Nomenclature for Factors of the HLA System
January 2010
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2010 76:161-4
- Human Immunology. 2010 71:634-7
- International Journal of Immunogenetics. 2010 37:313-6
The following sequences have been submitted to the Nomenclature Committee since the December 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). Together with the new format HLA allele sequence name, the designation prior to April 2010 is also listed. Full details of the change to the HLA nomenclature format is given in the recent nomenclature report (1). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Pre April 2010 Designation | Cell identification | Accession number | Submitting author |
|---|---|---|---|---|
| A*02:01:43 | A*020143 | BY00565 | GU138061 | Carolyn K Hurley, Washington DC, USA |
| A*11:56 | A*1156 | JMDP36K055 | AB538862 | Kenji Tadokoro, Tokyo, Japan |
| A*11:57 | A*1157 | 5790900200 | GU454859 | Lixing Yan, Hangzhou, China |
| A*24:02:31 | A*240231 | 700578 | GU322370 | Eduard Palou, Barcelona, Spain |
| A*26:03:02 | A*260302 | JMDP01K090 | AB540607 | Kenji Tadokoro, Tokyo, Japan |
| A*26:43 | A*2643 | JMDP36K067 | AB538864 | Kenji Tadokoro, Tokyo, Japan |
| A*26:44 | A*2644 | 10200383 | GU474516 | Daniel Fuerst, Ulm, Germany |
| A*30:35 | A*3035 | DA1901.3 | FJ769256 | Min Yu, Chicago, USA |
| A*31:01:07 | A*310107 | JMDP01K085 | AB540160 | Kenji Tadokoro, Tokyo, Japan |
| A*31:29 | A*3129 | JMDP36K056 | AB538863 | Kenji Tadokoro, Tokyo, Japan |
| A*31:30 | A*3130 | 328573 | FN658992 | Edward KL Yang, Hualien, Taiwan |
| A*32:22 | A*3222 | AN184529 | FN663944 | Francesca Poli, Milano, Italy |
| A*33:03:05 | A*330305 | JMDP01K082 | AB538861 | Kenji Tadokoro, Tokyo, Japan |
| A*80:02 | A*8002 | 1046782 | GU322369 | Eduard Palou, Barcelona, Spain |
| B*08:55 | B*0855 | BY00592 | GU299439 | Carolyn K Hurley, Washington DC, USA |
| B*08:56 | B*0856 | BY00611 | GU299420 | Carolyn K Hurley, Washington DC, USA |
| B*08:57 | B*0857 | 39517 | GU370890 | Jianping Li, Shenyang, Liaoning, China |
| B*15:187 | B*9587 | 440075(20091012) | GU329994 | Sung-Hee Han, Seoul, South Korea |
| B*15:188 | B*9588 | JMDP01K047 | AB538865 | Kenji Tadokoro, Tokyo, Japan |
| B*15:189 | B*9589 | 297488 | FN650331 | Edward KL Yang, Hualien, Taiwan |
| B*27:63 | B*2763 | BY00607 | GU299424 | Carolyn K Hurley, Washington DC, USA |
| B*35:42:02 | B*354202 | Gansu9320800372 | GU248313 | Zhaohui Tang, Lanzhou, China |
| B*37:04:02 | B*370402 | 39094 | GU391034 | Jianping Li, Shenyang, Liaoning, China |
| B*37:22 | B*3722 | BY00632 | GU320646 | Carolyn K Hurley, Washington DC, USA |
| B*39:01:11 | B*390111 | 20090673M | AB535718 | Hidetoshi Inoko, Isehara, Kanagawa, Japan |
| B*40:01:09 | B*400109 | JMDP01K049 | AB538866 | Kenji Tadokoro, Tokyo, Japan |
| B*44:02:13 | B*440213 | BY00604 | GU299427 | Carolyn K Hurley, Washington DC, USA |
