Nomenclature for Factors of the HLA System

February 2010

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the January 2010 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). Together with the new format HLA allele sequence name, the designation prior to April 2010 is also listed. Full details of the change to the HLA nomenclature format is given in the recent nomenclature report (1). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Pre April 2010 Designation Cell identification Accession number Submitting author
A*01:01:14A*010114HN-97802-3FJ969939Histogenetics, Ossining, USA
A*01:52NA*0152NHN-02568-3FJ875609Histogenetics, Ossining, USA
A*01:53NA*0153NHN-5622407FJ887800Histogenetics, Ossining, USA
A*01:54A*0154HN-20191-1FJ976736Histogenetics, Ossining, USA
A*01:55A*0155HN-9558FJ976740Histogenetics, Ossining, USA
A*02:01:44A*020144HN-72417-9FJ976732Histogenetics, Ossining, USA
A*02:01:45A*020145HN-5363285FJ976759Histogenetics, Ossining, USA
A*03:75A*0375HN-12730-7FJ940762Histogenetics, Ossining, USA
A*03:76A*0376BY00656,
BY00655		GU562432Carolyn K Hurley, Washington DC, USA
A*11:01:17A*11011710201213GU647073Daniel Fuerst, Ulm, Germany
A*11:58A*1158HN-3358731,
HN-1253498		FJ875688,
FJ976761		Histogenetics, Ossining, USA
A*11:59A*115993008023GU647074Daniel Fuerst, Ulm, Germany
A*25:12NA*2512NHN-39033-2,
HN-53651-3		FJ875610,
FJ875611		Histogenetics, Ossining, USA
A*25:13A*2513HN-03687-7FJ917722Histogenetics, Ossining, USA
A*26:45A*2645HN-02511-0,
HN-04517-5,
HN-93354-8,
HN-49539-5		FJ907385,
FJ969940,
FJ976735,
GQ401174		Histogenetics, Ossining, USA
A*30:01:03A*300103HN-40639-6FJ976738Histogenetics, Ossining, USA
A*30:36A*3036HN-78606-9FJ976869Histogenetics, Ossining, USA
A*30:36A*3036DA2202.4GU357633Min Yu, Chicago, USA
A*30:37A*3037HN-09953-0FJ976742Histogenetics, Ossining, USA
A*31:31A*3131HN-3982FJ907387Histogenetics, Ossining, USA
A*32:01:05A*320105HN-78085-0FJ976752Histogenetics, Ossining, USA
A*66:13A*6613HN-2124845,
HN-07132-6		FJ976739,
GQ240384		Histogenetics, Ossining, USA
A*68:49NA*6849NHN-12691-1FJ887802Histogenetics, Ossining, USA
B*07:05:04B*070504HN-98776-5FJ898489Histogenetics, Ossining, USA
B*08:58B*0858HN-73126-1FJ875575Histogenetics, Ossining, USA
B*08:59B*0859HN-000085FJ917714Histogenetics, Ossining, USA
B*08:60B*0860HN-44257-1FJ976764Histogenetics, Ossining, USA
B*08:61B*0861BY00663GU562436Carolyn K Hurley, Washington DC, USA
B*13:02:07B*130207HN-00888-4FJ976864Histogenetics, Ossining, USA
B*13:37B*1337HN-66484-6FJ917713Histogenetics, Ossining, USA
B*15:190NB*9590NHN-83032-3,
HN-21110-4		FJ875649,
FJ875652		Histogenetics, Ossining, USA
