Nomenclature for Factors of the HLA System
July 2010
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2011 77:162-6
- Human Immunology. 2011 72:91-4
- International Journal of Immunogenetics. 2011 38:83-7
The following sequences have been submitted to the Nomenclature Committee since the June 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:20 | BY00714 | HM641882 | Carolyn K Hurley, Washington DC, USA |
| A*01:67 | HN-30198-6 | GQ199694 | Histogenetics, Ossining, USA |
| A*01:68 | HN-52823-9 | GQ240357 | Histogenetics, Ossining, USA |
| A*01:69 | HN-09415-0 | GQ240520 | Histogenetics, Ossining, USA |
| A*01:70 | HN-31784-7 | GQ254317 | Histogenetics, Ossining, USA |
| A*01:71 | AX5237 | FN908085 | Xiang Liu, Beijing, China |
| A*02:267 | HN-6177807 | GQ245710 | Histogenetics, Ossining, USA |
| A*02:267 | BY00714 | HM641877 | Carolyn K Hurley, Washington DC, USA |
| A*02:268 | 93067155 | HM627244 | Daniel Fuerst, Ulm, Germany |
| A*02:269 | BW1386 | FN908089 | Xiang Liu, Beijing, China |
| A*02:270 | 96057749 | HM769864 | Daniel Fuerst, Ulm, Germany |
| A*02:271 | BY00701 | HM641869 | Carolyn K Hurley, Washington DC, USA |
| A*03:01:20 | HN-02000-9 | GQ859498 | Histogenetics, Ossining, USA |
| A*03:83 | HN-83742-4 | GQ240549 | Histogenetics, Ossining, USA |
| A*03:84 | HN-N96726 | GQ245711 | Histogenetics, Ossining, USA |
| A*03:85 | HN-32801-8 | GQ279255 | Histogenetics, Ossining, USA |
| A*03:86 | HN-76743-9, HN-76742-1, HN-09225-6 | GQ859505, GQ994051, GU228800 | Histogenetics, Ossining, USA |
| A*03:87 | HN-32041-8 | GQ900561 | Histogenetics, Ossining, USA |
| A*03:88 | BY00713 | HM641881 | Carolyn K Hurley, Washington DC, USA |
| A*03:89 | BY00711 | HM641879 | Carolyn K Hurley, Washington DC, USA |
| A*11:01:23 | HN-46123-4 | GQ859503 | Histogenetics, Ossining, USA |
| A*11:01:24 | BG9154 | FN908087 | Xiang Liu, Beijing, China |
| A*11:65 | HN-000057 | GQ240533 | Histogenetics, Ossining, USA |
| A*11:66 | HN-48680-2 | GQ468243 | Histogenetics, Ossining, USA |
| A*11:67 | HN-N034801, HN-N035065, HN-2712373 | GQ859504, GQ994045, GQ254313 | Histogenetics, Ossining, USA |
| A*11:68 | HN-23934-5 | GQ859514 | Histogenetics, Ossining, USA |
| A*11:69N | GDJ | HM596507 | Yunping Xu, Shenzhen, China |
| A*11:70 | BY00715 | HM641883 | Carolyn K Hurley, Washington DC, USA |
| A*23:01:03 | NT01064 | FJ976686 | Carolyn K Hurley, Washington DC, USA |
| A*23:01:04 | BY00706 | HM641874 | Carolyn K Hurley, Washington DC, USA |
| A*23:27 | HN-N92198, HN-N92196 | GQ240522, GQ240521 | Histogenetics, Ossining, USA |
| A*23:28 | HN-95581-5 | GQ240540 | Histogenetics, Ossining, USA |
| A*23:29 | HN-39027-6 | GQ468241 | Histogenetics, Ossining, USA |
| A*23:30 | HN-206340 | GU136150 | Histogenetics, Ossining, USA |
