Nomenclature for Factors of the HLA System
April 2009
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2009 74:272-5
- Human Immunology. 2009 70:760-3
- International Journal of Immunogenetics. 2009 36:309-12
The following sequences have been submitted to the Nomenclature Committee since the March 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*010107 | HN-34603-1 | FJ392136 | Histogenetics, Ossining, USA |
| A*0130 | HN-13116-0 | FJ224148 | Histogenetics, Ossining, USA |
| A*020123 | HN-43008-1, HN-04209-3, HN-00116-4, HN-32507-0, HN-62729-8 |
FJ224141, FJ224157, FJ224174, FJ392155, FJ600644 |
Histogenetics, Ossining, USA |
| A*020124 | HN-13730-6 | FJ224149 | Histogenetics, Ossining, USA |
| A*020125 | HN-95311-7, HN-02855-5, HN-03558-4, HN-37024-8 |
FJ224154, FJ224165, FJ224166, FJ224167 |
Histogenetics, Ossining, USA |
| A*020126 | HN-94748-1, HN-46549-4, HN-22363-0, HN-54671-6, HN-43494-7 |
FJ224163, FJ224190, FJ224211, FJ538271, FJ619452 |
Histogenetics, Ossining, USA |
| A*020127 | HN-51440-6, HN-30847-7, HN-68729-5 |
FJ392134, FJ392132, FJ392152 |
Histogenetics, Ossining, USA |
| A*030112 | HN-61746-5, HN-04652-4 |
FJ392138, FJ392139 |
Histogenetics, Ossining, USA |
| A*1143 | K19692 | AB485772 | Etsuko Maruya, Kyoto, Japan |
| A*230102 | HN-46329-8, HN-25543-9, HN-28515-4 |
FJ224143, FJ600646, FJ600647 |
Histogenetics, Ossining, USA |
| A*240220 | P3749 | FJ940681 | Lixing Yan, Hangzhou, China |
| A*2639 | HN-68453-0 | FJ224158 | Histogenetics, Ossining, USA |
| A*3125 | 08215667 | FJ868755 | Andrea Vigh, Ulm, Germany |
| A*3219N | CTM-1003575 | FJ951633 | Antonio Balas, Madrid, Spain |
| A*6610 | Sunxianjun | FJ810056 | Jun He, Suzhou, China |
| A*7414N | 008218395 | FJ868756 | Andrea Vigh, Ulm, Germany |
| A*9269 | BY00453 | FJ842964 | Carolyn K Hurley, Washington DC, USA |
| A*9270 | ZhangheA2 | FJ810057 | Jun He, Suzhou, China |
| A*9271 | YaobintaoA2 | FJ810060 | Jun He, Suzhou, China |
| A*9272 | HN-43576-7 | FJ222558 | Histogenetics, Ossining, USA |
| A*9273 | HN-12839-4, HN-81935-3 |
FJ222570, FJ224205 |
Histogenetics, Ossining, USA |
| A*9274 | HN-41136-0 | FJ224126 | Histogenetics, Ossining, USA |
| A*9275 | HN-72502-8 | FJ224153 | Histogenetics, Ossining, USA |
| A*9276 | HN-00973-7 | FJ224164 | Histogenetics, Ossining, USA |
| B*070209 | H09020 | FJ869339 | Lixing Yan, Hangzhou, China |
| B*0777 | 60638317 | FJ821318 | Antonio Balas, Madrid, Spain |
| B*130102 | 09006203 | FJ868754 | Andrea Vigh, Ulm, Germany |
| B*350108 | HN-42895-5 | FJ235052 | Histogenetics, Ossining, USA |
| B*3949 | CG077022121801 | FJ648688 | Hayley Hogan, Fremantle, Australia |
| B*3950 | 09000739 | FJ785834 | Antonio Balas, Madrid, Spain |
| B*400205 | 105479 | FJ807734 | Mary Sue Leffell, Baltimore, USA |