B*15:191B*9591HN-1688FJ917719Histogenetics, Ossining, USA
B*18:48B*1848HN-75812-6FJ875574Histogenetics, Ossining, USA
B*18:49B*1849HN-95351-3,
HN-21921-1		FJ969941,
GQ345039		Histogenetics, Ossining, USA
B*27:64NB*2764NHN-17382-2FJ875648Histogenetics, Ossining, USA
B*27:65NB*2765NHN-73824-6FJ875650Histogenetics, Ossining, USA
B*35:03:04B*350304HN-001534FJ917715Histogenetics, Ossining, USA
B*35:05:02B*350502HN-4979248FJ976775Histogenetics, Ossining, USA
B*39:57B*3957HN-83335-7FJ952585Histogenetics, Ossining, USA
B*40:01:10B*400110HN-7197432FJ976857Histogenetics, Ossining, USA
B*40:02:10B*400210HN-76066-9FJ976768Histogenetics, Ossining, USA
B*44:03:09B*440309HN-50508-9FJ875577Histogenetics, Ossining, USA
B*44:03:10B*440310HN-96323-1FJ976763Histogenetics, Ossining, USA
B*44:03:11B*440311HN-65746-0FJ976858Histogenetics, Ossining, USA
B*47:07B*4707HN-59835-6FJ917716Histogenetics, Ossining, USA
B*51:95B*5195HN-89539-7FJ917717Histogenetics, Ossining, USA
B*53:23B*5323HN-30307-0FJ976765Histogenetics, Ossining, USA
B*55:40B*5540HN-21295-5FJ976776Histogenetics, Ossining, USA
B*56:01:04B*560104HN-0054440,
HN-56875-7		FJ976773,
GQ149276		Histogenetics, Ossining, USA
B*56:28NB*5628NHN-5435,
HN-8211,
HN-7626,
HN-3007		FJ875641,
FJ875642,
FJ875643,
FJ875644		Histogenetics, Ossining, USA
B*56:29B*5629HN-30661-4FJ969944Histogenetics, Ossining, USA
B*57:01:07B*570107HN-44736501,
HN-61277-7		FJ875579,
GQ254345		Histogenetics, Ossining, USA
B*57:31B*5731HN-14316-0FJ976861Histogenetics, Ossining, USA
C*01:36Cw*0136HN-79074-7FJ875582Histogenetics, Ossining, USA
C*01:37NCw*0137NBM1950GU592508Zhihui Deng, ShenZhen, China
C*02:32Cw*0232HN-14669-2,
HN-48335-3,
HN-47316-4		FJ875614,
FJ976844,
GQ900569		Histogenetics, Ossining, USA
C*02:33Cw*0233HN-8869440FJ875615Histogenetics, Ossining, USA
C*02:34Cw*0234HN-86205-2FJ976784Histogenetics, Ossining, USA
C*02:35Cw*0235HN-76723-8FJ976804Histogenetics, Ossining, USA
C*02:36Cw*0236HN-56309-7FJ976845Histogenetics, Ossining, USA
C*03:81Cw*0381HN-01120-4FJ875590Histogenetics, Ossining, USA
C*03:82Cw*0382HN-32259-4FJ898484Histogenetics, Ossining, USA
C*03:83Cw*0383HN-84736-5FJ917724Histogenetics, Ossining, USA
C*03:84Cw*0384HN-000466FJ976783Histogenetics, Ossining, USA
C*04:01:16Cw*040116HN-38522-5FJ875595Histogenetics, Ossining, USA
C*04:56Cw*0456HN-84142-6,
HN-83881-0,
HN-85088-0,
HN-85259-7,
HN-86539-1,
HN-70365-0,
HN-33575-4,
HN-29003-3		FJ875612,
FJ875616,
FJ898486,
GQ254374,
GQ254375,
GQ449660,
GQ900581,
GU128055,
GQ254386,
GQ254396		Histogenetics, Ossining, USA
C*04:57Cw*0457HN-13051-9FJ976794Histogenetics, Ossining, USA