| A*23:30 | BY00698 | HM641866 | Carolyn K Hurley, Washington DC, USA |
| A*23:31 | BY00702 | HM641870 | Carolyn K Hurley, Washington DC, USA |
| A*24:02:37 | HN-N255872, HN-N276615, HN-N277161 | GQ859523, GU354088, GU354090 | Histogenetics, Ossining, USA |
| A*24:145 | 93068633 | HM769863 | Daniel Fuerst, Ulm, Germany |
| A*25:01:03 | HN-31873-5 | GQ859522 | Histogenetics, Ossining, USA |
| A*26:01:17 | HN-18090-7 | GQ449624 | Histogenetics, Ossining, USA |
| A*29:02:01:02 | 7550900355 | HM595424 | Yunping Xu, Shenzhen, China |
| A*29:02:06 | HN-52699-5 | GQ468245 | Histogenetics, Ossining, USA |
| A*29:23 | HN-57871-5 | GQ240353 | Histogenetics, Ossining, USA |
| A*29:24 | HN-82484-7 | GQ240555 | Histogenetics, Ossining, USA |
| A*30:42 | HN-22468-8 | GQ491081 | Histogenetics, Ossining, USA |
| A*30:43 | BG9496 | FN908088 | Xiang Liu, Beijing, China |
| A*30:44 | BY00712 | HM641880 | Carolyn K Hurley, Washington DC, USA |
| A*31:38 | HN-15561-0 | GQ449623 | Histogenetics, Ossining, USA |
| A*31:39 | HN-09642-6, HN-87772-0, HN-95669-5 | GQ859515, GQ160979, GU187920 | Histogenetics, Ossining, USA |
| A*31:40 | HN-9027847 | GQ240346 | Histogenetics, Ossining, USA |
| A*31:40 | BY00708 | HM641876 | Carolyn K Hurley, Washington DC, USA |
| A*32:01:06 | HN-69864-6 | GQ859510 | Histogenetics, Ossining, USA |
| A*32:26 | HN-37640-7 | GQ240358 | Histogenetics, Ossining, USA |
| A*33:01:04 | HN-54157-2 | GQ401185 | Histogenetics, Ossining, USA |
| A*33:32 | HN-N255360 | GQ449611 | Histogenetics, Ossining, USA |
| A*68:01:08 | HN-004903 | GQ401173 | Histogenetics, Ossining, USA |
| A*68:01:09 | HN-79493-8 | GQ914778 | Histogenetics, Ossining, USA |
| A*68:03:03 | BY00699 | HM641867 | Carolyn K Hurley, Washington DC, USA |
| A*68:55 | HN-1109, HN-37844-7, HN-1934, HN-9001, HN-3185, HN-2753, HN-9562, HN-0252, HN-2713, HN-2861 | GQ240371, GQ240372, GQ240557, GQ449618, GQ199679, GQ199680, GQ199681, GQ199682, GQ199683, GQ199684 | Histogenetics, Ossining, USA |
| A*68:56 | HN-64847-4 | GQ240552 | Histogenetics, Ossining, USA |
| A*68:57 | HN-39605-6 | GQ345031 | Histogenetics, Ossining, USA |
| A*68:58 | HN-005118 | GQ449617 | Histogenetics, Ossining, USA |
| A*74:02:01:02 | 7550800550 | HM595420 | Yunping Xu, Shenzhen, China |
| B*07:117 | 93070338 | HM627245 | Daniel Fuerst, Ulm, Germany |
| B*07:96:02 | HN-69505-1 | GQ900553 | Histogenetics, Ossining, USA |
| B*08:01:13 | HN-23564-4, HN-14360-8 | GQ345052, GQ449649 | Histogenetics, Ossining, USA |
| B*08:63 | HN-26632-2 | GQ859546 | Histogenetics, Ossining, USA |
| B*08:64 | HN-81782-0 | GQ900550 | Histogenetics, Ossining, USA |
| B*14:01:02 | HN-37908-6 | GQ401203 | Histogenetics, Ossining, USA |
