Nomenclature for Factors of the HLA System

March 2009

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the February 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*010106 HN-54982-5 FJ765908 Histogenetics, Ossining, USA
A*0135 NT01014 FJ797388 Carolyn K Hurley, Washington DC, USA
A*030111 HN-80503-6 FJ765913 Histogenetics, Ossining, USA
A*0350 NT01013 FJ797389 Carolyn K Hurley, Washington DC, USA
A*0351 NT01015 FJ797387 Carolyn K Hurley, Washington DC, USA
A*1141 ERCB-FO-01/00183-379CB08 FN178525 Sonia Nesci, Pesaro, Italy
A*1142 NT01021 FJ797381 Carolyn K Hurley, Washington DC, USA
A*2321 NT01022 FJ797380 Carolyn K Hurley, Washington DC, USA
A*240218 HN-59221-9 FJ619404 Histogenetics, Ossining, USA
A*240219 HN-78059-1 FJ619421 Histogenetics, Ossining, USA
A*2638 NT01020 FJ797382 Carolyn K Hurley, Washington DC, USA
A*6847 BY00445 FJ797354 Carolyn K Hurley, Washington DC, USA
A*9267 HN-67321-2 FJ554624 Histogenetics, Ossining, USA
A*9268 HN-87835-4 FJ765914 Histogenetics, Ossining, USA
B*070208 HN-24405-0 FJ549405 Histogenetics, Ossining, USA
B*0775 09d00312 FM995501 Jacqy DH Anholts, Leiden, The Netherlands
B*0776 NT01023 FJ797379 Carolyn K Hurley, Washington DC, USA
B*1834 HN-64083-9 FJ392181 Histogenetics, Ossining, USA
B*2750 NT01029 FJ797373 Carolyn K Hurley, Washington DC, USA
B*3598 HN-16151-4 FJ560459 Histogenetics, Ossining, USA
B*3599 BY00446 FJ797351 Carolyn K Hurley, Washington DC, USA
B*3819 NT01025 FJ797377 Carolyn K Hurley, Washington DC, USA
B*4468 HN-41637-0 FJ502323 Histogenetics, Ossining, USA
B*4469 NT01026 FJ797376 Carolyn K Hurley, Washington DC, USA
B*5169 HN-84899-5 FJ392179 Histogenetics, Ossining, USA
B*5170 HN-83758-5 FJ502327 Histogenetics, Ossining, USA
B*9558 NT01024 FJ797378 Carolyn K Hurley, Washington DC, USA
B*9559 NT01012 FJ797390 Carolyn K Hurley, Washington DC, USA
B*9560 NT01028 FJ797374 Carolyn K Hurley, Washington DC, USA
Cw*010207 HN-76798-8 FJ594542 Histogenetics, Ossining, USA
Cw*0126 NT01038 FJ797364 Carolyn K Hurley, Washington DC, USA
Cw*0127 NT01032 FJ797370 Carolyn K Hurley, Washington DC, USA
Cw*020207 HN-85664-1,
HN-60463-7
FJ594543,
FJ594540
Histogenetics, Ossining, USA
Cw*0224 HN-73058-3 FJ594525 Histogenetics, Ossining, USA
Cw*0225Q HN-24736-9 FJ594546 Histogenetics, Ossining, USA
Cw*0226 NT01041 FJ797361 Carolyn K Hurley, Washington DC, USA
Cw*0227 NT01036 FJ797366 Carolyn K Hurley, Washington DC, USA
Cw*030306 HN-12246-5 FJ594534 Histogenetics, Ossining, USA
Cw*0351 HN-11322-9 FJ594513 Histogenetics, Ossining, USA
Cw*0352 HN-92965-7 FJ594520 Histogenetics, Ossining, USA
Cw*0353 HN-25274-5 FJ594521 Histogenetics, Ossining, USA
Cw*0354 HN-64893-3 FJ594529 Histogenetics, Ossining, USA
Cw*0355 HN-21141-7 FJ594535 Histogenetics, Ossining, USA
Cw*0357 HN-51959-5,
HN-61018-8
FJ594539,
FJ594541
Histogenetics, Ossining, USA
Cw*0357 BY00450 FJ797349 Carolyn K Hurley, Washington DC, USA
Cw*0358 BY00444 FJ797358 Carolyn K Hurley, Washington DC, USA
Cw*040107 HN-44391-1 FJ594536 Histogenetics, Ossining, USA
Cw*040108 HN-46140-0 FJ594538 Histogenetics, Ossining, USA
Cw*0438 08d05807 FM995500 Jacqy DH Anholts, Leiden, The Netherlands
Cw*0439 HN-46107-9 FJ594537 Histogenetics, Ossining, USA
Cw*0440 NT01040 FJ797362 Carolyn K Hurley, Washington DC, USA
Cw*0525 SCU-505 FJ750479 Antonio Balas, Madrid, Spain
Cw*0621 HN-72910-6 FJ594524 Histogenetics, Ossining, USA
Cw*0622 RV156-101196 EU707573 Gustavo Kijak, Rockville, USA
Cw*0623 NT01033 FJ797369 Carolyn K Hurley, Washington DC, USA
Cw*0768 NT01039 FJ797363 Carolyn K Hurley, Washington DC, USA
Cw*0769 NT01031 FJ797371 Carolyn K Hurley, Washington DC, USA
Cw*0770 NT01034 FJ797368 Carolyn K Hurley, Washington DC, USA
Cw*0771 NT01037 FJ797365 Carolyn K Hurley, Washington DC, USA
Cw*0772 NT01042,
NT01035
FJ797360,
FJ797367
Carolyn K Hurley, Washington DC, USA
Cw*0822 009402 FJ785727 Yunping Xu, Shenzhen, China
Cw*0823 NT01030 FJ797372 Carolyn K Hurley, Washington DC, USA
Cw*1613 HN-68928-4 FJ594523 Histogenetics, Ossining, USA
Cw*1614 HN-08233-7 FJ594545 Histogenetics, Ossining, USA
DRB1*031302 N-634755 FM998808 Rainer Blasczyk, Hannover, Germany
DRB1*0717 AKB-642962 FM998810 Rainer Blasczyk, Hannover, Germany
DRB1*1485 K26647 AB485773 Etsuko Maruya, Kyoto, Japan