| B*46:01:04 | B*460104 | JMDP01K083 | AB540026 | Kenji Tadokoro, Tokyo, Japan |
| B*46:13:03 | B*461303 | 296430 | FN651781 | Edward KL Yang, Hualien, Taiwan |
| B*47:06 | B*4706 | BY00596 | GU299435 | Carolyn K Hurley, Washington DC, USA |
| B*48:22 | B*4822 | CTJ-12605 | GU570429 | Lina Yan, Tianjin, China |
| B*49:10 | B*4910 | BY00589 | GU299442 | Carolyn K Hurley, Washington DC, USA |
| B*51:01:17 | B*510117 | BY00590 | GU299441 | Carolyn K Hurley, Washington DC, USA |
| B*51:07:02 | B*510702 | JMDP01K052 | AB538867 | Kenji Tadokoro, Tokyo, Japan |
| B*51:90 | B*5190 | BY00584 | GU299447 | Carolyn K Hurley, Washington DC, USA |
| B*51:91 | B*5191 | BY00588 | GU299443 | Carolyn K Hurley, Washington DC, USA |
| B*51:92 | B*5192 | BY00598 | GU299433 | Carolyn K Hurley, Washington DC, USA |
| B*51:93 | B*5193 | BY00608 | GU299423 | Carolyn K Hurley, Washington DC, USA |
| B*51:94 | B*5194 | 1755-09 | FN557350 | Florian Emmerich, Freiburg, Germany |
| B*52:20 | B*5220 | JMDP01K061 | AB540025 | Kenji Tadokoro, Tokyo, Japan |
| B*53:22 | B*5322 | BY00603 | GU299428 | Carolyn K Hurley, Washington DC, USA |
| B*54:20 | B*5420 | BY00610 | GU299421 | Carolyn K Hurley, Washington DC, USA |
| B*54:21 | B*5421 | JMDP01K053 | AB540024 | Kenji Tadokoro, Tokyo, Japan |
| B*54:22 | B*5422 | JMDP01K084 | AB540027 | Kenji Tadokoro, Tokyo, Japan |
| B*57:30 | B*5730 | BY00583 | GU299448 | Carolyn K Hurley, Washington DC, USA |
| B*78:07 | B*7807 | BY00600 | GU299431 | Carolyn K Hurley, Washington DC, USA |
| C*01:35 | Cw*0135 | 20090681Mother, 20090681CB |
AB535719 | Hidetoshi Inoko, Isehara, Kanagawa, Japan |
| C*02:26:02 | Cw*022602 | BY00618 | GU320632 | Carolyn K Hurley, Washington DC, USA |
| C*03:04:19 | Cw*030419 | 93068719 | GU324267 | Daniel Fuerst, Ulm, Germany |
| C*03:80 | Cw*0380 | BY00614 | GU320628 | Carolyn K Hurley, Washington DC, USA |
| C*04:54 | Cw*0454 | BY00629 | GU320643 | Carolyn K Hurley, Washington DC, USA |
| C*04:55 | Cw*0455 | BY00628 | GU320642 | Carolyn K Hurley, Washington DC, USA |
| C*05:35 | Cw*0535 | BY00617 | GU320631 | Carolyn K Hurley, Washington DC, USA |
| C*05:36 | Cw*0536 | BY00615 | GU320629 | Carolyn K Hurley, Washington DC, USA |
| C*06:30 | Cw*0630 | BY00626 | GU320640 | Carolyn K Hurley, Washington DC, USA |
| C*06:31 | Cw*0631 | BY00616 | GU320630 | Carolyn K Hurley, Washington DC, USA |
| C*06:32 | Cw*0632 | NT01121 | GU440773 | Carolyn K Hurley, Washington DC, USA |
| C*12:10:02 | Cw*121002 | PBMC-QD650 | GQ999128 | JianQiong Zhang, Nanjing, China |
| C*14:16 | Cw*1416 | BY00630 | GU320644 | Carolyn K Hurley, Washington DC, USA |
| C*15:27 | Cw*1527 | BY00631 | GU320645 | Carolyn K Hurley, Washington DC, USA |
| C*16:20 | Cw*1620 | BY00623 | GU320637 | Carolyn K Hurley, Washington DC, USA |
| DRB1*01:01:18 | DRB1*010118 | BY00646 | GU320626 | Carolyn K Hurley, Washington DC, USA |
