HLA Nomenclature @ hla.alleles.org

Nomenclature for Factors of the HLA System

March 2009

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

Tissue Antigens. 2009 74:183-6
Human Immunology. 2009 70:556-9
International Journal of Immunogenetics. 2009 36:305-8

The following sequences have been submitted to the Nomenclature Committee since the February 2009 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences

Sequence	Cell identification	Accession number	Submitting author
A*010106	HN-54982-5	FJ765908	Histogenetics, Ossining, USA
A*0135	NT01014	FJ797388	Carolyn K Hurley, Washington DC, USA
A*030111	HN-80503-6	FJ765913	Histogenetics, Ossining, USA
A*0350	NT01013	FJ797389	Carolyn K Hurley, Washington DC, USA
A*0351	NT01015	FJ797387	Carolyn K Hurley, Washington DC, USA
A*1141	ERCB-FO-01/00183-379CB08	FN178525	Sonia Nesci, Pesaro, Italy
A*1142	NT01021	FJ797381	Carolyn K Hurley, Washington DC, USA
A*2321	NT01022	FJ797380	Carolyn K Hurley, Washington DC, USA
A*240218	HN-59221-9	FJ619404	Histogenetics, Ossining, USA
A*240219	HN-78059-1	FJ619421	Histogenetics, Ossining, USA
A*2638	NT01020	FJ797382	Carolyn K Hurley, Washington DC, USA
A*6847	BY00445	FJ797354	Carolyn K Hurley, Washington DC, USA
A*9267	HN-67321-2	FJ554624	Histogenetics, Ossining, USA
A*9268	HN-87835-4	FJ765914	Histogenetics, Ossining, USA
B*070208	HN-24405-0	FJ549405	Histogenetics, Ossining, USA
B*0775	09d00312	FM995501	Jacqy DH Anholts, Leiden, The Netherlands
B*0776	NT01023	FJ797379	Carolyn K Hurley, Washington DC, USA
B*1834	HN-64083-9	FJ392181	Histogenetics, Ossining, USA
B*2750	NT01029	FJ797373	Carolyn K Hurley, Washington DC, USA
B*3598	HN-16151-4	FJ560459	Histogenetics, Ossining, USA
B*3599	BY00446	FJ797351	Carolyn K Hurley, Washington DC, USA
B*3819	NT01025	FJ797377	Carolyn K Hurley, Washington DC, USA
B*4468	HN-41637-0	FJ502323	Histogenetics, Ossining, USA
B*4469	NT01026	FJ797376	Carolyn K Hurley, Washington DC, USA
B*5169	HN-84899-5	FJ392179	Histogenetics, Ossining, USA
B*5170	HN-83758-5	FJ502327	Histogenetics, Ossining, USA
B*9558	NT01024	FJ797378	Carolyn K Hurley, Washington DC, USA
B*9559	NT01012	FJ797390	Carolyn K Hurley, Washington DC, USA
B*9560	NT01028	FJ797374	Carolyn K Hurley, Washington DC, USA
Cw*010207	HN-76798-8	FJ594542	Histogenetics, Ossining, USA
Cw*0126	NT01038	FJ797364	Carolyn K Hurley, Washington DC, USA
Cw*0127	NT01032	FJ797370	Carolyn K Hurley, Washington DC, USA
Cw*020207	HN-85664-1, HN-60463-7	FJ594543, FJ594540	Histogenetics, Ossining, USA
Cw*0224	HN-73058-3	FJ594525	Histogenetics, Ossining, USA
Cw*0225Q	HN-24736-9	FJ594546	Histogenetics, Ossining, USA
Cw*0226	NT01041	FJ797361	Carolyn K Hurley, Washington DC, USA
Cw*0227	NT01036	FJ797366	Carolyn K Hurley, Washington DC, USA
Cw*030306	HN-12246-5	FJ594534	Histogenetics, Ossining, USA
Cw*0351	HN-11322-9	FJ594513	Histogenetics, Ossining, USA
Cw*0352	HN-92965-7	FJ594520	Histogenetics, Ossining, USA
Cw*0353	HN-25274-5	FJ594521	Histogenetics, Ossining, USA
Cw*0354	HN-64893-3	FJ594529	Histogenetics, Ossining, USA
Cw*0355	HN-21141-7	FJ594535	Histogenetics, Ossining, USA
Cw*0357	HN-51959-5, HN-61018-8	FJ594539, FJ594541	Histogenetics, Ossining, USA
Cw*0357	BY00450	FJ797349	Carolyn K Hurley, Washington DC, USA
Cw*0358	BY00444	FJ797358	Carolyn K Hurley, Washington DC, USA
Cw*040107	HN-44391-1	FJ594536	Histogenetics, Ossining, USA
Cw*040108	HN-46140-0	FJ594538	Histogenetics, Ossining, USA
Cw*0438	08d05807	FM995500	Jacqy DH Anholts, Leiden, The Netherlands
Cw*0439	HN-46107-9	FJ594537	Histogenetics, Ossining, USA
Cw*0440	NT01040	FJ797362	Carolyn K Hurley, Washington DC, USA
Cw*0525	SCU-505	FJ750479	Antonio Balas, Madrid, Spain
Cw*0621	HN-72910-6	FJ594524	Histogenetics, Ossining, USA
Cw*0622	RV156-101196	EU707573	Gustavo Kijak, Rockville, USA
Cw*0623	NT01033	FJ797369	Carolyn K Hurley, Washington DC, USA
Cw*0768	NT01039	FJ797363	Carolyn K Hurley, Washington DC, USA
Cw*0769	NT01031	FJ797371	Carolyn K Hurley, Washington DC, USA
Cw*0770	NT01034	FJ797368	Carolyn K Hurley, Washington DC, USA
Cw*0771	NT01037	FJ797365	Carolyn K Hurley, Washington DC, USA
Cw*0772	NT01042, NT01035	FJ797360, FJ797367	Carolyn K Hurley, Washington DC, USA
Cw*0822	009402	FJ785727	Yunping Xu, Shenzhen, China
Cw*0823	NT01030	FJ797372	Carolyn K Hurley, Washington DC, USA
Cw*1613	HN-68928-4	FJ594523	Histogenetics, Ossining, USA
Cw*1614	HN-08233-7	FJ594545	Histogenetics, Ossining, USA
DRB1*031302	N-634755	FM998808	Rainer Blasczyk, Hannover, Germany
DRB1*0717	AKB-642962	FM998810	Rainer Blasczyk, Hannover, Germany
DRB1*1485	K26647	AB485773	Etsuko Maruya, Kyoto, Japan