| B*4097 | CG077022121965 | FJ648687 | Hayley Hogan, Fremantle, Australia |
| B*4098 | JRCKBCA7915 | AB494701 | Yukari Kuroda, Fukuoka, Japan |
| B*4619 | WangweiB46 | FJ810061 | Jun He, Suzhou, China |
| B*510110 | HN-16784-0, HN-61488-2, HN-27714-4 |
FJ346266, FJ853775, FJ866147 |
Histogenetics, Ossining, USA |
| B*5418 | CG077022121979 | FJ648689 | Hayley Hogan, Fremantle, Australia |
| B*5905 | JMDP36K034 | AB477103 | Kenji Tadokoro, Tokyo, Japan |
| Cw*0624 | SZBM8943 | FJ804766 | Zhihui Deng, ShenZhen, China |
| Cw*070205 | SZ-23 | FJ811898 | Hong-Yan Zou, Shenzhen, China |
| Cw*075602 | SZBM033 | FJ804765 | Zhihui Deng, ShenZhen, China |
| Cw*080302 | BY00447 | FJ797353 | Carolyn K Hurley, Washington DC, USA |
| Cw*0824 | SZ-21 | FJ825144 | Hong-Yan Zou, Shenzhen, China |
| Cw*0825 | CTM-1003396 | FJ868794 | Antonio Balas, Madrid, Spain |
| Cw*1222 | SZ-22 | FJ811899 | Hong-Yan Zou, Shenzhen, China |
| DRB1*030503 | FP177512 | FN252190 | Francesca Poli, Milano, Italy |
| DRB1*030503 | 42856 | FN313509 | Thibaut Gervais, Brussels, Belgium |
| DRB1*0342 | P-643995 | FM998809 | Rainer Blasczyk, Hannover, Germany |
| DRB1*0342 | 1044283 | FJ877151 | Eduard Palou, Barcelona, Spain |
| DRB1*090105 | BY00454 | FJ842965 | Carolyn K Hurley, Washington DC, USA |
| DRB1*112802 | SZ-30 | FJ870104 | Zhen Li, Shenzhen, China |
| DRB1*1173 | WangyiDR11 | FJ810063 | Jun He, Suzhou, China |
| DRB1*1486 | 021084-CB | FN186134 | Francesca Poli, Milano, Italy |
| DRB1*1533 | DEMBG-5010128 | FJ827122 | Andreas Parkner, Magdeburg, Germany |
| DQB1*0325 | ZMK01 | EU770203 | Zahra M. Kashi, Beaverton, USA |
| DQB1*040102 | Bjztt | FJ938169 | Zhixin Zhang, Beijing, China |
| MICA*00203 | Allo4250 | FJ790821 | Diane Pidwell, Cleveland, USA |
| MICA*058 | Allo3587 | FJ790820 | Diane Pidwell, Cleveland, USA |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0129 | HN-08587-2 | FJ594683 | Histogenetics, Ossining, USA |
| A*020122 | HN-70104-9, HN-53152-5 |
FJ224202, FJ594711 |
Histogenetics, Ossining, USA |
| A*020502 | HN-68494-4, HN-04903-3, HN-94313-4 |
FJ224159, FJ224191, FJ224238 |
Histogenetics, Ossining, USA |
| A*0296 | HN-14542-6, HN-71569-0 |
FJ594675, FJ594681 |
Histogenetics, Ossining, USA |
| A*2315 | BY00459 | FJ842970 | Carolyn K Hurley, Washington DC, USA |
| A*3109 | NT01043 | FJ797355 | Carolyn K Hurley, Washington DC, USA |
| A*3116 | 00153823 | FM995167 | Christian Seidl, Frankfurt am Main, Germany |
| A*7413 | BY00459 | FJ842971 | Carolyn K Hurley, Washington DC, USA |
| A*9249 | HN-03878-5 | FJ224162 | Histogenetics, Ossining, USA |
| A*9251 | HN-95852-8 | FJ594703 | Histogenetics, Ossining, USA |
| A*9258 | HN-19193-4, HN-61351-2, HN-35480-4, HN-28120-2, HN-85226-8 |
FJ222574, FJ224136, FJ224183, FJ224217, FJ224227 |
Histogenetics, Ossining, USA |
