Nomenclature for Factors of the HLA System

January 2009

Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.

Published In:

The following sequences have been submitted to the Nomenclature Committee since the December 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.

All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.

Table 1: New Sequences


Sequence Cell identification Accession number Submitting author
A*0134N 37935 FM209476 Jane Rowlands, Pontyclun, United Kingdom
A*2320 BJ056 FJ518827 Zhixin Zhang, Beijing, China
A*2498 p3531 FJ560745 Lixing Yan, Hangzhou, China
A*2499 C4563 AB441825 Chizuko Horie, Seto, Japan
A*330303 p3540 FJ560746 Lixing Yan, Hangzhou, China
A*6609 192741 FM955271 Klaus Witter, M�nchen, Germany
A*9257 30883 FJ652064 Wei Dong, Philadelphia, USA
B*0769 IME725-08T,
IME726-08T,
IME728-08T		 FJ603314 Maneula Testi, Rome, Italy
B*0770 ALZ6703 EU184011 Dawn Thomas, Cleveland, USA
B*0771 BY00395 FJ619499 Carolyn K Hurley, Washington DC, USA
B*0772 BY00399 FJ619477 Carolyn K Hurley, Washington DC, USA
B*130205 p3568 FJ596198 Lixing Yan, Hangzhou, China
B*1324 SZ-18 FJ561483 Hong-Yan Zou, Shenzhen, China
B*1833 BY00396 FJ619498 Carolyn K Hurley, Washington DC, USA
B*2746 BY00401 FJ619494 Carolyn K Hurley, Washington DC, USA
B*350302 102570 FJ619519 Mary Sue Leffell, Baltimore, USA
B*3595 DEMBG-2009398 FJ639840 Andreas Parkner, Magdeburg, Germany
B*3595 BY00419 FJ649611 Carolyn K Hurley, Washington DC, USA
B*3818 SZ-17 FJ561482 Hong-Yan Zou, Shenzhen, China
B*3947 BY00417 FJ619478 Carolyn K Hurley, Washington DC, USA
B*4095 BY00418 FJ649612 Carolyn K Hurley, Washington DC, USA
B*4096 SDBC-HLA-2 FJ374890 Yi Zhang, Jinan, China
B*4466 C140734 FJ600545 Robert Endres, Tempe, USA
B*4467 BY00420 FJ649610 Carolyn K Hurley, Washington DC, USA
B*461302 BY00397 FJ619497 Carolyn K Hurley, Washington DC, USA
B*5164 BY00393 FJ619501 Carolyn K Hurley, Washington DC, USA
B*5165 BY00402 FJ619493 Carolyn K Hurley, Washington DC, USA
B*5317 CHE-B53 FM955319 Valerie Dubois, Lyon, France
B*5318 BY00394 FJ619500 Carolyn K Hurley, Washington DC, USA
B*9552 SDBC-HLA-3 FJ374888 Weidong He, Jinan, China
B*9553 1443/08 FM957458 Sandra Wienzek, Giessen, Germany
B*9554 BY00398 FJ619496 Carolyn K Hurley, Washington DC, USA
B*9555 BY00400 FJ619495 Carolyn K Hurley, Washington DC, USA
B*9556 BY00416 FJ619479 Carolyn K Hurley, Washington DC, USA
Cw*0123 015298X FJ594417 Zareen Goburdhun, London, United Kingdom
Cw*021602 PARAC FJ542024 Youri Serov, Indianapolis, USA
Cw*0620 1835-08 FM958448 Florian Emmerich, Freiburg, Germany
Cw*0766 SZBM02 FJ629179 Zhihui Deng, ShenZhen, China
Cw*0767 SZBM03 FJ629180 Zhihui Deng, ShenZhen, China
Cw*0820 SZBM383 FJ481115 Zhihui Deng, ShenZhen, China
Cw*0821 SZBM04 FJ650400 Zhihui Deng, ShenZhen, China
Cw*121402 77-2438-2412 AB441824 Chizuko Horie, Seto, Japan
G*01010106 CUI-79 FJ449755 Jorge Martinez-Laso, Madrid, Spain
DRB1*1219 SDBC-HLA-zwy FJ374889 Xiangmin Nie, Jinan, China
DRB1*1484 HB08101205 FJ594768 Tsung-Dao Lee, Taipei, Taiwan
DQB1*0324 JUR-DQ3 FM955320 Valerie Dubois, Lyon, France
DPB1*050102 166240 FM992365 Klaus Witter, M�nchen, Germany

Table 2: Confirmatory Sequences


Sequence Cell identification Accession number Submitting author
A*0103 RENOPhil FM882249 Anne Dormoy, Strasbourg, France
A*2495 100482 FJ619520 Mary Sue Leffell, Baltimore, USA
B*0751 BY00421 FJ669609 Carolyn K Hurley, Washington DC, USA
B*0764 BY00403 FJ619492 Carolyn K Hurley, Washington DC, USA
B*1310 BY00404 FJ619484 Carolyn K Hurley, Washington DC, USA
B*1311 BY00405 FJ619491 Carolyn K Hurley, Washington DC, USA
B*1530 1-5004,
1-5026		 FJ609980 Carmen Alaez, Mexico, Mexico
B*1574 BY00410 FJ619486 Carolyn K Hurley, Washington DC, USA
B*1813 BY00408 FJ619488 Carolyn K Hurley, Washington DC, USA
B*3574 BY00411 FJ619485 Carolyn K Hurley, Washington DC, USA
B*370103 BY00412 FJ619483 Carolyn K Hurley, Washington DC, USA
B*3929 BY00415 FJ619480 Carolyn K Hurley, Washington DC, USA
B*4044 BY00406 FJ619490 Carolyn K Hurley, Washington DC, USA
B*4462 BY00414 FJ619481 Carolyn K Hurley, Washington DC, USA
B*510902 BY00409 FJ619487 Carolyn K Hurley, Washington DC, USA
B*5806 BY00407 FJ619489 Carolyn K Hurley, Washington DC, USA
DPB1*0601 168621 FM992366 Klaus Witter, M�nchen, Germany
DPB1*1601 143058 FM992080 Klaus Witter, M�nchen, Germany
DPB1*1801 169716 FM991729 Klaus Witter, M�nchen, Germany
DPB1*2301 151979 FM956650 Klaus Witter, M�nchen, Germany
DPB1*2801 166240 FM992364 Klaus Witter, M�nchen, Germany

Table 3: Recently Published Sequences


Sequence References
A*1131 (1)
B*5620 (2)
B*5716 (2)
DRB1*110107 (2)
DRB1*1474 (2)
DPA1*010602 (3)

References

  1. Chen MJ, Chu CC, Shyr MH, Lin PY, Yang KL. Identification of a novel HLA-A allele, A*1131, in a Taiwanese. Int J Immunogenet. 2009 36:121-3.
  2. Rahal M, Kervaire B, Villard J, Tiercy JM. DNA typing by microbead arrays and PCR-SSP: apparent false-negative or -positive hybridization or amplification signals disclose new HLA-B and -DRB1 alleles. Tissue Antigens. 2008 71:238-41
  3. Peterson TA, Luo M, Mao X, Brunham RC, Plummer FA. Identification of a novel DPA1 allele, DPA1*010602, in an East African population. Hum Immunol. 2008 69:885-6