Nomenclature for Factors of the HLA System

May 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the April 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*01:01:1509-947GQ472096Kyung Won Kim, Seoul, South Korea
A*01:01:15HN-6410640GQ240558Histogenetics, Ossining, USA
A*01:56NSZGSQ-5HM131491Su-Qing Gao, Shenzhen, China
A*02:01:47D001438FN806797Jinghui Qu, Shenzhen, China
A*02:01:48D09017808FN806800Jinghui Qu, Shenzhen, China
A*02:01:49D09004527FN806795Jinghui Qu, Shenzhen, China
A*02:249D09015350FN806793Jinghui Qu, Shenzhen, China
A*02:250ND09005803FN806794Jinghui Qu, Shenzhen, China
A*02:251D09018350FN806796Jinghui Qu, Shenzhen, China
A*02:252D09017307FN806798Jinghui Qu, Shenzhen, China
A*02:253D09004544FN806801Jinghui Qu, Shenzhen, China
A*02:254D09016725FN806802Jinghui Qu, Shenzhen, China
A*02:255D09014233FN806819Jinghui Qu, Shenzhen, China
A*02:256D09019303FN806799Jinghui Qu, Shenzhen, China
A*03:77D09016503FN806803Jinghui Qu, Shenzhen, China
A*03:78D09012221FN806804Jinghui Qu, Shenzhen, China
A*11:01:19HLAD005376FN806807Jinghui Qu, Shenzhen, China
A*11:61D09011582FN806806Jinghui Qu, Shenzhen, China
A*11:62D09004891FN806808Jinghui Qu, Shenzhen, China
A*23:26D09002454FN806809Jinghui Qu, Shenzhen, China
A*24:02:32D09005740FN806812Jinghui Qu, Shenzhen, China
A*24:02:33D09012070FN806813Jinghui Qu, Shenzhen, China
A*24:02:34D09015023FN806820Jinghui Qu, Shenzhen, China
A*24:142D09005676FN806810Jinghui Qu, Shenzhen, China
A*24:143D09009882FN806815Jinghui Qu, Shenzhen, China
A*24:144D09021689FN806821Jinghui Qu, Shenzhen, China
A*30:38D09005773FN806824Jinghui Qu, Shenzhen, China
A*30:39D09010258FN806825Jinghui Qu, Shenzhen, China
A*31:32D09004472FN806817Jinghui Qu, Shenzhen, China
A*31:33D09018549FN806823Jinghui Qu, Shenzhen, China
A*31:34RC070720HM153754Oh-Joong Kwon, Seoul, South Korea
A*33:03:06D09007447FN806818Jinghui Qu, Shenzhen, China
A*68:51BY00675HM141079Carolyn K Hurley, Washington DC, USA
B*07:02:20D09019083HM122174Jinghui Qu, Shenzhen, China
B*07:68:025076FN820511Juergen Zingsem, Erlangen, Germany
B*08:6216789FN773171Sonia Nesci, Pesaro, Italy
B*13:01:04D09004358HM122175Jinghui Qu, Shenzhen, China
B*13:01:05D09015643HM122176Jinghui Qu, Shenzhen, China
B*13:02:08D09004597HM122177Jinghui Qu, Shenzhen, China
B*15:01:17D09009563HM122178Jinghui Qu, Shenzhen, China
B*15:07:02D09008808HM122182Jinghui Qu, Shenzhen, China
B*15:11:05D09016634HM122183Jinghui Qu, Shenzhen, China
B*15:193D09019079HM122179Jinghui Qu, Shenzhen, China
B*15:194D09004735HM122180Jinghui Qu, Shenzhen, China
B*15:195D09004267HM122181Jinghui Qu, Shenzhen, China
B*15:196D09020012HM122184Jinghui Qu, Shenzhen, China
B*15:197D09020710HM122185Jinghui Qu, Shenzhen, China
B*15:198D09019651HM122186Jinghui Qu, Shenzhen, China
B*15:199D09008493HM122187Jinghui Qu, Shenzhen, China
B*27:66ND09003359HM122188Jinghui Qu, Shenzhen, China
B*27:68D09011217HM122189Jinghui Qu, Shenzhen, China
B*27:69D09002973HM122190Jinghui Qu, Shenzhen, China
B*35:01:20D09009228HM122193Jinghui Qu, Shenzhen, China
B*35:01:21D09012129HM122194Jinghui Qu, Shenzhen, China
