Nomenclature for Factors of the HLA System

July 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the June 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:20BY00714HM641882Carolyn K Hurley, Washington DC, USA
A*01:67HN-30198-6GQ199694Histogenetics, Ossining, USA
A*01:68HN-52823-9GQ240357Histogenetics, Ossining, USA
A*01:69HN-09415-0GQ240520Histogenetics, Ossining, USA
A*01:70HN-31784-7GQ254317Histogenetics, Ossining, USA
A*01:71AX5237FN908085Xiang Liu, Beijing, China
A*02:267HN-6177807GQ245710Histogenetics, Ossining, USA
A*02:267BY00714HM641877Carolyn K Hurley, Washington DC, USA
A*02:26893067155HM627244Daniel Fuerst, Ulm, Germany
A*02:269BW1386FN908089Xiang Liu, Beijing, China
A*02:27096057749HM769864Daniel Fuerst, Ulm, Germany
A*02:271BY00701HM641869Carolyn K Hurley, Washington DC, USA
A*03:01:20HN-02000-9GQ859498Histogenetics, Ossining, USA
A*03:83HN-83742-4GQ240549Histogenetics, Ossining, USA
A*03:84HN-N96726GQ245711Histogenetics, Ossining, USA
A*03:85HN-32801-8GQ279255Histogenetics, Ossining, USA
A*03:86HN-76743-9,
HN-76742-1,
HN-09225-6
GQ859505,
GQ994051,
GU228800
Histogenetics, Ossining, USA
A*03:87HN-32041-8GQ900561Histogenetics, Ossining, USA
A*03:88BY00713HM641881Carolyn K Hurley, Washington DC, USA
A*03:89BY00711HM641879Carolyn K Hurley, Washington DC, USA
A*11:01:23HN-46123-4GQ859503Histogenetics, Ossining, USA
A*11:01:24BG9154FN908087Xiang Liu, Beijing, China
A*11:65HN-000057GQ240533Histogenetics, Ossining, USA
A*11:66HN-48680-2GQ468243Histogenetics, Ossining, USA
A*11:67HN-N034801,
HN-N035065,
HN-2712373
GQ859504,
GQ994045,
GQ254313
Histogenetics, Ossining, USA
A*11:68HN-23934-5GQ859514Histogenetics, Ossining, USA
A*11:69NGDJHM596507Yunping Xu, Shenzhen, China
A*11:70BY00715HM641883Carolyn K Hurley, Washington DC, USA
A*23:01:03NT01064FJ976686Carolyn K Hurley, Washington DC, USA
A*23:01:04BY00706HM641874Carolyn K Hurley, Washington DC, USA
A*23:27HN-N92198,
HN-N92196
GQ240522,
GQ240521
Histogenetics, Ossining, USA
A*23:28HN-95581-5GQ240540Histogenetics, Ossining, USA
A*23:29HN-39027-6GQ468241Histogenetics, Ossining, USA
A*23:30HN-206340GU136150Histogenetics, Ossining, USA
A*23:30BY00698HM641866Carolyn K Hurley, Washington DC, USA
A*23:31BY00702HM641870Carolyn K Hurley, Washington DC, USA
A*24:02:37HN-N255872,
HN-N276615,
HN-N277161
GQ859523,
GU354088,
GU354090
Histogenetics, Ossining, USA
A*24:14593068633HM769863Daniel Fuerst, Ulm, Germany
A*25:01:03HN-31873-5GQ859522Histogenetics, Ossining, USA
A*26:01:17HN-18090-7GQ449624Histogenetics, Ossining, USA
A*29:02:01:027550900355HM595424Yunping Xu, Shenzhen, China
A*29:02:06HN-52699-5GQ468245Histogenetics, Ossining, USA
A*29:23HN-57871-5GQ240353Histogenetics, Ossining, USA
