Nomenclature for Factors of the HLA System

June 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the May 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:16HN-27200-9,
HN-26911-2,
HN-58497-3		GQ149258,
GQ161021,
GQ180349		Histogenetics, Ossining, USA
A*01:01:17HN-53891-7,
HN-05431-3		GQ160975,
GQ161015		Histogenetics, Ossining, USA
A*01:01:18HN-80777-6GQ160997Histogenetics, Ossining, USA
A*01:01:19HN-37561-6,
HN-33930-7		GQ199669,
GQ199667		Histogenetics, Ossining, USA
A*01:57NHN-29130-3GQ160961Histogenetics, Ossining, USA
A*01:58HN-88715-8GQ160967Histogenetics, Ossining, USA
A*01:59HN-01686-3GQ160972Histogenetics, Ossining, USA
A*01:60HN-30374-2GQ160978Histogenetics, Ossining, USA
A*01:61HN-68083-4GQ160984Histogenetics, Ossining, USA
A*01:62HN-90877-2GQ160991Histogenetics, Ossining, USA
A*01:63HN-45826-6GQ161003Histogenetics, Ossining, USA
A*01:64HN-31005-4GQ161014Histogenetics, Ossining, USA
A*01:65HN-14595-2GQ180327Histogenetics, Ossining, USA
A*01:66BY00690HM363058Carolyn K Hurley, Washington DC, USA
A*02:01:50129715FN796427Christian Seidl, Frankfurt am Main, Germany
A*02:03:03D10000957FN870143Jinghui Qu, Shenzhen, China
A*02:257HN-2484FJ765919Histogenetics, Ossining, USA
A*02:258SZ100188HM159119Jun He, Suzhou, China
A*02:259D09013780FN820508Jinghui Qu, Shenzhen, China
A*02:259LHLAD000466FN908397Jinghui Qu, Shenzhen, China
A*02:260SZ090069GU564531Jun He, Suzhou, China
A*02:261WP-WSJGU564532Jun He, Suzhou, China
A*02:262UA2009tp2574FN869565Mats Bengtsson, Uppsala, Sweden
A*02:263BY00682HM363050Carolyn K Hurley, Washington DC, USA
A*02:264LHLAS000423FN908396Jinghui Qu, Shenzhen, China
A*02:265D09018126FN985097Jinghui Qu, Shenzhen, China
A*02:266D10000070FN870141Jinghui Qu, Shenzhen, China
A*03:01:18HN-95685-7,
HN-42702-2		GQ161004,
GU354094		Histogenetics, Ossining, USA
A*03:01:19HN-18072-0GQ161012Histogenetics, Ossining, USA
A*03:79HN-65896-4FJ997935Histogenetics, Ossining, USA
A*03:80HN-77621-2GQ161000Histogenetics, Ossining, USA
A*03:81HN-37637-4,
HN-91265-1,
HN-2637000		GQ161009,
GQ161016,
GQ449610		Histogenetics, Ossining, USA
A*03:82UA2010tp239FN820206Mats Bengtsson, Uppsala, Sweden
A*11:01:20HN-28318-7GQ132028Histogenetics, Ossining, USA
A*11:01:21HN-9418461GQ180309Histogenetics, Ossining, USA
A*11:01:22D09006943FN820506Jinghui Qu, Shenzhen, China
A*11:63HN-77681-6FJ997930Histogenetics, Ossining, USA
A*11:64HN-6736GQ160965Histogenetics, Ossining, USA
A*24:02:35BY00657GU562431Carolyn K Hurley, Washington DC, USA
A*24:02:36D09001657FN820504Jinghui Qu, Shenzhen, China
A*24:21:02D09004537FN820505Jinghui Qu, Shenzhen, China
A*26:01:14BY00653GU562435Carolyn K Hurley, Washington DC, USA
A*26:01:15HN-12408-3,
HN-61463-1		FJ997959,
GQ859524		Histogenetics, Ossining, USA
A*26:01:16HN-42602-0GQ180286Histogenetics, Ossining, USA
A*26:43:0210200383GU474516Daniel Fuerst, Ulm, Germany
A*26:47HN-78596-3,
HN-N256270		FJ997928,
GQ859509		Histogenetics, Ossining, USA
A*26:48HN-83477-2FJ997961Histogenetics, Ossining, USA
A*26:49HN-55062-3GQ180291Histogenetics, Ossining, USA
A*26:50D10000055FN870140Jinghui Qu, Shenzhen, China
A*30:40HN-05610-8,
HN-64119-0,
HN-63347-3,
HN-89114-7		GQ160993,
GQ180287,
GQ180352,