| DRB1*03:01:09 | DRB1*030109 | BY00635 | GU320616 | Carolyn K Hurley, Washington DC, USA |
| DRB1*04:04:05 | DRB1*040405 | AN190987 | FN640478 | Francesca Poli, Milano, Italy |
| DRB1*08:04:05 | DRB1*080405 | BY00642 | GU320622 | Carolyn K Hurley, Washington DC, USA |
| DRB1*09:01:07 | DRB1*090107 | 17927 | GU370889 | Jianping Li, Shenyang, Liaoning, China |
| DRB1*11:90 | DRB1*1190 | AN191323 | FN600162 | Francesca Poli, Milano, Italy |
| DRB1*11:91 | DRB1*1191 | BY00645 | GU320625 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:92 | DRB1*1192 | BY00638 | GU320619 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:93 | DRB1*1193 | BY00647 | GU368921 | Carolyn K Hurley, Washington DC, USA |
| DRB1*12:21 | DRB1*1221 | K38708 | AB542913 | Masaki Matsushita, Hiroshima, Japan |
| DRB1*13:66:02 | DRB1*136602 | BY00637 | GU320618 | Carolyn K Hurley, Washington DC, USA |
| DRB1*13:98 | DRB1*1398 | BY00641 | GU320621 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:97 | DRB1*1497 | BY00639 | GU320620 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:98 | DRB1*1498 | 09-108 | GU186855 | Kyung-won Kim, Seoul, South Korea |
| DRB1*16:16 | DRB1*1616 | 291022 | FN658993 | Edward KL Yang, Hualien, Taiwan |
| DQA1*01:07 | DQA1*0107 | EBV-II-2 | U77589 | Neubury M Lardy, Amsterdam, The Netherlands |
| DQB1*06:40 | DQB1*0640 | 9223070 | GU324266 | Daniel Fuerst, Ulm, Germany |
Table 2: Confirmatory Sequences
| Sequence | Pre April 2010 Designation | Cell identification | Accession number | Submitting author |
|---|---|---|---|---|
| A*02:01:22 | A*020122 | JMDP01K060 | AB540151 | Kenji Tadokoro, Tokyo, Japan |
| A*02:110 | A*9210 | JMDP01K081 | AB540155 | Kenji Tadokoro, Tokyo, Japan |
| A*02:41 | A*0241 | JMDP01K088 | AB540159 | Kenji Tadokoro, Tokyo, Japan |
| A*02:61 | A*0261 | JMDP01K080 | AB540154 | Kenji Tadokoro, Tokyo, Japan |
| A*02:80 | A*0280 | JMDP01K078 | AB540153 | Kenji Tadokoro, Tokyo, Japan |
| A*11:08 | A*1108 | NT01138 | GU440756 | Carolyn K Hurley, Washington DC, USA |
| A*26:18 | A*2618 | JMDP36K054 | AB540157 | Kenji Tadokoro, Tokyo, Japan |
| A*26:20 | A*2620 | 302922 | FN646405 | Edward KL Yang, Hualien, Taiwan |
| A*33:05 | A*3305 | JMDP36K053 | AB540156 | Kenji Tadokoro, Tokyo, Japan |
| A*34:05 | A*3405 | JMDP01K073 | AB540152 | Kenji Tadokoro, Tokyo, Japan |
| A*66:03 | A*6603 | JMDP36K057 | AB540158 | Kenji Tadokoro, Tokyo, Japan |
| B*07:02:03 | B*070203 | NT01136 | GU440758 | Carolyn K Hurley, Washington DC, USA |
| B*08:20 | B*0820 | NT01134 | GU440760 | Carolyn K Hurley, Washington DC, USA |
| B*08:52 | B*0852 | 96053461 | GU324265 | Daniel Fuerst, Ulm, Germany |
| B*15:03:03 | B*150303 | BY00585 | GU299446 | Carolyn K Hurley, Washington DC, USA |
| B*15:55 | B*1555 | NT01130 | GU440764 | Carolyn K Hurley, Washington DC, USA |
| B*18:01:06 | B*180106 | BY00594 | GU299437 | Carolyn K Hurley, Washington DC, USA |