| A*9260 | HN-69153-4 | FJ222556 | Histogenetics, Ossining, USA |
| A*9261 | HN-91271-1 | FJ224203 | Histogenetics, Ossining, USA |
| A*9264 | HN-76878-9 | FJ224173 | Histogenetics, Ossining, USA |
| A*9265 | HN-56502-0 | FJ224125 | Histogenetics, Ossining, USA |
| A*9266 | HN-30314-8 | FJ222557 | Histogenetics, Ossining, USA |
| B*070207 | HN-34589-1, HN-69548-0, HN-65317-7 |
FJ594497, FJ594599, FJ853762 |
Histogenetics, Ossining, USA |
| B*070208 | HN-76695-6 | FJ853793 | Histogenetics, Ossining, USA |
| B*0747 | HN-90158-1, HN-55850-5, HN-53392-9, HN-52240-1 |
FJ594589, FJ868470, FJ868472, FJ868489 |
Histogenetics, Ossining, USA |
| B*0748 | HN-174-4 | FJ594592 | Histogenetics, Ossining, USA |
| B*0754 | HN-01873-0 | FJ868468 | Histogenetics, Ossining, USA |
| B*0757 | HN-09475-9 | FJ594600 | Histogenetics, Ossining, USA |
| B*0762 | HN-39376-1, HN-84760-8, HN-01994-1, HN-31099-4 |
FJ594593, FJ594553, FJ853759, FJ853760 |
Histogenetics, Ossining, USA |
| B*0763 | HN-16465-0 | FJ600617 | Histogenetics, Ossining, USA |
| B*0768 | HN-64013-5 | FJ346242 | Histogenetics, Ossining, USA |
| B*0773 | HN-52511-6, HN-80443-9 |
FJ346302, FJ853796 |
Histogenetics, Ossining, USA |
| B*0774 | HN-69732-0 | FJ235059 | Histogenetics, Ossining, USA |
| B*0837 | HN-58346-4 | FJ235042 | Histogenetics, Ossining, USA |
| B*1306 | BY00457 | FJ842969 | Carolyn K Hurley, Washington DC, USA |
| B*1409 | HN-7102160 | FJ235046 | Histogenetics, Ossining, USA |
| B*1822 | BY00455, BY00456 |
FJ842967, FJ842968 |
Carolyn K Hurley, Washington DC, USA |
| B*2746 | HN-5092736 | FJ235045 | Histogenetics, Ossining, USA |
| B*390202 | NT01046 | FJ797357 | Carolyn K Hurley, Washington DC, USA |
| B*4005 | NT01045 | FJ797356 | Carolyn K Hurley, Washington DC, USA |
| B*4090 | HN-4038191 | FJ235013 | Histogenetics, Ossining, USA |
| B*550201 | BY00458 | FJ842972 | Carolyn K Hurley, Washington DC, USA |
| B*550203 | HN-17598-4, HN-7398230 |
FJ235039, FJ235047 |
Histogenetics, Ossining, USA |
| B*5531 | HN-0036645 | FJ235048 | Histogenetics, Ossining, USA |
| B*5821 | HN-B-173923 | FJ235054 | Histogenetics, Ossining, USA |
| B*9553 | HN-04085-5, HN-76459-8, HN-17386-8, , |
FJ235006, FJ235036, FJ235067 |
Histogenetics, Ossining, USA |
| B*9560 | HN-54413-3 | FJ235040 | Histogenetics, Ossining, USA |
| Cw*0106 | BY00451 | FJ842962 | Carolyn K Hurley, Washington DC, USA |
| Cw*021602 | I-643356 | FM991870 | Rainer Blasczyk, Hannover, Germany |
| Cw*0326 | HN-38895-2 | FJ594630 | Histogenetics, Ossining, USA |
| Cw*0335 | HN-41088-7 | FJ600668 | Histogenetics, Ossining, USA |
| Cw*0340 | HN-33303-0 | FJ600670 | Histogenetics, Ossining, USA |
| Cw*0342 | HN-00342-4, HN-82778-1, HN-81801-7 |
FJ594625, FJ594629, FJ594635 |
Histogenetics, Ossining, USA |