GQ180353		Histogenetics, Ossining, USA
A*30:41HN-50514-8GQ180289Histogenetics, Ossining, USA
A*31:35HN-37300-0GQ160974Histogenetics, Ossining, USA
A*31:36HN-2330335GQ180334Histogenetics, Ossining, USA
A*31:37HN-0710041GQ180338Histogenetics, Ossining, USA
A*32:24HN-N92125,
HN-N263658,
HN-N032840		GQ199641,
GQ994042,
GQ994044		Histogenetics, Ossining, USA
A*32:25HN-71569-7GQ199678Histogenetics, Ossining, USA
A*33:31D09005586FN820507Jinghui Qu, Shenzhen, China
A*66:15HN-65087-3FJ997963Histogenetics, Ossining, USA
A*68:52HN-44628-5GQ160982Histogenetics, Ossining, USA
A*68:53HN-02273-0GQ180294Histogenetics, Ossining, USA
A*68:54HN-94603-8GQ240538Histogenetics, Ossining, USA
A*68:54BY00688HM363056Carolyn K Hurley, Washington DC, USA
B*07:05:0520090122028FN821961Vicky Van Sandt, Mechelen, Belgium
B*08:01:12FFM34028FN821678Christian Seidl, Frankfurt am Main, Germany
B*13:02:09LHLAD000791FN870148Jinghui Qu, Shenzhen, China
B*15:01:18HSR119364FN689350Hien Tran, Heidelberg, Germany
B*15:200D09020999FN820509Jinghui Qu, Shenzhen, China
B*15:2013350900443FN824368Zhongren Shi, Hebei, China
B*15:2023350900778FN824369Xiaohu Liang, Hebei, China
B*27:05:14BE3972FN827053Xiang Liu, Beijing, China
B*27:6790125599FN870366Christian Seidl, Frankfurt am Main, Germany
B*35:01:01:027550800701GU812299Yunping Xu, Shenzhen, China
B*37:23CS00031HM535632Kai Cao, Los Angeles, USA
B*40:06:03D09011135HM122211Jinghui Qu, Shenzhen, China
B*40:10:02BE4025FN827052Xiang Liu, Beijing, China
B*40:124:02BJ086850HM347430Keying Zhang, Beijing, China
B*40:145HN-2523FJ765873Histogenetics, Ossining, USA
B*40:146D09005480FN820503Jinghui Qu, Shenzhen, China
B*40:147D10000668FN870144Jinghui Qu, Shenzhen, China
B*42:14HN-5645FJ765928Histogenetics, Ossining, USA
B*44:110HSR149244FN689351Hien Tran, Heidelberg, Germany
B*46:24LHLAD000448FN870147Jinghui Qu, Shenzhen, China
B*48:01:03100308-4504HM157283Sang-Hyan Hwang, Busan, South Korea
B*54:23AX5025FN827056Xiang Liu, Beijing, China
B*57:01:08HN-88900-3GQ149279Histogenetics, Ossining, USA
B*57:3281100222HM368522Daniel Fuerst, Ulm, Germany
B*58:01:06RD1000001FN820510Jinghui Qu, Shenzhen, China
B*58:01:07LHLAD000162FN870146Jinghui Qu, Shenzhen, China
B*73:0210209546HM347714Daniel Fuerst, Ulm, Germany
B*81:05HN-3067FJ765874Histogenetics, Ossining, USA
C*01:02:11D10001094FN908174Jinghui Qu, Shenzhen, China
C*01:40LHLAD000447FN908175Jinghui Qu, Shenzhen, China
C*02:40HN-77324-7,
HN-84928-2		GQ914783,
GQ149319		Histogenetics, Ossining, USA
C*03:93AS38645220HM135953Oh-Joong Kwon, Seoul, South Korea
C*03:94BY00684HM363052Carolyn K Hurley, Washington DC, USA
C*04:01:21UA2010tp1413FN907956Mats Bengtsson, Uppsala, Sweden
C*04:70D10000511FN908171Jinghui Qu, Shenzhen, China
C*05:44HN-33092-0GQ900582Histogenetics, Ossining, USA
C*05:45DonMASSValFN821090Sylvie Tourne, Strasbourg, France
C*06:4396053100HM347713Daniel Fuerst, Ulm, Germany
C*06:44BY00683HM363051Carolyn K Hurley, Washington DC, USA
C*06:452843520FN985088Ling Xia, Chengdu, China
C*07:04:04BY00660GU562428Carolyn K Hurley, Washington DC, USA
C*07:149D10000495FN823237Jinghui Qu, Shenzhen, China
C*08:02:04HN-5978FJ765989Histogenetics, Ossining, USA
C*08:35BY00685HM363053Carolyn K Hurley, Washington DC, USA