| B*35:10 | B*3510 | JMDP36K041 | AB537501 | Kenji Tadokoro, Tokyo, Japan |
| B*35:11 | B*3511 | NT01129 | GU440765 | Carolyn K Hurley, Washington DC, USA |
| B*35:58 | B*3558 | NT01135 | GU440759 | Carolyn K Hurley, Washington DC, USA |
| B*38:20 | B*3820 | BY00593 | GU299438 | Carolyn K Hurley, Washington DC, USA |
| B*39:14 | B*3914 | NT01128 | GU440766 | Carolyn K Hurley, Washington DC, USA |
| B*39:26 | B*3926 | NT01127 | GU440767 | Carolyn K Hurley, Washington DC, USA |
| B*39:34 | B*3934 | NT01133 | GU440761 | Carolyn K Hurley, Washington DC, USA |
| B*40:32 | B*4032 | NT01131 | GU440763 | Carolyn K Hurley, Washington DC, USA |
| B*44:64:01 | B*446401 | BY00595 | GU299436 | Carolyn K Hurley, Washington DC, USA |
| B*44:77 | B*4477 | 9799732 | FN646406 | Christian Seidl, Frankfurt am Main, Germany |
| B*45:02 | B*4502 | NT01132 | GU440762 | Carolyn K Hurley, Washington DC, USA |
| B*50:09 | B*5009 | BY00609 | GU299422 | Carolyn K Hurley, Washington DC, USA |
| B*56:05:02 | B*560502 | NT01126 | GU440768 | Carolyn K Hurley, Washington DC, USA |
| B*57:24 | B*5724 | BY00605 | GU299426 | Carolyn K Hurley, Washington DC, USA |
| C*01:12 | Cw*0112 | NT01124 | GU440770 | Carolyn K Hurley, Washington DC, USA |
| C*01:30 | Cw*0130 | 7550801170 | GU376469 | Yunping Xu, Shenzhen, China |
| C*02:02:03 | Cw*020203 | NT01122 | GU440774 | Carolyn K Hurley, Washington DC, USA |
| C*02:02:08 | Cw*020208 | HN-43240-3, HN-43238-7 |
GU017952, GU128052 | Histogenetics, Ossining, USA |
| C*03:21 | Cw*0321 | BY00651 | GU440772 | Carolyn K Hurley, Washington DC, USA |
| C*03:27 | Cw*0327 | NT01125 | GU440769 | Carolyn K Hurley, Washington DC, USA |
| C*03:78 | Cw*0378 | BY00621, BY00613 | GU320635, GU320627 | Carolyn K Hurley, Washington DC, USA |
| C*04:06 | Cw*0406 | 7550800938 | GU352934 | Yunping Xu, Shenzhen, China |
| C*05:35 | Cw*0535 | HN-09804-6 | GQ180448 | Histogenetics, Ossining, USA |
| C*06:24 | Cw*0624 | 2008943 | GU376470 | Yunping Xu, Shenzhen, China |
| C*07:02:06 | Cw*070206 | 7550800655 | GU376471 | Yunping Xu, Shenzhen, China |
| C*07:15 | Cw*0715 | NT01123 | GU440771 | Carolyn K Hurley, Washington DC, USA |
| C*07:56:02 | Cw*075602 | 2008961 | GU352936 | Yunping Xu, Shenzhen, China |
| C*08:20 | Cw*0820 | 7550800216 | FJ785725 | Yunping Xu, Shenzhen, China |
| C*08:27 | Cw*0827 | 7600800270 | GU352935 | Yunping Xu, Shenzhen, China |
| C*08:27 | Cw*0827 | BY00622 | GU320636 | Carolyn K Hurley, Washington DC, USA |
| C*12:03:09 | Cw*120309 | BY00627 | GU320641 | Carolyn K Hurley, Washington DC, USA |
| C*15:17 | Cw*1517 | 2008981 | GU352937 | Yunping Xu, Shenzhen, China |
| C*15:22 | Cw*1522 | BY00620 | GU320634 | Carolyn K Hurley, Washington DC, USA |
| C*15:26 | Cw*1526 | BJ09ZHL | GU474371 | Zhiyin Gong, Beijing, China |
| G*01:01:01:02 | G*01010102 | CUI-07 | GU370776 | Jorge Martinez-Laso, Madrid, Spain |