| B*14:19 | HN-03082-0, HN-54436-7 | GQ245740, GQ914794 | Histogenetics, Ossining, USA |
| B*15:02:05 | HN-70532-7 | GQ468253 | Histogenetics, Ossining, USA |
| B*15:203 | HN-83516-5 | GQ245734 | Histogenetics, Ossining, USA |
| B*15:204 | HN-004195 | GQ345041 | Histogenetics, Ossining, USA |
| B*15:205 | HN-14534-8 | GQ401195 | Histogenetics, Ossining, USA |
| B*15:206 | HN-28760-9 | GQ468248 | Histogenetics, Ossining, USA |
| B*15:207 | HN-00619-2 | GQ900546 | Histogenetics, Ossining, USA |
| B*15:208 | HN-68898-8 | GQ994055 | Histogenetics, Ossining, USA |
| B*15:39:02 | HN-83876-3 | GQ245735 | Histogenetics, Ossining, USA |
| B*18:01:09 | HN-12886-6 | GQ345053 | Histogenetics, Ossining, USA |
| B*18:51 | HN-57626-6, HN-57453-5, HN-57086-3, HN-57327-1 | GQ345057, GQ401197, GQ401198, GQ401201 | Histogenetics, Ossining, USA |
| B*18:52 | HN-41999-3 | GQ859552 | Histogenetics, Ossining, USA |
| B*27:05:15 | HN-74354-9, HN-61604-0 | GQ254340, GQ449630 | Histogenetics, Ossining, USA |
| B*27:70 | HN-85438-6, HN-18744-9 | GQ245738, GQ254342 | Histogenetics, Ossining, USA |
| B*27:71 | HN-N258280 | GQ449627 | Histogenetics, Ossining, USA |
| B*27:72 | HN-91490-2 | GQ859537 | Histogenetics, Ossining, USA |
| B*27:73 | HN-87758-4 | GQ994056 | Histogenetics, Ossining, USA |
| B*35:03:05 | HN-63512-0 | GQ401204 | Histogenetics, Ossining, USA |
| B*35:03:06 | BY00722 | HM641890 | Carolyn K Hurley, Washington DC, USA |
| B*37:24 | HN-28547-4 | GQ401190 | Histogenetics, Ossining, USA |
| B*38:02:03 | BE3846 | FN827054 | Xiang Liu, Beijing, China |
| B*38:24 | HN-97894-2 | GQ994064 | Histogenetics, Ossining, USA |
| B*39:01:12 | HN-23413-0 | GQ914795 | Histogenetics, Ossining, USA |
| B*39:61 | HN-10004-2 | GQ900551 | Histogenetics, Ossining, USA |
| B*40:01:13 | HN-37879-3 | GQ240388 | Histogenetics, Ossining, USA |
| B*40:01:14 | HN-12416-6, HN-12417-4 | GQ449631, GQ449632 | Histogenetics, Ossining, USA |
| B*40:01:15 | HN-53976-2 | GQ994067 | Histogenetics, Ossining, USA |
| B*40:148 | BY00720 | HM641888 | Carolyn K Hurley, Washington DC, USA |
| B*41:02:03 | HN-24884-1 | GQ914796 | Histogenetics, Ossining, USA |
| B*41:13 | HN-88047-3 | GQ859542 | Histogenetics, Ossining, USA |
| B*41:14 | BY00718 | HM641886 | Carolyn K Hurley, Washington DC, USA |
| B*41:15 | BY00725 | HM641893 | Carolyn K Hurley, Washington DC, USA |
| B*44:03:12 | HN-14550-7 | GQ345051 | Histogenetics, Ossining, USA |
| B*44:111 | BY00723 | HM641891 | Carolyn K Hurley, Washington DC, USA |
| B*46:21:02 | HN-14529-1 | GQ345050 | Histogenetics, Ossining, USA |
| B*48:24 | HN-32300-6 | GQ245742 | Histogenetics, Ossining, USA |
| B*49:11 | HN-57406-3 | GQ345056 | Histogenetics, Ossining, USA |
| B*49:12 | HN-58403-3 | GQ449641 | Histogenetics, Ossining, USA |