Table 2: Confirmatory Sequences

Sequence	Cell identification	Accession number	Submitting author
A*01010101	B4702	EU445470	Lixing Yan, Hangzhou, China
A*02010101	B9537	EU445471	Lixing Yan, Hangzhou, China
A*03010101	B9563	EU445472	Lixing Yan, Hangzhou, China
A*0347	NT01019	FJ797383	Carolyn K Hurley, Washington DC, USA
A*110101	B9910	EU445473	Lixing Yan, Hangzhou, China
A*2301	B6001	EU445474	Lixing Yan, Hangzhou, China
A*24020101	B9564	EU445475	Lixing Yan, Hangzhou, China
A*2493	NT01016	FJ797386	Carolyn K Hurley, Washington DC, USA
A*260101	B8596	EU445476	Lixing Yan, Hangzhou, China
A*29010101	B9545	EU445477	Lixing Yan, Hangzhou, China
A*300101	B10455	EU445478	Lixing Yan, Hangzhou, China
A*310102	B9736	EU445479	Lixing Yan, Hangzhou, China
A*320101	B9188	EU445480	Lixing Yan, Hangzhou, China
A*330301	B9445	EU445481	Lixing Yan, Hangzhou, China
A*340101	B10328	EU445482	Lixing Yan, Hangzhou, China
A*680102	B10496	EU445483	Lixing Yan, Hangzhou, China
A*6901	B11264	EU445484	Lixing Yan, Hangzhou, China
A*9254	HN-05973-4	FJ765945	Histogenetics, Ossining, USA
A*9258	HN-53878-6, HN-40256-2	FJ619450, FJ765905	Histogenetics, Ossining, USA
B*070207	HN-69654-1, HN-21410-5, HN-51978-7	FJ594498, FJ594577, FJ594579	Histogenetics, Ossining, USA
B*0762	HN-43686-6	FJ594562	Histogenetics, Ossining, USA
B*0763	HN-13211-7, HN-21642-3, HN-05697-8	FJ594502, FJ594503, FJ594588	Histogenetics, Ossining, USA
B*391902	HN-49180-3	FJ594494	Histogenetics, Ossining, USA
B*4090	NT01027	FJ973375	Carolyn K Hurley, Washington DC, USA
B*5143	HN-62470-2	FJ594584	Histogenetics, Ossining, USA
B*5150	HN-98621-5, HN-19150-3	FJ594496, FJ594575	Histogenetics, Ossining, USA
B*520602	HN-01589-2	FJ594570	Histogenetics, Ossining, USA
B*5525	HN-19679-3	FJ594583	Histogenetics, Ossining, USA
B*9553	HN-71150-9, HN-70918-2	FJ502329, FJ502331	Histogenetics, Ossining, USA
DRB1*110201	JVM	FM995499	Jacqy DH Anholts, Leiden, The Netherlands

