Nomenclature for Factors of the HLA System
December 2008
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System.
Published In:
- Tissue Antigens. 2009 73:629-31
- Human Immunology. 2009 70:208-9
- International Journal of Immunogenetics. 2009 36:197-8
The following sequences have been submitted to the Nomenclature Committee since the November 2008 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report.
Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released, in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles, a listing of recent publications which describe new HLA sequences is given in Table 3.
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided. The IMGT/HLA Database may be accessed via the world wide web at : http://ww.ebi.ac.uk/imgt/hla/.
The sequence previously named as DRB1*1171 has now been shown to be a correction of the DRB1*110201 allele sequence, as such the name DRB1*1171 has now been abandoned.
Table 1: New Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0133 | BY00386 | FJ517146 | Carolyn K Hurley, Washington DC, USA |
| A*030110 | BY00387 | FJ517145 | Carolyn K Hurley, Washington DC, USA |
| A*0346 | BY00374 | FJ464348 | Carolyn K Hurley, Washington DC, USA |
| A*1140 | BY00385 | FJ517147 | Carolyn K Hurley, Washington DC, USA |
| A*2497 | BY00373 | FJ464349 | Carolyn K Hurley, Washington DC, USA |
| A*2508 | By00377 | FJ464345 | Carolyn K Hurley, Washington DC, USA |
| A*260107 | LUMC-A56 | FM945329 | Jacqy DH Anholts, Leiden, The Netherlands |
| A*2919 | BY00367 | FJ464355 | Carolyn K Hurley, Washington DC, USA |
| A*3028 | BY00378 | FJ464344 | Carolyn K Hurley, Washington DC, USA |
| A*3124 | BY00372 | FJ464350 | Carolyn K Hurley, Washington DC, USA |
| A*3218 | BY00370 | FJ464352 | Carolyn K Hurley, Washington DC, USA |
| A*3218 | BY00371 | FJ464351 | Carolyn K Hurley, Washington DC, USA |
| A*3323 | BY00376 | FJ464346 | Carolyn K Hurley, Washington DC, USA |
| A*6845 | BY00368 | FJ464354 | Carolyn K Hurley, Washington DC, USA |
| A*6846 | BY00390 | FJ517142 | Carolyn K Hurley, Washington DC, USA |
| A*9253 | BY00375 | FJ464347 | Carolyn K Hurley, Washington DC, USA |
| A*9254 | BY00388 | FJ517144 | Carolyn K Hurley, Washington DC, USA |
| A*9255 | BY00389 | FJ517143 | Carolyn K Hurley, Washington DC, USA |
| A*9256 | BY00391 | FJ517141 | Carolyn K Hurley, Washington DC, USA |
| B*2745 | Henan-13 | FJ411059 | Bowei Zhang, Zhengzhou, China |
| B*4094 | LUMC-B40 | FM945330 | Jacqy DH Anholts, Leiden, The Netherlands |
| Cw*04010103 | 08009370 | FJ515899 | Yunping Xu, Shenzhen, China |
| Cw*05010102 | SSTO | BX243810 | Stephan Beck, London, United Kingdom |
| Cw*0523 | FRFLY15266 | FM865852 | Anne Dormoy, Strasbourg, France |
| G*010117 | BCCR-773, BCCR-1502 |
FJ460464 | Michel Roger, Montreal, Canada |
| G*010118 | BCCR-991 | FJ469162 | Michel Roger, Montreal, Canada |
| G*010119 | Rog338, Rog342, Rog366, Rog425 |
FJ464336 | Michel Roger, Montreal, Canada |
| G*010405 | Rog482, Rog500, Rog504 |
FJ464335 | Michel Roger, Montreal, Canada |
| DRB1*0478 | SZGSQ2 | FJ547092 | Su-Qing Gao, Shenzhen, China |
| DRB1*111302 | 97708 | FM878944 | Juergen Enczmann, Duesseldorf, Germany |
| DRB1*1218 | SZK1 | FJ481086 | Su-Qing Gao, Shenzhen, China |
| DRB3*0224 | W153 | FJ515276 | Erik Rozemuller, Utrecht, The Netherlands |
| DRB3*030103 | THAI742 | FJ515277 | Erik Rozemuller, Utrecht, The Netherlands |
| DPB1*2402 | 191849 | FM883600 | Klaus Witter, M�nchen, Germany |
Table 2: Confirmatory Sequences
| Sequence | Cell identification | Accession number | Submitting author |
|---|---|---|---|
| A*0287 | BY00382 | FJ464340 | Carolyn K Hurley, Washington DC, USA |
| A*1117 | BY00379 | FJ464343 | Carolyn K Hurley, Washington DC, USA |
| A*2495 | BY00363 | FJ358709 | Carolyn K Hurley, Washington DC, USA |