B*35:11:02D09011505HM122196Jinghui Qu, Shenzhen, China
B*35:145ND09018664HM122195Jinghui Qu, Shenzhen, China
B*35:43:02D09020777HM122197Jinghui Qu, Shenzhen, China
B*38:23Xian41785HM152529Mengli Liu, Xi�an, China
B*39:58D09010138HM122198Jinghui Qu, Shenzhen, China
B*39:59D09015825HM122199Jinghui Qu, Shenzhen, China
B*39:60RC070883HM140625Oh-Joong Kwon, Seoul, South Korea
B*40:01:11D09002611HM122201Jinghui Qu, Shenzhen, China
B*40:01:12D09007239HM122203Jinghui Qu, Shenzhen, China
B*40:02:11D09017057HM122206Jinghui Qu, Shenzhen, China
B*40:138D09012377HM122200Jinghui Qu, Shenzhen, China
B*40:139D09017043HM122202Jinghui Qu, Shenzhen, China
B*40:140D09020365HM122204Jinghui Qu, Shenzhen, China
B*40:141D09006789HM122205Jinghui Qu, Shenzhen, China
B*40:142ND1544HM122207Jinghui Qu, Shenzhen, China
B*40:143D09000777HM122208Jinghui Qu, Shenzhen, China
B*40:144ND09020395HM122210Jinghui Qu, Shenzhen, China
B*45:12BY00677HM141081Carolyn K Hurley, Washington DC, USA
B*46:23D09005772HM122212Jinghui Qu, Shenzhen, China
B*48:23D09016593HM122213Jinghui Qu, Shenzhen, China
B*51:96D09010052HM122214Jinghui Qu, Shenzhen, China
B*52:21ID1611572HM132054Gisele Rampim, Sao Paulo, Brazil
B*52:21BY00678HM141082Carolyn K Hurley, Washington DC, USA
B*55:41D09018167HM122215Jinghui Qu, Shenzhen, China
B*55:42D09017651HM122216Jinghui Qu, Shenzhen, China
B*55:43D09006806HM122217Jinghui Qu, Shenzhen, China
B*58:01:05D09003525HM122219Jinghui Qu, Shenzhen, China
B*58:29D09011107HM122218Jinghui Qu, Shenzhen, China
B*58:30D09002707HM122220Jinghui Qu, Shenzhen, China
C*01:02:10HN-71168-9GQ859555Histogenetics, Ossining, USA
C*02:02:12HN-73729-1GQ859558Histogenetics, Ossining, USA
C*02:02:13HN-30996-2GQ149299Histogenetics, Ossining, USA
C*02:37HN-91681-4,
HN-58739-6		GQ345082,
GU017948		Histogenetics, Ossining, USA
C*02:38NHN-05026-5,
HN-45316-2,
HN-20139-4,
HN-66252-7		GQ345098,
GQ491088,
FJ997939,
FJ997964		Histogenetics, Ossining, USA
C*02:39HN-24080-9GQ468259Histogenetics, Ossining, USA
C*03:03:12HN-60700-4GQ859573Histogenetics, Ossining, USA
C*03:88HN-P001-09,
HN-002530,
HN-000600,
HN-45917-7		GQ161052,
GQ180387,
GQ240562,
GQ401222		Histogenetics, Ossining, USA
C*03:89HN-6989GQ245753Histogenetics, Ossining, USA
C*03:90HN-07983-5GQ254366Histogenetics, Ossining, USA
C*03:91HN-07983-5GQ401225Histogenetics, Ossining, USA
C*03:92HN-03436-5GQ468262Histogenetics, Ossining, USA
C*04:01:17HN-37726-6GQ240470Histogenetics, Ossining, USA
C*04:01:18HN-03204-1GQ254369Histogenetics, Ossining, USA
C*04:01:19HN-31676-5GQ345070Histogenetics, Ossining, USA
C*04:01:20HN-04715-7GQ900566Histogenetics, Ossining, USA
C*04:63HN-61101-1,
HN-20323-2		GQ240471,
GQ180413		Histogenetics, Ossining, USA
C*04:64HN-61877-6GQ240472Histogenetics, Ossining, USA
C*04:65HN-31406-8,
HN-13690-3,
HN-13095-5		GQ254364,
GQ161074,
GQ180451		Histogenetics, Ossining, USA
C*04:66HN-56618-8GQ254378Histogenetics, Ossining, USA
C*04:67HN-80046-4GQ401208Histogenetics, Ossining, USA
C*04:68HN-18544-2,
HN-18541-8		GQ491105,
GQ859575		Histogenetics, Ossining, USA