A*29:24HN-82484-7GQ240555Histogenetics, Ossining, USA
A*30:42HN-22468-8GQ491081Histogenetics, Ossining, USA
A*30:43BG9496FN908088Xiang Liu, Beijing, China
A*30:44BY00712HM641880Carolyn K Hurley, Washington DC, USA
A*31:38HN-15561-0GQ449623Histogenetics, Ossining, USA
A*31:39HN-09642-6,
HN-87772-0,
HN-95669-5
GQ859515,
GQ160979,
GU187920
Histogenetics, Ossining, USA
A*31:40HN-9027847GQ240346Histogenetics, Ossining, USA
A*31:40BY00708HM641876Carolyn K Hurley, Washington DC, USA
A*32:01:06HN-69864-6GQ859510Histogenetics, Ossining, USA
A*32:26HN-37640-7GQ240358Histogenetics, Ossining, USA
A*33:01:04HN-54157-2GQ401185Histogenetics, Ossining, USA
A*33:32HN-N255360GQ449611Histogenetics, Ossining, USA
A*68:01:08HN-004903GQ401173Histogenetics, Ossining, USA
A*68:01:09HN-79493-8GQ914778Histogenetics, Ossining, USA
A*68:03:03BY00699HM641867Carolyn K Hurley, Washington DC, USA
A*68:55HN-1109,
HN-37844-7,
HN-1934,
HN-9001,
HN-3185,
HN-2753,
HN-9562,
HN-0252,
HN-2713,
HN-2861
GQ240371,
GQ240372,
GQ240557,
GQ449618,
GQ199679,
GQ199680,
GQ199681,
GQ199682,
GQ199683,
GQ199684
Histogenetics, Ossining, USA
A*68:56HN-64847-4GQ240552Histogenetics, Ossining, USA
A*68:57HN-39605-6GQ345031Histogenetics, Ossining, USA
A*68:58HN-005118GQ449617Histogenetics, Ossining, USA
A*74:02:01:027550800550HM595420Yunping Xu, Shenzhen, China
B*07:11793070338HM627245Daniel Fuerst, Ulm, Germany
B*07:96:02HN-69505-1GQ900553Histogenetics, Ossining, USA
B*08:01:13HN-23564-4,
HN-14360-8
GQ345052,
GQ449649
Histogenetics, Ossining, USA
B*08:63HN-26632-2GQ859546Histogenetics, Ossining, USA
B*08:64HN-81782-0GQ900550Histogenetics, Ossining, USA
B*14:01:02HN-37908-6GQ401203Histogenetics, Ossining, USA
B*14:19HN-03082-0,
HN-54436-7
GQ245740,
GQ914794
Histogenetics, Ossining, USA
B*15:02:05HN-70532-7GQ468253Histogenetics, Ossining, USA
B*15:203HN-83516-5GQ245734Histogenetics, Ossining, USA
B*15:204HN-004195GQ345041Histogenetics, Ossining, USA
B*15:205HN-14534-8GQ401195Histogenetics, Ossining, USA
B*15:206HN-28760-9GQ468248Histogenetics, Ossining, USA
B*15:207HN-00619-2GQ900546Histogenetics, Ossining, USA
B*15:208HN-68898-8GQ994055Histogenetics, Ossining, USA
B*15:39:02HN-83876-3GQ245735Histogenetics, Ossining, USA
B*18:01:09HN-12886-6GQ345053Histogenetics, Ossining, USA
B*18:51HN-57626-6,
HN-57453-5,
HN-57086-3,
HN-57327-1
GQ345057,
GQ401197,
GQ401198,
GQ401201
Histogenetics, Ossining, USA
B*18:52HN-41999-3GQ859552Histogenetics, Ossining, USA
B*27:05:15HN-74354-9,
HN-61604-0
GQ254340,
GQ449630
Histogenetics, Ossining, USA
B*27:70HN-85438-6,
HN-18744-9
GQ245738,
GQ254342
Histogenetics, Ossining, USA
B*27:71HN-N258280GQ449627Histogenetics, Ossining, USA
B*27:72HN-91490-2GQ859537Histogenetics, Ossining, USA
B*27:73HN-87758-4GQ994056Histogenetics, Ossining, USA