| G*01:01:05 | G*010105 | BCI-16 | GU324263 | Jorge Martinez-Laso, Madrid, Spain |
| G*01:08 | G*0108 | BCI-17 | GU319111 | Jorge Martinez-Laso, Madrid, Spain |
| DRB1*01:23 | DRB1*0123 | BY00636 | GU320617 | Carolyn K Hurley, Washington DC, USA |
| DRB1*04:17:02 | DRB1*041702 | BY00634, BY00633, BY00648, BY00649 |
GU320615 | Carolyn K Hurley, Washington DC, USA |
| DRB1*08:32 | DRB1*0832 | BY00652 | GU440755 | Carolyn K Hurley, Washington DC, USA |
| DRB1*11:57 | DRB1*1157 | NT01137 | GU440757 | Carolyn K Hurley, Washington DC, USA |
| DRB1*13:01:07 | DRB1*130107 | HN-8552155 | FJ502337 | Histogenetics, Ossining, USA |
| DRB1*13:93 | DRB1*1393 | BY00640 | GU320647 | Carolyn K Hurley, Washington DC, USA |
| DRB1*13:97 | DRB1*1397 | BY00644 | GU320624 | Carolyn K Hurley, Washington DC, USA |
| DRB1*14:71 | DRB1*1471 | BY00643 | GU320623 | Carolyn K Hurley, Washington DC, USA |
| DPB1*39:01 | DPB1*3901 | Ter963 | FN599520 | Klaus Witter, M�nchen, Germany |
| DPB1*59:01 | DPB1*5901 | 198696 | FN651783 | Klaus Witter, M�nchen, Germany |
Table 3: Recently Published Sequences
| Sequence | Pre April 2010 Designation | References |
|---|---|---|
| B*07:02:09 | B*070209 | (2) |
| B*13:02:05 | B*130205 | (2) |
| B*46:21 | B*4621 | (3) |
| B*55:35 | B*5535 | (4) |
| C*01:02:01 | Cw*010201 | (5) |
| C*01:03 | Cw*0103 | (6) |
| C*01:08 | Cw*0108 | (6) |
| C*07:06 | Cw*0706 | (5) |
| C*07:56:02 | Cw*075602 | (7) |
| C*08:02:01 | Cw*080201 | (5) |
| C*12:03:01:01 | Cw*12030101 | (6) |
| DRB3*01:14 | DRB3*0114 | (8) |
References:
- Marsh SGE, Albert ED, Bodmer WF, et al. Nomenclature for Factors of the HLA system, 2010. Tissue Antigens. 2010 75:291-455.
- Zhu FM, Zhang W, He J, Yan LX. Identification of two novel alleles HLA-B*070209 and HLA-B*130205 by polymerase chain reaction sequence-based typing. Tissue Antigens. 2010 75:174-5.
- Gao SQ, Deng ZH, Xu YP. Characterization of the novel HLA-B allele, B*4621, in a Chinese individual. Tissue Antigens. 2010 75:175-8.
- Zhuang YL, Song YH, Zhang Y, Nie XM, Zhu CF. A novel HLA-B allele, B*5535, was identified by sequence-based typing in a Chinese individual. Tissue Antigens. 2010 75:178-9.
- Xu YP, Yang BC, Zeng JQ, Wang DM, Deng ZH. Characterization of the genomic full-length sequence of HLA-Cw*010201, Cw*0706, and Cw*0801 in Chinese individuals. Tissue Antigens. 2010 75:179-81.
- Xu YP, Yang BC, Gao SQ, Deng ZH, Xie Z. Genomic full-length sequence of HLA-Cw*0103 and *0108, identified by cloning and sequencing. Tissue Antigens. 2010 75:181-3.
- Deng ZH, Wang DM. Characterization of a novel HLA-Cw*07 variant allele, Cw*075602. Tissue Antigens. 2010 75:183-5.
- Garritsen HS, Fae I, Legath N, Hannig H, Fischer GF. Identification of a novel HLA-DRB3*01 variant, HLA-DRB3*0114, containing a DRB1 sequence motif by micro-temperature gradient gel electrophoresis confirmed by sequence-based typing. Tissue Antigens. 2010 75:185-6.