C*08:36ND10000970FN908173Jinghui Qu, Shenzhen, China
C*12:44BY00686HM363054Carolyn K Hurley, Washington DC, USA
C*14:21ND10000838FN908172Jinghui Qu, Shenzhen, China
DRB1*03:55CTM-10900145HM177480Antonio Balas, Madrid, Spain
DRB1*07:19336-10FN824404Florian Emmerich, Freiburg, Germany
DRB1*11:96B09-2131HM217755Kyung Wha Lee, Anyang City, South Korea
DRB1*12:24N20090820039FN821957Vicky Van Sandt, Mechelen, Belgium
DRB1*13:10120090727106FN821958Vicky Van Sandt, Mechelen, Belgium
DRB1*15:47BE3856FN827049Xiang Liu, Beijing, China
DRB1*15:4820090807007FN821959Vicky Van Sandt, Mechelen, Belgium
DRB1*15:49BR6217FN827051Xiang Liu, Beijing, China
DQB1*03:27SZ090124GU564533Jun He, Suzhou, China
DQB1*05:06AS31774886HM135954Oh-Joong Kwon, Seoul, South Korea
DPB1*127:01UA2009TP1157FN820205Mats Bengtsson, Uppsala, Sweden
DPB1*128:01UA2009TP2841FN820204Mats Bengtsson, Uppsala, Sweden
MICA*062SY, QTHM019306Wei Tian, Changsha, China

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:11HN-51938-8,
HN-72954-0,
HN-L777255,
HN-5348548		GQ180320,
GU127989,
GU228797,
GU289878		Histogenetics, Ossining, USA
A*01:01:13HN-93075-2,
HN-58860-8		GQ161017,
GQ180329		Histogenetics, Ossining, USA
A*01:037550801001HM484299Yunping Xu, Shenzhen, China
A*01:51HN-09639-7GQ161010Histogenetics, Ossining, USA
A*02:03:017550801512HM357872Yunping Xu, Shenzhen, China
A*02:107550801147HM357870Yunping Xu, Shenzhen, China
A*02:200BY00689HM363057Carolyn K Hurley, Washington DC, USA
A*02:251SZGSQ-6HM245348Su-Qing Gao, Shenzhen, China
A*02:29CS00030HM461986Kai Cao, Los Angeles, USA
A*02:33NT01198HM141088Carolyn K Hurley, Washington DC, USA
A*03:01:17HN-50370-5,
HN-40630-7,
HN-79267-2,
HN-00301-7,
HN-98441-6,
HN-39216-9		GQ160986,
GQ161007,
GQ240363,
GQ240535,
GQ240546,
GQ859508		Histogenetics, Ossining, USA
A*03:027550800701HM357867Yunping Xu, Shenzhen, China
A*03:16NT01196HM141090Carolyn K Hurley, Washington DC, USA
A*03:63HN-39920-6GQ180306Histogenetics, Ossining, USA
A*11:24:01NT01197HM141089Carolyn K Hurley, Washington DC, USA
A*11:60D10000765FN870142Jinghui Qu, Shenzhen, China
A*23:01:017550801544HM357873Yunping Xu, Shenzhen, China
A*24:02:31SZ-41HM237362Hong-Yan Zou, Shenzhen, China
A*24:077550801512HM357871Yunping Xu, Shenzhen, China
A*24:208009379HM484297Yunping Xu, Shenzhen, China
A*24:22CS00026HM172612Kai Cao, Los Angeles, USA
A*26:07:02CS00028HM357238Kai Cao, Los Angeles, USA
A*29:01:01:017550800776HM357874Yunping Xu, Shenzhen, China
A*29:02:03BY00687HM363055Carolyn K Hurley, Washington DC, USA
A*30:01:017550800752HM357875Yunping Xu, Shenzhen, China
A*30:047550801590HM484298Yunping Xu, Shenzhen, China
A*30:2920080620044FN821962Vicky Van Sandt, Mechelen, Belgium
A*31:01:027550801131HM357877Yunping Xu, Shenzhen, China
A*32:01:017550801133HM357869Yunping Xu, Shenzhen, China
A*33:04BY00691HM363059Carolyn K Hurley, Washington DC, USA
A*34:01:017550801630HM484295Yunping Xu, Shenzhen, China
A*66:017550800309HM357868Yunping Xu, Shenzhen, China
A*68:01:027550801527HM357876Yunping Xu, Shenzhen, China
B*08:18NT01199HM141087Carolyn K Hurley, Washington DC, USA
B*08:209048430AF056483Carolyn K Hurley, Washington DC, USA