B*35:03:05HN-63512-0GQ401204Histogenetics, Ossining, USA
B*35:03:06BY00722HM641890Carolyn K Hurley, Washington DC, USA
B*37:24HN-28547-4GQ401190Histogenetics, Ossining, USA
B*38:02:03BE3846FN827054Xiang Liu, Beijing, China
B*38:24HN-97894-2GQ994064Histogenetics, Ossining, USA
B*39:01:12HN-23413-0GQ914795Histogenetics, Ossining, USA
B*39:61HN-10004-2GQ900551Histogenetics, Ossining, USA
B*40:01:13HN-37879-3GQ240388Histogenetics, Ossining, USA
B*40:01:14HN-12416-6,
HN-12417-4
GQ449631,
GQ449632
Histogenetics, Ossining, USA
B*40:01:15HN-53976-2GQ994067Histogenetics, Ossining, USA
B*40:148BY00720HM641888Carolyn K Hurley, Washington DC, USA
B*41:02:03HN-24884-1GQ914796Histogenetics, Ossining, USA
B*41:13HN-88047-3GQ859542Histogenetics, Ossining, USA
B*41:14BY00718HM641886Carolyn K Hurley, Washington DC, USA
B*41:15BY00725HM641893Carolyn K Hurley, Washington DC, USA
B*44:03:12HN-14550-7GQ345051Histogenetics, Ossining, USA
B*44:111BY00723HM641891Carolyn K Hurley, Washington DC, USA
B*46:21:02HN-14529-1GQ345050Histogenetics, Ossining, USA
B*48:24HN-32300-6GQ245742Histogenetics, Ossining, USA
B*49:11HN-57406-3GQ345056Histogenetics, Ossining, USA
B*49:12HN-58403-3GQ449641Histogenetics, Ossining, USA
B*49:13HN-63623-5GQ449647Histogenetics, Ossining, USA
B*50:10HN-85693-6GQ180222Histogenetics, Ossining, USA
B*50:11HN-N94477GQ245730Histogenetics, Ossining, USA
B*50:12HN-40368-9GQ449648Histogenetics, Ossining, USA
B*51:01:18HN-N93713,
HN-N94361
GQ245727,
GQ245729
Histogenetics, Ossining, USA
B*51:01:19HN-55571-9GQ449637Histogenetics, Ossining, USA
B*51:100HN-60975-2GQ449640Histogenetics, Ossining, USA
B*51:101BY00721HM641889Carolyn K Hurley, Washington DC, USA
B*51:97HN-02479-9GQ161025Histogenetics, Ossining, USA
B*51:98NHN-87997-9GQ245716Histogenetics, Ossining, USA
B*51:99HN-41212-7GQ401192Histogenetics, Ossining, USA
B*52:01:06HN-61984-3,
HN-96899-8
GQ345058,
FJ392172
Histogenetics, Ossining, USA
B*52:22HN-59535-1GQ449642Histogenetics, Ossining, USA
B*55:44HN-31867-4GQ345040Histogenetics, Ossining, USA
B*55:45HN-58356-9GQ859548Histogenetics, Ossining, USA
B*56:30HN-30280-4GQ491087Histogenetics, Ossining, USA
B*57:01:09HN-14793-9GQ180220Histogenetics, Ossining, USA
B*57:33HN-98451-5GQ245746Histogenetics, Ossining, USA
B*57:34HN-49431-8GQ859536Histogenetics, Ossining, USA
B*57:35HN-N260466GQ914789Histogenetics, Ossining, USA
B*58:01:08HN-N035620GQ994059Histogenetics, Ossining, USA
C*04:01:22R43879FN995095Hien Tran, Heidelberg, Germany
C*04:71H558FN999910Carlos Vilches, Madrid, Spain
C*06:46ND10000220FN908170Jinghui Qu, Shenzhen, China
C*06:47BY00695HM641863Carolyn K Hurley, Washington DC, USA
C*07:150QBY00716HM641884Carolyn K Hurley, Washington DC, USA