C*04:69HN-56535-0GQ859579Histogenetics, Ossining, USA
C*05:43HN-12351-9GQ859567Histogenetics, Ossining, USA
C*06:02:06HN-83532-9,
HN-05643-4,
HN-19926-3		GQ254373,
GQ180266,
GQ180401		Histogenetics, Ossining, USA
C*06:02:07HN-N100288,
HN-47960-9,
HN-N255401,
HN-N264266		GQ279281,
GQ401212,
GQ491091,
GQ900564		Histogenetics, Ossining, USA
C*06:02:08HN-41015-4GQ401219Histogenetics, Ossining, USA
C*06:38HN-48531-7GQ240467Histogenetics, Ossining, USA
C*06:39HN-54695-1GQ240563Histogenetics, Ossining, USA
C*06:40HN-61744-1GQ345078Histogenetics, Ossining, USA
C*06:41HN-60482-8GQ401213Histogenetics, Ossining, USA
C*06:42HN-60967-9GQ491106Histogenetics, Ossining, USA
C*07:02:15HN-85931-3FJ976789Histogenetics, Ossining, USA
C*07:02:16HN-63618-2,
HN-32566-2		GQ401205,
GQ180429		Histogenetics, Ossining, USA
C*07:148HN-19541-4GQ900573Histogenetics, Ossining, USA
C*08:32HN-35546-0,
HN-32626-3		GQ345065,
GQ345072		Histogenetics, Ossining, USA
C*08:33HN-35513-8GQ345087Histogenetics, Ossining, USA
C*08:34HN-03543-8GQ401224Histogenetics, Ossining, USA
C*12:02:06HN-57987-9GQ279285Histogenetics, Ossining, USA
C*12:03:12HN-51500-3,
HN-47410-6		GQ254367,
GQ180398		Histogenetics, Ossining, USA
C*12:36HN-61985-0GQ345079Histogenetics, Ossining, USA
C*12:37HN-28143-2GQ345084Histogenetics, Ossining, USA
C*12:38HN-20943-3GQ449661Histogenetics, Ossining, USA
C*12:39NHN-50636-5,
HN-10140-6		GQ491089,
GQ161030		Histogenetics, Ossining, USA
C*12:40HN-006194GQ491092Histogenetics, Ossining, USA
C*12:41HN-006280GQ491093Histogenetics, Ossining, USA
C*12:42QHN-09163-9GQ859565Histogenetics, Ossining, USA
C*12:43HN-40533-4GQ859569Histogenetics, Ossining, USA
C*14:02:05HN-32215-2,
HN-19090-5,
HN-13968-4		GQ401216,
GQ900583,
GU128035		Histogenetics, Ossining, USA
C*15:02:06HN-27942-1GQ468256Histogenetics, Ossining, USA
C*15:05:05HN-74801-8GQ900571Histogenetics, Ossining, USA
C*15:31HN-66069-6,
HN-74303-9		FJ976881,
GQ254394		Histogenetics, Ossining, USA
C*15:32QHN-000408,
HN-90502-6,
HN-005239		FJ997966,
GQ345085,
GQ859572		Histogenetics, Ossining, USA
C*15:33HN-003284,
HN-003228		GQ345066,
GQ468260		Histogenetics, Ossining, USA
C*15:34HN-40783-2GQ449657Histogenetics, Ossining, USA
C*15:35HN-05803-7GQ859577Histogenetics, Ossining, USA
C*16:22HN-14471-6GQ161054Histogenetics, Ossining, USA
C*16:23HN-18740-7GQ279287Histogenetics, Ossining, USA
C*16:24HN-N252553GQ345067Histogenetics, Ossining, USA
C*16:25HN-8473088GQ859553Histogenetics, Ossining, USA
C*16:26HN-07672-1GQ859578Histogenetics, Ossining, USA
C*17:01:04HN-45414-9,
HN-17304-9,
HN-06174-5		GQ279282,
GQ180253,
GQ180402		Histogenetics, Ossining, USA
C*17:07HN-41977-2,
HN-89865-4		GQ859562,
FJ997953		Histogenetics, Ossining, USA
DRB1*11:95RC070842HM140624Oh-Joong Kwon, Seoul, South Korea
DRB1*13:100D09017930FN794393Jinghui Qu, Shenzhen, China
DRB1*13:99RC075618HM140626Oh-Joong Kwon, Seoul, South Korea

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*11:56D09010262FN806805Jinghui Qu, Shenzhen, China
A*24:02:31HLAD004355FN806816Jinghui Qu, Shenzhen, China
A*24:128D09017053FN806811Jinghui Qu, Shenzhen, China