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*01010101 B4702 EU445470 Lixing Yan, Hangzhou, China
A*02010101 B9537 EU445471 Lixing Yan, Hangzhou, China
A*03010101 B9563 EU445472 Lixing Yan, Hangzhou, China
A*0347 NT01019 FJ797383 Carolyn K Hurley, Washington DC, USA
A*110101 B9910 EU445473 Lixing Yan, Hangzhou, China
A*2301 B6001 EU445474 Lixing Yan, Hangzhou, China
A*24020101 B9564 EU445475 Lixing Yan, Hangzhou, China
A*2493 NT01016 FJ797386 Carolyn K Hurley, Washington DC, USA
A*260101 B8596 EU445476 Lixing Yan, Hangzhou, China
A*29010101 B9545 EU445477 Lixing Yan, Hangzhou, China
A*300101 B10455 EU445478 Lixing Yan, Hangzhou, China
A*310102 B9736 EU445479 Lixing Yan, Hangzhou, China
A*320101 B9188 EU445480 Lixing Yan, Hangzhou, China
A*330301 B9445 EU445481 Lixing Yan, Hangzhou, China
A*340101 B10328 EU445482 Lixing Yan, Hangzhou, China
A*680102 B10496 EU445483 Lixing Yan, Hangzhou, China
A*6901 B11264 EU445484 Lixing Yan, Hangzhou, China
A*9254 HN-05973-4 FJ765945 Histogenetics, Ossining, USA
A*9258 HN-53878-6,
HN-40256-2
FJ619450,
FJ765905
Histogenetics, Ossining, USA
B*070207 HN-69654-1,
HN-21410-5,
HN-51978-7
FJ594498,
FJ594577,
FJ594579
Histogenetics, Ossining, USA
B*0762 HN-43686-6 FJ594562 Histogenetics, Ossining, USA
B*0763 HN-13211-7,
HN-21642-3,
HN-05697-8
FJ594502,
FJ594503,
FJ594588
Histogenetics, Ossining, USA
B*391902 HN-49180-3 FJ594494 Histogenetics, Ossining, USA
B*4090 NT01027 FJ973375 Carolyn K Hurley, Washington DC, USA
B*5143 HN-62470-2 FJ594584 Histogenetics, Ossining, USA
B*5150 HN-98621-5,
HN-19150-3
FJ594496,
FJ594575
Histogenetics, Ossining, USA
B*520602 HN-01589-2 FJ594570 Histogenetics, Ossining, USA
B*5525 HN-19679-3 FJ594583 Histogenetics, Ossining, USA
B*9553 HN-71150-9,
HN-70918-2
FJ502329,
FJ502331
Histogenetics, Ossining, USA
DRB1*110201 JVM FM995499 Jacqy DH Anholts, Leiden, The Netherlands