| Cw*0344 | HN-40784-0, HN-35750-8, HN-10455-3, HN-54110-4, HN-77802-1, HN-80741-6, HN-72263-1, HN-99786-3, HN-15878-1, HN-86144-4, HN-57227-2, HN-46636-8, HN-46637-6, HN-46669-9, HN-70518-7, HN-72921-1, HN-21520-3, HN-57401-3 |
FJ594626, FJ594627, FJ594628, FJ594631, FJ594633, FJ594634, FJ594636, FJ594637, FJ600655, FJ600657, FJ600659, FJ600660, FJ600661, FJ600662, FJ600663, FJ600665, FJ600666, FJ600667 |
Histogenetics, Ossining, USA |
| Cw*0351 | HN-47650-5 | FJ554593 | Histogenetics, Ossining, USA |
| Cw*0353 | HN-32447-5, HN-35684-9, HN-90575-2 |
FJ554591, FJ554592, FJ554604 |
Histogenetics, Ossining, USA |
| Cw*0355 | HN-84164-4 | FJ554602 | Histogenetics, Ossining, USA |
| Cw*0437 | HN-70426-3 | FJ618912 | Histogenetics, Ossining, USA |
| Cw*0618 | HN-3171-5, HN-20198-1 |
FJ392218, FJ618926 |
Histogenetics, Ossining, USA |
| Cw*0623 | HN-65149-5, HN-31137-6 |
FJ392208, FJ618918 |
Histogenetics, Ossining, USA |
| Cw*0760 | HN-50519-9, HN-73447-9 |
FJ618916, FJ618931 |
Histogenetics, Ossining, USA |
| Cw*0767 | ChengyizeC7 | FJ810062 | Jun He, Suzhou, China |
| Cw*140201 | 009411 | FJ785736 | Yunping Xu, Shenzhen, China |
| Cw*1614 | HN-83251-3 | FJ618933 | Histogenetics, Ossining, USA |
| DRB1*1511 | BY00452 | FJ842963 | Carolyn K Hurley, Washington DC, USA |
| DPB1*200101 | 191833 | FN256255 | Klaus Witter, M�nchen, Germany |
| DPB1*260102 | 193322 | FN252853 | Klaus Witter, M�nchen, Germany |
| DPB1*4501 | 193320 | FN256251 | Klaus Witter, M�nchen, Germany |
| DPB1*5501 | 176633 | FN256253 | Klaus Witter, M�nchen, Germany |
| DPB1*8501 | 173643 | FN256254 | Klaus Witter, M�nchen, Germany |
| DPB1*8801 | 193326 | FN256250 | Klaus Witter, M�nchen, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| B*0838 | (1) |
| B*460102 | (2) |
| B*5158 | (3) |
| B*5719 | (4) |
| Cw*0819 | (5) |
| G*010115 | (6) |
| G*010116 | (6) |
| G*010117 | (6) |
| G*010118 | (6) |
| G*010119 | (6) |
| G*010405 | (6) |
References
- Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-B*08 variant--B*0838. Tissue Antigens. 2009 73:373-4.
- Chu CC, Lee HL, Lin M. Identification of a novel HLA-B allele, B*460102, in three Taiwanese individuals. Tissue Antigens. 2009 73:374-5.
- Roh EY, Shin S, Yoon JH, Ahn BM, Chang JY. A new HLA-B*51 variant, B*5158, identified by sequence-based typing in a Korean individual. Tissue Antigens. 2009 73:375-6.
- Figueiredo C, Mbulaiteye S, Ndugwa CM, Schulz T, Eiz-Vesper B. Assessment of the amino acid substitution in HLA-B*5719 for allorecognition. Tissue Antigens. 2009 73:376-8.
- Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-C allele: Cw*0819. Tissue Antigens. 2009 73:378-9.
- Lajoie J, Boivin AA, Jeanneau A, Faucher MC, Roger M. Identification of six new HLA-G alleles with non-coding DNA base changes. Tissue Antigens. 2009 73:379-80.