C*04:58Cw*0458HN-53937-8FJ976829Histogenetics, Ossining, USA
C*04:59QCw*0459QHN-25503-3,
HN-17296-0,
HN-40381-9		FJ976834,
GQ491104,
GQ180246		Histogenetics, Ossining, USA
C*04:60Cw*0460HN-77452-0FJ976836Histogenetics, Ossining, USA
C*04:61Cw*0461HN-25738-5FJ976840Histogenetics, Ossining, USA
C*04:62Cw*0462HN-99617-0,
HN-26419-4		FJ976873,
GQ491097		Histogenetics, Ossining, USA
C*05:01:12Cw*050112HN-23768-4,
HN-23769-2,
HN-20225-1		FJ969922,
FJ969923,
GQ859566		Histogenetics, Ossining, USA
C*05:01:13Cw*050113HN-65794-9FJ969928Histogenetics, Ossining, USA
C*05:37Cw*0537196329FN667018Elizabeth Keller, Munich, Germany
C*05:38Cw*0538HN-45439-6FJ969927Histogenetics, Ossining, USA
C*05:39Cw*0539HN-76525-6,
HN-80618-6		FJ969933,
FJ969937		Histogenetics, Ossining, USA
C*05:40Cw*0540HN-43400-5FJ969935Histogenetics, Ossining, USA
C*05:41Cw*0541HN-73181-4FJ969938Histogenetics, Ossining, USA
C*05:42Cw*0542HN-03728-4FJ976813Histogenetics, Ossining, USA
C*06:33Cw*0633HN-64221-2,
HN-N260534		FJ898488,
GQ994079		Histogenetics, Ossining, USA
C*06:34Cw*0634HN-94615-3,
HN-10379-5		FJ976795,
FJ976797		Histogenetics, Ossining, USA
C*06:35Cw*0635HN-91937-5FJ976817Histogenetics, Ossining, USA
C*06:36Cw*0636HN-37362-4FJ976824Histogenetics, Ossining, USA
C*06:37Cw*0637HN-84755-7FJ976842Histogenetics, Ossining, USA
C*07:01:12Cw*070112HN-05902-3FJ976814Histogenetics, Ossining, USA
C*07:02:14Cw*070214HN-94098-8FJ976787Histogenetics, Ossining, USA
C*12:02:05Cw*120205BY00659GU562429Carolyn K Hurley, Washington DC, USA
C*12:03:10Cw*120310HN-90188-6,
HN-55079-3,
HN-67670-2,
HN-14256-2,
HN-21862-1		FJ976818,
GQ900579,
GU128043,
GQ180433,
FJ997984		Histogenetics, Ossining, USA
C*12:03:11Cw*120311HN-25484-6,
HN-88867-4,
HN-53707-6		FJ976833,
GQ345094,
GQ240492		Histogenetics, Ossining, USA
C*12:32Cw*1232HN-75544-3FJ875584Histogenetics, Ossining, USA
C*12:33Cw*1233HN-73542-9FJ875617Histogenetics, Ossining, USA
C*12:34Cw*1234HN-98341-8,
HN-09558-4,
HN-26973-9		FJ976788,
GQ994081,
FJ997998		Histogenetics, Ossining, USA
C*12:35Cw*1235HN-91242-1,
HN-35211-7		FJ976816,
GQ468263		Histogenetics, Ossining, USA
C*14:17Cw*1417HN-80178-3FJ898485Histogenetics, Ossining, USA
C*14:18Cw*1418HN-98486-1,
HN-42571-2		FJ898497,
GQ900577		Histogenetics, Ossining, USA
C*14:19Cw*1419HN-47210-9FJ976791Histogenetics, Ossining, USA
C*15:06:02Cw*150602HN-85277-9,
HN-25325-8		FJ898487,
GQ449659		Histogenetics, Ossining, USA
C*15:28Cw*1528HN-94408-4FJ976812Histogenetics, Ossining, USA
C*16:02:03Cw*160203HN-63503-8,
HN-36385-2		FJ976800,
FJ997975		Histogenetics, Ossining, USA
C*16:02:04Cw*160204HN-07796-4FJ976831Histogenetics, Ossining, USA