B*13:02:017550801096HM370044Yunping Xu, Shenzhen, China
B*15:01:01:017550801306HM370045Yunping Xu, Shenzhen, China
B*15:327550801498HM370046Yunping Xu, Shenzhen, China
B*15:38:0220090109023FN821960Vicky Van Sandt, Mechelen, Belgium
B*27:17NT01192HM141094Carolyn K Hurley, Washington DC, USA
B*35:23CS00027HM451494Kai Cao, Los Angeles, USA
B*35:47NT01195HM141091Carolyn K Hurley, Washington DC, USA
B*40:135NT01189HM141097Carolyn K Hurley, Washington DC, USA
B*51:02:017550801497HM370042Yunping Xu, Shenzhen, China
B*52:01:017550801562HM370043Yunping Xu, Shenzhen, China
C*01:21SZ-12HM536198Hong-Yan Zou, Shenzhen, China
C*03:04:04D10001351FN908176Jinghui Qu, Shenzhen, China
C*03:07CS00029HM461985Kai Cao, Los Angeles, USA
C*03:46LHLAD000974FN823236Jinghui Qu, Shenzhen, China
C*03:492020007HM179543Duck Cho, Jeolanam-do, South Korea
C*04:01:0820090116062FN821963Vicky Van Sandt, Mechelen, Belgium
C*06:1212260005HM179542Duck Cho, Jeolanam-do, South Korea
C*15:24HN-26317-4,
HN-69265-8,
HN-19931-9,
HN-20258-4,
HN-62237-3,
HN-72722-4		GQ345086,
GQ149324,
GQ161047,
GQ180272,
GQ180404,
GQ240514		Histogenetics, Ossining, USA
DRB1*01:01:1420070821149FN821964Vicky Van Sandt, Mechelen, Belgium
DRB1*04:01:05NT01190HM141096Carolyn K Hurley, Washington DC, USA
DRB1*04:50NT01193HM141093Carolyn K Hurley, Washington DC, USA
DRB1*08:03:02LHLAD000280FN823238Jinghui Qu, Shenzhen, China
DRB1*13:93NT01191HM141095Carolyn K Hurley, Washington DC, USA
DRB1*14:20NT01194HM141092Carolyn K Hurley, Washington DC, USA
DRB1*15:01:02NT01201HM141085Carolyn K Hurley, Washington DC, USA

Table 3: Recently Published Sequences


Sequence References
A*01:31N (3)
A*24:02:20 (4)
B*15:153 (5)
B*35:02:03 (6)
B*45:09 (7)
B*52:12 (7)
B*55:02:05 (8)
C*15:26 (9)
DRB1*11:89 (10)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Liu N, An SP, Li SY, Yan LN, Yuan YH. Identification of the novel allele HLA-A*0131N by sequence-based typing in a Chinese individual. Tissue Antigens. 2010; 76: 149-50.
  4. Zhu FM, Wang W, Zhang W, Lv HJ, Yan LX. Identification of a novel allele HLA-A*240220 by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2010; 76: 150-1.
  5. Wienzek-Lischka S, Ernst-Schlegel M, Lang C, Scharf M, Mueller K, Bein G. HLA-B*9553: a novel HLA allele shown in three generations of a family. Tissue Antigens. 2010; 76: 156-8.
  6. Martinez-Martinez L, Gonzalez-Santesteban C, Agusti-Marti M, Perez-Ranz E, de la Calle-Martin O. A novel HLA-B*35 variant, HLA-B* 35:02:03, identified by sequence-based typing in a bone marrow donor. Tissue Antigens. 2010; 76: 153-3.
  7. Veiga TR, Rampim GF, Gerbase de Lima M. Identification of two novel HLA-B alleles in the Brazilian population: B*4509 and B*5212. Tissue Antigens. 2010; 76: 153-4.
  8. Yan LX, Zhu FM, Zhang W, Lv HJ. A novel allele HLA-B*550205 was identified by polymerase chain reaction sequence-based typing in a Chinese individual. Tissue Antigens. 2010; 76: 155-6.
  9. Wang D, Deng Z. Identification of a novel HLA-Cw*15 variant allele, Cw*1526. Tissue Antigens. 2010; 76: 158-9.
  10. Curcio M, Fornaciari S, Pistello M, et al. Identification of a novel HLA-DRB1*11 variant allele, DRB1*1189. Tissue Antigens. 2010; 76: 156-60.