 | FR686493 | Sylvie Tourne, Strasbourg, France |
| C*07:156 | D10012007 | FR690466 | Jinghui Qu, Shenzhen, China |
| C*07:157 | D10010200 | FR690467 | Jinghui Qu, Shenzhen, China |
| C*07:158 | D10010746 | FR690468 | Jinghui Qu, Shenzhen, China |
| C*07:159 | D10012306 | FR690469 | Jinghui Qu, Shenzhen, China |
| C*07:160 | SD430 | FR690470 | Jinghui Qu, Shenzhen, China |
| C*08:42 | BY00726 | HQ127363 | Carolyn K Hurley, Washington DC, USA |
| C*08:43 | CS00039 | HQ215835 | Kai Cao, Los Angeles, USA |
| C*08:44 | D10006515 | FR690471 | Jinghui Qu, Shenzhen, China |
| C*14:24 | D10008779 | FR690472 | Jinghui Qu, Shenzhen, China |
| C*14:25 | D10009731 | FR690473 | Jinghui Qu, Shenzhen, China |
| C*15:02:07 | D10007839, |
FR690474 | Jinghui Qu, Shenzhen, China |
| C*15:06:03 | 81103132 | HQ168401 | Daniel Fuerst, Ulm, Germany |
| C*15:44 | DED390 | FR686470 | Sylvie Tourne, Strasbourg, France |
| C*15:45 | FRFVA39921 | FR688114 | Dominique Masson, La Tronche, France |
| C*16:15:02 | FRFGR27627 | FR686902 | Dominique Masson, La Tronche, France |
| DRB1*01:33N | 20834 | HM590628 | Susana G Marino, Chicago, USA |
| DRB1*01:34 | 93071156 | HQ168402 | Daniel Fuerst, Ulm, Germany |
| DRB1*03:56 | 143KZ | FN908199 | Kuvat Momynaliev, Astana, Kazakhstan |
| DRB1*03:57 | 41KZ | FN908202 | Kuvat Momynaliev, Astana, Kazakhstan |
| DRB1*03:58 | FRFGR25937 | FR687365 | Dominique Masson, La Tronche, France |
| DRB1*04:92 | CTM-10900005 | HQ198249 | Antonio Balas, Madrid, Spain |
| DRB1*08:41 | 68 | HM627215 | Jun Hu, Xian, China |
| DRB1*11:04:06 | 153KZ | FN908201 | Kuvat Momynaliev, Astana, Kazakhstan |
| DRB1*13:02:04 | 130KZ | FN908204 | Kuvat Momynaliev, Astana, Kazakhstan |
| DRB1*13:102 | 145KZ | FN908200 | Kuvat Momynaliev, Astana, Kazakhstan |
| DRB1*13:103 | 71kz | FN908203 | Kuvat Momynaliev, Astana, Kazakhstan |
| DRB1*14:12:02 | 140KZ | FN908205 | Kuvat Momynaliev, Astana, Kazakhstan |
| MICA*002:04 | GZP2213 | HM856618 | Xin Ye, Guangzhou, China |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:16 | 1276-10 | FR682860 | Florian Emmerich, Freiburg, Germany |
| A*02:01:50 | FRFVA39584 | FR687367 | Dominique Masson, La Tronche, France |
| A*02:08 | HN-47518-7 | HQ258917 | Histogenetics, Ossining, USA |
| A*02:207 | FRFGR28402 | FR687362 | Dominique Masson, La Tronche, France |
| A*02:36 | NT01142 | HMO21759 | Carolyn K Hurley, Washington DC, USA |
| A*11:03 | NT01170 | HQ189132 | Carolyn K Hurley, Washington DC, USA |
| A*11:33:02 | FRFVA40159 | FR687368 | Dominique Masson, La Tronche, France |
| A*26:49 | HN-41380-7 | GQ199691 | Histogenetics, Ossining, USA |
| A*32:26 | FRFVA00987 | FR687363 | Dominique Masson, La Tronche, France |
| B*07:63 | HN-12411-2 | FJ588693 | Histogenetics, Ossining, USA |
| B*08:01:02 | HN-45088-0 | FJ588696 | Histogenetics, Ossining, USA |
| B*35:01:05 | HN-69161-6 | FJ588698 | Histogenetics, Ossining, USA |
| B*39:24 | CS00037 | HQ184435 | Kai Cao, Los Angeles, USA |
| B*39:31 | HN-37890-9 | FJ588697 | Histogenetics, Ossining, USA |
| B*40:115 | HN-006154 | GQ449629 | Histogenetics, Ossining, USA |
| B*40:49 | HN-17003-2 | FJ588699 | Histogenetics, Ossining, USA |
| B*44:02:12 | NT001169 | HMO21734 | Carolyn K Hurley, Washington DC, USA |
| B*51:01:01 | P3666 | HM543717 | Lixing Yan, Hangzhou, China |
| B*51:90 | BY00740 | HQ189131 | Carolyn K Hurley, Washington DC, USA |
| B*55:23 | CS00038 | HQ189746 | Kai Cao, Los Angeles, USA |
| B*57:01:07 | FRFLY14898 | FR688112 | Dominique Masson, La Tronche, France |
| C*03:16 | 5984206 | FR687254 | Katherine Poole, Leeds, United Kingdom |
| C*04:61 | BY00728 | HQ127361 | Carolyn K Hurley, Washington DC, USA |
| C*12:03:05 | HN-20102-4 | GQ180384 | Histogenetics, Ossining, USA |
| DRB1*12:24N | FRFGR27180 | FR687366 | Dominique Masson, La Tronche, France |
| DRB1*13:96 | HN-22035-9 | GQ859582 | Histogenetics, Ossining, USA |
| DRB1*15:01:11 | HN-58560-0 | GQ900585 | Histogenetics, Ossining, USA |
| DRB1*15:33 | HN-97374-3 | GU128060 | Histogenetics, Ossining, USA |
| DRB1*15:37 | HN-31685-4 | GQ449663 | Histogenetics, Ossining, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| B*15:144 | (3) |
| B*51:94 | (4) |
| C*06:20 | (5) |
| C*12�10:02 | (6) |
| DRB1*08:36 | (7) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Dong L, Yan LN, Xie JH, An SP, Yuan YH. A new HLA-B*15 variant, B*15:144, identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2010; 76: 421-2.
- Daskalakis M, Emmerich F, Niemeyer C. Identification of a novel HLA-B51 allele, HLA-B*51:94. Tissue Antigens. 2010; 76: 423.
- Emmerich F, Daskalakis M, Niemeyer CM. A novel HLA-C allele, HLA-Cw*06:20. Tissue Antigens. 2010; 76: 425.
- Sun H, Miao F, Pan N, Shen Y, Xie W, Zhang J. Identification of a novel HLA-C allele, C*12:10:02, in a Chinese individual. Tissue Antigens. 2010; 76: 424-5.
- Liu J, Liu N, Shan X, Li W, Zhang Z. A novel HLA-DRB1 allele, DRB1*08:36, identified by sequence-based typing. Tissue Antigens. 2010; 76: 426-7.