C*16:21Cw*1621HN-44529-3FJ875619Histogenetics, Ossining, USA
DRB1*01:32DRB1*0132HN-76179-8FJ898496Histogenetics, Ossining, USA
DRB1*04:05:10DRB1*040510BY00661GU562427Carolyn K Hurley, Washington DC, USA
DRB1*08:40DRB1*0840HN-75684-9FJ952590Histogenetics, Ossining, USA
DRB1*11:94DRB1*1194HN-72673-6FJ888509Histogenetics, Ossining, USA
DRB1*13:03:05DRB1*130305HN-52661-2FJ888508Histogenetics, Ossining, USA
DRB1*14:99DRB1*1499HN-76266-3FJ898495Histogenetics, Ossining, USA
DRB1*14:99DRB1*149920091898FN421416Kremena Todorova, Berlin, Germany
DRB1*15:44DRB1*1544HN-03018-8FJ875600Histogenetics, Ossining, USA
MICA*060MICA*060TW-HFFJ556895Wei Tian, Changsha, China

Table 2: Confirmatory Sequences


Sequence Pre April 2010 Designation Cell identification Accession number Submitting author
A*01:01:03A*010103HN-33780-2GQ240343Histogenetics, Ossining, USA
A*01:21A*0121HN-B-186125GQ240331Histogenetics, Ossining, USA
A*01:23A*0123HN-60675-8GQ240324Histogenetics, Ossining, USA
A*01:24A*0124HN-4805229GQ180317Histogenetics, Ossining, USA
A*01:25A*0125HN-20143-7,
HN-15642-2		FJ594679,
GQ240314		Histogenetics, Ossining, USA
A*01:26A*0126HN-6847062FJ594680Histogenetics, Ossining, USA
A*01:40A*0140HN-69181-8GQ180340Histogenetics, Ossining, USA
A*02:01:18A*020118HN-70011-6GQ240532Histogenetics, Ossining, USA
A*02:01:31A*020131HN-57893-2GQ132047Histogenetics, Ossining, USA
A*02:01:37A*020137HN-35479-3GQ132049Histogenetics, Ossining, USA
A*02:60A*0260CS00025GU808340Kai Cao, Los Angeles, USA
A*02:77A*0277HN-9373357GQ254328Histogenetics, Ossining, USA
A*02:96A*0296HN-1789210GQ279259Histogenetics, Ossining, USA
A*02:119A*9219HN-6150186FJ594682Histogenetics, Ossining, USA
A*02:121A*9221HN-63710-2FJ594684Histogenetics, Ossining, USA
A*02:128A*9228HN-2058441GQ240339Histogenetics, Ossining, USA
A*02:158A*9258HN-32925-4GQ132050Histogenetics, Ossining, USA
A*02:172A*9272HN-11795-8GQ345029Histogenetics, Ossining, USA
A*03:01:01:01A*03010101NT01119,
NT01120		GQ924085,
GQ924084		Carolyn K Hurley, Washington DC, USA
A*03:01:05A*030105HN-83474-8GQ240317Histogenetics, Ossining, USA
A*03:01:11A*030111HN-91618-3GQ180347Histogenetics, Ossining, USA
A*03:01:14A*030114HN-79708-8,
HN-B-186904,
HN-B-175317,
HN-B-176247,
HN-38246-8,
HN-B-181742,
HN-B-174670		FJ765901,
GQ180307,
GQ180345,
GQ180346,
GQ240377,
GQ240380,
GQ240382		Histogenetics, Ossining, USA
A*03:28A*0328HN-36659-4,
HN-151995		GQ240328,
GQ240335		Histogenetics, Ossining, USA
A*03:33A*0333HN-44321-1GQ240326Histogenetics, Ossining, USA
A*03:49A*0349HN-22515-5GQ240347Histogenetics, Ossining, USA
A*03:65A*0365HN-53213-7GQ180343Histogenetics, Ossining, USA