| B*49:13 | HN-63623-5 | GQ449647 | Histogenetics, Ossining, USA |
| B*50:10 | HN-85693-6 | GQ180222 | Histogenetics, Ossining, USA |
| B*50:11 | HN-N94477 | GQ245730 | Histogenetics, Ossining, USA |
| B*50:12 | HN-40368-9 | GQ449648 | Histogenetics, Ossining, USA |
| B*51:01:18 | HN-N93713, HN-N94361 | GQ245727, GQ245729 | Histogenetics, Ossining, USA |
| B*51:01:19 | HN-55571-9 | GQ449637 | Histogenetics, Ossining, USA |
| B*51:100 | HN-60975-2 | GQ449640 | Histogenetics, Ossining, USA |
| B*51:101 | BY00721 | HM641889 | Carolyn K Hurley, Washington DC, USA |
| B*51:97 | HN-02479-9 | GQ161025 | Histogenetics, Ossining, USA |
| B*51:98N | HN-87997-9 | GQ245716 | Histogenetics, Ossining, USA |
| B*51:99 | HN-41212-7 | GQ401192 | Histogenetics, Ossining, USA |
| B*52:01:06 | HN-61984-3, HN-96899-8 | GQ345058, FJ392172 | Histogenetics, Ossining, USA |
| B*52:22 | HN-59535-1 | GQ449642 | Histogenetics, Ossining, USA |
| B*55:44 | HN-31867-4 | GQ345040 | Histogenetics, Ossining, USA |
| B*55:45 | HN-58356-9 | GQ859548 | Histogenetics, Ossining, USA |
| B*56:30 | HN-30280-4 | GQ491087 | Histogenetics, Ossining, USA |
| B*57:01:09 | HN-14793-9 | GQ180220 | Histogenetics, Ossining, USA |
| B*57:33 | HN-98451-5 | GQ245746 | Histogenetics, Ossining, USA |
| B*57:34 | HN-49431-8 | GQ859536 | Histogenetics, Ossining, USA |
| B*57:35 | HN-N260466 | GQ914789 | Histogenetics, Ossining, USA |
| B*58:01:08 | HN-N035620 | GQ994059 | Histogenetics, Ossining, USA |
| C*04:01:22 | R43879 | FN995095 | Hien Tran, Heidelberg, Germany |
| C*04:71 | H558 | FN999910 | Carlos Vilches, Madrid, Spain |
| C*06:46N | D10000220 | FN908170 | Jinghui Qu, Shenzhen, China |
| C*06:47 | BY00695 | HM641863 | Carolyn K Hurley, Washington DC, USA |
| C*07:150Q | BY00716 | HM641884 | Carolyn K Hurley, Washington DC, USA |
| C*07:151 | BY00705 | HM641873 | Carolyn K Hurley, Washington DC, USA |
| C*15:36 | BY00697 | HM641865 | Carolyn K Hurley, Washington DC, USA |
| C*16:27 | HN-89947-5 | GU017941 | Histogenetics, Ossining, USA |
| C*16:27 | BY00704 | HM641872 | Carolyn K Hurley, Washington DC, USA |
| DRB1*12:25 | ANCBB101120C | FR668236 | Steven GE Marsh, London, United Kingdom |
| DQB1*05:01:03 | 10G09 | FR667215 | Arturas Jakubauskas, Vilnius, Lithuania |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*01:01:09 | HN-83855-2 | GQ914779 | Histogenetics, Ossining, USA |
| A*01:01:10 | HN-09078-2, HN-81036-3 | GQ345033, GQ401180 | Histogenetics, Ossining, USA |
| A*01:01:12 | HN-91466-0 | GQ345036 | Histogenetics, Ossining, USA |
| A*01:48 | HN-0340 | GQ199708 | Histogenetics, Ossining, USA |
| A*02:01:34 | HN-0340 | GQ345030 | Histogenetics, Ossining, USA |
| A*02:01:46 | BY00710 | HM641878 | Carolyn K Hurley, Washington DC, USA |