Table 3: Recently Published Sequences

Sequence	References
A*0115N	(1)
A*0123	(1)
A*0124	(1)
A*0125	(1)
A*0126	(1)
A*0129	(1)
A*0130	(1)
A*020604	(1)
A*020605	(1)
A*023503	(1)
A*0329	(1)
A*0332	(1)
A*2315	(1)
A*2472	(1)
A*2477	(1)
A*2481	(1)
A*2482	(1)
A*2635	(1)
A*2917	(1)
A*3022	(1)
A*3116	(1)
A*3118	(1)
A*320103	(1)
A*3311	(1)
A*3312	(1)
A*3313	(1)
A*6839	(1)
A*6840	(1)
A*9214	(1)
A*9215	(1)
A*9218	(1)
A*9219	(1)
A*9220	(1)
A*9222	(1)
A*9223	(1)
A*9228	(1)
A*9236	(1)
B*072202	(1)
B*0764	(1)
B*0836	(1)
B*0838	(2)
B*1322	(1)
B*1408	(1)
B*1409	(1)
B*1829	(1)
B*2741	(1)
B*2742	(1)
B*2743	(1)
B*356802	(1)
B*3584	(1)
B*3590	(1)
B*3591	(1)
B*390105	(1)
B*391902	(1)
B*4087	(1)
B*4090	(1)
B*4460	(1)
B*4508	(1)
B*460102	(3)
B*5153	(1)
B*5154	(1)
B*5155	(1)
B*5156	(1)
B*5158	(4)
B*5213	(1)
B*5316	(1)
B*5531	(1)
B*5622	(1)
B*5623	(1)
B*5717	(1)
B*5719	(5)
B*5816	(1)
B*5817N	(1)
B*5818	(1)
B*8104N	(1)
B*9543	(1)
B*9545	(1)
B*9547	(1)
Cw*0819	(6)
G*010115	(7)
G*010116	(7)
G*010117	(7)
G*010118	(7)
G*010119	(7)
G*010405	(7)
DRB1*0117	(1)
DRB1*0118	(1)
DRB1*0119	(1)
DRB1*0337	(1)
DRB1*0338	(1)
DRB1*0339	(1)
DRB1*040103	(1)
DRB1*040505	(1)
DRB1*0468	(1)
DRB1*0469	(1)
DRB1*0470	(1)
DRB1*0471	(1)
DRB1*0834	(1)
DRB1*1002	(1)
DRB1*116501	(1)
DRB1*1166	(1)
DRB1*1380	(1)
DRB1*1381	(1)
DRB1*144402	(1)
DRB1*1469	(1)
DRB1*1470	(1)
DRB1*1471	(1)
DRB1*1472	(1)
DRB1*1473	(1)
DRB1*1523	(1)
DRB1*1524	(1)
DRB1*1525	(1)
DRB1*1526	(1)
DRB1*1527	(1)
DRB1*1612	(1)

References

Lazaro AM, Xiao Y, Regenscheid A, Ng J, Hurley CK, Posch PE. Characterization of 104 novel alleles at the HLA-A, -B, and -DRB1 loci from National Marrow Donor Program volunteer donors. Tissue Antigens. 2009 73:364-72.
Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-B*08 variant--B*0838. Tissue Antigens. 2009 73:373-4.
Chu CC, Lee HL, Lin M. Identification of a novel HLA-B allele, B*460102, in three Taiwanese individuals. Tissue Antigens. 2009 73:374-5.
Roh EY, Shin S, Yoon JH, Ahn BM, Chang JY. A new HLA-B*51 variant, B*5158, identified by sequence-based typing in a Korean individual. Tissue Antigens. 2009 73:375-6.
Figueiredo C, Mbulaiteye S, Ndugwa CM, Schulz T, Eiz-Vesper B. Assessment of the amino acid substitution in HLA-B*5719 for allorecognition. Tissue Antigens. 2009 73:376-8.
Johnson J, Street J, Hammond L, Pepperall J, Darke C. A new HLA-C allele: Cw*0819. Tissue Antigens. 2009 73:378-9.
Lajoie J, Boivin AA, Jeanneau A, Faucher MC, Roger M. Identification of six new HLA-G alleles with non-coding DNA base changes. Tissue Antigens. 2009 73:379-80.