A*03:74A*0374HN-05504-7,
HN-84680-4		FJ888506,
GQ180283		Histogenetics, Ossining, USA
A*11:01:15A*110115HN-0380441GQ180355Histogenetics, Ossining, USA
A*11:29A*1129HN-19685-9,
HN-30165-7		GQ240325,
GQ240336		Histogenetics, Ossining, USA
A*11:30A*1130HN-B-181439,
HN-B-173228,
HN-B-173745		GQ240330,
GQ240332,
GQ240333		Histogenetics, Ossining, USA
A*11:44A*1144HN-1477162GQ279261Histogenetics, Ossining, USA
A*23:01:02A*230102HN-61311-1GQ149297Histogenetics, Ossining, USA
A*24:43A*2443HN-89962-7,
HN-17022-9,
HN-27195-1,
HN-1547923		GQ149292,
GQ149294,
GQ149296,
GQ149298		Histogenetics, Ossining, USA
A*24:53A*2453HN-3832109,
HN-1226007		GQ149293,
GQ149295		Histogenetics, Ossining, USA
A*24:58A*2458HN-49379-5GQ240348Histogenetics, Ossining, USA
A*24:70A*2470HN-B-174698GQ149284Histogenetics, Ossining, USA
A*24:72A*2472HN-144165,
HN-08444-4		GQ149286,
GQ149291		Histogenetics, Ossining, USA
A*24:81A*2481HN-0527932,
HN-3598858		GQ149269,
GQ149290		Histogenetics, Ossining, USA
A*29:02:04A*290204HN-30971-7GQ254327Histogenetics, Ossining, USA
A*29:21A*2921HN-71140-8GQ254326Histogenetics, Ossining, USA
A*30:29A*3029HN-00134-7GQ180351Histogenetics, Ossining, USA
A*31:01:04A*310104HN-2682919,
HN-1953477		GQ240379,
GQ279260		Histogenetics, Ossining, USA
A*31:12A*3112HN-3718332GQ240342Histogenetics, Ossining, USA
A*31:15A*3115HN-0717642GQ240340Histogenetics, Ossining, USA
A*31:26A*3126HN-16313-3,
HN-38968-2,
HN-34412-1		GQ161019,
GQ161020,
GQ240344		Histogenetics, Ossining, USA
A*32:01:04A*320104HN-46438-0GQ240376Histogenetics, Ossining, USA
A*32:16A*3216HN-20795-1GQ240529Histogenetics, Ossining, USA
A*32:18A*3218HN-64028-6,
HN-75393-9,
HN-85759-0		GQ240378,
GQ254324,
GQ254325		Histogenetics, Ossining, USA
A*33:01:02A*330102HN-90695-2GQ161018Histogenetics, Ossining, USA
A*68:02:04A*680204HN-66064-9GU127988Histogenetics, Ossining, USA
A*68:35A*6835HN-35612-4,
HN-62242-7		GQ240327,
GQ240337		Histogenetics, Ossining, USA
A*68:37A*6837HN-66416-3,
HN-143227		GQ240329,
GQ240334		Histogenetics, Ossining, USA
A*68:40A*6840HN-9599886GQ240341Histogenetics, Ossining, USA
A*74:13A*7413HN-01191-6GQ180308Histogenetics, Ossining, USA
B*37:04:02B*370402HN-5101313,
HN-004484,
HN-57738-6		FJ976777,
GQ345044,
GQ449638		Histogenetics, Ossining, USA
B*37:04:02B*370402BY00658GU562430Carolyn K Hurley, Washington DC, USA
B*40:32B*403245189FN666597Thibaut Gervais, Brussels, Belgium
C*01:02:08Cw*010208HN-25237-1FJ998005Histogenetics, Ossining, USA
C*01:32Cw*0132HN-60288-7FJ997941Histogenetics, Ossining, USA
C*02:02:07Cw*020207HN-89126-8,
HN-73668-6,
HN-33332-9		FJ997945,
FJ997986,
FJ997999		Histogenetics, Ossining, USA