| A*02:05:01 | 7550900252 | HM595423 | Yunping Xu, Shenzhen, China |
| A*02:118 | BY00696 | HM641864 | Carolyn K Hurley, Washington DC, USA |
| A*02:221 | FGR26423 | FN985046 | Dominique Masson, La Tronche, France |
| A*02:251 | SSH-IGH10162 | HM773273 | Yunping Xu, Shenzhen, China |
| A*02:48 | YQ | HM595427 | Yunping Xu, Shenzhen, China |
| A*11:01:17 | HN-75506-2, HN-90240-7 | GQ254318, GQ180342 | Histogenetics, Ossining, USA |
| A*11:01:18 | 7550801591 | HM595419 | Yunping Xu, Shenzhen, China |
| A*24:02:29 | HN-25059-9, HN-93264-0 | GQ859521, GU354091 | Histogenetics, Ossining, USA |
| A*24:03:01 | HSX | HM595426 | Yunping Xu, Shenzhen, China |
| A*24:08 | 7550900468 | HM595425 | Yunping Xu, Shenzhen, China |
| A*24:10 | 7550900244 | HM773272 | Yunping Xu, Shenzhen, China |
| A*30:02:05 | HN-32248-7 | GQ279257 | Histogenetics, Ossining, USA |
| A*30:02:05 | BY00700 | HM641868 | Carolyn K Hurley, Washington DC, USA |
| A*32:19N | BY00703 | HM641871 | Carolyn K Hurley, Washington DC, USA |
| A*68:02:01:01 | 7550900065 | HM595422 | Yunping Xu, Shenzhen, China |
| A*68:24 | CS00032 | HM636498 | Kai Cao, Los Angeles, USA |
| B*07:02:01 | 7550801026 | HM596506 | Yunping Xu, Shenzhen, China |
| B*07:02:01 | HN-07021-1 | GQ401193 | Histogenetics, Ossining, USA |
| B*07:31 | BY00717 | HM641885 | Carolyn K Hurley, Washington DC, USA |
| B*08:62 | BY00719 | HM641887 | Carolyn K Hurley, Washington DC, USA |
| B*13:01:01 | 7550801026 | HM484300 | Yunping Xu, Shenzhen, China |
| B*15:01:01:01 | H10009 | HM543709 | Lixing Yan, Hangzhou, China |
| B*15:02:01 | 7550801157 | HM595430 | Yunping Xu, Shenzhen, China |
| B*15:07:01 | 7550800743 | HM484303 | Yunping Xu, Shenzhen, China |
| B*15:18:01 | 7550801124 | HM595432 | Yunping Xu, Shenzhen, China |
| B*15:25:01 | 7550800206 | HM595433 | Yunping Xu, Shenzhen, China |
| B*15:58 | 7550801093 | HM595431 | Yunping Xu, Shenzhen, China |
| B*27:04:01 | 7550801077 | HM596502 | Yunping Xu, Shenzhen, China |
| B*35:02:01 | 7550800768 | HM595434 | Yunping Xu, Shenzhen, China |
| B*37:01:01 | 7550801036 | HM596503 | Yunping Xu, Shenzhen, China |
| B*38:01:01 | 7550801157 | HM595436 | Yunping Xu, Shenzhen, China |
| B*38:02:01 | P3618 | HM543711 | Lixing Yan, Hangzhou, China |
| B*40:01:02 | P4416 | HM543713 | Lixing Yan, Hangzhou, China |
| B*40:06:01:01 | P4502 | HM543714 | Lixing Yan, Hangzhou, China |
| B*40:129 | 18406PHDP | HM640217 | Margareth Torres, Sao Paulo, Brazil |
| B*44:02:01:01 | 7550800776 | HM595428 | Yunping Xu, Shenzhen, China |
| B*44:27 | CS00033 | HM636499 | Kai Cao, Los Angeles, USA |
| B*51:01:01 | P4291 | HM543718 | Lixing Yan, Hangzhou, China |
| B*51:07:01 | 7550801734 | HM484302 | Yunping Xu, Shenzhen, China |