| A*3118 | BY00381 | FJ464341 | Carolyn K Hurley, Washington DC, USA |
| A*3217 | BY00369 | FJ464353 | Carolyn K Hurley, Washington DC, USA |
| A*7408 | BY00383 | FJ464339 | Carolyn K Hurley, Washington DC, USA |
| A*9246 | BY00384 | FJ464338 | Carolyn K Hurley, Washington DC, USA |
| B*4442 | BT00380 | FJ464342 | Carolyn K Hurley, Washington DC, USA |
| G*010112 | SSTO | BX247949 | Stephan Beck, London, United Kingdom |
| DRB1*0474 | FFM5175 | FM886832 | Veronika Brixner, Frankfurt/Main, Germany |
| DRB1*110201 | 72393 | FM209426 | Juergen Enczmann, Duesseldorf, Germany |
| DPB1*1701 | UCLA0584 | FM882212 | Klaus Witter, M�nchen, Germany |
Table 3: Recently Published Sequences
| Sequence | References |
|---|---|
| A*1135 | (1) |
| A*2486N | (2) |
| A*9250 | (3) |
| B*3572 | (4) |
| B*370103 | (4) |
| B*3714 | (5) |
| B*4076 | (6) |
| B*4081 | (7) |
| B*4617 | (8) |
| B*580102 | (9) |
| B*9509 | (4) |
| Cw*0222 | (10) |
| Cw*0434 | (10) |
| Cw*0436 | (11) |
| DRB1*0462 | (4) |
| DRB1*1157 | (4) |
| DRB1*1167 | (12) |
| DRB1*1478 | (13) |
| DRB1*150204 | (4) |
| DRB3*010105 | (14) |
| DRB3*0112 | (14) |
| DRB3*0113 | (14) |
| DPA1*010602 | (15) |
| MICA*054 | (16) |
| MICA*056 | (16) |
References
- Han SH, Jung SM, Park SR, Chung SY, Han H. Identification of a new HLA-A*11 allele, HLA-A*1135, by sequence-based typing in Korean individual. Tissue Antigens. 2009 73:62-3.
- Yan LX, Zhu FM, Zhang W, He YM, He JJ. Full-length sequence of a novel null allele, HLA-A*2486N. Tissue Antigens. 2009 73:63-5.
- Canossi A, Del Beato T, Liberatore G, Papola F, Adorno D. Identification of the novel HLA-A*9250 allele by sequence-based typing in a Caucasian bone marrow donor from Italy. Tissue Antigens. 2009 73:65-7.
- Lazaro AM, Hwang WY, Yeoh AE, Ng J, Posch PE. Characterization of new HLA-B and -DRB1 alleles from Singapore. Tissue Antigens. 2009 73:75-6.
- Emmerich F, Schonemann C, Diederich G, Salama A. Haplotype-specific sequencing reveals a novel HLA-B*37 allele, B*3714. Tissue Antigens. 2009 73:67.
- Li SY, Xie JH, Dong L, Yan LN, Yuan YH. Identification of the novel allele HLA-B*4076 by sequence-based typing in a Chinese individual. Tissue Antigens. 2009 73:68-9.
- Zou HY, Li Z, Cheng LH, Wang DM, Deng ZH. Identification of a new HLA-B*40 allele, HLA-B*4081, in a Chinese individual. Tissue Antigens. 2009 73:70-2.
- Sohn YH, Oh HB, Heo YS, Kwon OJ. Structural aspects of B*4617 molecule, a novel HLA-B*46 allele identified by sequence-based typing. Tissue Antigens. 2009 73:72-4.
- Zhu FM, Zhang W, He J, Yan LX. Identification of the novel allele HLA-B*580102 by sequence-based typing in a Chinese individual. Tissue Antigens. 2009 73:74-5.
- Johnson J, Street J, Hammond L, Iley C, Darke C. Two new HLA-C alleles: Cw*0222 and Cw*0434. Tissue Antigens. 2009 73:76-8.
- Lim J, Kim Y, Cho B, Chung NG, Bok JN. A novel HLA-Cw*0436 allele identified by haplotype-specific extraction and sequence-based typing. Tissue Antigens. 2009 73:78-9.
- Testi M, Lai S, Alba F, Andreani M, Carcassi C. Identification of a new HLA DRB1 allele (HLA-DRB1*1167) in a potential hematopoietic stem cell donor from Iraqi Kurdistan. Tissue Antigens. 2009 73:80-1.
- Han SH, Jung SM, Park SR, Chung SY, Han H. Identification of a new HLA-DRB1*14 variant, HLA-DRB1*1478, in a Korean individual. Tissue Antigens. 2009 73:81-3.
- Lee KW, Jung YA. Description of three novel HLA-DRB3 alleles: DRB3*010105, DRB3*0112 and DRB3*0113. Tissue Antigens. 2009 73:83-4.
- Peterson TA, Luo M, Mao X, Brunham RC, Plummer FA. Identification of a novel DPA1 allele, DPA1*010602, in an East African population. Hum Immunol. 2008 69:885-6.
- Cox ST, Stephens HA, Fernando R, Grant J, Madrigal JA, Little AM. Two novel MICA alleles, MICA*054 and MICA*056. Tissue Antigens. 2009 73:85-7.