C*02:02:09Cw*0202092008-4215FN295561Kremena Todorova, Berlin, Germany
C*02:24Cw*0224HN-15071-7FJ997954Histogenetics, Ossining, USA
C*04:01:08Cw*040108HN-78915-9,
HN-93751-9,
HN-68106-4,
HN-08543-3		FJ997950,
FJ997952,
FJ997982,
GU128054		Histogenetics, Ossining, USA
C*04:01:13Cw*040113HN-73939-2,
HN-50859-7		FJ997947,
GQ121337		Histogenetics, Ossining, USA
C*04:01:15Cw*040115HN-13173-9FJ997943Histogenetics, Ossining, USA
C*04:47Cw*0447HN-16277-1FJ997991Histogenetics, Ossining, USA
C*05:07NCw*0507NX61189,
X10311,
X74723,
X83165,
X47025		FN661493Tatiana Lebedeva, Dedham, USA
C*05:28Cw*0528HN-69011-3FJ997949Histogenetics, Ossining, USA
C*05:29Cw*0529HN-66270-0GQ121339Histogenetics, Ossining, USA
C*07:01:10Cw*070110HN-78407-5GQ121340Histogenetics, Ossining, USA
C*07:02:08Cw*070208HN-98904-6,
HN-40715-6		FJ997970,
FJ997994		Histogenetics, Ossining, USA
C*07:91Cw*0791HN-71726-5FJ997948Histogenetics, Ossining, USA
C*07:93Cw*0793HN-11142-6,
HN-08108-4,
HN-51577-4,
HN-11265-2,
HN-24394-7,
HN-14078-2,
HN-67305-5,
HN-36814-0		FJ976799,
FJ976815,
FJ976847,
GQ240478,
GQ914781,
GU017958,
GU128050,
FJ997989		Histogenetics, Ossining, USA
C*08:28Cw*0828HN-37540-1,
HN-86336-5		FJ997978,
GQ121338		Histogenetics, Ossining, USA
C*12:19Cw*1219CS00024GU593057Kai Cao, Los Angeles, USA
C*12:27Cw*1227HN-80071-3FJ997976Histogenetics, Ossining, USA
C*15:02:05Cw*150205HN-98786-6,
HN-01119-7		FJ997977,
FJ997981		Histogenetics, Ossining, USA
C*15:23Cw*1523HN-27638-8FJ998006Histogenetics, Ossining, USA
C*15:24Cw*1524HN-34589-4FJ998001Histogenetics, Ossining, USA
C*16:16QCw*1616QHN-28325-1FJ997955Histogenetics, Ossining, USA
C*17:01:03Cw*170103HN-27784-9,
HN-87693-6		GQ149330,
FJ997972		Histogenetics, Ossining, USA
MICA*030MICA*030FH71GU575125Daniel Fuerst, Ulm, Germany

Table 3: Recently Published Sequences


Sequence Pre April 2010 Designation References
B*49:07B*4907 (2)
DRB1*16:15DRB1*1615 (3)
DQA1*05:10DQA1*0510 (4)
MICA*059MICA*059 (5)

References:

  1. Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
  2. Balas A, Garcia-Sanchez F, Vicario JL. HLA-B*4907 and B*490101 differs by residue 163 placed in a dominant serologic epitope. Tissue Antigens. 2010 75:286-7.
  3. Balas A, Garcia-Sanchez F, Vicario JL. Sequencing of a new HLA-DRB1*16 allele (DRB1*1615) with valine at residue 86. Tissue Antigens. 2010 75:288-9.
  4. Balas A, Garcia-Sanchez F, Vicario JL. A new DQA1 allele (DQA1*0510) in a Spanish celiac disease patient. Tissue Antigens. 2010 75:287-8.
  5. Tian W, Cai JH, Wang F, Li LX. MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059. Hum Immunol. 2010 71:423-7.