| B*51:64 | BY00724 | HM641892 | Carolyn K Hurley, Washington DC, USA |
| B*52:01:01 | H10059 | HM543720 | Lixing Yan, Hangzhou, China |
| B*54:01 | P3913 | HM543721 | Lixing Yan, Hangzhou, China |
| B*55:12 | 7550801093 | HM595435 | Yunping Xu, Shenzhen, China |
| B*57:29 | 7550801706 | HM596505 | Yunping Xu, Shenzhen, China |
| B*58:01:01 | P4500 | HM543722 | Lixing Yan, Hangzhou, China |
| B*58:01:01 | 7550801051 | HM595429 | Yunping Xu, Shenzhen, China |
| B*67:01:01 | 7550801051 | HM595437 | Yunping Xu, Shenzhen, China |
| C*01:02:01 | H10021 | HM543696 | Lixing Yan, Hangzhou, China |
| C*03:02:02:01 | P4500 | HM543697 | Lixing Yan, Hangzhou, China |
| C*03:03:01 | H09094 | HM543698 | Lixing Yan, Hangzhou, China |
| C*03:04:01:02 | P4135 | HM543699 | Lixing Yan, Hangzhou, China |
| C*04:01:01:01 | P4379 | HM543700 | Lixing Yan, Hangzhou, China |
| C*06:02:01:01 | H09056 | HM543701 | Lixing Yan, Hangzhou, China |
| C*07:02:01:01 | P4487 | HM543702 | Lixing Yan, Hangzhou, China |
| C*07:108 | 20101998 | FR668076 | Kremena Todorova, Berlin, Germany |
| C*08:01:01 | P4142 | HM543703 | Lixing Yan, Hangzhou, China |
| C*12:02:02 | H10059 | HM543704 | Lixing Yan, Hangzhou, China |
| C*14:02:01 | P4290 | HM543705 | Lixing Yan, Hangzhou, China |
| DQB1*03:01:04 | CS00034 | HM807525 | Kai Cao, Los Angeles, USA |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*11:49 | (3) |
| B*15:152 | (4) |
| B*15:187 | (5) |
| B*51:78 | (6) |
| DRB1*03:43 | (7) |
| DRB1*04:04:05 | (8) |
| DRB1*11:90 | (8) |
| DQB1*04:04 | (9) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
- Yan LX, Zhu FM, Wang W, Zhang W, Lv HJ. Identification of a novel allele HLA-A*1149 in a Chinese leukemia patient. Tissue Antigens. 2010; 76: 250-1.
- He WD, Zhu YB, Zhang CX, Pang LB, Zhu CF. Identification of a novel HLA-B*15 allele (B*9552) by sequence-based typing in a Chinese donor. Tissue Antigens. 2010; 76: 251-3.
- Han SH, Heo YA, Kwon OJ, Yoon HR, Lee KR. A new HLA-B*15 allele, HLA-B*9587, identified by sequence-based typing in a Korean individual. Tissue Antigens. 2010; 76: 253-5.
- Cosentini E, Longhi E, Frison S, et al. Sequence of a novel HLA-B*51 allele in a volunteer haematopoietic stem cell donor. Int J Immunogenet. 2010; 37: 399-400.
- Street J, Johnson J, Pepperall J, Cao K, Darke C. A new HLA-DRB1 allele: DRB1*0343. Tissue Antigens. 2010; 76: 255-6.
- Mantovani M, Longhi E, Frison S, de Arias AE, Mosca A, Poli F. Identification of two new HLA-DRB1 alleles, DRB1*040405 and DRB1*1190. Int J Immunogenet. 2010; 37: 397-8.
- Witter K, Zahn R, Volgger A, Reininger AJ. HLA-DQB1*0404, a novel DQB1-allele detected in a volunteer blood platelet donor typed for HLA. Tissue Antigens. 2010; 76: 256-8.