A*24:132ND09007125FN806814Jinghui Qu, Shenzhen, China
A*31:31D09003232FN806822Jinghui Qu, Shenzhen, China
B*14:12100929HM125710Mary Sue Leffell, Baltimore, USA
B*18:50BY00676HM141080Carolyn K Hurley, Washington DC, USA
B*35:137D09007979HM122192Jinghui Qu, Shenzhen, China
B*40:122D09001191HM122209Jinghui Qu, Shenzhen, China
C*02:02:09HN-12569-2,
HN-75584-5,
HN-58634-7		GQ468258,
GU128034,
GQ180412		Histogenetics, Ossining, USA
C*03:04:18HN-99124-0GQ240560Histogenetics, Ossining, USA
C*04:54HN-60366-7,
HN-69788-0		GQ491095,
GU128044		Histogenetics, Ossining, USA
C*05:01:11HN-10512-1,
HN-48688-5,
HN-22060-8,
HN-42502-5		GQ240469,
GQ491094,
GQ180437,
GQ240497		Histogenetics, Ossining, USA
C*05:34HN-78978-1,
HN-26893-0,
HN-47758-3		GQ279286,
GQ900568,
GU128051		Histogenetics, Ossining, USA
C*06:30HN-74296-2,
HN-08966-7,
HN-22722-3		GQ345092,
GQ180427,
GQ180441		Histogenetics, Ossining, USA
C*08:30HN-86103-9,
HN-82876-4,
HN-69622-8		GQ254368,
GQ345081,
GQ859561		Histogenetics, Ossining, USA
C*12:30HN-69835-4,
HN-81675-2,
HN-41317-1,
HN-71816-8,
HN-34323-7,
HN-65522-5		GQ401214,
GQ149317,
GQ149335,
GQ994085,
FJ997995,
GQ121342		Histogenetics, Ossining, USA
C*14:16HN-09343-4GQ279283Histogenetics, Ossining, USA
C*15:30HN-97585-0GQ240476Histogenetics, Ossining, USA
DRB1*08:35BY00681HM141084Carolyn K Hurley, Washington DC, USA
DRB1*11:43NT01200HM141086Carolyn K Hurley, Washington DC, USA
DRB1*13:01:019000610018570AHM067855Lixing Yan, Hangzhou, China
DRB1*13:02:019000610018569X,
9000610011023S,
90006100185830		HM067856Lixing Yan, Hangzhou, China
DRB1*13:129000610018585XHM067857Lixing Yan, Hangzhou, China
DRB1*14:0490006100182670HM067858Lixing Yan, Hangzhou, China
DRB1*14:07:019000610018255wHM067859Lixing Yan, Hangzhou, China
DRB1*14:549000610010815H,
90006100003613		HM067860Lixing Yan, Hangzhou, China
DRB1*15:01:01:0190006100053900,
9000610010721T,
9000610010815H		HM067861Lixing Yan, Hangzhou, China
DRB1*15:02:0190006100003613HM067862Lixing Yan, Hangzhou, China
DRB1*16:02:019000610018470IHM067863Lixing Yan, Hangzhou, China

Table 3: Recently Published Sequences


Sequence References
A*03:01:14 (3)
B*57:28N (4)
DQB1*06:36 (5)
DPA1*02:01:07 (6)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database--a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000; 55: 280-7.
  3. Jakubauskas A, Griskevicius L. Haplotype-specific sequencing reveals a novel HLA-A*03 allele, A*030114. Tissue Antigens. 2010; 76: 71-2.
  4. Cosentini E, Frison S, Longhi E, et al. A discrepancy between serological and molecular typing results led to identification of a novel HLA-B*57 allele: HLA-B*5728N. Int J Immunogenet. 2010; 37: 299-300.
  5. Skrablin PS, Richter R, Brixner V, Seifried E, Seidl C. The novel allele HLA-DQB1*0636 of Caucasian origin has a unique amino acid exchange at position 186 of the beta 2 region. Tissue Antigens. 2010; 76: 72-4.
  6. Czarnecki C, Luo M, Brunham R, Broliden K, Karlsson AC, Plummer FA. Identification of HLA-DPA1*020107 in an individual of Ugandan descent. Hum Immunol. 2010; 71: 733-5.