C*07:151BY00705HM641873Carolyn K Hurley, Washington DC, USA
C*15:36BY00697HM641865Carolyn K Hurley, Washington DC, USA
C*16:27HN-89947-5GU017941Histogenetics, Ossining, USA
C*16:27BY00704HM641872Carolyn K Hurley, Washington DC, USA
DRB1*12:25ANCBB101120CFR668236Steven GE Marsh, London, United Kingdom
DQB1*05:01:0310G09FR667215Arturas Jakubauskas, Vilnius, Lithuania

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:09HN-83855-2GQ914779Histogenetics, Ossining, USA
A*01:01:10HN-09078-2,
HN-81036-3
GQ345033,
GQ401180
Histogenetics, Ossining, USA
A*01:01:12HN-91466-0GQ345036Histogenetics, Ossining, USA
A*01:48HN-0340GQ199708Histogenetics, Ossining, USA
A*02:01:34HN-0340GQ345030Histogenetics, Ossining, USA
A*02:01:46BY00710HM641878Carolyn K Hurley, Washington DC, USA
A*02:05:017550900252HM595423Yunping Xu, Shenzhen, China
A*02:118BY00696HM641864Carolyn K Hurley, Washington DC, USA
A*02:221FGR26423FN985046Dominique Masson, La Tronche, France
A*02:251SSH-IGH10162HM773273Yunping Xu, Shenzhen, China
A*02:48YQHM595427Yunping Xu, Shenzhen, China
A*11:01:17HN-75506-2,
HN-90240-7
GQ254318,
GQ180342
Histogenetics, Ossining, USA
A*11:01:187550801591HM595419Yunping Xu, Shenzhen, China
A*24:02:29HN-25059-9,
HN-93264-0
GQ859521,
GU354091
Histogenetics, Ossining, USA
A*24:03:01HSXHM595426Yunping Xu, Shenzhen, China
A*24:087550900468HM595425Yunping Xu, Shenzhen, China
A*24:107550900244HM773272Yunping Xu, Shenzhen, China
A*30:02:05HN-32248-7GQ279257Histogenetics, Ossining, USA
A*30:02:05BY00700HM641868Carolyn K Hurley, Washington DC, USA
A*32:19NBY00703HM641871Carolyn K Hurley, Washington DC, USA
A*68:02:01:017550900065HM595422Yunping Xu, Shenzhen, China
A*68:24CS00032HM636498Kai Cao, Los Angeles, USA
B*07:02:017550801026HM596506Yunping Xu, Shenzhen, China
B*07:02:01HN-07021-1GQ401193Histogenetics, Ossining, USA
B*07:31BY00717HM641885Carolyn K Hurley, Washington DC, USA
B*08:62BY00719HM641887Carolyn K Hurley, Washington DC, USA
B*13:01:017550801026HM484300Yunping Xu, Shenzhen, China
B*15:01:01:01H10009HM543709Lixing Yan, Hangzhou, China
B*15:02:017550801157HM595430Yunping Xu, Shenzhen, China
B*15:07:017550800743HM484303Yunping Xu, Shenzhen, China
B*15:18:017550801124HM595432Yunping Xu, Shenzhen, China
B*15:25:017550800206HM595433Yunping Xu, Shenzhen, China
B*15:587550801093HM595431Yunping Xu, Shenzhen, China
B*27:04:017550801077HM596502Yunping Xu, Shenzhen, China
B*35:02:017550800768HM595434Yunping Xu, Shenzhen, China
B*37:01:017550801036HM596503Yunping Xu, Shenzhen, China
B*38:01:017550801157HM595436Yunping Xu, Shenzhen, China
B*38:02:01P3618HM543711Lixing Yan, Hangzhou, China
B*40:01:02P4416HM543713Lixing Yan, Hangzhou, China
B*40:06:01:01P4502HM543714Lixing Yan, Hangzhou, China