Table 3: Recently Published Sequences


Sequence References
A*0115N (1)
A*0123 (1)
A*0124 (1)
A*0125 (1)
A*0126 (1)
A*0129 (1)
A*0130 (1)
A*020604 (1)
A*020605 (1)
A*023503 (1)
A*0329 (1)
A*0332 (1)
A*2315 (1)
A*2472 (1)
A*2477 (1)
A*2481 (1)
A*2482 (1)
A*2635 (1)
A*2917 (1)
A*3022 (1)
A*3116 (1)
A*3118 (1)
A*320103 (1)
A*3311 (1)
A*3312 (1)
A*3313 (1)
A*6839 (1)
A*6840 (1)
A*9214 (1)
A*9215 (1)
A*9218 (1)
A*9219 (1)
A*9220 (1)
A*9222 (1)
A*9223 (1)
A*9228 (1)
A*9236 (1)
B*072202 (1)
B*0764 (1)
B*0836 (1)
B*0838 (2)
B*1322 (1)
B*1408 (1)
B*1409 (1)
B*1829 (1)
B*2741 (1)
B*2742 (1)
B*2743 (1)
B*356802 (1)
B*3584 (1)
B*3590 (1)
B*3591 (1)
B*390105 (1)
B*391902 (1)
B*4087 (1)
B*4090 (1)
B*4460 (1)
B*4508 (1)
B*460102 (3)
B*5153 (1)
B*5154 (1)
B*5155 (1)
B*5156 (1)
B*5158 (4)
B*5213 (1)
B*5316 (1)
B*5531 (1)
B*5622 (1)
B*5623 (1)
B*5717 (1)
B*5719 (5)
B*5816 (1)
B*5817N (1)
B*5818 (1)
B*8104N (1)
B*9543 (1)
B*9545 (1)
B*9547 (1)
Cw*0819 (6)
G*010115 (7)
G*010116 (7)
G*010117 (7)
G*010118 (7)
G*010119 (7)
G*010405 (7)
DRB1*0117 (1)
DRB1*0118 (1)
DRB1*0119 (1)
DRB1*0337 (1)
DRB1*0338 (1)
DRB1*0339 (1)
DRB1*040103 (1)
DRB1*040505 (1)
DRB1*0468 (1)
DRB1*0469 (1)
DRB1*0470 (1)
DRB1*0471 (1)
DRB1*0834 (1)
DRB1*1002 (1)
DRB1*116501 (1)
DRB1*1166 (1)
DRB1*1380 (1)
DRB1*1381 (1)
DRB1*144402 (1)
DRB1*1469 (1)
DRB1*1470 (1)
DRB1*1471 (1)
DRB1*1472 (1)
DRB1*1473 (1)
DRB1*1523 (1)
DRB1*1524 (1)
DRB1*1525 (1)
DRB1*1526 (1)
DRB1*1527 (1)
DRB1*1612 (1)

References

  1. Lazaro AM, Xiao Y, Regenscheid A, Ng J, Hurley CK, Posch PE. Characterization of 104 novel alleles at the HLA-A, -B, and -DRB1 loci from National Marrow Donor Program volunteer donors. Tissue Antigens. 2009 73:364-72.
  2. Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-B*08 variant--B*0838. Tissue Antigens. 2009 73:373-4.
  3. Chu CC, Lee HL, Lin M. Identification of a novel HLA-B allele, B*460102, in three Taiwanese individuals. Tissue Antigens. 2009 73:374-5.
  4. Roh EY, Shin S, Yoon JH, Ahn BM, Chang JY. A new HLA-B*51 variant, B*5158, identified by sequence-based typing in a Korean individual. Tissue Antigens. 2009 73:375-6.
  5. Figueiredo C, Mbulaiteye S, Ndugwa CM, Schulz T, Eiz-Vesper B. Assessment of the amino acid substitution in HLA-B*5719 for allorecognition. Tissue Antigens. 2009 73:376-8.
  6. Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-C allele: Cw*0819. Tissue Antigens. 2009 73:378-9.
  7. Lajoie J, Boivin AA, Jeanneau A, Faucher MC, Roger M. Identification of six new HLA-G alleles with non-coding DNA base changes. Tissue Antigens. 2009 73:379-80.