B*40:12918406PHDPHM640217Margareth Torres, Sao Paulo, Brazil
B*44:02:01:017550800776HM595428Yunping Xu, Shenzhen, China
B*44:27CS00033HM636499Kai Cao, Los Angeles, USA
B*51:01:01P4291HM543718Lixing Yan, Hangzhou, China
B*51:07:017550801734HM484302Yunping Xu, Shenzhen, China
B*51:64BY00724HM641892Carolyn K Hurley, Washington DC, USA
B*52:01:01H10059HM543720Lixing Yan, Hangzhou, China
B*54:01P3913HM543721Lixing Yan, Hangzhou, China
B*55:127550801093HM595435Yunping Xu, Shenzhen, China
B*57:297550801706HM596505Yunping Xu, Shenzhen, China
B*58:01:01P4500HM543722Lixing Yan, Hangzhou, China
B*58:01:017550801051HM595429Yunping Xu, Shenzhen, China
B*67:01:017550801051HM595437Yunping Xu, Shenzhen, China
C*01:02:01H10021HM543696Lixing Yan, Hangzhou, China
C*03:02:02:01P4500HM543697Lixing Yan, Hangzhou, China
C*03:03:01H09094HM543698Lixing Yan, Hangzhou, China
C*03:04:01:02P4135HM543699Lixing Yan, Hangzhou, China
C*04:01:01:01P4379HM543700Lixing Yan, Hangzhou, China
C*06:02:01:01H09056HM543701Lixing Yan, Hangzhou, China
C*07:02:01:01P4487HM543702Lixing Yan, Hangzhou, China
C*07:10820101998FR668076Kremena Todorova, Berlin, Germany
C*08:01:01P4142HM543703Lixing Yan, Hangzhou, China
C*12:02:02H10059HM543704Lixing Yan, Hangzhou, China
C*14:02:01P4290HM543705Lixing Yan, Hangzhou, China
DQB1*03:01:04CS00034HM807525Kai Cao, Los Angeles, USA

Table 3: Recently Published Sequences


Sequence References
A*11:49 (3)
B*15:152 (4)
B*15:187 (5)
B*51:78 (6)
DRB1*03:43 (7)
DRB1*04:04:05 (8)
DRB1*11:90 (8)
DQB1*04:04 (9)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Yan LX, Zhu FM, Wang W, Zhang W, Lv HJ. Identification of a novel allele HLA-A*1149 in a Chinese leukemia patient. Tissue Antigens. 2010; 76: 250-1.
  4. He WD, Zhu YB, Zhang CX, Pang LB, Zhu CF. Identification of a novel HLA-B*15 allele (B*9552) by sequence-based typing in a Chinese donor. Tissue Antigens. 2010; 76: 251-3.
  5. Han SH, Heo YA, Kwon OJ, Yoon HR, Lee KR. A new HLA-B*15 allele, HLA-B*9587, identified by sequence-based typing in a Korean individual. Tissue Antigens. 2010; 76: 253-5.
  6. Cosentini E, Longhi E, Frison S, et al. Sequence of a novel HLA-B*51 allele in a volunteer haematopoietic stem cell donor. Int J Immunogenet. 2010; 37: 399-400.
  7. Street J, Johnson J, Pepperall J, Cao K, Darke C. A new HLA-DRB1 allele: DRB1*0343. Tissue Antigens. 2010; 76: 255-6.
  8. Mantovani M, Longhi E, Frison S, de Arias AE, Mosca A, Poli F. Identification of two new HLA-DRB1 alleles, DRB1*040405 and DRB1*1190. Int J Immunogenet. 2010; 37: 397-8.
  9. Witter K, Zahn R, Volgger A, Reininger AJ. HLA-DQB1*0404, a novel DQB1-allele detected in a volunteer blood platelet donor typed for HLA. Tissue Antigens. 2010; 76: 256-8.